ライフサイエンスコーパス: metal ion

1 -center containing proteins (homo and hetero metal ions).

2 on, and the nature of the centrally chelated metal ion.

3 of the aqueous medium, and the nature of the metal ion.

4 reaction has been exploited for sensing of a metal ion.

5 not significantly affected by the choice of metal ion.

6 nvolved in the coordination of the substrate metal ion.

7 nd most selective binding towards a specific metal ion.

8 le that of the pistol ribozyme is a hydrated metal ion.

9 e radical complexes without oxidation of the metal ion.

10 e, and each vertex is occupied by a divalent metal ion.

11 ld(I/III) ions but is nonemissive with other metal ions.

12 umns for the enhanced extraction of multiple metal ions.

13 ation effects in the absence of paramagnetic metal ions.

14 atalyzed by naturally occurring minerals and metal ions.

15 mer that binds several biologically relevant metal ions.

16 ive, 'one-pot' coordination of soft and hard metal ions.

17 class of ratiometric fluorescent sensors for metal ions.

18 ctural stabilization of this domain by bound metal ions.

19 forming the coordination assemblies with the metal ions.

20 ng affinity toward a broad range of divalent metal ions.

21 ins that interact with endogenous lipids and metal ions.

22 cess through addition of differently charged metal ions.

23 le reduction and oxidation of the transition metal ions.

24 5 allows an adequate catalytic effect of the metal ions.

25 large oligomeric states with the addition of metal ions.

26 rase active site without involving catalytic metal ions.

27 bled with Mn, Fe, Co, Ni, Cu, or Zn bridging metal ions.

28 e the redox centers to reversibly react with metal ions.

29 to relatively high concentrations of Ca(2+) metal ions.

30 9%, and afterwards by its complexation with metal ions.

31 ical conductivity is provided by sorption of metal ions.

32 based on CsPbX(3) NCs doped with transition metal ions.

33 n by eliminating the release of heavy metals/metal ions.

34 antiopure tetrahedral cages of square-planar metal ions.

35 ite that positions the 5'SS at two catalytic metal ions.

36 c DNA, AA-TT condenses in all alkaline earth metal ions.

37 cage held together exclusively by trivalent metal ions.

38 ll as sensory materials for the detection of metal ions.

39 lves around its interactions with transition metal ions.

40 for the coordination of different transition metal ions.

41 IV) (O) intermediates binding redox-inactive metal ions (1-M(n+) ).

42 es as an ion pump that continuously provides metal ion activators that greatly promote the enzymatic

43 al ion intermittently bound close to the two-metal-ion active site, to which recessed ends or 5'-flap

44 nstruction, we were able to resolve a Zn(2+) metal ion adjacent to the coreceptor binding site, which

45 ntal insight into the thermodynamics driving metal-ion adsorption reactions and provides the specific

46 ched for phosphopeptides through immobilized metal ion affinity chromatography (IMAC), followed by en

47 g amount of gallium ion provides immobilized metal ion affinity for phosphopeptides enrichment.

48 Immobilized metal-ion affinity chromatography (IMAC) used to purify

49 A metal ion also plays an important role in ligand binding

50 ed to the requirement for both an open-shell metal ion and a redox non-innocent ligand.

51 ls and the resulting interaction between the metal ion and ligand.

52 ifier, functional class, bioinorganic class, metal ion and metal-containing cofactor, which will serv

53 recognizing As(III) in the presence of other metal ions and a complex matrix of waste water samples w

54 D, which are linked to different active site metal ions and coordination modes.

55 cooperative binding of a full complement of metal ions and deeper membrane insertion.

56 nto 3D lattices upon coordination of various metal ions and ditopic, hydroxamate-based linkers.

57 erentially modulated by oxidative stress and metal ions and induce distinct patterns of global gene e

58 versatile coordination chemistry of abundant metal ions and inexpensive organic ligands.

59 The arrangement of metal ions and ligands in this pentametallic assembly wa

60 orks (MOFs) are hybrid materials composed of metal ions and organic linkers featuring high porosity,

61 nvolving frameworks based on a wide range of metal ions and organic linkers.

