ライフサイエンスコーパス: metal-free

1 is operationally simple, mild, additive, and metal-free.

2 One-pot metal-free [3 + 2] cycloaddition of CF(3)-substituted al

3 The resolved metal-free 819 knot enantiomers have pronounced features

4 an unexpectedly stable form, and produce a "metal-free" A-D-A (acceptor-donor-acceptor) oligomer emi

5 -H oxygenation of aliphatic amines through a metal-free activation of molecular oxygen has been devel

6 phan and co-workers clearly implies that the metal-free activation of N2 with frustrated Lewis pairs

7 erelectrophile starts another chapter in the metal-free activation of particularly inert compounds an

8 carbon are the most efficient platinum group metal free active sites for the oxygen reduction reactio

9 Here, we report on the metal-free active template synthesis of [2]rotaxanes in

10 We report here the intermolecular metal-free addition reaction of functionalized benzyl ha

11 ghly atom-efficient, and nontoxic transition-metal free aldol polycondensation.

12 We demonstrate the metal-free alkenylation reactions of aryl esters with al

13 ronic modulation strategy is used to realize metal-free all-pH catalysis towards the hydrogen evoluti

14 Here, we report the development of a new metal-free allylic amination of alkenes that allows the

15 The method provides a simple, metal-free alternative for the synthesis of biologically

16 A metal-free alternative to the regioselective synthesis o

17 A metal-free aminoarylation of internal alkynes is describ

18 We report herein versatile, transition metal-free and additive-free (hetero)aryl-aryl coupling

19 of phenyliodosophthalate (PhI(Phth)), a new metal-free and low toxic hypervalent iodine reagent, are

20 In this metal-free and low-density environment, neutral helium a

21 synthesis of homopropargylic alcohols under metal-free and mild condition is described.

22 The metal-free and mild conditions allowed the formation of

23 The reaction takes place under metal-free and mild conditions.

24 phenes with complete regioselectivity, under metal-free and mild conditions.

25 -fashion was the key step for the transition-metal-free and mild cross-dehydrogenative coupling of 2-

26 A metal-free and mild, photoinduced decarboxylative 4-posi

27 This operationally straightforward, metal-free and modular transformation forms tertiary ami

28 A novel, transition metal-free and one-pot methodology to synthesize various

29 This metal-free and operationally simple reaction proceeds in

30 in good to excellent yields under transition-metal-free and peroxide-free conditions.

31 This process is metal-free and produces multifunctionalized heterocycles

32 substrates, short reaction time, transition metal-free, and gram-scale synthesis are the advantages

33 Herein, we report a transition-metal-free annulation reaction of benzynes and 1,3-oxope

34 A novel transition metal-free approach for the construction of the benzene

35 A novel and efficient transition-metal-free approach for the exclusive synthesis of Z-3-(

36 This metal-free approach stands out as it uses inexpensive re

37 An efficient, metal-free approach to 3-substituted 3-hydroxyoxindole b

38 An efficient, metal-free approach to access pyrazolo-[1,5-c]quinazolin

39 This study describes a metal-free approach to catalyzing the reduction of O(2)

40 dition, we presented a method for transition-metal-free arylation of difluoro enol silyl ethers based

41 a straightforward, practical, and transition-metal-free assembly of 2-aryl indoles.

42 P4') demonstrates the potential of P4' for a metal-free asymmetric syn-dihydroxylation of alkenes.

43 hances further the development of transition-metal-free, atom-economical homogeneous catalysis using

44 n mechanism is proposed for the tribofilm of metal-free AW additives, including direct tribochemical

45 etal-bound complex of the azirinium ylide to metal-free azirinium ylide, ring-opening of the latter t

46 ed by incorporation of a Ni(II) ion into the metal-free B(12) ligand hydrogenobalamin (Hbl), itself p

47 in this vivid area of research showing even metal-free bond activation and catalysis.

48 Here we report a mechanistically distinct, metal-free borylation using hydrogen atom transfer catal

49 manner, we present, among others, the first metal-free borylene(I) species containing a nitrogen-bas

50 A mild, metal-free bromination method of arenes has been develop

51 A metal-free, Bronsted acid, pTsOH-catalyzed intramolecula

52 nduced hydrogen atom transfer strategy, this metal-free C(sp(3))-H borylation enables unreactive alka

53 oach represents a new catalytic manifold for metal-free C-C bond formation.

