ライフサイエンスコーパス: metastasis suppressor

1 in invasion and metastasis (degradation of a metastasis suppressor).

2 is a p53 family member and potent tumor and metastasis suppressor.

3 ntly broadens the clinical relevance of this metastasis suppressor.

4 These results suggest that MTBP is a metastasis suppressor.

5 tosis-inducing TRAIL receptor (TRAIL-R) as a metastasis suppressor.

6 e coding sequence of CD82 molecule (CD82), a metastasis suppressor.

7 tein that has been identified as a tumor and metastasis suppressor.

8 DRIP130, a transcriptional coactivator, as a metastasis suppressor.

9 argets, including LIFR, a well-characterized metastasis suppressor.

10 family and has been rediscovered as a cancer metastasis suppressor.

11 of bi-directional interaction with the nm23 metastasis suppressor.

12 ght to contain a gene that may function as a metastasis suppressor.

13 ed a dual role, both as a tumor promoter and metastasis suppressor.

14 lation machinery can act as both a tumor and metastasis suppressor.

15 and with downregulation of SMAD4, a known PC metastasis suppressor.

16 ubiquitin transferase, as a potent tumor and metastasis suppressor.

17 havbeta3 and down-regulating CD9, a putative metastasis suppressor.

18 asGAP gene, RASAL2, functions as a tumor and metastasis suppressor.

19 s (BAR) domain protein family and a putative metastasis suppressor.

20 hat members of the miR-196 family are potent metastasis suppressors.

21 ng protein 1)-two genes that we implicate as metastasis suppressors.

22 tic 2 (NME2) as a key MSG from a pool of >30 metastasis suppressors.

23 DA-MB-435 when it is transfected with breast metastasis suppressor 1 (BRMS1) cDNA.

24 Breast cancer metastasis suppressor 1 (BRMS1) functions as a metastasi

25 Breast cancer metastasis suppressor 1 (BRMS1) inhibits formation of ma

26 Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppress

27 Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nucle

28 Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nucle

29 Breast cancer metastasis suppressor 1 (BRMS1) is decreased in non-smal

30 Breast cancer metastasis suppressor 1 (BRMS1) is downregulated in non-

31 Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis of

32 The metastasis suppressor breast cancer metastasis suppressor 1 (BRMS1) upregulates GJIC and dec

33 of the novel genes, designated breast-cancer metastasis suppressor 1 (BRMS1), which maps to human chr

34 Breast cancer metastasis suppressor 1 (BRMS1)-transfected MDA-MB-435 c

35 tic genes identified the scaffolding protein metastasis suppressor 1 (MTSS1) as a novel Akt2-regulate

36 Metastasis Suppressor 1 (MTSS1) was originally identifie

37 Missing in Metastasis (MIM), or Metastasis Suppressor 1 (MTSS1), is a highly conserved p

38 lling functional evidence that breast-cancer metastasis suppressor 1 is a novel mediator of metastasi

39 nced methylation of the BRMS1 (breast cancer metastasis suppressor 1) metastasis suppressor gene prom

40 We show here that Metastasis suppressor-1 (Mtss1; Missing in Metastasis, M

41 NME1 is a metastasis suppressor, a class of proteins which inhibit

42 f the mechanism of action of KAI1 shows that metastasis suppressor activity can be dependent on inter

43 The ER gene, which has growth and metastasis suppressor activity in many different cell ty

44 uence-tagged site markers indicates that the metastasis suppressor activity is located in the q24.2 r

45 c-suppressed protein kinase C substrate with metastasis suppressor activity, is the rodent orthologue

46 /AKAP12, is a large scaffolding protein with metastasis suppressor activity.

47 have recently demonstrated a prostate cancer metastasis-suppressor activity encoded by a discontinuou

48 was sufficient to reverse aspects of SSeCKS metastasis-suppressor activity in both the experimental

49 is a kinase scaffolding protein that encodes metastasis-suppressor activity through the suppression o

50 Mechanisms by which metastasis suppressors alter tumor cells are well charac

51 GAP) for Rad revealed nm23, a putative tumor metastasis suppressor and a development gene in Drosophi

52 mono- and dimethylation of chromatin at key metastasis suppressor and EMT genes, defining a new mech

53 ying signalling pathways downstream of a key metastasis suppressor and indicate that analysis of gene

54 , highlights the importance of RKIP as a key metastasis suppressor and potential therapeutic agent.