62 thalpy change showed that that adsorption of metal ions and other parameters was feasible, spontaneou

63 antiferromagnetically coupled chromium(III) metal ions and provides a classic example of a magnetic

64 rdination networks that incorporate chromium metal ions and pyrazine building blocks.

65 signaling and stress pathways, particularly metal ions and small molecules.

66 tudies revealed that PfA-M17 and Pv-M17 bind metal ions and substrates in a conserved fashion, althou

67 ups of proteins, the connectivity of the two metal ions and the chemistry each cofactor performs are

68 effective method to affect the reduction of metal ions and the formation of nanocrystals.

69 The acquisition of metal ions and the proper maturation of holo-metalloprot

70 alkali, alkaline earth, transition and other metal ions and their global structural effects on alpha-

71 This enzyme was highly stable to different metal ions and was able to hydrolyze kappa-casein simila

72 tentially pre-organizing them for additional metal-ion and membrane-binding events.

73 s with nucleic acids, lipids, carbohydrates, metal ions, and aromatic molecules are discussed in rela

74 e ligands, pai-interactions, coordination to metal ions, and few halogen bonds in chloropyrazines.

75 inst pH changes and the presence of divalent metal ions, and their high homogeneity make them an effi

76 m ions given that complexes containing these metal ions are already in clinical use or have advanced

77 Elevated levels of certain metal ions are found in protein aggregates in neurons of

78 Here, the metal ions are initially anchored onto the active bipyri

79 Metal ions are known to play various roles in living org

80 More notably, heavy metal ions are removed effectively by forming hydrogen a

81 cation for heavy metal ion removal, as heavy metal ions are the most harmful and widespread contamina

82 lar switches, in conjunction with transition metal ions, are shown to operate as reversible polymer c

83 t are activated by the binding of transition metal ions as a promising class of antibiotics, and for

84 site bound beta-galactosidase on addition of metal ions as compared to the native and other bound enz

85 result of the synergistic effect of the five metal ions as Lewis acid in epoxide activation.

86 frameworks that contain at least 2 different metal ions as nodes of their frameworks.

87 ortionation of Jahn-Teller-active transition-metal ions, as exemplified by the broad classes of respe

88 ionally, our simulations show that the third metal ion assists the departure, through the mobile arch

89 ther hand, has endonuclease activity and one metal ion at the active site and is predominantly a mono

90 nfluence of temperature on the adsorption of metal ions at the solid-water interface is often overloo

91 lly abundant polyphenols (>8000 species) and metal ions available, the present cubosome-enabled strat

92 efficient mean to enhance the performance of metal-ion batteries by minimizing electronic and ionic t

93 e as ideal anodes for 'Rocking-Chair' alkali metal-ion batteries.

94 ly differing ligand preferences of competing metal ions become amplified by the coupling of local wit

95 hiometric concentrations of the investigated metal ions bind specifically to the N-terminal region of

96 electrostatic and chemical contributions to metal ion binding by nanoparticulate complexants, and th

97 In all cases the metal ion binding dominated the velocity of the carrier.

98 Mutation of residues involved in metal ion binding impaired catalytic activity and the fo

99 herein the extent of band bending induced by metal ion binding is the primary driver of photoelectroc

100 for engineering such a selective multivalent metal ion binding site into target macromolecules for st

101 ng a clamshell and the structure defines two metal ion binding sites, one in each domain.

102 The successive folding, metal ion binding, and disulphide acquisition steps in t

103 se results establish the structural basis of metal ion binding, transport and inhibition in ferroport

104 , or triazolo-pyridines, which should enable metal ion binding.

105 Metallothioneins, a group of cysteine-rich metal-ion binding proteins, are known to be a key physio

106 ive was to understand the role of individual metal-ion binding sites of these domains in the membrane

107 e propose a model that links the microscopic metal-ion binding to Abeta monomers to its macroscopic i

108 ences of delaying Abeta aggregation via weak metal-ion binding, quantitatively linking the contributi

109 rotein the conformational changes induced by metal-ion binding.

