ライフサイエンスコーパス: methylase

1 an open reading frame (ORF) encoding an rRNA methylase.

2 off early, preventing excessive synthesis of methylase.

3 in" VI that clearly encodes a viral mRNA cap methylase.

4 to RNA polymerase and ectopic bacterial dam methylase.

5 t this region is necessary for binding PRMT1 methylase.

6 rm82, is the non-catalytic subunit of a tRNA methylase.

7 ly assayed DNA-modifying activity of hDNMT3a methylase.

8 d the unusual protective role of the LlaKR2I methylase.

9 a coli DNA despite the presence of the EcoRI methylase.

10 tially applying bisulfite PCR and SssI (CpG) methylase.

11 ion and is modulated by PapI and DNA adenine methylase.

12 st other SET proteins, is exclusively a mono-methylase.

13 a homologue of the mammalian SUV39H1 histone methylase.

14 s from BclI restriction endonuclease and dam methylase.

15 hion by the OxyR-DNA binding protein and Dam methylase.

16 ere methylated with the bacterial SssI (CpG) methylase.

17 ion of the endonuclease from the independent methylase.

18 y using cellular expression of a prokaryotic methylase.

19 aldococcus jannaschii is likely this missing methylase.

20 ry of small-molecule modulators of m(6)A (de)methylases.

21 ongs to a new subclass of B(12)-dependent RS methylases.

22 gulated methylases that include Dam and CcrM methylases.

23 s the structural motifs usually required for methylases.

24 repressors such as histone deacetylases and methylases.

25 ne the DNA substrate preferences of cytosine methylases.

26 ily of predicted archaeal and bacterial rRNA methylases.

27 scribe a new class of recently discovered RS methylases.

28 during the life cycle and are candidate DNA methylases.

29 ins are likely to function as small-molecule methylases.

30 s217-mediated guanylyl transfer, and an open methylase-1 domain for SAM binding and methyl transfer.

31 n the egg cell depends on DOMAINS REARRANGED METHYLASE 2 (DRM2) and RNA polymerase V (Pol V), two mai

32 hionine (SAM) acts as a signal and binds the methylase-2 domain of TP to induce conformational change

33 tone methyl-transferases, 5 of 29 histone de-methylases, 5 of 20 acetyl-transferases, 5 of 19 de-acet

34 ve been examined contain two classes of H3K4 methylases, a yeast (Saccharomyces cerevisiae) Set1 clas

35 e synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine s

36 nt of the transfected DNA fragments with CpG methylase abolished the promoter activity.

37 In addition, we show that the 2'-O and G-N-7 methylase activities act specifically on RNA substrates

38 c and biochemical evidence that its mRNA cap methylase activities are also unique.

39 s new mechanistic insights into the mRNA cap methylase activities of VSV L, demonstrates that 2'-O me

40 gmented negative-strand RNA viruses, the two methylase activities share a binding site for the methyl

41 tudies provide genetic evidence that the two methylase activities share an S-adenosyl-l-methionine-bi

42 sequence and length requirement for the two methylase activities.

43 only retain some sequence-specific activity; methylase activity can be detected on hemimethylated DNA

44 The mox gene is necessary for methylase activity in vivo, because an amber mutation in

45 This methylase activity is associated with Hox gene activatio

46 chemical analysis in S. pombe shows that the methylase activity of Clr4 is necessary for the correct

47 ignificantly increased the histone H3K27 tri-methylase activity of reconstituted PRC2 in vitro, and s

48 in the 762-Set1 strain are due to the rogue methylase activity of this mutant, resulting in the misl

49 acter pylori geographical origin and type II methylase activity, we examined 122 strains from various

50 regulating gene expression, dependent on the methylase activity.

51 e3 marks at the promoter, which involves its methylase activity.