54 foxidation, herein, we discovered a mild and metal-free C-H sulfenylation/intramolecular rearrangemen

55 The sulfoxides engage in metal-free C-H trifluoromethylthiolation with a range of

56 Scope, tolerance for these transition-metal-free C-H/C-Li coupling reactions, and photophysica

57 t nucleophiles for performing regioselective metal-free C-O and C-N bond-cleaving to afford prevalent

58 theoretical analysis and material design of metal-free carbon nanomaterials as efficient photo-/elec

59 lored for achieving competitive and feasible metal-free carbon nanomaterials, among which doping and

60 ing operando characterization techniques for metal-free carbon-based catalyst system is considered, f

61 ochemical outcome of the reported transition-metal-free carbon-carbon bond formation reactions.

62 compounds has emerged recently as a powerful metal-free carbon-carbon bond forming method.

63 ed acridones were synthesized via a one-pot, metal-free cascade reaction.

64 A mechanistic pathway of the new metal-free catalysis is predicted on the basis of our ES

65 findings will also open new possibilities in metal-free catalysis or organic crystal engineering, whe

66 hers in terms of its operational simplicity, metal-free catalysis, use of water as a solvent, ambient

67 low-cost alternative, the first carbon-based metal-free catalyst (C-MFC based on N-doped carbon nanot

68 This approach features the use of a metal-free catalyst (eosin Y), an energy-economical ligh

69 uture perspectives in the doped carbon-based metal-free catalyst field are also discussed.

70 mmercially available 2-mercaptopyridine as a metal-free catalyst for the transfer borylation of heter

71 has several advantages such as a transition-metal-free catalyst, a short reaction time, easy separat

72 ctionalities are tolerated by the transition metal-free catalyst.

73 ivity, and excellent stability, carbon-based metal-free catalysts (CMFCs) are promising alternatives

74 anding and design principles of carbon-based metal-free catalysts are illustrated, along with the cha

75 operando techniques, it can be expected that metal-free catalysts can achieve exceptional technologic

76 nanotube fiber (B-NCNT) as flexible, durable metal-free catalysts for both CO(2) reduction and evolut

77 Ps) have recently been advanced as efficient metal-free catalysts for catalytic hydrogenation, but th

78 oad opportunities for rational design of new metal-free catalysts for challenging chemical reactions.

79 Carbon nanomaterials are promising metal-free catalysts for energy conversion and storage,

80 temperature; they are among the most active metal-free catalysts for epsilon-caprolactone polymeriza

81 elopment of low-cost, efficient carbon-based metal-free catalysts for renewable energy technologies a

82 ficient development of improved and precious metal-free catalysts for renewable energy technologies.

83 aNHCs have also been shown to be efficient metal-free catalysts for ring opening polymerization of

84 Therefore, carbon-based metal-free catalysts have received increasing interest a

85 recent advances in the field of carbon-based metal-free catalysts is provided.

86 ress has been made toward the development of metal-free catalysts of enantioselective transformations

87 ce of operando characterization performed on metal-free catalysts.

88 materials have attracted growing interest as metal-free catalysts.

89 r the next-generation high-performance noble-metal-free catalysts.

90 Herein, we describe the first transition-metal-free catalytic carboalkoxylation of styrenes with

91 ecently, aNHCs successfully accomplished the metal-free catalytic formylation of amides using CO(2) a

92 st decade has seen the subject of transition metal-free catalytic hydrogenation develop incredibly ra

93 ironmental contamination make the transition metal-free catalytic systems especially important.

94 e findings pave the way for the discovery of metal-free catalyzed carbonylation reactions.

95 We report a novel metal-free chemical reduction of CO(2) by a recyclable b

96 Transition-metal-free chemo-, regio-, and stereoselective synthesis

97 ed by recently available liganded (open) and metal-free (closed) Aplysia BK channel structures.

98 lyst particles for applications that require metal-free CNTs.

99 is among the best performances reported for metal-free CO(2) reduction electrocatalysts.

100 iby) was similarly synthesized from Hby, the metal-free cobyric acid ligand.