110 the silver ion, that, similarly to divalent metal ions, binds to monomeric Abeta peptide and efficie

111 The metal-ion bound state appears to be incapable of aggrega

112 eneration and properties of copper (or other metal ion) bound O(2)-derived reduced species, such as p

113 edox and thermodynamic relationships between metal-ion-bound O(2) and its reduced (and protonated) de

114 in many food products, through chelation of metal ions, breakdown of radical chains and hydrogen per

115 ility of His to coordinate Zn(2+) to promote metal ion bridges, and we have found that the histidine

116 embly of isostructural frameworks with mixed-metal ion bridges, or with clusters that have been doped

117 In experimental studies, we use metal-ion bridges to show that promoting an M101-F99 bon

118 e suggests that several enzymes use a single-metal ion, but the precise catalytic mechanism is unknow

119 lay key biological roles for a wide range of metal ions, but unlike many other metalloproteins, the s

120 A cytosolic accumulation of metal ions can lead to mismetallation of proteins and ce

121 conventional intercalation cathodes, alkali metal ions can move in and out of a layered material wit

122 ncy of the immobilized enzyme in presence of metal ions can promote its economic use for lactose hydr

123 f the second magnesium necessary for the two-metal ion catalysis.

124 useful as ligands or gel matrixes for other metal-ion catalyzed organic reactions.

125 the administered compounds and that, if the metal ion changes its oxidation state in the cytosol as

126 model for flexible co-targeting, addition of metal ion chelators as models for imaging and radiothera

127 y can be ascribed to the presence of reduced metal ions, chemically or photochemically generated duri

128 y of six dimers controlled by their divalent metal ion cofactors.

129 res driven by coordination interactions with metal ions commonly present in environment and serve a s

130 al surfaces can be used to probe kinetics of metal ion complexation and establish the success of elec

131 ction and the genetic response to changes in metal ion concentrations.

132 organic ligands and square-planar transition metal ions connected into two-dimensional (2D) sheets st

133 ected metal oxides via the use of an aqueous metal-ion-containing photoresin is presented.

134 nd class offers interesting possibilities of metal ion coordination and hydrogen bond formation via i

135 not only provide deeper insight into PrP(C) metal ion coordination but they also suggest new perspec

136 IIs, we demonstrate that the characteristic metal ion coordination geometries (tetrahedral for Zn(2+

137 orter in direct contact with residues of the metal ion coordination site, thereby interfering with su

138 ds within a discrete layer by anion-template metal-ion coordination opens the way for the synthesis o

139 In an unanticipated finding, metal-ion coordination was also found to translocate an

140 ding to a formal 2-electron reduction of the metal-ion core of FeMo-co.

141 ng stoichiometries found upon titration with metal ions correlate with their specific binding affinit

142 Here, we investigated whether metal ions could affect allele-dependent structural vari

143 Exchanging Ni(II) for other metal ions could broaden the scope of metalloenzyme targ

144 (2+), Zn(2+), and Cd(2+), but not monovalent metal ions, Cr(3+), Mg(2+), Y(3+), Sr(2+) or Ba(2+).

145 gels to verify that stoichiometric excessive metal ion cross-linker concentrations can still result i

146 urthermore, we found that the binding of the metal ion Cu(2+) or Ni(2+), but not Mn(2+), Zn(2+), or H

147 ar photoactive complexes with Earth-abundant metal ions (Cu, Zr, Fe, Cr) for potential eco-friendly a

148 rand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associa

149 will contribute to the development of novel metal ion-dependent protease inhibitors, which might hel

150 ins provide evidence that the proteins share metal ion-dependent RNA 3' polyadenylation activities th

151 toxin component is distinguished by a broad metal-ion-dependent endonuclease activity with specifici

152 luorescent proteins (FPs) have been used for metal ion detection.

153 lication to an important analytical problem, metal ion discrimination and quantitation, by constructi

154 ween the metalloproteins and the dye with no metal ion dissociation.

