ライフサイエンスコーパス: metaplastic

1 January 2010 and May 2023 including the term metaplastic.

2 Metaplastic acinar structures were highly proliferative,

3 Metaplastic activation of ryanodine receptors (RyRs) in

4 We examined the extent of ectopy and metaplastic activity as risks for HPV16 acquisition in a

5 ization to evaluate the expression of p27 in metaplastic and dysplastic Barrett's epithelium and to a

6 message and protein parallel one another in metaplastic and dysplastic Barrett's epithelium, suggest

7 nodes but to a lesser extent in a subset of metaplastic and dysplastic Barrett's samples.

8 at present there is no direct evidence that metaplastic and dysplastic epithelia are clonal precurso

9 As infection progresses, metaplastic and dysplastic glands appear, which are resi

10 As disease progresses, metaplastic and dysplastic glands arise which express Fa

11 Metaplastic and dysplastic glands can be genetically rel

12 We have established metaplastic and dysplastic organoid lines, derived from

13 ct cellular behaviors and characteristics of metaplastic and dysplastic organoids.

14 nal profiling of patient cells isolated from metaplastic and healthy tissue.

15 that dopamine may constitute a new player in metaplastic and homeostatic processes in the prefrontal

16 The overexpression of c-neu in the metaplastic and malignant neoplastic glands also correla

17 nts that result in the curative depletion of metaplastic and neoplastic cell populations in BE in ter

18 ed the pattern of CDX1 protein expression in metaplastic and neoplastic tissue to provide insight int

19 ffected organs showed variable hyperplastic, metaplastic, and connective tissue changes, indicating t

20 receptor were performed on normal, inflamed, metaplastic, and malignant esophageal mucosa.

21 lates LI-cadherin gene expression in normal, metaplastic, and neoplastic tissues of the gastrointesti

22 nt with those results, we observed that both metaplastic areas and (pre)malignant lesions of the esop

23 GHPs are associated with autoimmune metaplastic atrophic gastritis (AMAG).

24 ia, we measured expression of these genes in metaplastic Barrett's and esophageal adenocarcinomas.

25 In metaplastic Barrett's epithelium, p27 protein and mRNA w

26 es that hAEC2 loss and expansion of alveolar metaplastic basal cells in severe human lung injuries ar

27 In a model of metaplastic basal-like breast carcinoma progression, we

28 Expression of a newly defined cancer-related metaplastic biomarker was confirmed through immunofluore

29 er, triple-negative breast cancer (TNBC) and metaplastic breast cancer (MBC) tissues led to the ident

30 Metaplastic breast cancer (MpBC) is a highly chemoresist

31 Metaplastic breast cancer (MpBC) is a rare, heterogeneou

32 of stromal-dense tumors that resemble human metaplastic breast cancer and metastasize to lungs and l

33 Furthermore, we show that the development of metaplastic breast cancer is attributable, in part, to t

34 tify mesenchymal TNBC are under development, metaplastic breast cancer serves as a clinically identif

35 associates closely with the claudin-low and metaplastic breast cancer subtypes and correlates negati

36 ary carcinoma, adenoid cystic carcinoma, and metaplastic breast cancer were analyzed.

37 mal TNBC can be classified histologically as metaplastic breast cancer, a chemorefractory group of tu

38 Metaplastic breast cancers (MBC) are aggressive, chemore

39 Human carcinosarcomas or metaplastic breast cancers (MpBC) are a rare, chemorefra

40 Finally, we found that 63% of metaplastic breast cancers, a rare type of basal-like ca

41 hese cells are one of the cells-of-origin of metaplastic breast cancers.

42 Metaplastic breast carcinoma (MBC) is a highly aggressiv

43 Metaplastic breast carcinoma (MBC) is a rare histologica

44 Significance: CCN6 deficiency drives metaplastic breast carcinoma growth and metastasis by in

45 Metaplastic breast carcinoma is an aggressive form of in

46 sed as primary osteosarcoma of the breast or metaplastic breast carcinoma.

47 )N depletion was higher in a more aggressive metaplastic breast carcinoma.

48 ed in clinical samples of human spindle cell metaplastic breast carcinoma.

49 Metaplastic breast carcinomas (mBrCA) are a highly aggre

50 iles," described for infiltrating lobular or metaplastic breast carcinomas.

51 na fide EMT, histologically similar to human metaplastic breast carcinomas.

