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1 ough the system Xc- antiporter to activate a metabotropic glutamate receptor.
2 Ca(2+) -permeable AMPA receptors and group I metabotropic glutamate receptors.
3 f glutamate release by presynaptic Group III metabotropic glutamate receptors.
4 esponses were depressed by the activation of metabotropic glutamate receptors.
5 strocytic glutamate release, and presynaptic metabotropic glutamate receptors.
6 nsmission, through the activation of type 1a metabotropic glutamate receptors.
7 Ca(2+) -permeable AMPA receptors and group I metabotropic glutamate receptors.
8 vagal afferent fibre-dependent activation of metabotropic glutamate receptors.
9 pic receptors is independent of signaling by metabotropic glutamate receptors.
10 mature granule cells (mGCs) through group II metabotropic glutamate receptors.
11 ynaptic ionotropic and metabotropic GABA and metabotropic glutamate receptors.
12 mediated by GABA(A/B)-R in combination with metabotropic glutamate receptors.
13 ent inhibition via the activation of group I metabotropic glutamate receptors.
14 elanoma due to ectopic overexpression of the metabotropic glutamate receptor 1 (Grm1) in melanocytes.
15 Previously, we have illustrated the role of metabotropic glutamate receptor 1 (GRM1) in neoplastic t
16 G protein-coupled receptor (GPCR) family C, metabotropic glutamate receptor 1 (mGluR1) and mGluR5.
18 an excellent PET radioligand for quantifying metabotropic glutamate receptor 1 (mGluR1) in monkey bra
20 well as the emergence of glutamate-activated metabotropic glutamate receptor 1 (mGluR1) signaling, ar
22 utamate to the ionotropic AMPA receptors and metabotropic glutamate receptor 1 and members of group 2
23 hese results highlight the important role of metabotropic glutamate receptor 1 in modulating sleep du
24 nd two different mutations in the same gene (metabotropic glutamate receptor 1) from two independent
25 iated protein 29, glutamate decarboxylase 1, metabotropic glutamate receptor 1, and excitatory amino
28 finity, selective antibody antagonist of the metabotropic glutamate receptor-1 (BBB-mGluR1), a widely
29 roteins: ankyrin-R, cell adhesion molecules, metabotropic glutamate receptor-1 (mGluR1), voltage-gate
30 nctional evidence that ERbeta interacts with metabotropic glutamate receptor 1a (mGluR1a) signaling t
32 ogenous beta-III spectrin interacts with the metabotropic glutamate receptor 1alpha (mGluR1alpha) and
34 L-ITCcs are GABAergic, and strongly express metabotropic glutamate receptor 1alpha and GABAA recepto
35 t the presynaptic G protein-coupled receptor metabotropic glutamate receptor 2 (mGlu(2)) robustly inh
38 the localization and trafficking of class C metabotropic glutamate receptor 2 (mGluR2) through a mec
39 ry, biology, and light to control endogenous metabotropic glutamate receptor 2 (mGluR2), a Family C G
42 blot analysis shows increased expression of metabotropic glutamate receptor 2 in THL synaptosomes of
43 We also determined the effect of the novel metabotropic glutamate receptor 2 positive allosteric mo
44 ggest that positive allosteric modulators of metabotropic glutamate receptor 2 should be considered f
46 ynaptic long-term depression mediated by the metabotropic glutamate receptor 2/3 (mGluR2/3-LTD) remai
47 e allosteric modulators selective for either metabotropic glutamate receptors 2 (mGlu(2)) or 3 (mGlu(
49 n in the NAc via bilateral injections of the metabotropic glutamate receptor-2/3 agonist LY379268 red
50 o LAC responsiveness (leptin receptors Lepr, metabotropic glutamate receptors-2 mGlu2, neuropeptide-Y
51 ies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect perform
54 Negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 5 (mGlu(5)) hold great p
56 Negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu5) have potential
58 regulator of synaptic protein synthesis, the metabotropic glutamate receptor 5 (mGlu5) protein, is si
59 hol drinking increases signaling through the metabotropic glutamate receptor 5 (mGlu5) receptor withi