155 , the higher tendency of unwanted transition-metal-ion dissolution and side-reactions in Jahn-Teller-

156 isproportionation, phase transformation, and metal-ion dissolution in transition-metal oxides upon ex

157 (6) quaternary oxide with high uniformity of metal ion distribution as confirmed by electron microsco

158 resented show that MAS-DNP from paramagnetic metal ion dopants provides an efficient approach for pro

159 ughs in substituting precious and rare-Earth metal ions (e.g. Ru, Ir, Pt, Au, Eu) in these applicatio

160 Metal ions, especially Mg(2+), neutralize these negative

161 In this study, we found that the active site metal ions essential for catalytic activity have a secon

162 Moreover, transition and post-transition metal ions, establishing coordinative interactions with

163 can likely be applied to imaging many other metal ions, expanding the range of the current genetical

164 the important role that adsorption plays in metal-ion fate and transport in the natural environment

165 of a sea urchin HCN channel using transition metal ion fluorescence resonance energy transfer (tmFRET

166 t that S. aureus gyrase uses a single moving-metal ion for cleavage and that the central four base pa

167 natural metallonucleases relying on a single metal ion for their activity.

168 Pt and RE metal ions from the most common hydrated metal salts are

169 ry, for efficient remediation of trace heavy metal ions from water.

170 In addition, we reveal that the metal ions have a long-range (~10 angstrom) electrostati

171 only Al(3+) with no interference from other metal ions, having a limit detection of 0.5 and 2.1 uM,

172 uctural frameworks containing redox-inactive metal ions, highlighting the importance of energy alignm

173 Disruptions in metal ion homeostasis have been described in association

174 However, metal ion homeostasis is a double-edged sword.

175 of group ECF56, regulates morphogenesis and metal-ions homeostasis during development to ensure the

176 ids, known for their gas storage ability(1), metal-ion immobilization(2), proton conduction(3), and s

177 In C2A, a divalent metal ion in site 1 is sufficient to drive its weak asso

178 The determination of nickel metal ion in the crab tissue, oyster tissue and rice sam

179 present study was the measurement of nickel metal ion in the real samples of crab, oyster and rice b

180 designed method for determination of nickel metal ion in the real samples.

181 Here, we report on the catalytic roles of metal ions in a model metalloenzyme system, human carbon

182 hly oxidizing radicals and bind redox-active metal ions in a similar manner as antioxidants used as m

183 s for ultrasensitive SERS-based detection of metal ions in complex fluids.

184 troscopy (ICP/OES) to trace some toxic heavy metal ions in eight select farmed and four select import

185 visualization of neuromelanin and associated metal ions in human brain tissue can be achieved using s

186 Our study provides evidence that the metal ions in metalloenzymes have a crucial impact on th

187 Mixing different metal ions in one polymer offers another degree of contr

188 The detection of these metal ions in several reference materials (CASS-4, SLEW-

189 Luminescence from Earth-abundant metal ions in solution at room temperature is a very cha

190 is proportional to the concentration of the metal ions in solution.

191 The mechanism for the adsorption of metal ions in tannery wastewater onto the nano-adsorbent

192 In addition to the two canonical metal ions in the active site, a third Mn(2+) that coord

193 , we investigate the effects of changing the metal ions in the M-HAB system, with HAB = hexaaminobenz

194 apability(6,7) owing to the high mobility of metal ions in the Si switching medium(8).

195 These results enlighten the roles of the two metal ions in the specificity of DNA polymerases.

196 dies reveal an intact active site with bound metal ions in the structure of YejM periplasmic domain.

197 the local ordering of lithium and transition metal ions in the transition metal layers.

198 iving organisms; therefore, the detection of metal ions in water resources is essential for monitorin

199 We find that the metal-ion-induced folding can proceed with stereoinducti

200 Here we study effects of metal ion interaction with alpha-synuclein at the molecu

201 These hExo1 structures show a third metal ion intermittently bound close to the two-metal-io

202 he difficulty in transforming the binding of metal ions into a change of fluorescent signal.

203 Displacement of transition metal ions into the alkali metal layers has been propose

204 study also identifies the previously unknown metal ion involved in YbeY function to be Zn2+ and shows

205 on is highly elevated in AD brains, and this metal ion is believed to be an important player in the p

206 system containing exchangeable sites at the metal ion is re-cast as a surrogate of a coordinatively-

207 Metal ion leaching from the beads under storage and appl

208 Herein we quantitatively investigate how metal ion Lewis acidity and steric properties influence

209 and oxidative stress, both of which involve metal ions like copper, manganese and iron.