52 otein, a putative RNA-binding protein, a DNA methylase, an ATPase-domain protein, and a protein of un

53 The absence of a cognate methylase and cleavage of modified DNA indicate that Sau

54 M is composed of five genes, including a DNA methylase and four other genes annotated as a helicase d

55 ase and putative replicase components: RdRp, methylase and helicase.

56 ifications that require guide RNAs to direct methylase and pseudouridylase enzymes to the appropriate

57 Both the methylase and restriction subunits are encoded on a poly

58 heterochromatin of an ectopic bacterial dam methylase and the decreased mobility of an HML heterochr

59 including MtbA, the methylamine-specific CoM methylase and the pyl operon required for co-translation

60 Metnase contains a SET histone methylase and transposase nuclease domain, and is a comp

61 nhancer-of-zeste and trithorax (SET) histone methylase and transposase nuclease domain.

62 tially involved in virulence, including SpoU methylase and U3 small nucleolar ribonucleoprotein IMP3.

63 e presence of the base-flipping enzymes HhaI methylase and uracil DNA glycosylase, as well as with TA

64 hose associated with chromatin modification (methylases and acetylases), transcription (RNA polymeras

65 gions within chromatin by recruiting histone methylases and deacetylases.

66 ery, genetic and biochemical studies of H3K4 methylases and demethylases have provided important mech

67 hylation is dynamically regulated by histone methylases and demethylases such as LSD1 and JHDM1, whic

68 The selectivity of the screen for several methylases and demethylases suggests that SUMO interacti

69 tic processes, such as histone deacetylases, methylases and demethylases, can elicit similar effects

70 etic modifiers, specifically histone and DNA methylases and demethylases, drive hematopoietic cancer

71 ation of histone methylation by both histone methylases and demethylases.

72 factors and addition of BMP4 reduced histone methylases and increased demethylases mRNAs in cultured

73 e, Mox, and integrase, Int, related to other methylases and integrases.

74 nnose pathway genes and genes encoding sugar methylases and nucleotide sugar epimerase-dehydratase pr

75 e information about restriction enzymes, DNA methylases and related proteins such as nicking enzymes,

76 on (phosphatases and kinases) or protection (methylases), and scaffold or cofactor proteins.

77 undermethylation using Z-DNA sensitive SssI methylase, and by circular dichroism.

78 CbiF is the C-11 methylase, and CbiG, an enzyme which shows homology with

79 e used is the target sequence for the HaeIII methylase, and this partially flipped cytosine is the sa

80 se, with close evolutionary ties to type IIS methylases, and a trisubunit restriction complex.

81 he control of both Dam and GidA modification methylases, and Dam regulates Act production via GidA.

82 ruits histone deacetylase complexes, histone methylases, and heterochromatin proteins.

83 Enhancer-of-Zeste, which are H3K4 and H3K27 methylases, and Polycomb continuously associate with the

84 Therefore, both classes of H3K4 methylases appear to be required for proper regulation o

85 of RSVIgmyc methylation preimposed with SssI methylase appears to be specific to the early, undiffere

86 ocus tested, suggesting that the primary CpG methylases are encoded by the MET1 class of genes.

87 These studies show that the VSV methylases are inhibited by SIN, and they define new reg

88 In this study, we describe low-input methylase-assisted bisulfite sequencing (liMAB-seq ) and

89 We have recently developed a methylase-assisted bisulfite sequencing (MAB-seq) method

90 Here, we describe M.SssI methylase-assisted bisulfite sequencing (MAB-seq), a met

91 ssisted, chemical-modification assisted, and methylase-assisted bisulfite sequencing data.

92 Dot1, the H3-Lys79 methylase, associates with transcriptionally active gene

93 of hpnP, the gene encoding the C-2 hopanoid methylase, at the molecular level.

94 ycin resistance - the erythromycin ribosomal methylase B (ermB) gene - found in C. perfringens and C.

