ライフサイエンスコーパス: methionine sulfoxide

1 ynureninyl products as well as betaMet-55 to methionine sulfoxide.

2 elding both the (R) and (S) diastereomers of methionine sulfoxide.

3 non-polar methionine to the more hydrophilic methionine sulfoxide.

4 ected SO band at 1025 cm-1 characteristic of methionine sulfoxide.

5 of one of the peptides had been oxidized to methionine sulfoxide.

6 could not grow, in the presence of H2O2 and methionine sulfoxide.

7 yeast strain could grow on either form of L-methionine sulfoxide.

8 on of surface-exposed methionine residues to methionine sulfoxide.

9 ontaining DmsABC enzymatic complex to reduce methionine sulfoxide.

10 ted four out of nine Met residues of RecA to methionine sulfoxide.

11 by phagocytes oxidize methionine, generating methionine sulfoxide.

12 residues are posttranslationally oxidized to methionine sulfoxide.

13 eferentially targeted, forming predominantly methionine sulfoxide.

14 HypT is activated by methionine oxidation to methionine sulfoxide.

15 e reaction, oxidizing methionine residues to methionine sulfoxide.

16 ic oxidation and reduction of methionine and methionine sulfoxide.

17 thionine and is specific for the S epimer of methionine sulfoxide.

18 rrelated and also correlated positively with methionine sulfoxide.

19 ic oxidation and reduction of methionine and methionine sulfoxide.

20 ndogenous methionines to their corresponding methionine sulfoxides.

21 ated CaMox, which varies from three to eight methionine sulfoxides.

22 multiple methionines to their corresponding methionine sulfoxides.

23 r/MsrA mutant could not grow on a mixture of methionine sulfoxides.

24 olysis of methionine gives rise primarily to methionine sulfoxide (+16 Da mass shift); this can be fu

25 Furthermore, peptides containing methionine sulfoxide, 3-chlorotyrosine, and nonspecific

26 d amino acid profile and increased levels of methionine sulfoxide, an oxidative stress biomarker, in

27 ich both methionine residues are oxidized to methionine sulfoxide and a control peptide consisting of

28 e msrA gene increases free and protein-bound methionine sulfoxide and decreases cell viability.

29 correlated with an increase in the levels of methionine sulfoxide and dityrosine.

30 rew better, had lower free and protein-bound methionine sulfoxide and had a better survival rate unde

31 Singlet oxygen forms methionine sulfoxide and methionine sulfone.

32 al oxidative protein modifications involving methionine sulfoxide and nitrotyrosine.

33 shed through mass spectrometric detection of methionine sulfoxide and the reactivation of a significa

34 HOCl can oxidize methionine to methionine sulfoxide and tyrosine to chlorotyrosine.

35 amino acid methionine is readily oxidized to methionine sulfoxide, and its reduction is catalyzed by

36 malondialdehyde, protein carbonyls, protein methionine sulfoxide, and oxidized glutathione as well a

37 on of microcystins containing methionine and methionine sulfoxide, and reveals the oxidation state of

38 idants react readily with methionine to form methionine sulfoxide, and surface exposed methionine res

39 xygen species oxidize methionine residues to methionine sulfoxide, and the methionine sulfoxide reduc

40 n spectroscopy reveals the presence of H2O2, methionine sulfoxide, and tryptophan metabolites; i.e.,

41 We show that ortho-tyrosine and methionine sulfoxide are formed in concert with Nepsilon

42 eir corresponding oxidized forms cystine and methionine sulfoxide are presented.

43 This suggests that microcystins containing methionine sulfoxide are primarily postextraction oxidat

44 ver tissue confirms that both methionine and methionine-sulfoxide are significantly more elevated in

45 ereospecific methionine oxidase, producing S-methionine sulfoxide as its product.

46 to its facile oxidation via the formation of methionine sulfoxide, as shown by mass spectrometry.

47 is demonstrated that oxidation of Met-148 to methionine sulfoxide associated quantitatively with loss

48 the effects of oxidative damage by reducing methionine sulfoxide back to methionine and recovering p

49 MSRs reduce the methionine sulfoxide back to methionine, restoring the a

50 oxidized methionine in proteins by reducing methionine sulfoxide back to methionine.