55 R-335 locus on 7q32.2 as the first selective metastasis suppressor and tumor initiation suppressor lo

56 Our findings identify miRNA-196s as potent metastasis suppressors and reveal that the ratio of miR-

57 upregulated the expression of KISS1, a tumor metastasis suppressor, and attenuated metastasis in the

58 Genes affected by WNT5A include KISS-1, a metastasis suppressor, and CD44, involved in tumor cell

59 CD82 is a metastasis suppressor, and its expression is often downr

60 r1c/ALK7 has recently been described to be a metastasis suppressor, and we establish herein that it i

61 Tumour metastasis suppressors are inhibitors of metastasis but

62 In contrast to tumor suppressors, metastasis suppressors are rarely mutated or deleted, an

63 s suggest that PKD1 functions as a tumor and metastasis suppressor, at least partly by regulating Sna

64 The metastasis suppressor breast cancer metastasis suppresso

65 ely ten proteins have been characterized as 'metastasis suppressors', but how these proteins function

66 ndicate that merlin functions as a tumor and metastasis suppressor by controlling cadherin-mediated c

67 e for post-translational downregulation of a metastasis suppressor by its ubiquitin ligase, resulting

68 that the miR-23b/-27b cluster functions as a metastasis-suppressor by decreasing HIP1R levels in pre-

69 Elucidating targets of physiological tumor metastasis suppressors can highlight key signaling pathw

70 The 'metastasis suppressor' CD82/KAI-1, a member of the tetra

71 Metastasis suppressors comprise a growing class of genes

72 ed in gastrointestinal cancers, as a pivotal metastasis suppressor correlating with improved colorect

73 of 10 of these genes, including the putative metastasis suppressor CST6, the apoptosis-inducer BIK, a

74 e showed that miR-103/107 targeted the known metastasis suppressors death-associated protein kinase (

75 ry factor receptor (LIFR) as a breast cancer metastasis suppressor downstream of the microRNA miR-9 a

76 Expression of the invasion/metastasis suppressor, E-cadherin, is diminished or lost

77 sting that NMU might be a target of the lung metastasis suppressor effect of RhoGDI2.

78 Metastasis suppressor expression levels can impact tradi

79 asmic and nuclear compartments, modulated by metastasis suppressor expression.

80 iosemicarbazone, but was independent of this metastasis suppressor for di-2-pyridylketone 4-cyclohexy

81 RKIP has been implicated as a metastasis suppressor for prostate cancer, but the mecha

82 These results suggest that CD44 is a metastasis suppressor for prostatic cancer and that decr

83 The human gene CC3 is a metastasis suppressor for small cell lung carcinoma (SCL

84 Human gene CC3 is a metastasis suppressor for variant small cell lung carcin

85 n, but importantly, dramatically reduces the metastasis suppressor function of BRMS1 in both in vitro

86 ly, we show that BRMS1v2 A273V abolishes the metastasis suppressor function of BRMS1v2 and promotes r

87 ogether, our data indicate that the invasion/metastasis suppressor function of E-cadherin is frequent

88 The powerful metastasis suppressor function of KiSS1 gene products ha

89 th roles for these genes as mediators of the metastasis suppressor function of NME1 and NME2.

90 tion of OBSCN by an antisense lncRNA and the metastasis suppressor function of the OBSCN-AS1/OBSCN ge

91 ll growth and apoptosis, how PTEN exerts the metastasis suppressor function remains largely unknown.

92 However, how Drg-1 exerts its metastasis suppressor function remains unknown.

93 RRM1 is the most likely candidate gene with metastasis suppressor function.

94 support the novel hypothesis that IRS-1 has metastasis suppressor functions for breast cancer.