52 ble, in part, to the transformation of these metaplastic breast epithelial cells.

53 persist after sAPPalpha washout, revealing a metaplastic capability of exogenous sAPPalpha administra

54 Environmental factors are closely linked to metaplastic carcinogenesis.

55 ars, medullary carcinoma was most common and metaplastic carcinoma had the worst 5-year OS among the

56 Factors associated with a poor prognosis for metaplastic carcinoma included advanced stage, lung meta

57 comparison of orthologous genes with a human metaplastic carcinoma signature revealed a significant o

58 th HRas(G12V) +/- SV40-T/t antigens generate metaplastic carcinoma suggesting that these cells are on

59 Metaplastic carcinoma was the most commonly diagnosed hi

60 o adenocarcinoma, whereas WAP+ cells yielded metaplastic carcinoma with severe squamous differentiati

61 inoma and 63 (52-74) years for patients with metaplastic carcinoma.

62 ole for Ccn6 deletion in the pathogenesis of metaplastic carcinomas with histological and molecular s

63 cinomas), and others very poor outcome (e.g. metaplastic carcinomas), whereas the broader immunohisto

64 gets in the diagnosis and treatment of human metaplastic carcinomas, and a new disease relevant model

65 e also rare types of breast cancers, such as metaplastic carcinomas, where tumor cells exhibit featur

66 uctal, 5 of 13 invasive lobular, and 1 of 13 metaplastic carcinomas.

67 which display similarities to human clinical metaplastic carcinomas.

68 Comparison of Trim24(COE) metaplastic carcinosarcoma morphology, TRIM24 protein le

69 rogeneity and the emergence of a tumor fetal metaplastic cell (TFMC) population endowed with invasive

70 flammation, parietal cell loss, atrophy, and metaplastic cell changes.

71 a expression was observed beginning from the metaplastic cell line CP-A towards dysplasia (CP-B) and

72 Metaplastic cell lineages in AR-/- mice showed increases

73 The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicob

74 Notably, Hp infection did not drive a unique metaplastic cell phenotype.

75 ck cells are plastic and converge into a pre-metaplastic cell type that progresses to metaplasia.

76 infection and AIG trigger a diverse array of metaplastic cell types.

77 Identification of a cancer-related metaplastic cell uniquely expressing ANPEP/CD13, present

78 It increased the number of squamous metaplastic cells and prolonged survival in mice consumi

79 taplasia, possible distinctions in resulting metaplastic cells and their respective cancer risks requ

80 l healing(4), we now implicate pyloric gland metaplastic cells in inflammation through recruitment of

81 c gastric glands atrophy and are replaced by metaplastic cells in response to chronic gastritis.

82 The metaplastic cells of Barrett's oesophagus are predispose

83 licobacter pylori infection) identified more metaplastic cells throughout the corpus than previously

84 Molecular features of metaplastic cells were defined using single-cell transcr

85 to those found in Dicer-deficient acini and metaplastic cells, namely induction of HNF6 and hepatic

86 iated tumorigenic properties of Kras-induced metaplastic cells, which leads to pancreatic cancer onse

87 /+) mice result from the clonal expansion of metaplastic cells.

88 ion for endocervical (columnar epithelial or metaplastic) cells and erythrocytes.

89 yofibroblast transdifferentiation (MFT) is a metaplastic change in phenotype producing profibrotic ef

90 cinoma may develop from Barrett esophagus, a metaplastic change of the esophageal epithelium from squ

91 Barrett's oesophagus is a metaplastic change of the lining of the oesophagus, such

92 n bronchial epithelium is a marker for early metaplastic changes and the loss of its expression is as

93 It might also be relevant to mediate the metaplastic changes in the respiratory epithelium that o

94 mation of the gastric mucosa can progress to metaplastic changes in the stomach and to decreased colo

95 chial epithelial cells is a marker for early metaplastic changes induced by various toxicants/carcino

96 The relation between H pylori and these metaplastic changes is unclear.

97 orpus by promoting and exploiting epithelial metaplastic changes that can lead to tumorigenesis.

98 led that mGlu(3) receptor activation induced metaplastic changes, biasing afferent stimulation to ind

99 tion of biomarkers signifying progression of metaplastic changes.

100 interact to generate striking bidirectional metaplastic changes.

101 h inflammatory breast carcinoma and one with metaplastic chondrosarcomatous carcinoma.