51 atalyze a thioredoxin-dependent reduction of methionine sulfoxide back to methionine.

52 he presence of Sec improves the reduction of methionine sulfoxide by MsrAs.

53 Quantification of the abundant methionine sulfoxide by NMR and MS gave highly comparabl

54 n be repaired via reduction of the resulting methionine sulfoxides by methionine-S-sulfoxide reductas

55 susceptible to oxidation, and the resulting methionine sulfoxides can be reduced back to methionines

56 oxidized proteins and MsrA, which reduces S-methionine sulfoxide, can protect lens cells against oxi

57 s are particularly sensitive to oxidation to methionine sulfoxide derivatives, these oxidations are r

58 sidues in proteins and peptides to (R and S)-methionine sulfoxide diasteriomers.

59 ification of methionine to the corresponding methionine sulfoxide does not predispose CaM to further

60 n was through the oxidation of methionine to methionine sulfoxide, established through mass spectrome

61 ctivate the PM Ca-ATPase results solely from methionine sulfoxide formation and (ii) MsrA can repair

62 idation of protein-bound methionines to form methionine sulfoxides has a broad range of biological ra

63 e roles of MsrB1, -B2 and -B3 which reduce R-methionine sulfoxide have not been established for any m

64 Substitution of methionine with methionine sulfoxide in a medium lacking hydrogen peroxi

65 ctional domains of ADAMTS13 were oxidized to methionine sulfoxide in an HOCl concentration-dependent

66 ine residues of ingested Escherichia coli to methionine sulfoxide in high yield.

67 , except that the myristoylated form reduced methionine sulfoxide in protein much faster than the non

68 e discuss how the oxidation of methionine to methionine sulfoxide in signalling proteins such as ion

69 -Raman Spectroscopy revealed the presence of methionine sulfoxide in the depigmented skin of patients

70 of Bacillus species were readily oxidized to methionine sulfoxide in vitro by t-butyl hydroperoxide (

71 hat MsrA is responsible for the reduction of methionine sulfoxide in vivo as well as in vitro in euka

72 Repair of selected methionine sulfoxides in CaMox by MsrA results in a part

73 Oxidation of methionine to methionine sulfoxide is a common form of damage observed

74 Oxidation of methionine to methionine sulfoxide is a major oxidative stress product

75 However, no single methionine sulfoxide is completely repaired in all CaM o

76 The oxidation of methionine in proteins to methionine sulfoxide is implicated in aging as well as i

77 lysis by reducing agents such as TCEP, while methionine sulfoxide is refractory to reduction by this

78 gments of CaMox vary by a factor of 2, where methionine sulfoxides located within hydrophobic sequenc

79 osition (x = 7, 9, and 11) of methionine (M)/methionine sulfoxide (M-ox) within the peptide sequences

80 that oxidation of the Met-35 side chain to a methionine sulfoxide (Met-35(ox)) significantly hinders

81 ctase (MsrA; EC ) catalyzes the reduction of methionine sulfoxide (Met-O) in proteins to methionine (

82 lot in association with a functional loss of methionine sulfoxide (Met-S=O) repair in the entire gray

83 An enzyme that reduces methionine sulfoxide [Met(O)] residues in proteins [pept

84 epair enzyme that catalyzes the reduction of methionine sulfoxide [Met(O)] residues in proteins to me

85 ling, and their reversible oxidation to form methionine sulfoxides [Met(O)] in calmodulin (CaM) and o

86 of critical methionine residues by reducing methionine sulfoxide, Met(O), to methionine.

87 We show that methionine sulfoxide, methionine sulfone, N-formylkynure

88 The reduction of methionine sulfoxide (MetO) is mediated by methionine su

89 Mammals contain two methionine sulfoxide (MetO) reductases, MsrA and MsrB, t

90 Reduction of methionine sulfoxide (MetO) residues in proteins is cata

91 These latter small peptides are enriched in methionine sulfoxides (MetO), suggesting a preferential

92 e oxygen species (ROS) oxidize methionine to methionine sulfoxide (MetSO) and thereby inactivate prot

93 e oxygen species (ROS) oxidize methionine to methionine sulfoxide (MetSO) and thereby inactivate prot

94 ve developed a new technique for quantifying methionine sulfoxide (MetSO) in protein to assess levels

95 the oxidative stress-induced R enantiomer of methionine sulfoxide (MetSO), reducing it to methionine

96 ROS oxidize methionine to methionine sulfoxide (MetSO), rendering several proteins

97 ies that reduce the S and R stereoisomers of methionine sulfoxide (MetSO), respectively, and together

98 es, which is illustrated in the synthesis of methionine sulfoxide (MSO).