101 We present novel noble-metal free complexes that can be photochemically charged

102 New chromophores (sodium, zinc, and metal-free compounds) were characterized by NMR, UV-vis,

103 nyl-3-alkyl/aryl 2-oxindole under transition-metal free condition.

104 lides, alkenes, etc.) and simple, transition-metal-free conditions and display broad substrate scope

105 process at an ambient temperature and under metal-free conditions and visible-light irradiation usin

106 ly using only LiTMP reagent under transition metal-free conditions and without the use of halogen-con

107 cetic acids into aryl carboxylic acids under metal-free conditions has been described.

108 n under room temperature (rt) and transition-metal-free conditions have been developed.

109 zole ring proceeds smoothly under transition-metal-free conditions in the presence of Cs(2)CO(3) in d

110 phosphabenzene-based POPs (Phos-POPs) under metal-free conditions is reported, without the use of un

111 3))-C(sp(2)) bond formation under transition-metal-free conditions offers an atom-economical, inexpen

112 es and amines at low catalytic loading under metal-free conditions without the need of any external b

113 ha-chain, and the N-substituent) under mild, metal-free conditions, affording products with high opti

114 Under metal-free conditions, delta-acetoxy allenoates react wi

115 H trifluoromethylation of 2 H-indazole under metal-free conditions, which proceeds via a radical mech

116 ation along with the C-C bond cleavage under metal-free conditions.

117 m anilines under solvent-free and transition-metal-free conditions.

118 tern of substrates under open-atmosphere and metal-free conditions.

119 with CO(2) into 2-arylpropionic acids under metal-free conditions.

120 available substrates, high atom-economy and metal-free conditions.

121 s and (secondary) amines under base-free and metal-free conditions.

122 reaction could be synthesized under mild and metal-free conditions.

123 yanation of benzyl cyanides in one pot under metal-free conditions.

124 lylic silylation under simple and transition-metal-free conditions.

125 ion and cyclization of sp(3) C-H bonds under metal-free conditions.

126 g/electron-releasing/aliphatic groups under "metal-free" conditions.

127 A one-pot metal-free conversion of unprotected amino acids to term

128 on nanotubes to construct a hybrid, precious-metal-free coupled AlcOx-CO(2) R electrolyzer.

129 We report an unprecedented transition metal-free coupling of indoles with aryl halides.

130 A transition-metal-free coupling reaction of aryne, DMSO, and activat

131 This is the first transition-metal-free cross-coupling of azaallyls with vinyl bromid

132 An operationally simple and metal-free cross-coupling of quinone monoacetals (QMAs)

133 Herein we report a transition-metal-free cross-coupling strategy utilizing aryl(hetero

134 A metal-free cross-dehydrogenative coupling between quinox

135 Here, we demonstrate that by using heavy-metal-free CuInSe(2) quantum dots, we can address the pr

136 ivatives, respectively, in turn prepared via metal-free cycloaddition of halogenoximes and propargyli

137 Advances in the transition-metal-free cyclobutanol ring expansion to 4-tetralones u

138 A metal free DBU catalyzed synthesis of 1,2,3-triazole-fus

139 M-520 and confirm its potential for precious-metal-free deNO(x) technologies.

140 Herein we report the metal-free direct C-H arylation of enones mediated by hy

141 d activation of white phosphorus (P(4)), the metal-free direct functionalization of P(4) has remained

142 Herein, a metal-free domino synthesis of Z-selective alpha,beta-di

143 Then the emerging metal-free doped carbon and aromatic N-heterocycle catal

144 A one-pot, metal-free, double cyclization for the synthesis of bicy

145 erview on the doping of carbon materials for metal-free electrocatalysis, especially the development

146 he first K-CO(2) battery with a carbon-based metal-free electrocatalyst.

147 st, much of the mechanistic understanding of metal-free electrocatalysts continues to be elusive in c

148 Ss) in carbon enables the synthesis of noble-metal-free electrocatalysts for clean energy conversion

149 An overview of the defects in carbon-based, metal-free electrocatalysts for ORR and various defects

150 Metal-free electrocatalysts have been extensively develo

151 for Pt/C catalyst and state-of-the-art noble metal-free electrocatalysts.

152 limited current (3 A cm(-2) ) for a precious metal free electrode.