210 their replacement by complexes of essential metal ions, like Mn(II).

211 n staining is ideal for His-tag detection by metal ion-loaded and fluorescently labeled chelator head

212 imple approach, called UVHis-PAGE, that uses metal ion-loaded and fluorescently labeled chelator head

213 The His-tag can also be directly detected by metal ion-loaded nickel-nitrilotriacetic acid-based chel

214 complexation with seven divalent transition metal ions M(II) (M = Mn, Co, Ni, Cu, Zn, Pd, and Cd) un

215 emonstrating a remarkable IMAC-metalloenzyme metal ion match.

216 lecular dynamics simulations support the two-metal ion mechanism and the kinetic data indicating weak

217 he fidelity of DNA polymerases through a two-metal ion mechanism.

218 orted so far for catalysts based on a single metal ion mechanism.

219 nt luminescence nanoparticles (D-PLNPs) with metal ions (MIs) and for the first time proposed an MIs-

220 ly bind a wide array of first-row transition metal ions (Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(I

221 was demonstrated against 13 other competing metal ions (Na(+), K(+), Mg(2+), Ca(2+), Mn(2+), Fe(2+),

222 bridging N(2) ligand by employing different metal ions of differing Lewis acidities.

223 d to be independent of alkali salts or other metal ions, offering robustness with regard to samples c

224 es (OCS) when vacant Lewis acid sites on the metal ions or cluster nodes have been generated.

225 ous materials that can be readily built from metal ions or clusters and organic linkers.

226 dination bonding between organic ligands and metal ions or clusters.

227 al oxides for OER is still limited to either metal ions or lattice oxygen.

228 predict whether they can bind nucleic acids, metal-ions or are involved in chaperone functions.

229 ations are restricted to a limited number of metal ions owing to the lack of available metal-binding

230 eviously overlooked active sites, transition-metal-ion oxidation states, reaction intermediates, and

231 Importantly, cellular interactions with metal ions, particularly Ca(2+), have recently been repo

232 iments revealed that binding of one divalent metal ion per C2 domain results in loss of conformationa

233 rast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive

234 hat HIV reverse transcriptase binds only two metal ions prior to incorporation of a correct base pair

235 polymeric ligand coordinated with different metal ions produces elastomers with vastly different cha

236 We observe that the metal ion profoundly influences the electrical conductiv

237 s, and additionally facilitates a regulatory metal ion-promoted interaction between the PrP(C) N- and

238 oring charge on the oxide and the transition metal ions, rather than on the transition metal alone(1-

239 This is the first example of using metal ion redox for the MR imaging of pathologic change

240 )](+).(H(2)O) (n) clusters indicate that the metal ion remains directly bound to the head group in a

241 discuss their field of application for heavy metal ion removal, as heavy metal ions are the most harm

242 tle direct spectroscopic confirmation of the metal ion's coordination details.

243 dent on the occupancy and orientation of the metal ion's d-orbitals and the resulting interaction bet

244 ther, our results indicate that upon partial metal ion saturation of the intra-loop region, Syt1 adop

245 The interplay between metal ion sensing and metal-dependent expression of viru

246 ons of residues anchoring this non-catalytic metal ion severely impair DNA binding and cleavage.

247 the tighter 5(2) knot can bind two different metal ions simultaneously, the looser 3(1) isomer can bi

248 tion correlates with the occupancy of the C2 metal ion sites.

249 ions is verified by screening six different metal ion solutions containing potentially interfering i

250 s multiway junctions or pseudoknots in mixed metal ion solutions.

251 delineated for determining intraparticulate metal ion speciation, and for evaluating intrinsic chemi

252 the protein states with well-defined protein-metal ion stoichiometry.

253 n(II) with respect to trans-chelation with a metal ion such as Cu(II).