99 nd conversion of some methionine residues to methionine sulfoxide (MSOX) residues.

100 tified the major metabolite, 3-nitrotyrosine-methionine-sulfoxide (NSO)-MENK, using liquid chromatogr

101 mmunosuppressive activity than their reduced methionine sulfoxide peptide forms 4 and 6, respectively

102 loped a sensitive method of quantitating the methionine sulfoxide present at position 213 (MetSO213)

103 r Met(146) in wheat germ calmodulin (CaM) to methionine sulfoxide prevents the CaM-dependent activati

104 commentary shows that both diastereomers of methionine sulfoxide (R and S) can be repaired in the hu

105 rves as an excellent model for protein-bound methionine sulfoxide recognition and repair.

106 these genes are fused to form a bifunctional methionine sulfoxide reductase (i.e., MsrBA) enzyme.

107 enerally accepted, primarily from studies on methionine sulfoxide reductase (Msr) A, that the biologi

108 The methionine sulfoxide reductase (MSR) enzyme converts Met

109 Methionine sulfoxide reductase (MSR) enzyme converts Met

110 presses antioxidant enzymes, among which are methionine sulfoxide reductase (Msr) enzymes, which are

111 The role of methionine sulfoxide reductase (Msr), a methionine repai

112 Met5 of alphaS are excellent substrates for methionine sulfoxide reductase (Msr), thereby providing

113 Met sulfoxide can be repaired back to Met by methionine sulfoxide reductase (Msr).

114 Peptide methionine sulfoxide reductase (MsrA) repairs oxidative

115 Peptide methionine sulfoxide reductase (MsrA) reverses oxidative

116 We have investigated the ability of methionine sulfoxide reductase (MsrA) to maintain optima

117 A gene homologous to methionine sulfoxide reductase (msrA) was identified as

118 The yeast peptide-methionine sulfoxide reductase (MsrA) was overexpressed

119 ty with the carboxyl terminus of the peptide-methionine sulfoxide reductase (MsrA), a repair enzyme,

120 We report that peptide methionine sulfoxide reductase (MsrA), a repair enzyme,

121 ted by an unrelated protein known as peptide methionine sulfoxide reductase (MsrA), an antioxidant re

122 an mutants in cytochrome c peroxidase (ccp), methionine sulfoxide reductase (msrA), or the metal-bind

123 oxidized alpha/beta-type SASP with peptidyl methionine sulfoxide reductase (MsrA), which can reduce

124 ly matches that of only one protein, peptide methionine sulfoxide reductase (MsrA).

125 ations are readily repaired by the action of methionine sulfoxide reductase (MsrA).

126 Peptide methionine sulfoxide reductase (MsrA; EC ) catalyzes the

127 Peptide methionine sulfoxide reductase (MsrA; EC ) reverses the

128 Peptide methionine sulfoxide reductase (MsrA; EC 1.8.4.6) is a u

129 Moreover, we show that periplasmic methionine sulfoxide reductase (MsrP) is part of the Cpx

130 the E. coli periplasmic molybdenum-dependent methionine sulfoxide reductase (MsrP).