60 Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a pr
61 entified a novel role of GluD1 in regulating metabotropic glutamate receptor 5 (mGlu5) signaling in t
62 genic procedures to investigate the role for metabotropic glutamate receptor 5 (mGlu5) signaling with
63 e allosteric modulators (NAMs) targeting the metabotropic glutamate receptor 5 (mGlu5) subtype are cu
65 ntify regional dopamine D(2/3) receptors and metabotropic glutamate receptor 5 (mGluR5) and assessed
66 lnesses, including disorders associated with metabotropic glutamate receptor 5 (mGluR5) and dopaminer
67 Here we investigated how Gq-protein-coupled metabotropic glutamate receptor 5 (mGluR5) and oxytocin
68 ly (within 30 min) and require activation of metabotropic glutamate receptor 5 (mGluR5) and protein s
70 sts with or without prior treatment with the metabotropic glutamate receptor 5 (mGluR5) antagonist 2-
80 While abnormal signaling mediated through metabotropic glutamate receptor 5 (mGluR5) is involved i
82 over of synaptic glutamate, which stimulates metabotropic glutamate receptor 5 (mGluR5) on a small po
83 cally, neurons release glutamate to activate metabotropic glutamate receptor 5 (mGluR5) on astrocytes
84 clinical data suggest that inhibition of the metabotropic glutamate receptor 5 (mGluR5) receptor migh
86 ligation induces a re-emergence of immature metabotropic glutamate receptor 5 (mGluR5) signaling in
88 esses developmental expression of astroglial metabotropic glutamate receptor 5 (mGluR5), a major rece
90 The most recently identified include the metabotropic glutamate receptor 5 (mGluR5), dipeptidyl-p
91 mouse model of Rett syndrome (Mecp2 KO) that metabotropic glutamate receptor 5 (mGluR5)- and protein-
92 esult from glutamate spillover, initiating a metabotropic glutamate receptor 5 (mGluR5)-dependent inc
93 h the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent syn
103 apparently equivalent PKC regulatory site in metabotropic glutamate receptor 5 (Ser-839) aligns not w
104 e receptors) or nonhyperbolic relationships (metabotropic glutamate receptor 5 and calcium-sensing re
109 r prion protein associates via transmembrane metabotropic glutamate receptor 5 with the intracellular
110 induced in GABA cells that was dependent on metabotropic glutamate receptor 5, and cannabinoid recep
111 ceptors, NMDA receptors, P2Y1 ATP receptors, metabotropic glutamate receptor 5, and TRP channels did
112 GluR1, GABABR1, and GABABR2 levels, whereas metabotropic glutamate receptor 5, NMDA receptor 2B, Glu
113 on domain containing protein 12, mitofusin2, metabotropic glutamate receptor 5, p21-activated kinase
114 gamma-aminobutyric acidergic dysfunction and metabotropic glutamate receptor 5-associated long-term d
117 ed from photoreceptors in the dark activates metabotropic glutamate receptor 6 (mGluR6) receptors in
118 bipolar cell glutamatergic transmission, the metabotropic glutamate receptor 6 and voltage-dependent
119 as normal in the Rs1-KO retina; however, the metabotropic glutamate receptor 6/transient receptor pot
120 a new, orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu(7)) negative all
121 two separate presynaptic components: mGluR7 (metabotropic glutamate receptor 7) and GluK2-KARs (kaina
123 -intrinsic manner, with postsynaptic Group 1 metabotropic glutamate receptor activation triggering lo
126 y, reducing glutamate release by the group 2 metabotropic glutamate receptor agonist LY379268 amelior
128 ed signaling pathways, activated via Group I metabotropic glutamate receptors and cholecystokinin 2 r
130 ranscriptionally dysregulated ionotropic and metabotropic glutamate receptors and glutamate transport
131 vation of both g-protein coupled GABA(B) and metabotropic glutamate receptors and involved an increas
132 c to connections with VLEs, requires group I metabotropic glutamate receptors, and has a presynaptic
133 ntagonists targeting multiple ionotropic and metabotropic glutamate receptors, and intracellular casc
134 d by systemic administration of the group II metabotropic glutamate receptor antagonist LY341495.
