ライフサイエンスコーパス: methyl-CpG-binding protein 2

1 sed by mutations in the X-linked gene MECP2 (methyl-CpG-binding protein 2).

2 , hypoxia-related transcription factors, and methyl CpG binding protein 2.

3 d with mutations in MECP2, the gene encoding methyl CpG-binding protein 2.

4 ansducin beta-like 1 X-linked receptor 1 and methyl-CpG binding protein 2.

5 of de novo DNA methyltransferase DNMT3a and methyl-CpG-binding protein 2.

6 order caused by mutations in MECP2, encoding methyl-CpG-binding protein 2.

7 from mutation in the mecp2 gene that encodes methyl CpG binding protein 2, a transcriptional represso

8 NA methyltransferases (DNMT1 and DNMT3A) and methyl-CpG binding protein 2, a DNA methylation reader p

9 so notable are two neuron-enriched proteins, methyl CpG-binding protein 2 and polypyrimidine tract-bi

10 in repression of PPARgamma: increased MeCP2 (methyl CpG binding protein 2) and HP-1alpha co-repressor

11 We found transcription factors MECP2 (methyl CpG binding protein 2) and SNAIL (Zinc Finger Pro

12 RTT), caused by mutations in MECP2 (encoding methyl CpG binding protein 2), and Angelman syndrome (AS

13 tone methyltransferases and demethylases, or methyl CpG binding protein 2, and a significant decrease

14 he heterochromatin-associated proteins MBD1, methyl-CpG-binding protein 2, and HP1alpha.

15 Mutations in MECP2, encoding methyl-CpG-binding protein 2, are responsible for approx

16 in MECP2, encoding the epigenetic regulator methyl-CpG-binding protein 2, are the predominant cause

17 1 and 2, histone methyl-transferase G9a, and methyl CpG binding protein 2 at the promoters of target

18 Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome.

19 Mutations in MECP2, encoding methyl CpG-binding protein 2, cause Rett syndrome, the m

20 5-hmC levels were inversely correlated with methyl-CpG-binding protein 2 dosage, a protein encoded b

21 nuclear antigen, heterochromatin protein 1, methyl-CpG binding protein 2, Enhancer of Zeste homolog

22 Methyl-CpG binding protein 2-expressing neurons were mor

23 T) arises from loss-of-function mutations in methyl-CpG binding protein 2 gene (Mecp2), but fundament

24 Mutations in the methyl-CpG binding protein 2 gene, Mecp2, affect primari

25 The aim of this study was to examine methyl-CpG-binding protein 2 gene (MECP2) polymorphisms

26 ace since the identification of mutations in methyl-CpG-binding protein 2 gene (MECP2) was first repo

27 sorder most often caused by mutations in the methyl-CpG-binding protein 2 gene (MECP2).

28 The methyl-CpG-binding protein 2 gene, MECP2, is an X chromo

29 rodevelopmental disorder in which the MECP2 (methyl CpG-binding protein 2) gene is mutated.

30 l disorder caused by mutations in the MECP2 (methyl-CpG binding protein 2) gene, because overexpressi

31 n two such factors, CREB-binding protein and methyl-CpG-binding protein 2, have begun to reveal how e

32 se 1, ten-eleven-translocation hydroxylases, methyl CpG binding protein 2, histone deacetylases, and

33 decreased C/EBPbeta and pCREB and increased methyl-CpG binding protein-2, histone-deacetylase-2, and

34 MeCP2 (methyl CpG binding protein 2) is a key player in recogni

35 X-linked gene encoding the epigenetic factor methyl-CpG-binding protein-2, is mutated in Rett syndrom

36 nction mutations of the X-linked gene MECP2 (methyl-CpG binding protein 2) lead to severe neurodevelo

37 nteraction between histone deacetylase 2 and methyl-CpG-binding protein 2, leading to suppressed hist

38 n immunoprecipitation analysis revealed that methyl-CpG-binding protein 2 (MBD2) is associated prefer

39 activity by 30%, and reduced the binding of methyl CpG binding protein 2 (MeCP2) and increased the b

40 Mutations in methyl CpG binding protein 2 (MeCP2) are mainly responsi

41 Mutations in the transcriptional repressor methyl CpG binding protein 2 (MeCP2) are responsible for

42 Mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) are the primary cau

43 mal expression of the X-linked gene encoding methyl CpG binding protein 2 (MeCP2) cause a spectrum of

44 opmental disorder caused by mutations in the Methyl CpG binding protein 2 (MeCP2) gene.