95 a reveals that Dnmt3a is predominantly a CpG methylase but also is able to induce methylation at CpA

96 a class C radical S-adenosylmethionine (SAM) methylase, but its true function is to transfer a C1 uni

97 The methylase can function in either a monomeric or oligomer

98 ng increased expression of the histone H3R26-methylase CARM1 and is lowered following CARM1 inhibitio

99 In the NUMAC complex, the methylase, CARM1, acquires the ability to covalently mod

100 ing a substrate-centered radical; class B RS methylases catalyze methyl transfer from SAM to cobalami

101 d class C radical S-adenosylmethionine (SAM) methylase, catalyzes both the transfer of a C1 unit from

102 al of the D/anticodon arm modifications, but methylases catalyzing post-transcriptional m(2)G synthes

103 A related methylase, Cfr, modifies C8 of A2503 via a similar mecha

104 Removal of the H3K9 methylase Clr4 partially suppressed the slow growth phen

105 y unclassified fliB gene, encoding flagellin methylase, clustered as a class 2 gene, which was verifi

106 , including a previously uncharacterized CHH methylase, CMT2.

107 lation and alters the recruitment of histone methylase (COMPASS)-, histone demethylase (Jmjd2a/Jmjd3)

108 gh-molecular-weight DNA, and an endonuclease/methylase competition assay was employed to partially cl

109 thylation by knocking down components of the methylase complex and then examined 661 transcripts with

110 methylase Set1 and Ash2, a component of the methylase complex, are required for memory.

111 MLL complex, is a histone H3 lysine 4 (H3K4) methylase consisting of Set1 (KMT2) and seven other poly

112 was demethylated by the purified 480-kDa CoM methylase, consuming 1 mol of CoM and producing 1 mol of

113 ic reaction was found to produce expected RS methylase coproducts S-adenosylhomocysteine and 5'-deoxy

114 model, whereas mutants that lack DNA adenine methylase (Dam(-)) are highly attenuated and elicit full

115 tains the target "GATC" site for DNA adenine methylase (Dam) and is present in both promoter proximal

116 tein Ag43 in E. coli requires deoxyadenosine methylase (Dam) and OxyR.

117 tions: error-prone polymerase IV (DinB), DNA methylase (Dam) and sigma S factor (RpoS).

118 serovar Typhimurium deficient in DNA adenine methylase (Dam) are attenuated for virulence in mice and

119 sis mutants that overproduce the DNA adenine methylase (Dam) are highly attenuated, confer fully prot

120 trains that lack and overproduce DNA adenine methylase (Dam) conferred cross-protective immunity to s

121 rovar Typhimurium that lacks the DNA adenine methylase (Dam) ectopically expresses multiple genes tha

122 strains that lack or overproduce DNA adenine methylase (Dam) elicit a protective immune response to d

123 solates that lack or overproduce DNA adenine methylase (Dam) elicited a cross-protective immune respo

124 Salmonella DNA adenine methylase (Dam) mutants that lack or overproduce Dam are

125 hat altered levels of Salmonella DNA adenine methylase (Dam) resulted in acute defects in virulence-a

126 Salmonella typhimurium lacking DNA adenine methylase (Dam) were fully proficient in colonization of

127 ive regulatory protein (Lrp) and DNA adenine methylase (Dam) were required for pef transcription.

128 e DNA, which is essential for deoxyadenosine methylase (Dam)- and OxyR-dependent phase variation of a

129 ive regulatory protein (Lrp) and DNA adenine methylase (Dam).

130 ive regulatory protein (Lrp) and DNA adenine methylase (Dam).

131 onsive regulatory protein (Lrp), DNA adenine methylase (Dam)] and local regulators (PapI and PapB) co

132 sis mutants that overproduce the DNA adenine methylase (DamOP Yersinia) are attenuated, confer robust

133 reading frame potentially encoding cytosine methylase (dcm) was identified upstream of IS1469 in the

134 Expression of mutations at A1518/A1519 in a methylase deficient ksgA(-)strain had divergent effects

135 microg of circular vector prepared in a DNA methylase-deficient Escherichia coli (1.9 +/- 1.1 x 10(-

136 Expression of a similar level of a methylase-deficient SETMAR changed the expression of man

137 ence homologies suggest that the B. maritima methylase defines a new family of plant methyl transfera

138 romatin-modifying proteins tested, including methylases, demethylases, acetyltransferases and a deace

139 l levels of histone marks targeted by lysine methylases/demethylases.