135 om a therapeutic standpoint because numerous metabotropic glutamate receptor antagonists are availabl
138 g by stimulating release-regulating group II metabotropic glutamate receptor autoreceptors to inhibit
139 l elements, AD-related genes, ionotropic and metabotropic glutamate receptors, cholinergic enzymes an
140 absence of FMRP in neurons abolishes group 1 metabotropic glutamate receptor-dependent DGK activity c
141 oreover, hippocampal NMDAR-dependent but not metabotropic glutamate receptor-dependent plasticity is
142 sent study showed that activation of group I metabotropic glutamate receptors enhanced spontaneous gl
144 Pharmacological manipulations of Group 1 metabotropic glutamate receptors (G1 mGluRs) demonstrate
147 us studies showing that FMRP couples Group I metabotropic glutamate receptor (GpI mGluR) signaling to
148 (P </= 2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously o
153 umption in a manner requiring intact group 1 metabotropic glutamate receptors, Homer2, phospholipase
154 tingly, eCB-LTD in PE animals was rescued by metabotropic glutamate receptor I activation, suggesting
155 ublished for the transmembrane domain of two metabotropic glutamate receptors in complex with negativ
156 ries that control the trafficking of group I metabotropic glutamate receptors in the central nervous
157 DISC1 disruption resulted in an increase of metabotropic glutamate receptor-induced intracellular ca
158 and behavioral measures to demonstrate that metabotropic glutamate receptor-induced sensitization of
159 Activation of the FMRP pathway by group I metabotropic glutamate receptors is involved in regulati
160 atergic transmission, through ionotropic and metabotropic glutamate receptors, is necessary for the c
161 ct to the resting membrane potential, type-1 metabotropic glutamate receptors locally enhance Ca(2+)
162 tudy demonstrates that expression of GRM3, a metabotropic glutamate receptor mainly expressed in mamm
164 ivity through the loss of cAMP regulation of metabotropic glutamate receptor-mediated intracellular C
166 Purkinje cells (PCs), where it mediates slow metabotropic glutamate receptor-mediated synaptic respon
167 e AMPA-type glutamate receptor GLR-1 and the metabotropic glutamate receptor MGL-1 in one of the prim
168 egrating neurons through a G protein-coupled metabotropic glutamate receptor, MGL-1, to release local
170 ssive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu1/5) is a core pat
171 ippocampal subfields, we speculated that the metabotropic glutamate receptor mGlu5 may regulate infor
172 sponses, some receptors, such as the group 1 metabotropic glutamate receptor, mGlu5, are also localiz
174 release, and its distribution overlaps with metabotropic glutamate receptor (mGluR) 5 in regional br
178 genic phenotype that is triggered by group I metabotropic glutamate receptor (mGluR) activation.
180 ing inhibition was abolished by group II/III metabotropic glutamate receptor (mGluR) antagonists in w
181 e impairments were rescued by treatment with metabotropic glutamate receptor (mGluR) antagonists or l
182 combination of P2 purinergic and group I/II metabotropic glutamate receptor (mGluR) antagonists redu
184 orders have been connected to alterations in metabotropic glutamate receptor (mGluR) signalling.
185 s altered at steady state and in response to metabotropic glutamate receptor (mGluR) stimulation, but
186 whether activation of one particular GPCR, a metabotropic glutamate receptor (mGluR), can reduce cone
187 )-knockout (KO) mice, and treatment with the metabotropic glutamate receptor (mGluR)-5 antagonist MTE
188 how increases in basal protein synthesis and metabotropic glutamate receptor (mGluR)-dependent long-t
189 ddition to the spine changes at basal state, metabotropic glutamate receptor (mGluR)-induced dendriti
190 eceptors (CP-AMPARs) and a switch in group I metabotropic glutamate receptor (mGluR)-mediated suppres
195 am and downstream signaling specificities of metabotropic glutamate receptors (mGluR), we have examin
197 SCA28 mice, partial genetic silencing of the metabotropic glutamate receptor mGluR1 decreased Ca(2)(+
198 show that agonist activation of the group I metabotropic glutamate receptor mGluR1 increases the str
204 anol excitation requires the activity of the metabotropic glutamate receptor, mGluR1, which is known
206 Glutamate directs GAD67 expression via the metabotropic glutamate receptor mGluR1beta on GABApre te
207 linear Ca(2+) signals are mediated by type-1 metabotropic glutamate receptors (mGluR1s) when the CF i
214 Here, we examine the significance of type 5 metabotropic glutamate receptors (mGluR5s) for behaviora
216 s, synaptic transmission is initiated by the metabotropic glutamate receptor, mGluR6, that signals vi
218 ith movement execution, EAAC1 limits group I metabotropic glutamate receptor (mGluRI) activation, fac
219 indings show that EAAC1 limits activation of metabotropic glutamate receptors (mGluRIs) in the striat
221 quires co-activation of postsynaptic group I metabotropic glutamate receptors (mGluRs) and Ca(2+) -pe
222 we focus on the class C GPCRs, which include metabotropic glutamate receptors (mGluRs) and gamma-amin
223 regulation of SPN activity via activation of metabotropic glutamate receptors (mGluRs) and muscarinic
224 e, is a potent agonist against the group III metabotropic glutamate receptors (mGluRs) and, thus, is
233 evoked responses, we show that activation of metabotropic glutamate receptors (mGluRs) by general and
234 ation of these two distinct release modes by metabotropic glutamate receptors (mGluRs) constitutes cr
237 brain and a selective binding with group III metabotropic glutamate receptors (mGluRs) in trans.