45 tification of mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) in Rett syndrome re

46 Methyl CpG binding protein 2 (MeCP2) is a key component

47 mainly caused by mutations of a single gene methyl CpG binding protein 2 (MeCP2) on the X chromosome

48 der caused by mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) that occur sporadic

49 chromatin immunoprecipitation (ChIP) assays, methyl CpG binding protein 2 (MeCP2) was shown to bind t

50 polypeptide backbone dynamics of full-length methyl CpG binding protein 2 (MeCP2) when free in soluti

51 MECP2 codes for methyl CpG binding protein 2 (MECP2), a transcriptional

52 (HP1), polycomb protein complex 1 (PRC1) and methyl CpG binding protein 2 (MeCP2), at the COX-2 promo

53 The X-linked transcriptional repressor methyl CpG binding protein 2 (MeCP2), known for its role

54 tone H1, high mobility group D1 (HMGD1), and methyl CpG binding protein 2 (MeCP2), on the biophysical

55 n the gene encoding the transcription factor Methyl CpG Binding Protein 2 (MECP2).

56 ction mutations in the transcription factor, Methyl CpG binding protein 2 (MECP2).

57 We also demonstrate that methyl CpG binding protein-2 (MeCP2) levels affect TRPC6

58 CNV disorder caused by duplications spanning methyl CpG-binding protein 2 (MECP2) and other genes on

59 r the expression of the epigenetic regulator methyl CpG-binding protein 2 (MeCP2) in key brain reward

60 Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurod

61 ontal cortex vasopressin receptor (V1aR) and methyl CpG-binding protein 2 (MeCP2) mRNA expression, bu

62 y loss-of-function heterozygous mutations of methyl CpG-binding protein 2 (MECP2) on the X chromosome

63 l activity-induced phosphorylation (NAIP) of methyl CpG-binding protein 2 (MeCP2) precedes its releas

64 munoprecipitation analysis revealed that the methyl CpG-binding protein 2 (MeCP2) was enriched in the

65 eport that HMGN1 modulates the expression of methyl CpG-binding protein 2 (MeCP2), a DNA-binding prot

66 tion in the brain, the Rett syndrome protein methyl CpG-binding protein 2 (MeCP2), and discuss how di

67 structure and domain organization of native methyl CpG-binding protein 2 (MeCP2), the recombinant hu

68 is active epigenetic state was replaced by a methyl CpG-binding protein 2 (MeCP2)-containing repressi

69 n caused by mutations in the gene coding for methyl CpG-binding protein 2 (MECP2).

70 is caused by mutations in the gene encoding methyl CpG-binding protein 2 (MeCP2).

71 by mutations in a transcriptional regulator, methyl CpG-binding protein 2 (MECP2).

72 s caused by mutations in the gene coding for methyl CpG-binding protein 2 (MeCP2).

73 ostnatal disorder, results from mutations in Methyl CpG-binding protein 2 (MECP2).

74 ontrol of levels of the epigenetic regulator methyl CpG-binding protein 2 (MeCP2).

75 inked gene encoding the transcription factor methyl-CpG binding protein 2 (MECP2) are the most freque

76 Loss-of-function mutations in methyl-CpG binding protein 2 (MECP2) cause Rett syndrome

77 gene encoding the transcriptional repressor methyl-CpG binding protein 2 (MeCP2) cause the neurodeve

78 ss of function of the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2) causes the progress

79 function and gain-of-function alterations in methyl-CpG binding protein 2 (MeCP2) expression, respect

80 orrelates with the dissociation of DNMT1 and methyl-CpG binding protein 2 (MeCP2) from the promoter,

81 in which most patients have mutations in the methyl-CpG binding protein 2 (MECP2) gene and suffer fro

82 Inactivating mutations in the Methyl-CpG Binding Protein 2 (MECP2) gene are the main c

83 Mutations in the methyl-CpG binding protein 2 (MECP2) gene cause Rett syn

84 s and results from duplications spanning the methyl-CpG binding protein 2 (MECP2) gene locus.