140 erved as the most abundant function with DNA methylase detected at levels 4.2-fold higher than other

141 restriction enzymes and their corresponding methylases, determination of the recognition sequence of

142 he phage's damL gene, coding for DNA adenine methylase, did not make DNA cuttable.

143 ive pathogens suggest multiple roles for Dam methylase: directing post-replicative DNA mismatch repai

144 t be determined due to the presence of other methylases, DNA binding proteins, and chromatin structur

145 by stimulating lysine methylation of the DNA methylase DNMT1 and triggering its degradation via the u

146 n vivo cofactors as the metazoan maintenance methylase Dnmt1.

147 This would be mediated by the DNA methylase, DNMT3A, which is down-regulated in cells lack

148 ncestral species lost the gene for a de novo methylase, DnmtX, between 50-150 mya.

149 This led to the suggestion that a single methylase domain functions for both 2'-O and G-N-7 methy

150 a flexible "hinge" region separates the cap methylase domain of L proteins from upstream functions a

151 tnase (also SETMAR), which has a SET histone methylase domain, localized to an induced DSB and direct

152 iquitinylating enzyme, Rad6p, or the histone methylases, Dot1p, Set1p, or Set2p.

153 ations in the Arabidopsis DOMAINS REARRANGED METHYLASE (DRM) genes and provide evidence that they enc

154 ecently reported that the DOMAINS REARRANGED METHYLASE (DRM) genes are required for de novo DNA methy

155 hylases (KDM1A inhibitor S2101), and histone methylases (EHMT2 inhibitor UNC0638 and EZH2 inhibitor G

156 s, we propose that this archaeal radical SAM methylase employs a previously uncharacterized mechanism

157 Here, we identify a radical SAM methylase encoded by the hpnP gene that is required for

158 f A1518/A1519 caused by mutation of the ksgA methylase enhanced the deleterious effect of many of the

159 sence of a functional erythromycin ribosomal methylase (erm) gene in most species of pathogenic rapid

160 Erm methylase (ermA and ermB) was the most common resistance

161 Molecular Cell, Sampath et al. show a lysine methylase exhibits substrate promiscuity and variability

162 from various locations around the world for methylase expression.

163 7 methylation owing to overexpression of the methylase EZH2 has been implicated in metastatic prostat

164 The histone methylase EZH2 is frequently dysregulated in melanoma an

165 flagellin in Salmonella, which requires the methylase FliB.

166 methyltransferases, the enzyme contains the methylase fold and has well-defined substrate binding po

167 acid sequence of PFC1 has identity with rRNA methylases found in bacteria and yeast that modify speci

168 vious paper reports the purification of this methylase from Batis maritima and the isolation of a cDN

169 to the evolution of the cell cycle-regulated methylases from an existing R/M system.

170 t R. palustris also contains a SAM-dependent methylase, FufM, that produces 9D5-FuFA from 9M5-FuFA.

171 A ParB-methylase fusion protein appears to nick DNA nonspecific

172 that physically bridges REST and the histone methylase G9a to repress transcription.

173 ere we report that NRSF recruits the histone methylase G9a to silence NRSF target genes in nonneurona

174 methylation site within p53 mediated by the methylases G9a and Glp and indicate that G9a is a potent

175 is encoded by three genes: the 2,739-bp BslI methylase gene (bslIM), the bslIRalpha gene, and the bsl

176 ribe the isolation of a genomic clone of the methylase gene and the expression of recombinant methyl

177 the chromosomally located erythromycin rRNA methylase gene ermA and the plasmid-borne ermC gene were

178 ranged in an operon and that it requires the methylase gene from the LlaKR2I R/M system.