153 The scope of this review is limited to the metal-free elemental photocatalysts (i.e. B, C, P, S, Si

154 A metal-free, environmentally friendly protocol for the ar

155 This metal-free, Et(3)N-catalyzed cascade reaction proceeded

156 These predictions strongly suggest the metal-free ferroelectric family of materials as the best

157 The metal-free flavin/NO(x)/TEMPO catalytic cycles are uniqu

158 This transition-metal-free fluorination protocol tolerates a broad range

159 ion, we disclosed a new approach towards the metal-free fluorination using selectfluor and the C=C bo

160 Overall, this metal-free formal [2 + 2 + 2] cycloaddition provides acc

161 Metal-free, formal [2 + 2 + 2] cycloaddition strategies

162 A highly efficient transition-metal-free general method for the synthesis of polycycli

163 he key steps in the synthesis of chromane is metal-free generation of C1-substituted glucal from d-ma

164 Here, growth of large single crystals of metal-free halide perovskite DABCO-NH(4) Br(3) (DABCO =

165 electronic properties and demonstration, of metal-free halide perovskite optoelectronics.

166 Metal-free halide perovskites, as a specific category of

167 ss infall rate above some critical value) in metal-free haloes is a requirement for the formation of

168 early galaxy formation(11,12) that produces metal-free haloes massive enough and with sufficiently h

169 The reaction is metal-free, has a broad substrate scope, is operationall

170 Active and stable metal-free heterogeneous catalysts for CO(2) fixation ar

171 The development of noble-metal-free heterogeneous catalysts is promising for sele

172 m marine waste and its use demonstrated in a metal-free heterogeneous selective oxidation of 5-hydrox

173 sign and fabrication of novel platinum-group-metals-free highly active ORR electrocatalysts in alkali

174 te solar cells (PSC) are manufactured with a metal-free hole contact based on press-transferred singl

175 zation were the choice of components for the metal-free HPLC-DAD system and sector-field ICP-MS detec

176 This precious-metal-free hybrid catalyst selectively converts CO(2) to

177 The metal-free hydrofluorination of alkynes constitutes an a

178 This report represents the first example of metal-free hypervalent iodine electrocatalysis for C-H f

179 strate the design, fabrication, and use of a metal-free (i.e., LSPR-free), topologically tailored nan

180 ves that self-react to grow a tribofilm, the metal-free ILs require a supplier of metal cations in th

181 Arduengo et al. reported the isolation of a metal-free imidazol-2-ylidene in 1991.

182 Metal-free insertion of a methylene group was achieved f

183 Inexpensive, transition metal-free intermetallic compounds have received almost

184 mizing the long-term stability of transition metal-free intermetallic hydrogen absorbing compounds fo

185 t, (ii) air as the oxidant, (iii) transition metal-free, (iv) no base required, (v) no toxic byproduc

186 A rapid, efficient, and metal-free Lewis acid-mediated methodology has been deve

187 benefits of this reaction include the use of metal-free, low-cost Rose Bengal catalyst and practical

188 stability in harsh conditions, carbon-based metal-free materials have become promising advanced elec

189 This work describes a new type of transition-metal-free mediated transformation to enable the constru

190 Herein, we present a one-step and metal-free method for carbonyl deoxy-borylation under mi

191 A versatile, efficient, and metal-free method for construction of discrete oligomers

192 tho-EMe (E=S, O) groups represents a simple, metal-free method for the formation of C3-borylated benz

193 ectrophilic boranes is a powerful transition metal free methodology for forming C-B bonds.

194 A metal-free methodology for the photoarylation of pyridin

195 alysts, cryogenic metalation strategies, and metal-free methods.