102 tions from stratified squamous epithelium to metaplastic columnar epithelium that predisposes individ

103 sition of oesophageal squamous epithelium to metaplastic columnar epithelium.

104 In patients with Barrett's esophagus (BE), metaplastic columnar mucosa containing epithelial cells

105 xpression of IVL, KRTDAP, DSG1, and GRHL1 in metaplastic compared to squamous epithelia.

106 d led to the persistence of acinar-to-ductal metaplastic complexes, with prolonged Sox9 expression an

107 ve cancer (TNBC), defined by the presence of metaplastic components of spindle, squamous, or sarcomat

108 Barrett's esophagus is a common metaplastic condition that increases the risk for esopha

109 Barrett esophagus (BE) is a human metaplastic condition that is the only known precursor t

110 carcinoma arises from Barrett's esophagus, a metaplastic condition.

111 breast cells could acquire invasiveness in a metaplastic context.

112 In gastrointestinal epithelium, metaplastic conversion between predominant cell types is

113 function in the pancreas by antagonizing the metaplastic conversion of acinar cells toward a ductal f

114 that MLE may be a transitional stage in the metaplastic conversion of squamous to columnar epitheliu

115 Furthermore, we show that intestinal metaplastic crypts are clonal, possess multiple stem cel

116 the pathways responsible for dysplastic and metaplastic development, selection of patient population

117 uodenal reflux in the etiology of esophageal metaplastic development.

118 Aberrant epithelial reprogramming can induce metaplastic differentiation at sites of tissue injury th

119 e to myofibroblasts during scarring, promote metaplastic differentiation of airway progenitors into K

120 sions in people with Barrett's oesophagus--a metaplastic disorder that confers a high risk of oesopha

121 man pancreatic intraepithelial neoplasia and metaplastic duct lesions in human and mouse.

122 s studying the transition of acinar cells to metaplastic ductal cells in vivo is complicated by analy

123 ofound hyperglycemia and/or proliferation of metaplastic ductal epithelium.

124 up-regulated Pdx1 expression in premalignant metaplastic ductal epithelium.

125 g pancreatic epithelium through formation of metaplastic ductal intermediates.

126 These metaplastic ductal lesions (MDL) are called tubular comp

127 Three different types of metaplastic ductal lesions are observed and analyzed.

128 Metaplastic ductal lesions are seen in pancreatitis as w

129 Pancreatic metaplastic ducts are usually associated with pancreatit

130 H. pylori was detected inside metaplastic, dysplastic, and neoplastic epithelial cells

131 Here we demonstrate metaplastic effect of a change in NMDA receptor (NMDAR)

132 Stress and glucocorticoids appear to exert a metaplastic effect through the modulation of Ca2+ levels

133 Experience-dependent, pathway-specific metaplastic effects in a cortical structure have broad i

134 n light of these findings, we tested for the metaplastic effects of atRA, that is, for its ability to

135 Further, we showed that this metaplastic endometrial mucosa was the source of ectopic

136 alignancy, but the cells of origin for these metaplastic epithelia and subsequent malignancies remain

137 so have the potential to induce formation of metaplastic epithelia in the pancreas.

138 se 7 (MMP-7), a proteinase expressed in most metaplastic epithelia in vivo.

139 ther analyses of these cells, in healthy and metaplastic epithelia, is required.

140 eration was elevated in undifferentiated and metaplastic epithelial cells in H/K-IFN-gamma transgenic

141 esence of one or more columnar epithelial or metaplastic epithelial cells or the presence of more tha

142 rat cholangiocarcinomas and in a majority of metaplastic epithelial cells within earlier formed preca

143 mmation, fibrosis, mucus hypersecretion, and metaplastic epithelial lesions are hallmarks of this dis

144 twofold change; P <= 0.05) and 6 proteins in metaplastic epithelium (>=twofold change; P <= 0.05) wer

145 in cervical cancer development: infection of metaplastic epithelium at the cervical transformation zo

146 n to Pdx1 gene activation, TGF-alpha-induced metaplastic epithelium demonstrated a pluripotent differ

147 h pathway is characterized by persistence of metaplastic epithelium expressing markers of pancreatic

148 ferentiation of normal gastric epithelium to metaplastic epithelium in chronically inflamed stomachs.

149 lium and in putative precancerous intestinal metaplastic epithelium induced in the liver of furan-tre

150 Therefore, genotyping of Barrett's metaplastic epithelium may supplement the histopathologi

151 oth in esophageal adenocarcinomas and in the metaplastic epithelium of Barrett's esophagus.