95 KiSS-1 has been shown to function as a tumor metastasis suppressor gene and reduce the number of meta

96 The mechanisms through which the metastasis suppressor gene BRMS1 functions are poorly un

97 tion and transcriptional repression of tumor metastasis suppressor gene BRMS1, highlights a new mecha

98 murine orthologue of the human breast cancer metastasis suppressor gene Brms1, suggesting that alleli

99 entified a novel anti-tumor activity for the metastasis suppressor gene CC3.

100 NA-methyltransferase (MGMT) and the putative metastasis suppressor gene death-associated protein kina

101 the tumor suppressor gene p16, the putative metastasis suppressor gene death-associated protein kina

102 The tumor metastasis suppressor gene Drg-1 has been shown to suppr

103 These studies implicate MKK4/SEK1 as a metastasis suppressor gene encoded by human chromosome 1

104 Erk kinase 1 (MKK4/SEK1) gene as a candidate metastasis suppressor gene encoded by the approximately

105 KAI1 is a metastasis suppressor gene for human prostate cancer and

106 s strongly suggest that Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may s

107 Previous studies demonstrated that CD44 is a metastasis suppressor gene for prostate cancer and that

108 e human chromosome 8p21-p12 region encodes a metastasis suppressor gene for rat prostate cancer.

109 uman chromosome 8p21-p12 region contains the metastasis suppressor gene for the AT6.3 cells.

110 Studies of metastasis suppressor gene function are providing a crit

111 are example demonstrating the relevance of a metastasis suppressor gene function utilized in a develo

112 Here we show that the metastasis suppressor gene homolog Nm23/awd is a negativ

113 tumor suppressor genes Tbx5 and Pten and the metastasis suppressor gene Hoxd10 are significantly upre

114 results show that KiSS-1 also functions as a metastasis suppressor gene in at least some human breast

115 tastasis suppressor 1 (BRMS1) functions as a metastasis suppressor gene in breast cancer and melanoma

116 ytes, suggesting that RND3 might represent a metastasis suppressor gene in HCC.

117 d site markers, and this analysis placed the metastasis suppressor gene in the interval between D8S22

118 cancer patients and suggest that there is a metastasis suppressor gene in this region that may play

119 lls, similar to the overexpression of KiSS-1 metastasis suppressor gene in those cells.

120 We hypothesize that metastasis suppressor gene inactivation or down-regulati

121 l four susceptibility loci: 11q23.3 CADM1, a metastasis suppressor gene involved in modifying tumour

122 This suggests that an additional metastasis suppressor gene is located within the human c

123 s, combined with recent studies of the tumor metastasis suppressor gene KAI1 and plasminogen activato

124 The metastasis suppressor gene KAI1 was identified by its ab

125 Metastin, the gene product of metastasis suppressor gene KiSS-1, is the endogenous lig

126 The metastasis suppressor gene known as Nm23-H1 regulates tu

127 state cancer, which suggests that our target metastasis suppressor gene may also play an important ro

128 a functional link between expression of the metastasis suppressor gene nm23 and cancer cell sensitiv

129 The expression levels of the metastasis suppressor gene Nm23 have been shown to corre

130 Exogenous overexpression of the metastasis suppressor gene Nm23-H1 reduces the metastati

131 was recently identified as a prostate cancer metastasis suppressor gene on human chromosome 11p1.2.

132 KAI1 is a metastasis suppressor gene on human chromosome 11p11.2 t

133 RMS1 (breast cancer metastasis suppressor 1) metastasis suppressor gene promoter via direct recruitme

134 KiSS1 is a metastasis suppressor gene that has been shown to inhibi

135 KAI1 is a tumor metastasis suppressor gene that is capable of inhibiting

136 These findings define caspase-8 as a metastasis suppressor gene that, together with integrins

137 We conclude that RRM1 functions as a metastasis suppressor gene through induction of PTEN exp

138 parental (C8161) metastatic cells, the KISS1 metastasis suppressor gene was isolated.

139 cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene whose mechanisms of action ar

140 SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer pro

141 static cancer cells to map the location of a metastasis suppressor gene(s).