238 cordings, we show that activation of Group I metabotropic glutamate receptors (mGluRs) induces long-t
239 hippocampal synapses, activation of group I metabotropic glutamate receptors (mGluRs) induces long-t
241 gonists of ionotropic glutamate receptors or metabotropic glutamate receptors (mGluRs) or orthosteric
245 st synapse in the visual system, presynaptic metabotropic glutamate receptors (mGluRs) regulate cone
248 diverse ligand response specificities among metabotropic glutamate receptors (mGluRs), we combined c
249 single-molecule subunit counting on class C metabotropic glutamate receptors (mGluRs), we map dimeri
250 ed in adult mice with antagonists of group I metabotropic glutamate receptors (mGluRs), which have be
257 ologically inhibited and genetically ablated metabotropic glutamate receptors (mGluRs, especially mGl
258 c and allosteric antagonists of the group II metabotropic glutamate receptors (mGlus) have been used
259 glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which are clas
261 inal ON and OFF bipolar cells, and the novel metabotropic glutamate receptors of ON bipolar-cell dend
263 the tonic activation of presynaptic group II metabotropic glutamate receptors on inhibitory nerve ter
264 glutamate receptor 1 and members of group 2 metabotropic glutamate receptors on the plasma membrane.
265 t comprehensive structural comparison of all metabotropic glutamate receptors, placing selective nega
266 when coupled with concomitant activation of metabotropic glutamate receptors postsynaptic to cortica
268 h-power state because blocking ionotropic or metabotropic glutamate receptors results in high-power L
269 ment, we detect excess "gain of function" of metabotropic glutamate receptor signaling at an importan
270 hypothesized that the activation of group I metabotropic glutamate receptor signaling though the fra
271 e with high pharmacological specificity that metabotropic glutamate receptor signaling triggers openi
272 lso highlight emerging evidence that altered metabotropic glutamate receptor signalling and disrupted
273 Altered function of the Gq-coupled, Group 1 metabotropic glutamate receptors, specifically mGlu5, is
274 hine and cocaine exposure, we identified the metabotropic glutamate receptor subtype 4 (mGluR4) as a
279 ld be less disruptive have been proposed and metabotropic glutamate receptor subtype 5 (mGluR5) repre
280 is a potent and specific radioligand for the metabotropic glutamate receptor subtype 5 (mGluR5).
283 dvance the novel concept that a breakdown of metabotropic glutamate receptor subtype mGluR5 and endoc
284 cohol may be related, in part, to changes in metabotropic glutamate receptors-subtype 5 (mGluR5) in t
285 s in the discovery of allosteric ligands for metabotropic glutamate receptor subtypes 1-5 and 7 (mGlu
288 nchronous stimulation of a dimeric GPCR, the metabotropic glutamate receptor type 1 (mGluR1), by two
289 Moreover, contextual fear learning induced a metabotropic glutamate receptor type 1 (mGluR1)-mediated
292 recently showed marked global reductions in metabotropic glutamate receptor type 5 (mGluR5) binding
293 ng cocaine exposure, including a decrease in metabotropic glutamate receptor type 5 (mGluR5) expressi
295 in striatal astrocytes through activation of metabotropic glutamate receptor type 5 (mGluR5) signalin
297 trasynaptic signaling through ionotropic and metabotropic glutamate receptors, ultimately resulting i
298 ons was abolished with antagonists of type I metabotropic glutamate receptor, validating the glutamat
300 logical changes, we find the localization of metabotropic glutamate receptors within cone bipolar, bu