131 Peptide methionine sulfoxide reductase (PMSR) is a ubiquitous en

132 ild-type plants and a mutant lacking peptide methionine sulfoxide reductase (pmsr2-1) showed increase

133 hesin (one UGA) of Mycoplasma pneumoniae and methionine sulfoxide reductase (two UGAs) of Mycoplasma

134 thione peroxidase, ascorbate peroxidase, and methionine sulfoxide reductase 2) are slightly up-regula

135 cardial CaMKII inhibition, overexpression of methionine sulfoxide reductase A (an enzyme that reduces

136 The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the re

137 Methionine sulfoxide reductase A (MsrA) catalyzes the re

138 o lower laying rate, egg mass, expression of methionine sulfoxide reductase A (MSRA) gene, and antiox

139 Methionine sulfoxide reductase A (MsrA) is an antioxidan

140 Methionine sulfoxide reductase A (MsrA) is an enzyme inv

141 Methionine sulfoxide reductase A (MsrA) maintains the fu

142 quitously expressed methionine repair enzyme methionine sulfoxide reductase A (MsrA) on the metabolic

143 Methionine sulfoxide reductase A (MsrA) repairs oxidized

144 that a mutant form of M. genitalium lacking methionine sulfoxide reductase A (MsrA), an antioxidant

145 CaMKII oxidation is reversed by methionine sulfoxide reductase A (MsrA), and MsrA-/- mic

146 Here, we report that methionine sulfoxide reductase A (MSRA), which can reduc

147 n that can be reversed through the action of methionine sulfoxide reductase A (MsrA), which is implic

148 n-like domain (NT domain) is fused to tandem methionine sulfoxide reductase A and B domains (MsrA/B).

149 r, we demonstrate almost absent catalase and methionine sulfoxide reductase A and B protein expressio

150 horesis (CE) method for the determination of methionine sulfoxide reductase A and methionine sulfoxid

151 Methionine sulfoxide reductase A is an essential enzyme

152 Methionine sulfoxide reductase A is an essential enzyme

153 Lipidation of methionine sulfoxide reductase A occurs in the mouse, in

154 have unraveled the redox relay mechanisms of methionine sulfoxide reductase A of the pathogen Coryneb

155 quinone reductase, glutathione reductase and methionine sulfoxide reductase A proteins were significa

156 xpressions of only glutathione reductase and methionine sulfoxide reductase A proteins were significa

157 ecies signaling by targeting the antioxidant methionine sulfoxide reductase A to modulate liposarcoma

158 TARD3 as an in vivo binding partner of MSRA (methionine sulfoxide reductase A), an enzyme that reduce

159 dium-restricted transgenic overexpression of methionine sulfoxide reductase A, an enzyme that reduces

160 dants superoxide dismutase (SOD2), catalase, methionine sulfoxide reductase A, and the 20S proteasome

161 ysine residues of diverse targets, including methionine sulfoxide reductase A, myosin light chain kin

162 whereas over-expression of a repair enzyme, methionine sulfoxide reductase A, rendered them resistan

163 of myristoylated and nonmyristoylated mouse methionine sulfoxide reductase A.

164 ained by uniform selenium deficiency because methionine sulfoxide reductase activities were similar i

165 Besides, higher expression of methionine sulfoxide reductase and cysteine peroxiredoxi

166 tion of methionine sulfoxide reductase A and methionine sulfoxide reductase B activities in mouse liv

167 o binding MSRA, STARD3 binds all three MSRB (methionine sulfoxide reductase B), enzymes that reduce m

168 fraction of inactivated GroEL by the enzyme methionine sulfoxide reductase B/A (MsrB/A).

169 We further expressed mouse methionine sulfoxide reductase B1 (MsrB1), a selenoenzym

170 lly, we found that a cytosolic pool of human methionine sulfoxide reductase B2 (MsrB2) is strongly re

171 The enzymatic activity of the methionine sulfoxide reductase DmsABC helps Salmonella m

172 Methionine sulfoxide reductase enzymes MsrA and MsrB hav

173 liquid-like droplets in a manner reversed by methionine sulfoxide reductase enzymes.

174 ossesses significant homology to the peptide methionine sulfoxide reductase family of enzymes, specif

175 Here, a methionine sulfoxide reductase gene (AdMsrB1) was identi

176 s of apoA-I and oxidized apoA-I treated with methionine sulfoxide reductase implicate oxidation of sp

177 This characteristic supports a role for methionine sulfoxide reductase in redox signaling.

178 ding or the repair of oxidized calmodulin by methionine sulfoxide reductase induces comparable change

179 e pK(a) of the active site cysteine of mouse methionine sulfoxide reductase is 7.2 even in the absenc

180 of oxidized methionine residues performed by methionine sulfoxide reductase is important for the gast