179 conclude that promoters of the CATG-specific methylase gene hpyIM differ between iceA1 and iceA2 stra

180 , a carbapenemase gene bla(NDM-5), and a 16S methylase gene rmtB were identified on different plasmid

181 No companion methylase gene was found near the SauUSI restriction gen

182 udied for the presence of ermAM (a ribosomal methylase gene), mefE (a macrolide efflux gene), and tet

183 f.I1, was found to be inserted into the bmhA methylase gene.

184 sposon integrated downstream of a SET-domain methylase gene.

185 ntibiotics by expressing two paralogous rRNA methylase genes pikR1 and pikR2 with seemingly redundant

186 ught about, for example, by knockouts of the methylase genes-result in embryo lethality or developmen

187 d plasmid harbored the gentamicin resistance methylase (grm), which has not previously been reported

188 s the only mapped modification for which the methylase has not been assigned.

189 In fact, RS methylases have been grouped into three classes based on

190 Dam methylase (HI0209) in strain Rd KW20 was inactivated in

191 ific m6A-driven networks for 4 known m6A (de)methylases, i.e., FTO, METTL3, METTL14 and WTAP.

192 ASS was the first histone H3 lysine 4 (H3K4) methylase identified over 10 years ago.

193 In Escherichia coli, IE is methylated by Dam methylase (IE(ME)).

194 e Hsmar1 transposase downstream of a protein methylase in anthropoid primates.

195 A possible function for this novel methylase in halophytic plants is discussed.

196 By expressing a prokaryotic DNA methylase in P. falciparum, we directly assayed accessib

197 was the founding member and is the only H3K4 methylase in Saccharomyces cerevisiae; however, in mamma

198 stantiated the novel function of the LlaKR2I methylase in the AbiR system but also illustrated the ev

199 ators, nuclear pore components, and arginine methylases in mediating DPR toxicity.

200 t in mammalian cells there are multiple H3K4 methylases, including Set1A/B, forming human COMPASS com

201 out restriction enzymes and their associated methylases, including their recognition and cleavage sit

202 ferent pancreatic cancer cell lines with the methylase inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR).

203 Treatment of cells with the methylase inhibitor 5-azacytidine restored CREB binding

204 The DNA methylase inhibitor, 5-aza-2'-deoxycytidine, induced KIR

205 When combined with histone methylase inhibitors, the extent of gene upregulation by

206 in the globular domain of histone H3 by Dot1 methylase is important for transcriptional silencing and

207 experimental evidence that inhibition of cap methylases is a potential strategy for development of an

208 The activity of DNA methylases is influenced by the differentiation status o

209 Set1, the yeast histone H3-lysine 4 (H3-K4) methylase, is recruited by the Pol II elongation machine

210 RELATED7 (ATXR7), a putative Set1 class H3K4 methylase, is required for proper FLC expression.

211 27 demethylase (UTX/KDM6A) or a H3 lysine 4 methylase (KMT2D).

212 esulting from mutations in the KMT2D histone methylase (KS1) or the UTX histone demethylase (KS2).

213 of mouse and human Mettl3, one of the m(6)A methylases, led to m(6)A erasure on select target genes,

214 oup complexes together with histone arginine methylases like PRMT5 and lysine demethylases like JARID

215 , shuttle plasmids were treated with the CpG methylase M.SssI prior to the electroporation of a varie

216 convergently transcribed restriction (R) and methylase (M) genes of the Restriction-Modification syst

217 restriction endonuclease holoenzymes contain methylase (M), restriction (R) and specificity (S) subun

218 ependently in E. coli in the absence of BslI methylase (M.BslI) protection.