85 der that is associated with mutations in the methyl-CpG binding protein 2 (MECP2) gene.

86 sults from loss of function mutations in the methyl-CpG binding protein 2 (MECP2) gene.

87 lopmental disease caused by mutations in the methyl-CpG binding protein 2 (MECP2) gene.

88 al deficits associated with mutations in the methyl-CpG binding protein 2 (MECP2) gene.

89 e we report that Htt directly interacts with methyl-CpG binding protein 2 (MeCP2) in mouse and cellul

90 transcription in vitro and are recognized by methyl-CpG binding protein 2 (MeCP2) in neurons in vivo.

91 Methyl-CpG binding protein 2 (MeCP2) is a chromatin regu

92 Methyl-CpG binding protein 2 (MeCP2) is a DNA methylatio

93 Methyl-CpG binding protein 2 (MeCP2) is a nuclear protei

94 The methyl-CpG binding protein 2 (MeCP2) is a widely express

95 Methyl-CpG binding protein 2 (MeCP2) is critical for pro

96 n intriguing finding about the gene encoding methyl-CpG binding protein 2 (MeCP2) is that the loss-of

97 Functional deficiency of the X-linked methyl-CPG binding protein 2 (MeCP2) leads to the neurod

98 gic neurons, including key components of the methyl-CpG binding protein 2 (MECP2) pathway.

99 Here, we focus on methyl-CpG binding protein 2 (MECP2) restoration for RTT

100 tation (ChIP) assays assessed the binding of methyl-CpG binding protein 2 (MeCP2) to PPARgamma and ch

101 nding proteins (MBDs) demonstrated that only methyl-CpG binding protein 2 (MeCP2) was associated with

102 with mutations in the X-linked gene encoding methyl-CpG binding protein 2 (MeCp2), a transcriptional

103 is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2), a transcriptional

104 is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MECP2), an epigenetic regu

105 ssed TFPI-2 promoter was associated with the methyl-CpG binding protein 2 (MeCP2), and that gene reac

106 MECP2 and its product, Methyl-CpG binding protein 2 (MeCP2), are mostly known f

107 ene coding for the transcriptional regulator methyl-CpG binding protein 2 (MeCP2), but despite much e

108 and several transcription factors including methyl-CpG binding protein 2 (MeCP2), histone deacetylas

109 is of an X-linked, Rett syndrome (RTT) gene, methyl-CpG binding protein 2 (MECP2), in both rhesus and

110 yndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2 (MeCP2), is one of the most

111 Mutations in the transcriptional repressor, methyl-CpG binding protein 2 (MeCP2), result in a neurod

112 Mutations in methyl-CpG binding protein 2 (MeCP2), such as the T158M,

113 Mutations in the X-linked gene, methyl-CpG binding protein 2 (Mecp2), underlie a wide ra

114 The responsible gene, encoding methyl-CpG binding protein 2 (MeCP2), was recently disco

115 caused by mutations in the epigenetic factor methyl-CpG binding protein 2 (MECP2).

116 d by mutations in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2).

117 ily caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2).

118 d by mutations in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2).

119 omain (MBD) of one member of the MBP family, methyl-CpG binding protein 2 (MeCP2).

120 is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2).

121 t arises from mutations in the X-linked gene methyl-CpG binding protein 2 (MeCP2).

122 caused by mutations in the gene encoding for methyl-CpG binding-protein 2 (MeCP2).

123 cts to address CLN3 dosage effects using the methyl-CpG-binding protein 2 (MeCP2) and beta-actin prom

124 cts to address CLN3 dosage effects using the methyl-CpG-binding protein 2 (MeCP2) and beta-actin prom

125 -function mutations in the gene encoding the methyl-CpG-binding protein 2 (MeCP2) and is characterize

126 identify the mechanism of regulation of the methyl-CpG-binding protein 2 (MeCP2) and its functional

127 tions in the gene (MECP2 ) encoding X-linked methyl-CpG-binding protein 2 (MeCP2) as the cause of som

128 We identify methyl-CpG-binding protein 2 (MeCP2) as the major 5hmC-b

129 In contrast, there was decreased methyl-CpG-binding protein 2 (MeCP2) association with BD

130 Methyl-CpG-binding protein 2 (MeCP2) binds methylated DN

131 s-of-function mutations in the X-linked gene Methyl-CpG-binding protein 2 (MECP2) cause a devastating