142 These results indicate that RhoGDI2 is a metastasis suppressor gene, a marker of aggressive human

143 To define further the region harboring the metastasis suppressor gene, a truncated human chromosome

144 Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions

145 Loss of the metastasis suppressor gene, KiSS-1 has been strongly cor

146 ether the recently discovered human melanoma metastasis suppressor gene, KiSS-1, which maps to chromo

147 on of the cell cycle inhibitor, p21, and the metastasis suppressor gene, NDRG1 (N-myc downstream-regu

148 ic lineage for the identification of a novel metastasis suppressor gene, serum deprivation response (

149 with a potential oncogenic function of this metastasis suppressor gene.

150 ) kinase 4 (JNKK1/MKK4) as a prostate cancer metastasis suppressor gene.

151 e, is thought to be a tumor suppressor and a metastasis suppressor gene.

152 quely acts by transcriptionally activating a metastasis suppressor gene.

153 ctively, this research implicates FBXL7 as a metastasis-suppressor gene and suggests therapeutic stra

154 e also tested whether chromosome 6 harbors a metastasis-suppressor gene for breast cancer as observed

155 y also indicate that chromosome 11 encodes a metastasis-suppressor gene for human breast cancer.

156 Expression of nm23-H1 (NME1), a known metastasis-suppressor gene in this breast cancer cell li

157 Conventional dogma has regarded E-cad as a metastasis-suppressor gene involved in epithelial-mesenc

158 Decreased expression of the human KAI1 metastasis-suppressor gene is involved in the progressio

159 The finding that DLC-1 can act as a metastasis-suppressor gene supports an influential role

160 ranscript (>300 kb) running antisense to the metastasis-suppressor gene TFPI-2.

161 We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is ass

162 rids, which suggests the presence of a novel metastasis-suppressor gene(s) or novel function of a kno

163 d symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published.

164 g cascade, has been identified recently as a metastasis-suppressor gene.

165 ing hemizygous deletion of the Nme1 and Nme2 metastasis suppressor genes (HPN mice).

166 Twelve metastasis suppressor genes (MSGs) have been identified

167 Although >30 metastasis suppressor genes (MSGs) that negatively regul

168 uggesting that there are tumor suppressor or metastasis suppressor genes encoded by this chromosomal

169 city, suggesting the presence of one or more metastasis suppressor genes encoded on human chromosome

170 However, the discovery of new metastasis suppressor genes in breast cancer using genom

171 We reveal these genes to be novel metastasis suppressor genes in breast cancer.

172 Metastasis suppressor genes inhibit one or more steps re

173 The loss of function of metastasis suppressor genes is a major rate-limiting ste

174 To discover novel metastasis suppressor genes that are clinically relevant

175 t revealed a novel regulatory network of two metastasis suppressor genes, NDRG1 and KAI1, which toget

176 ocused on genetic mechanisms for the loss of metastasis suppressor genes, our results provide new evi

177 pG island promoter methylation, invasion and metastasis suppressor genes, telomere shortening, and ge

178 NDRG1 and KAI1 belong to metastasis suppressor genes, which impede the disseminat

179 NAi screening strategy to identify candidate metastasis suppressor genes.

180 g strategy that enables the discovery of new metastasis suppressor genes.

181 dentifying therapeutic targets downstream of metastasis suppressor genes.

182 t has been demonstrated to repress tumor and metastasis suppressor genes.

183 Metastasis-suppressor genes are attractive candidates fo

184 nctional characterization of prostate cancer metastasis-suppressor genes are discussed.

185 t regulate metastasis, and the importance of metastasis-suppressor genes in this process.

186 SPIR can also up-regulate the expression of metastasis-suppressor genes TIMP2 and TIMP3, thereby red

187 l facilitate the identification of candidate metastasis-suppressor genes.

188 ther a control vector (C-100) or the Nm23-H1 metastasis suppressor (H1-177).