152 have identified serum proteins secreted from metaplastic epithelium that can be used to predict disea

153 table SA and 1647 symptomatic SA proteins in metaplastic epithelium were quantified.

154 GLA-13(+) cells may give rise to respiratory metaplastic epithelium where GBCs are eliminated.

155 Most EAs arise in a metaplastic epithelium, Barrett's esophagus (BE), which

156 To assess Pdx1 gene expression in normal and metaplastic epithelium, we performed in vivo reporter ge

157 ch cancers arise in a specialized intestinal metaplastic epithelium, which is diagnostic of Barrett's

158 in transformed barriers composed of scar and metaplastic epithelium.

159 on was found at every evaluated level of the metaplastic epithelium.

160 gs demonstrate altered BMP activation in the metaplastic epithelium.

161 Metaplastic esophageal columnar epithelium that does not

162 influence the initiation and maintenance of metaplastic events in pancreatic epithelium, explaining

163 ransmitted stress in adult male mice trigger metaplastic facilitation of long-term depression (LTD) i

164 monstrate that transmitted stress can elicit metaplastic facilitation of LTD induction as authentic s

165 n in normal pancreata they display PanIN and metaplastic features, such as expression of Shh and gast

166 The same changes were observed even in some metaplastic foci adjacent to dysplasia.

167 VICE 1: Non-neoplastic duodenal lesions (eg, metaplastic foveolar epithelium and gastric heterotopia)

168 Metaplastic gastric mucosa was analyzed by dual immunost

169 on-neoplastic cells, including in intestinal metaplastic, gastritis and inflammatory cells.

170 We investigated whether cells within a metaplastic gland share a common origin, whether glands

171 ntestinal metaplasia (non-IM) and intestinal metaplastic glands (IM).

172 lly expand by fission, and determine if such metaplastic glands are genetically related to the associ

173 The metaplastic glands expressed markers of SPEM and IM, and

174 be three to four times higher in intestinal metaplastic glands in precancerous cholangiofibrotic tis

175 ial cells of both early-appearing intestinal metaplastic glands in precancerous hepatic cholangiofibr

176 In individuals with gastric cancer, metaplastic glands often show elevated mutation burdens

177 Metaplastic glands were derived from the same clone-all

178 Cytochrome c oxidase-deficient (CCO(-)) metaplastic glands were identified using a dual enzyme h

179 In comparison, epithelium from intestinal metaplastic glands within furan-induced hepatic cholangi

180 Mist1-Kras mice developed metaplastic glands, which completely replaced normal fun

181 or of apoptosis, is expressed in LPS-induced metaplastic goblet cells of rat airways.

182 During lactation, the mice develop multiple metaplastic growths which, surprisingly, do not spontane

183 erved in NeuNT tumors, which showed distinct metaplastic histology and worse survival.

184 JNK contribute fundamentally to a long-range metaplastic inhibition of LTP in rats.

185 y explores the role of mGluRs and PKC in the metaplastic inhibition of spinal cord learning using a c

186 Finally, a PKC inhibitor blocked the metaplastic inhibition of spinal learning produced by a

187 ound to be both necessary and sufficient for metaplastic inhibition of spinal learning.

188 carcinogenesis, being more pronounced in the metaplastic intestinal glands of cholangiofibrotic tissu

189 tinal-type cholangiocarcinomas as well as of metaplastic intestinal glands that precede their develop

190 r and tubular carcinomas); group B (IBC-NST, metaplastic, invasive apocrine and micropapillary carcin

191 he balance towards BMP activation attenuated metaplastic KRT5(+) differentiation while promoting adap

192 haron, ectropion, entropion, trichiasis, and metaplastic lashes also were analyzed.

193 n in 8% (2/25; P = 0.47), and trichiasis and metaplastic lashes in 24% (6/25; P = 0.03) eyes.

194 ession was significantly higher in bronchial metaplastic lesions (23 of 49 lesions, 47%) than in hist

195 d2-null tumors contain severe dysplastic and metaplastic lesions and express aberrant amounts of beta

196 Whereas the majority of metaplastic lesions are not of acinar origin, acinar-to-

197 stric cancer by gene expression profiling of metaplastic lesions from patients.

198 are prominently overexpressed in intestinal metaplastic lesions in early putative precancerous chola

199 nking early putative precancerous intestinal metaplastic lesions in liver to later-developed mucin-pr

200 generation of normal tissue and formation of metaplastic lesions of a ductal phenotype.