196 Herein, we have reported a metal-free, mild, and novel protocol for the synthesis o

197 among components to endow the newly designed metal-free multi-sensing air electrode (MSAE) with bifun

198 ect-rich Bi nanoplates as an efficient noble-metal-free N(2) reduction electrocatalyst via a low-temp

199 ce of some N-heterocycles that enables mild, metal-free N-H functionalization reactions of carbazole

200 Metal-free N-H functionalization reactions represent an

201 tes bifunctional enzyme mimicking roles of a metal-free nanozyme hybrid of chemically modified graphi

202 Metal-free near-infrared (NIR) active unsymmetrical squa

203 acile one-electron oxidation to the acyclic, metal-free, neutral radical L(.) on reaction with FeBr2

204 e photoabsorber and an earth-abundant, noble-metal-free nickel-thiolate hexameric cluster co-catalyst

205 .1%, the highest value achieved so far by a "metal-free" NIR-OLED not intentionally benefitting from

206 Here we report metal-free nitrogen-assembly carbons (NACs) with closely

207 A transition metal-free one-pot stereoselective approach to substitut

208 el, efficient, and regioselective transition-metal-free one-pot synthesis of aryl sulfones via the re

209 Metal-free one-pot synthesis, broader substrate scope, g

210 A transition metal-free one-pot, three-steps protocol combining N-alk

211 this C-H functionalization strategy include metal-free open air reaction conditions, which offer a m

212 An environmentally benign, transition-metal-free organic base promoted one-pot cascade synthes

213 inone (AQ) redox mediators are introduced to metal-free organic dye sensitized photo-electrochemical

214 talysis is an emerging field, in which small metal-free organic structures catalyze a diversity of re

215 ion of CO(2) by sustainable, recyclable, and metal-free organo-hydrides.

216 ng branch in this area has been carbon-based metal-free ORR electrocatalysts.

217 s for the future development of carbon-based metal-free ORR electrocatalysts.

218 moalkenyl ynones via base mediated, one-pot, metal free, orthogonal strapping (tethering) mediated by

219 anil/H(+) reagent as the recyclable organic (metal-free) oxidant system to afford benzidines/naphthid

220 nd chemoselective methods for the transition-metal-free oxidation of amides to alpha-keto amides and

221 Compared to metal-free oxidation of the substrates, which is caused

222 A highly regioselective, efficient, and metal-free oxidative cross dehydrogenative coupling (CDC

223 A metal-free oxidative cyclization of N-Boc-acrylamides wi

224 and extraordinarily large EC strengths of a metal-free perovskite ferroelectric [MDABCO](NH(4) )I(3)

225 This makes metal-free perovskites novel candidates for the next gen

226 sly highly active and durable platinum group metal-free (PGM-free) catalysts and electrodes.

227 chieved in the development of platinum group metal-free (PGM-free) oxygen reduction reaction (ORR) ca

228 g character of the polymerization technique (metal-free photo-ROMP) is demonstrated by consecutive ch

229 A metal-free photoanode nanojunction architecture, compose

230 can serve as efficient and robust, precious-metal free, photoassisted redox catalysts.

231 rogress and remaining challenges in selected metal-free photocatalysts for hydrogen production.

232 Hydrogen generation from water using noble metal-free photocatalysts presents a promising platform

233 Herein, we present a metal-free photocatalyzed decarboxylative Giese-type add

234 Harnessing metal-free photoinduced reversible-deactivation radical

235 is the design of a redox stimuli activatable metal-free photosensitizer (aPS), also functioning as a

236 Mechanistic studies by comparison tests with metal-free phthalocyanine MOF analogs supported the domi

237 We investigate the metal-free porphyrin derivative tetra(tert-butyl)porphyr

238 0 nm), exhibiting a black dye property as a "metal-free" porphyrinoid.

239 alid alternative materials to ZIFs: they are metal free, possess larger pore apertures, and are stabl

240 An effective method for transition-metal-free postfunctionalization of thiazolo[3,2-c][1,3,

241 We report a metal-free postpolymerization modification approach to i

242 le waste, (iv) 100% of carbon economy, (v) a metal-free process, and (vi) nontoxic and reusable organ

243 It is an economical, efficient, catalytic, metal-free protocol for the quick gram-scale synthesis o

244 The metal-free protocol operates at low catalyst loading, to

245 The present one-pot transition-metal-free protocol provides the facile and highly effic

246 th transition-metal-catalyzed and transition-metal-free protocols will be covered and discussed in de

247 permeable polystyrene cores crosslinked with metal-free purely organic phosphors.

248 These heavy-metal-free QDs eliminate MDR pathogenic bacteria, while

249 n with the stronger oxidant AgBF4 formed the metal-free radical dication L(.2+) .