189 BRMS1, like other metastasis suppressors, halts ectopic growth (metastasis

190 Our findings reveal CIC as a conserved metastasis suppressor, highlighting new anti-metastatic

191 nase, NME1/NM23-H1, has been identified as a metastasis suppressor; however, its contribution to loca

192 tion of the metastasis inducer Snail and the metastasis suppressor/immunosurveillance cancer gene pro

193 is a member of the GDI family that acts as a metastasis suppressor in a variety of cancer types; howe

194 hibitor 2 (RhoGDI2) has been identified as a metastasis suppressor in bladder and possibly other canc

195 , our data suggest that KISS1 functions as a metastasis suppressor in PCas and may serve as a useful

196 protein-coupled-receptor-1 (OGR1) is a tumor metastasis suppressor in prostate cancer (PCa).

197 traspanin protein, was first identified as a metastasis suppressor in prostate cancer.

198 ator in Fas-mediated apoptosis pathway and a metastasis suppressor in solid tumors and that metastati

199 trates that miR-127 functions as a tumor and metastasis suppressor in TNBC and that delivery of miR-1

200 Although KISS1 functions as a metastasis suppressor in various cancers, its expression

201 any system, that SPDEF functions as a tumor metastasis suppressor in vivo.

202 ation and invasion in vitro and acts a tumor metastasis suppressor in vivo.

203 ide a mechanism for its role as a tumor- and metastasis-suppressor in breast cancer.

204 ative breast cancers as a tumor promoter and metastasis suppressor, inhibiting TGFbeta-regulated EMT

205 determine how tetraspanin KAI1/CD82, a tumor metastasis suppressor, inhibits cell migration, we asses

206 e inhibitor (Maspin) represents an important metastasis suppressor initially identified in breast can

207 Additionally, an iron-regulated metastasis suppressor interacts with the epidermal growt

208 The BRMS1 metastasis suppressor interacts with the protein AT-rich

209 When wild-type KISS1 metastasis suppressor is expressed, aerobic glycolysis d

210 Cancer metastasis suppressor KAI1/CD82 belongs to the tetraspan

211 ssociates with and targets the transmembrane metastasis suppressor, KAI1 (also known as CD82), for de

212 We show that KDELR3 regulates the metastasis suppressor, KAI1, and report an interaction w

213 ast cancer may account for the loss of tumor metastasis suppressor KiSS-1 expression and thus increas

214 The mechanism of action of the metastasis suppressor KiSS1 and its receptor GPR54 is st

215 lity, and ceramide is proposed to serve as a metastasis-suppressor lipid in ovarian cancer.

216 s correlated with elevated expression of the metastasis suppressor Maspin, the ablation of which rest

217 miR-335 and miR-126 are thus identified as metastasis suppressor microRNAs in human breast cancer.

218 00 family, and the pleiotropic nature of the metastasis suppressor miR-31.

219 ng the expression and functions of the tumor metastasis suppressors miR-200a and miR-141.

220 propose that therapeutic replacement of the metastasis suppressor miRNA-768-3p holds clinical promis

221 The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1

222 tion, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1

223 The metastasis suppressor, N-Myc downstream-regulated gene-1

224 We further show that SGK3 targets the metastasis suppressor NDRG1 for degradation by Fbw7.

225 ytic function of VHL is mediated through the metastasis suppressor Nm23, a protein known to regulate

226 issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apopt

227 It is highly homologous to the putative metastasis suppressor nm23-H1 gene and the closely relat

228 Reduced expression of the metastasis suppressor NM23-H1 is associated with aggress

229 in phosphatase 2A (PP2A), and inhibiting the metastasis suppressor nm23-H1.

230 of the tumor suppressor PP2A, as well as the metastasis suppressor nm23-H1.

231 altering the transcription activities of the metastasis suppressor Nm23-H1.

232 altering the transcription activities of the metastasis suppressor Nm23-H1.

233 rs by targeting and altering the role of the metastasis suppressor Nm23-H1.

234 tosis-related genes Bad and Siva, as well as metastasis suppressor NM23-H2.

235 Here, we demonstrate that the metastasis suppressor, NM23-H1, is degraded by lysosomal

236 t STK15 associates with a putative tumor and metastasis suppressor, NM23-H1.