201 Up-regulated transcripts in metaplastic lesions were confirmed by immunostaining ana

202 n normal oxyntic mucosa, rare in established metaplastic lesions, and lost in intraepithelial neoplas

203 cer using gene expression profiling of human metaplastic lesions.

204 enitors epigenetically committed to distinct metaplastic lesions.

205 However, it accounts for only a minority of metaplastic lesions.

206 tion is identified in a minority of mucinous metaplastic lesions.

207 t airways was not caused by an inflammatory, metaplastic-like response: bronchial-alveolar lavage leu

208 of Mist1-Kras mice led to the full range of metaplastic lineage transitions, including SPEM and IM.

209 the fundic mucosa leads to the emergence of metaplastic lineages associated with an increased suscep

210 tissues, whereas it was detected in <10% of metaplastic lung tissues, squamous cell carcinoma, and a

211 ses in intrinsic excitability may serve as a metaplastic mechanism for memory formation.

212 These findings reveal a novel metaplastic mechanism through which group II mGlu recept

213 timulus, LPS, disrupts hippocampal LTP via a metaplastic mechanism.

214 We propose that RyR-mediated metaplastic mechanisms can be considered as a possible t

215 Further, targeting metaplastic mechanisms presents therapeutic advantages i

216 ng psoriatic plaques to hard palate, a novel metaplastic model is presented.

217 Finally, we found that metaplastic models are robust to changes in model parame

218 lity estimation task, we found that superior metaplastic models perform close to optimally for a wide

219 e Carlo simulations we identified 'superior' metaplastic models that can substantially overcome the a

220 ntiated and highly aggressive carcinoma with metaplastic morphology.

221 esophagus, we took biopsy specimens from the metaplastic mucosa before and after esophageal perfusion

222 Initially, at least 95% ablation of the metaplastic mucosa was achieved in all treated patients.

223 ected wild-type mice had severe atrophic and metaplastic mucosal changes.

224 its expression is responsible for sustaining metaplastic mucous cells.

225 may maintain MCM by preventing cell death in metaplastic mucous cells.

226 cells in the corpus and the appearance of a metaplastic mucous epithelium.

227 t maximum MCM, that IFN-gamma induces Bax in metaplastic mucus cells, and that Bax plays a critical r

228 n and the role of regulators of apoptosis in metaplastic mucus cells.

229 found that cortical inclusion cysts lined by metaplastic Mullerian epithelium abundantly express the

230 In NP, IL-19 is highly expressed in the metaplastic nasal epithelium when compared to normal or

231 nts in the development of malignancy: benign metaplastic never-dysplastic Barrett's esophagus (NDBE;

232 were verified as being expressed in squamous metaplastic NHTBE cells but not in normal mucous NHTBE o

233 ASF) from aberrantly differentiated squamous metaplastic normal human tracheobronchial epithelial (NH

234 both ulcerative colitis (UC) and colonic CD, metaplastic Paneth cells were found to express ITLN2.

235 scription patterns that converged upon a pre-metaplastic pattern, which lacked the metaplasia-associa

236 2 but not p21 Global p53 activation caused a metaplastic phenotype in the pancreas that was missing i

237 e lining epithelia transform into a squamous metaplastic phenotype in vitamin A-deficient animals.

238 acute parietal cell loss revealed that this metaplastic phenotype might arise in part through transd

239 mucous neck cells and chief cells into a pre-metaplastic phenotype that ultimately progressed to meta

240 t predict a shift in the gastric mucosa to a metaplastic phenotype.

241 ent microenvironments in nude mice displayed metaplastic phenotypes, including squamous and basal cha

242 metriosis, by definitively demonstrating the metaplastic potential of stem cells within the peritonea

243 scaling synaptic strength and enhancement of metaplastic potentiating plasticity.

244 In the case of BE, which is a metaplastic precursor to esophageal adenocarcinoma (EAC)

245 the absence of a pathologically identifiable metaplastic precursor, illuminating early detection stra

246 ions, clarifies the role of PanIN lesions as metaplastic precursors to human PDAC, and suggests poten

247 for the clonal expansion and propagation of metaplastic premalignant lesions.

248 ins that are uniquely secreted from squamous metaplastic primary human bronchial epithelial cells cul

249 mechanisms are slowly emerging, much of the metaplastic process remains unknown.