254 or H(+), Na(+), K(+), Ca(2+), and transition metal ions such as Cu(I), Zn(II), and Cd(II).

255 good selectivity toward Hg(2+) against other metal ions such as V(4+), Pb(2+), Cr(3+), Cd(2+), Cu(2+)

256 aches to limit the availability of key heavy metal ions such as zinc and iron.

257 The effect of other alkali metal ions (such as Li and K) on the enantioselectivity

258 Transition metal ions, such as water-soluble iron (WS-Fe), are toxi

259 re we demonstrate that by using an anion and metal ion template, woven molecular 'tiles' can be tesse

260 ing effect for any other divalent transition metal ions tested, including Mn(2+), Fe(2+), Co(2+), Ni(

261 riations in the numbers and positions of the metal ions that perverted the active sites into off-path

262 esence of heterogeneous spatial sequences of metal ions that we describe, depending on the metal and

263 e or decompose in the presence of transition metal ions, the reactivity of this metastable species is

264 ensity redistribution from Fe-H bonds to the metal ions themselves enables N(2) to bind with concomit

265 M/COF-DB allows for the easy replacement of metal ions through a postsynthetic exchange.

266 conformational flipping of Glu89 allows one metal ion to be recruited from the bulk and promptly pos

267 order for a scissile phosphate to attract a metal ion to the A-site to catalyze cleavage, after whic

268 Manipulating symmetry environments of metal ions to control functional properties is a fundame

269 tures can serve as ligands and assemble with metal ions to form MOFs.

270 Binding of metal ions to library compounds and substrates is an und

271 secondary site, which both serves to attract metal ions to the ferroxidase center and acts as a flow-

272 ng of cellular levels of ligand and divalent metal ions to tightly control gene expression.

273 mulation using customized enzyme activators (metal ions) to directly construct metal-organic framewor

274 top of all these advantages, intermolecular metal-ion translocation is a well-known factor in biolog

275 CorA, a divalent-selective channel in the metal ion transport superfamily, is the major Mg(2+)-inf

276 se findings reveal that MavN is a transition-metal-ion transporter that plays a critical role in resp

277 In wild type plants, genes encoding metal ion transporters, such as copper, iron and zinc tr

278 trategies to maintain access to bioavailable metal ions under conditions of extreme restriction of tr

279 opyran-functionalized polymer and transition metal ions underwent reversible thermally triggered (lig

280 We determine that metal ion uptake does not act as a rigidification elemen

281 Metal ions, usually bound by various amino-acid side cha

282 welve uncoordinated pyridyl units around its metal-ion vertices.

283 array of monovalent, divalent, and trivalent metal ions, we demonstrated that this metal binding site

284 ince serine proteases are often sensitive to metal ions, we investigated the influence of different d

285 030-5.0 ug L(-1) for determination of nickel metal ion were obtained.

286 ce-the extraction efficiencies of the listed metal ions were all greater than 99.2%, and the detectio

287 The following representative metal ions were examined: Pb, Cd, Zn, Ce (III), Ba, Ni,

288 f fluorescence response to Fe(3+) over other metal ions which was attributed to a charge transfer mec

289 able to form coordination bonds with various metal ions, which can be reduced to metal nanoparticles

290 gand field splitting of first-row transition metal ions, which leads to efficient nonradiative deacti

291 ployed to recognize and sense phosphate with metal ions will be detailed, and their advantages and sh

292 exploited to detect various light and heavy metal ions with a breakthrough detection limit of 50 nM.

293 rdinate all mid-to-late first-row transition-metal ions with high affinity.

294 TOFs) up to 560 s(-1) and those that oxidize metal ions with low TOFs, ~1 s(-1) or less.

295 he contributions of specific interactions of metal ions with monomeric Abeta to their effects on bulk

296 ithin a self-assembled cage composed of four metal ions with six identical antiaromatic walls.

297 al selectivity for Gd(3+) over physiological metal ions with strong translational potential in facili

298 terspersing coordination sites for different metal ions within an artificial molecular strand enables

299 However, the metal ions within biolattices and the submicrometer dime

300 mer design because one ligand binds multiple metal ions, yielding bonds of different strengths.