132 Mutations in the methyl-CpG-binding protein 2 (MECP2) cause more than 95%

133 Mutations in X-linked methyl-CpG-binding protein 2 (MECP2) cause Rett syndrome

134 Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome

135 Mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome

136 Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome

137 Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome

138 and SRFS1-interacting protein 1 (DFS70) and methyl-CpG-binding protein 2 (MeCp2) could be documented

139 dissociation of the transcription repressor methyl-CpG-binding protein 2 (MeCP2) from the promoter,

140 ong with the fact that chimeric mice lacking methyl-CpG-binding protein 2 (MeCP2) function die during

141 Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene cause Rett syn

142 of function of the transcriptional regulator methyl-CpG-binding protein 2 (MeCP2) gene, is associated

143 isorder caused primarily by mutations in the methyl-CpG-binding protein 2 (MECP2) gene, which encodes

144 ntal disorder, is caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene.

145 opmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene.

146 ological disorder caused by mutations in the methyl-CpG-binding protein 2 (MeCP2) gene.

147 ouse models of the transcriptional modulator Methyl-CpG-Binding Protein 2 (MeCP2) have advanced our u

148 Methyl-CpG-binding protein 2 (MeCP2) is a multifunctiona

149 Methyl-CpG-binding protein 2 (MeCP2) is a transcriptiona

150 Methyl-CpG-binding protein 2 (MeCP2) is a ubiquitously e

151 Using the methyl-CpG-binding protein 2 (Mecp2) knockout (KO) mouse

152 Mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2) lead to disrupted n

153 The broad range of deficits caused by methyl-CpG-binding protein 2 (MeCP2) overexpression pose

154 Here we show that methyl-CpG-binding protein 2 (MeCP2) phosphorylation at

155 Our team designed a new truncated methyl-CpG-binding protein 2 (MECP2) promoter allowing w

156 The methyl-CpG-binding protein 2 (MeCP2) protein is an epige

157 Here we show that methyl-CpG-binding protein 2 (MeCP2) regulates behaviora

158 Mutations in the methyl-CpG-binding protein 2 (MeCP2) result in Rett synd

159 The Rett-syndrome-associated methyl-CpG-binding protein 2 (MeCP2) selectively binds m

160 We identified the epigenetic factor methyl-CpG-binding protein 2 (MeCP2) to be a direct and

161 to immunomodulate behavioral impairment in a Methyl-CpG-binding protein 2 (Mecp2) transgenic mouse mo

162 Mutations in methyl-CpG-binding protein 2 (MECP2) underlie most cases

163 Loss- and gain-of-function mutations in methyl-CpG-binding protein 2 (MECP2) underlie two distin

164 disorder caused by mutations or deletions in Methyl-CpG-binding Protein 2 (MeCP2), a brain-enriched t

165 RTT is caused by mutations in methyl-CpG-binding protein 2 (MeCP2), a nuclear protein

166 n in rodents are increased in the absence of methyl-CpG-binding protein 2 (MeCP2), a protein involved

167 Methyl-CpG-binding protein 2 (MeCP2), a reader of DNA me

168 evelopmental disorder caused by mutations in methyl-CpG-binding protein 2 (MECP2), a transcriptional

169 which encodes the transcriptional regulator methyl-CpG-binding protein 2 (MeCP2), cause Rett syndrom

170 Mutations in MECP2, encoding methyl-CpG-binding protein 2 (MeCP2), cause the neurodev

171 Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2), encoding a transcr

172 ipts previously shown to be repressed by the Methyl-CpG-binding protein 2 (MeCP2), including serum- a

173 CA), together with the Rett syndrome protein methyl-CpG-binding protein 2 (MeCP2), to control gene ex

174 Germline mutations in the X-linked gene, methyl-CpG-binding protein 2 (MECP2), underlie most case

175 MECP2 encodes methyl-CpG-binding protein 2 (MeCP2), which represses ge

176 evelopmental disorder caused by mutations in methyl-CpG-binding protein 2 (MECP2), with known disturb

177 duct Fos in the brains of wild-type (Wt) and methyl-CpG-binding protein 2 (Mecp2)-null (Null) mice, a

178 loss of function of the transcription factor methyl-CpG-binding protein 2 (MeCP2).