250 n clinical course and has been regarded as a metaplastic process.

251 pithelium by a columnar epithelium through a metaplastic process.

252 veral infiltrating immune populations in the metaplastic progression following inflammation.

253 tigated, for the first time, the directional metaplastic properties in human pharyngeal motor cortex

254 We calculated metaplastic rate as the difference in ectopy between vis

255 Metaplastic rate between the two visits before HPV16 det

256 stochemistry that gene expression changes in metaplastic recombinants reflected human urothelium unde

257 satellite unstable CRCs contain distinct non-metaplastic regions where tumor cells acquire stem cell

258 Metaplastic replacement of epithelial cell composition a

259 inish in number and generate a novel type of metaplastic respiratory cell that is RALDH(-) and secret

260 e whether specific EGFR ligands regulate the metaplastic response to oxyntic atrophy.

261 estrogen depletion might change the squamous metaplastic response to vitamin A deficiency and affect

262 eward learning in adulthood is paralleled by metaplastic restoration of oxytocin-mediated long-term d

263 M) computational model, which incorporates a metaplastic sliding threshold for LTP induction, account

264 y at the transformation zone, a region where metaplastic squamous cells are detected in otherwise col

265 expressed in the lower portions of normal or metaplastic squamous mucosa but that telomerase positive

266 ogical subtypes and uncovers an intermediate metaplastic state during tumorigenesis for multiple gast

267 ells undergoing transition to a precancerous metaplastic state in mouse and human stomach.

268 levels of synaptic activation will induce a metaplastic state that spreads across dendritic compartm

269 In particular, for binary synapses with metaplastic states, we demonstrate for the first time th

270 eal epithelium, mainly by directly affecting metaplastic stem cells.

271 cently been documented in tumors of the rare metaplastic subtype, here we report that rare Id1-expres

272 One metaplastic subtype, which resembled incomplete intestin

273 ormone receptor positivity, ERBB2 status, or metaplastic subtype.

274 Diverse metaplastic subtypes were identified across both disease

275 c glutamate receptor subtype 7 (mGluR7) is a metaplastic switch at MF-SLIN synapses, whose activation

276 fic response to inflammation, we postulate a metaplastic switch by which prepsoriatic skin is convert

277 erneuron (SLIN) synapses, mGluR7 serves as a metaplastic switch controlling bidirectional plasticity.

278 ggests that mGluR2 activation may serve as a metaplastic switch to permit the induction of LTD by inh

279 p, we investigated a biophysically inspired, metaplastic synaptic model within the context of a well-

280 In contrast, DNA from matched normal or metaplastic tissue (containing genetic material of both

281 otein; however, adjacent areas of intestinal metaplastic tissue intensely stained for CDX1.

282 However, squamous metaplastic tissue may be more influential.

283 Finally, we found that normal and metaplastic tissues from patients with evidence of assoc

284 Fifty-two women with metaplastic TNBC (median age, 58 years; range, 37-79 yea

285 Using metaplastic TNBC as a surrogate for mesenchymal TNBC, DA

286 should be performed to test DAT and DAE for metaplastic TNBC, as well as nonmetaplastic, mesenchymal

287 rson Cancer Center of patients with advanced metaplastic TNBC.

288 in and bevacizumab in patients with advanced metaplastic TNBC.

289 s no expression was found in either squamous metaplastic tracheal epithelium or in sections of human

290 e the existence of CD10(+) breast cells with metaplastic traits that can give rise to skin and epider

291 IL13 and IL25 as gatekeepers and enablers of metaplastic transformation and gastric tumorigenesis, th

292 miR-32 increases proliferation and promotes metaplastic transformation in mouse prostate epithelium,

293 lial cells; these cells probably arise via a metaplastic transformation of preexisting endothelium.

294 e a microenvironment that sets the scene for metaplastic transformation of the oesophageal epithelium

295 romoted more extensive gastric inflammation, metaplastic transformation, and tumorigenesis than obser

296 , MMP-7 progressively accumulates during the metaplastic transition, resulting in a concomitant incre

297 bust to changes in model parameters and that metaplastic transitions are crucial for adaptive learnin

298 However, the mechanisms regulating metaplastic transitions in adult epithelia are largely u

299 (+) cells results in the development of rare metaplastic tumors reminiscent of the claudin-low subtyp

300 od for social reward learning and leads to a metaplastic upregulation of oxytocin-dependent long-term