181 versible and is regulated by the cytoplasmic methionine sulfoxide reductase Mxr1 (MsrA) and a previou

182 Reversing oxidation with methionine sulfoxide reductase restored HDL's ability to

183 MsrPQ is a newly identified methionine sulfoxide reductase system found in bacteria,

184 MtsZ is a molybdenum-containing methionine sulfoxide reductase that supports virulence i

185 ine in proteins involving the enzyme peptide methionine sulfoxide reductase type A (MSRA) is postulat

186 m Escherichia coli and the electron acceptor methionine sulfoxide reductase, also from E. coli, stron

187 Methionine sulfoxide reductase, which reduces methionine

188 In contrast, CshA- and methionine sulfoxide reductase-negative (MsrA-) strains

189 ould be reversed by treating the enzyme with methionine sulfoxide reductase.

190 and the oxidized protein was incubated with methionine sulfoxide reductase.

191 ribonucleotide reductase, peroxiredoxin, and methionine sulfoxide reductase.

192 s, in particular alkenal reductase PTGR1 and methionine sulfoxide reductase.

193 it is reversed by coexpression with peptide methionine sulfoxide reductase.

194 ion mediated by a ubiquitous enzyme, peptide methionine sulfoxide reductase.

195 BC transporter solute-binding protein, and a methionine sulfoxide reductase.

196 nt study on the reducing requirement for the methionine sulfoxide reductases (Msr), we have shown tha

197 f methionine sulfoxide (MetO) is mediated by methionine sulfoxide reductases (Msr).

198 ein functional changes through the action of methionine sulfoxide reductases (Msr).

199 Peptide methionine sulfoxide reductases (MsrA) from many differe

200 Methionine sulfoxide reductases (MSRs) are key enzymes i

201 Methionine sulfoxide reductases (Msrs) are oxidoreductas

202 s damage is reversible through the action of methionine sulfoxide reductases (MSRs), which play key r

203 n is catalyzed by a family of enzymes called methionine sulfoxide reductases (MSRs).

204 oxidized methionine residues is catalyzed by methionine sulfoxide reductases (Msrs).

205 ically oxidized, and subsequently reduced by methionine sulfoxide reductases (Msrs).

206 revisiae as a model, we show that of the two methionine sulfoxide reductases (MXR1, MXR2), deletion o

207 rx2) and the intracellular and extracellular methionine sulfoxide reductases (SpMsrAB1 and SpMsrAB2,

208 (MetO) residues in proteins is catalyzed by methionine sulfoxide reductases A (MSRA) and B (MSRB), w

209 In normal healthy human skin, methionine sulfoxide reductases A and B specifically red

210 S) can be repaired in the human epidermis by methionine sulfoxide reductases A and B, respectively.

211 MSRAs (methionine sulfoxide reductases A) are enzymes that reve

212 Inactivation of HypT depends on the methionine sulfoxide reductases A/B.

213 Methionine sulfoxide reductases are conserved enzymes th

214 Peptide methionine sulfoxide reductases are conserved enzymes th

215 Methionine sulfoxide reductases are key enzymes that rep

216 ne residues to methionine sulfoxide, and the methionine sulfoxide reductases catalyze their reduction

217 activity of plastidial thiol peroxidases and methionine sulfoxide reductases employing a single cyste

218 a proof of principle, fluorogenic probes for methionine sulfoxide reductases have been developed.

219 However, the identity of all methionine sulfoxide reductases involved, their cellular

220 Deletion or mutation in conserved methionine sulfoxide reductases leads to aging and sever

221 Here we used yeast methionine sulfoxide reductases MsrA and MsrB to address

222 teins or repair oxidized residues, including methionine sulfoxide reductases MsrA and MsrB, which red

223 erations of RecA activity were suppressed by methionine sulfoxide reductases MsrA and MsrB.

224 The highly conserved methionine sulfoxide reductases protect proteins from ox

225 sporadically evolved Sec-containing forms of methionine sulfoxide reductases reflect catalytic advant

226 Reduction back to methionine by methionine sulfoxide reductases would allow the antioxid

227 Most cells contain methionine sulfoxide reductases, which catalyze a thiore

228 so observed that are catalyzed by endogenous methionine sulfoxide reductases.