250 carbenes into the Si-H bond of silanes under metal-free reaction conditions (23 examples, up to 83% y

251 s reaction can be performed under very mild, metal-free reaction conditions using molecular iodine as

252 oup compatibility, operates under transition-metal-free reaction conditions, and is suitable for vari

253 ) and dimethyl sulfoxide as an oxidant under metal-free reaction conditions.

254 yields from simple precursors under mild and metal-free reaction conditions.

255 The transition-metal-free reaction proceeds in a regio- and stereoselec

256 s in moderate to good yields in a completely metal-free reaction.

257 utarimides in metal-catalyzed and transition-metal-free reactions.

258 one product cleanly, and faster than in the metal-free reactions.

259 is demonstrated in the presence of organic (metal-free) recyclable oxidants, such as DDQ or CA/H(+),

260 Overall, the use of a metal-free, recyclable photocatalytic system allows effi

261 roenzymatic nitrogen fixation system using a metal-free redox polymer, namely neutral-red-modified po

262 A method for the metal-free reduction of carboxylic amides using oxalyl c

263 A transition-metal-free reductive hydroxymethylation reaction has bee

264 Herein we describe a metal-free regioselective alpha-amination of ethers medi

265 A one-pot, three-component, transition-metal-free regioselective sulfenylation of 2-iminothiazo

266 ciples and a universal strategy to construct metal-free room temperature phosphorescence materials wi

267 ctures of the excited triplet states for the metal-free room-temperature triplet emitters are correla

268 The advantages of the reaction include metal-free, room-temperature, mild reaction conditions a

269 A metal-free, simultaneous triple C-C coupling cyclization

270 The "sulfonated carbons" are a new class of metal-free solid protonic acids characterized by their u

271 reveals the potential of derivative DA1 in "metal-free" Sonogashira coupling involving activated ary

272 njunctive coupling reactions, and transition metal-free sp(2) -sp(3) couplings.

273 l proof of the lactam-embedded smallest ever metal-free stable Huckel antiaromatic trans-doubly N-con

274 zo compounds with aromatic compounds using a metal-free strategy are described.

275 An efficient and transition-metal-free strategy for the synthesis of 3-keto-isoquino

276 An efficacious, metal-free strategy has been developed for the synthesis

277 om 3-hydroxy piperidines, a novel transition-metal-free strategy to 5-hydroxy-5,6-dihydro-2(1H)pyrido

278 ications, from ultrathin optical elements to metal-free sub-diffraction light confinement and wavegui

279 ditionally, this system was employed for the metal-free synthesis of 2-substituted benzo[b]thiophenes

280 A novel metal-free synthesis of 3,3-disubstituted benzofuran-2-(

281 Unprecedented metal-free synthesis of a variety of amines and amides i

282 icle reports for the first time the targeted metal-free synthesis of any 1,4-disubstituted 1,2,3-tria

283 A mild and metal-free synthesis of aryl isocyanates from arylamines

284 Metal-free synthesis of benzimidazole-fused phenanthridi

285 yl)aryltriflates resulting in the transition-metal-free synthesis of N-H and N-aryl benzotriazoles ha

286 his reaction offers a broad substrate scope, metal-free synthesis, excellent regioselectivity, easily

287 roducts represent an attractive strategy for metal-free synthesis, few examples have been reported.

288 crafted pyridyl ynones through a transition-metal-free, tandem Michael addition-S(N)Ar process is de

289 d impact on drug resistance in comparison to metal-free thiosemicarbazones.

290 A metal-free three-component coupling reaction of aryl alk

291 We expect that this new metal-free transamidation will have broad implications f

292 Metal-catalyzed and metal-free transformations are covered in reactions invo

293 Visible-light-induced metal-free trifluoromethylation of activated, carbocycli

294 ting from the far-red to deep-blue region in metal-free triplet-triplet annihilation upconversion (TT

295 B(C(6)F(5))(3) enables the metal-free unprecedented substrate-controlled direct alp

296 C or 5 min under sonication) and transition-metal-free, using glycerol as a green solvent.

297 Herein, we report a general, metal-free visible light-induced photocatalytic borylati

298 Very recently, transition-metal-free visible-light-induced radical approaches have

299 ges of being bright, easy to synthesize, and metal-free when compared with QDs, but they frequently p

300 Purified HypX proved to be metal-free, which makes it a unique catalyst among the g