179 in MECP2, encoding the epigenetic regulator methyl-CpG-binding protein 2 (MeCP2).

180 der caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2).

181 e births and is often caused by mutations in Methyl-CpG-binding protein 2 (MECP2).

182 der caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2).

183 h additional chromatin components, including methyl-CpG-binding protein 2 (MeCP2).

184 ures, results from mutations in the gene for methyl-CpG-binding protein 2 (MeCP2).

185 adic mutations in the transcriptional factor methyl-CpG-binding protein 2 (MeCP2).

186 e caused by aberrations in the gene encoding methyl-CpG-binding protein 2 (MECP2).

187 and use, is primarily caused by mutations in methyl-CpG-binding protein 2 (MECP2).

188 the absence of the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2).

189 s-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2).

190 order caused by mutations in MECP2, encoding methyl-CpG-binding protein 2 (MeCP2).

191 order caused by mutations in MECP2, encoding methyl-CpG-binding protein 2 (MeCP2).

192 d by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2).

193 r caused by mutations in MECP2, encoding the methyl-CpG-binding protein 2 (MeCP2).

194 d by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2).

195 is caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2).

196 r caused by loss of function of the X-linked methyl-CpG-binding protein 2 (MECP2).

197 gene encoding the transcriptional regulator methyl-CpG-binding protein 2 (MeCP2).

198 gene encoding the transcriptional regulator methyl-CpG-binding protein 2 (MeCP2).

199 mplexes with transcriptional factors such as methyl-CpG-binding protein 2 (MeCP2).

200 evelopmental disorder caused by mutations in Methyl-CpG-binding protein 2 (MECP2).

201 evelopmental disorder caused by mutations in Methyl-CpG-binding protein 2 (MECP2).

202 on, respectively, of the same critical gene, methyl-CpG-binding protein 2 (MECP2).

203 order that is usually caused by mutations in Methyl-CpG-binding Protein 2 (MECP2).

204 al disorder primarily caused by mutations in Methyl-CpG-binding Protein 2 (MECP2).

205 gene encoding the transcriptional modulator methyl-CpG-binding protein 2 (MeCP2).

206 sors [histone deacetylases, mSin3A, Brm, and methyl-CpG-binding protein 2 (MeCP2)].

207 ological disorder, is caused by mutations in methyl-CpG-binding protein 2 (MECP2; OMIM 300005), a ubi

208 m, we revealed a genotype-specific effect of methyl-CpG-binding protein-2 (MeCP2) dysfunction on iPSC

209 caused by loss-of-function mutations in the Methyl-CpG-binding protein-2 (MECP2) gene and is charact

210 rity of cases, by a sporadic mutation in the Methyl-CpG-binding protein-2 (MeCP2) gene.

211 cent identification of mutations in the gene methyl-Cpg-binding protein-2 (MECP2) in girls with Rett

212 ool and downstream signaling in mice lacking methyl-CpG-binding protein-2 (Mecp2) is unknown.

213 Increased dosage of methyl-CpG-binding protein-2 (MeCP2) results in a dramat

214 d by duplications spanning the gene encoding methyl-CpG-binding protein-2 (MeCP2), a protein involved

215 P-3 promoter influenced the binding of Sp-1, methyl-CpG-binding protein-2 (MeCP2), and histone deacet

216 rder caused by loss-of-function mutations in methyl-CpG-binding protein-2 (MeCP2).

217 Methyl-CpG-binding-Protein 2 (MeCP2) is an abundant nucl

218 Mutations in MECP2 and Mecp2 (encoding methyl-CpG binding protein 2 [MeCP2]) cause distinct neu

219 Methyl-CpG binding protein 2, MECP2, which binds to meth

220 , peripherin, plasma glutathione peroxidase, methyl CpG-binding protein 2, retinal S-antigen, ErbB2 p

221 MECP2 encodes methyl-CpG-binding protein 2 that acts as a transcriptio

222 e found a significant increase in binding of methyl-CpG binding protein 2 to the "cytosine-phosphate-

223 in remodelling by its interaction with MBD2 (methyl CpG-binding protein 2), underlying FAK regulation