237 Surprisingly, here we found occupancy of the metastasis suppressor non-metastatic 2 (NME2) within the

238 icated in inhibiting metastasis is the tumor metastasis suppressor nonmetastatic protein 23 homologue

239 entify novel crosstalk between oncogenic and metastasis suppressor pathways, thereby providing mechan

240 ed protein kinase kinase 4 (JNKK1/MKK4) as a metastasis suppressor protein in a mouse xenograft model

241 K1/SEK1, hereafter referred to as MKK4) as a metastasis suppressor protein in ovarian carcinoma.

242 The cancer metastasis suppressor protein KAI1/CD82 is a member of t

243 that deferasirox increased expression of the metastasis suppressor protein N-myc downstream-regulated

244 tein kinase pathway coimmunoprecipitated the metastasis suppressor protein Nm23-H1.

245 Furthermore, the metastasis suppressor protein PDCD4 (programmed cell dea

246 Diminished expression of the metastasis suppressor protein RKIP was previously report

247 sor 1 (MTSS1) was originally identified as a metastasis suppressor protein whose expression is lost i

248 E-cadherin is a metastasis-suppressor protein and its loss of function i

249 a transcriptional regulatory network for the metastasis suppressor Raf kinase inhibitory protein (RKI

250 Expression levels of the novel tumor and metastasis suppressor Raf-1 kinase inhibitor protein (RK

251 To identify downstream targets of the metastasis suppressor Raf-1 kinase inhibitory protein (R

252 iple underlies the action of a physiological metastasis suppressor, Raf Kinase Inhibitory Protein (RK

253 the lung but are growth-inhibited unless the metastasis suppressor region is lost.

254 the lung but are growth-inhibited unless the metastasis-suppressor region is lost.

255 d by the presence of the approximately 70-cM metastasis-suppressor region will facilitate the identif

256 a mouse xenograft model to determine how the metastasis suppressor RKIP influences transcription in a

257 two novel signaling pathways targeted by the metastasis suppressor RKIP that regulate remodeling of t

258 reviously unsuspected mechanism by which the metastasis-suppressor RKIP regulates tumor invasiveness,

259 suggests a physiological lung and lymph node metastasis suppressor role for RhoA GTPase in breast can

260 lysis of TNBC cells stably integrated with a metastasis suppressor SH3GL2 identified SPANXB1 as a pot

261 rdingly, ATF3 promoted the expression of the metastasis suppressor SHARP1 in mutp53-expressing cells.

262 The individual genetic loss of the metastasis suppressor, SSeCKS/Gravin/AKAP12 or Rb, genes

263 BC is characterized by reduced expression of metastasis suppressors such as Raf kinase inhibitory pro

264 Therefore, TRAIL-R is a novel metastasis suppressor, suggesting that TRAIL-related tum

265 roteins that interact with a breast tumor or metastasis suppressor, SYK (spleen tyrosine kinase).

266 P53 lead to the inhibition of the tumour and metastasis suppressor TAp63, a p53 family member.

267 ell stiffness by restoring expression of the metastasis suppressor TbetaRIII/betaglycan decreases inv

268 ulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory e

269 These findings identify LIFR as a metastasis suppressor that functions through the Hippo-Y

270 CC3 is a metastasis suppressor that inhibits metastasis of the va

271 0, also called CC3 or Htatip2, is a putative metastasis suppressor that promotes apoptosis and inhibi

272 NM23 (NME) is a metastasis suppressor that significantly reduces metasta

273 These results suggest that miR-23b/-27b are metastasis suppressors that might serve as novel biomark

274 tyrosine kinase (Syk) is a candidate tumor (metastasis) suppressor that is highly expressed in mamma

275 downregulates miR-452, which acts as a novel metastasis suppressor to directly target the SNAI2 3'-un

276 inhibiting ROCK signaling and repressing the metastasis suppressor TSP-1.

277 the expression of FOXA2, a crucial tumor and metastasis suppressor via coordinated epigenetic mechani

278 RNA editing hotspot in miR-200b, a key tumor metastasis suppressor, we found that the miR-200b editin

279 Maspin is a type II tumour metastasis suppressor which has multiple cellular effect

280 The human orthologue of Ndk is the NM23 metastasis suppressor, which we found to exhibit a simil

281 nstream regulated gene 1 (NDRG1) is a potent metastasis suppressor with an undefined role in the stre