229 he action of stereospecific enzymes known as methionine sulfoxide reductases.

230 Methionine-sulfoxide reductases are unique, in that thei

231 Comparable extents of methionine sulfoxide reduction are also observed that ar

232 Cd-MsrB catalyzes methionine sulfoxide reduction involving three redox-act

233 Alternatively, MsrA catalyzes methionine sulfoxide reduction linked to the mycothiol/m

234 rved SelR enzyme family, define a pathway of methionine sulfoxide reduction, reveal a case of converg

235 Disruption of bacterial methionine sulfoxide repair systems rendered E. coli mor

236 metry to investigate the extent and rates of methionine sulfoxide repair within CaMox.

237 sulfoxide reductase (MsrA), which can reduce methionine sulfoxide residues back to methionine, restor

238 4.6) is a ubiquitous protein that can reduce methionine sulfoxide residues in proteins as well as in

239 fense against oxidative stresses by reducing methionine sulfoxide residues in proteins back to methio

240 MsrA and MsrB in E. coli are able to reduce methionine sulfoxide residues in proteins to methionines

241 Oxidative damage, mainly methionine sulfoxide residues, was also increased: 2.5 v

242 and to conversion of methionine residues to methionine sulfoxide residues.

243 were modified to cysteine sulfenic acid and methionine sulfoxide, respectively.

244 24) thiolate, which directly interacted with methionine sulfoxide, resulting in methionine and a Cys(

245 oxide reductases A and B specifically reduce methionine sulfoxides (S) and (R), respectively, back to

246 activity and the reduction activity of free methionine sulfoxide(s) were stereoselective toward the

247 Raman bands characteristic of methionine sulfoxide show that extensive methionine oxid

248 usly unrecognized part that accommodates the methionine sulfoxide side chain via interaction with His

249 ous substitution by glutamine, mimicking the methionine sulfoxide state, increased the viability of E

250 ge into methionine, N-glycyl-methionine, and methionine sulfoxide suggests that a prominent solvent e

251 )H incorporation into the gamma-methylene of methionine sulfoxide that is absent for N-glycyl-methion

252 For methionine sulfoxide the inflection point energy is 2.8

253 nonoxidized), and with increasing numbers of methionine sulfoxides the kinetics of fibrillation becam

254 When this methionine residue is oxidized to methionine sulfoxide, the inactivation is disrupted, and

255 tein repair each targeting a diastereomer of methionine sulfoxide, their deletion resulted in differe

256 ble to oxidation with a 25-75% loss, forming methionine sulfoxide through a two-electron oxidation pa

257 with methionine residues in proteins to form methionine sulfoxide, thus scavenging the reactive speci

258 eductase A (MsrA) catalyzes the reduction of methionine sulfoxide to methionine and is specific for t

259 ethionine sulfoxide reductase, which reduces methionine sulfoxide to methionine in a thioredoxin-depe

260 Taken together, MSRB3-catalyzed reduction of methionine sulfoxides to methionine is essential for hea

261 so capable of reducing nicotinamide N-oxide, methionine sulfoxide, trimethylamine-N-oxide, and dimeth

262 However, much more methionine sulfoxide was generated by peroxide treatment

263 rmore, high levels of free and protein-bound methionine sulfoxide were detected in extracts of msrA m

264 metformin therapy, arginine-derived AGE and methionine sulfoxide were lower than in patients not rec

265 -Glu-cys, gamma-Glu-met-gly, methionine, and methionine sulfoxide were not transported by Seo1p.

266 markers of oxidative stress such as urinary methionine sulfoxide were observed in Hhip (+/-) but not

267 of a variety of other substrates, including methionine sulfoxide, with decreased efficiencies, sugge

268 sulfoxide formation and (ii) MsrA can repair methionine sulfoxides within cytosolic proteins.

269 air by MsrA, there remains a distribution of methionine sulfoxides within functionally reactivated Ca

270 The rates of repair of methionine sulfoxides within individual tryptic fragment

271 dary structure, suggesting that MsrA repairs methionine sulfoxides within unfolded sequences until na

272 e report the synthesis of amphiphilic poly(l-methionine sulfoxide)(x)-b-poly(dehydroalanine)(y), dibl