219 An orphan methylase, M.BceSV, was found to modify GCNGC, GGCC, CCG

220 This set the stage for Suv39H1 methylase-mediated di-methylation of H3.K9 and increased

221 es by manipulating the levels of the m6A RNA methylase methyltransferase-like 3 (METTL3) both in cult

222 whereas increased expression of the m6A RNA methylase METTL3 was sufficient to promote cardiomyocyte

223 with various ER coregulators such as histone methylases MLL1 (mixed lineage leukemia 1) and MLL3 and

224 Similarly, knockdown of histone methylases MLL2 and MLL3 decreased the E2-mediated activ

225 6 is an E2-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha a

226 such as mixed lineage leukemia (MLL) histone methylases (MLL2 and MLL3) and histone acetyltransferase

227 DNA and that the B. paralicheniformis DISARM methylase modifies host CCWGG motifs as a marker of self

228 with the loss of chromatin-associated H4K20 methylase, mono- and dimethyl H4K20, and a delay in the

229 Mx8 makes a DNA adenine methylase, Mox, and integrase, Int, related to other met

230 evelopment, Mx8 expresses a nonessential DNA methylase, Mox, which modifies adenine residues in occur

231 erase (PRNT) and a dual-specificity mRNA cap methylase (MT).

232 thaliana, the METTL3 homolog, mRNA adenosine methylase (MTA) introduces N (6)-methyladenosine (m(6)A)

233 Dam methylase mutants were recovered in a screen for mutants

234 This new role for the LlaKR2I methylase offers a unique snapshot into the evolution of

235 on, Set1A but not Mll2 functions as the H3K4 methylase on bivalent genes and is required for their ex

236 d when the fungal DNA was treated with a CpG methylase or with CpG-specific endonucleases.

237 , which has histone demethylases but not DNA methylases or demethylases.

238 n ATX1, which encodes a Trithorax class H3K4 methylase, partially suppress the delayed flowering of w

239 Radical S-adenosylmethionine (SAM) (RS) methylases perform methylation reactions at unactivated

240 by in vitro artificial methylation with Sss1 methylase prior to transient transfections.

241 t A1518 in strains lacking a functional KsgA methylase produces a kasugamycin resistance phenotype.

242 cient when the PNA-binding site embodies the methylase-recognition site rather than overlaps it.

243 inhibited division gene (gidA) encoding tRNA methylase reduced Act levels, while overproduction of DN

244 Class B methylases require a cobalamin cofactor to methylate bot

245 Expression of the mutation-specific chimeric methylase resulted in the selective methylation of cytos

246 e Lactobacillus caseiTS mutant N229D, a dCMP methylase, revealed that there is a steric clash between

247 Metnase is a human protein with methylase (SET) and nuclease domains that is widely expr

248 n mutants demonstrated that the histone H3K4 methylase Set1 and Ash2, a component of the methylase co

249 ription elongation complex Paf1, the histone methylase Set1-COMPASS, and the translation-related Trm1

250 H3 lysine-4 by the trithorax-related histone methylase Set1.

251 siae; however, in mammals, at least six H3K4 methylases, Set1A and Set1B and MLL1 to MLL4, are found

252 Moreover, depletion of the H3K36 methylase Setd2 leads to upregulation of Xist, suggestin

253 Class C methylases share significant sequence homology with the

254 investigated how the uniquely clustered Dam methylase sites, GATCs, in the origin of Escherichia col

255 ted to 5-methylcytosines by the CpG-specific methylase SssI and the DNA was subsequently treated with

256 All of the methylases studied were present in all major human popul

257 us encodes an endonuclease subunit (HsdR), a methylase subunit (HsdM) and two DNA specificity subunit

258 Mmp10 has little sequence homology to known methylases, suggesting this enzyme belongs to a new subc

259 requires the chromodomains (CDs) of the H3K9 methylase Suv39/Clr4 and the HP1/Swi6 protein.

260 In eukaryotic cells the histone methylase SUV39H1 and the methyl-lysine binding protein

261 for Sm and Lsm complexes as well as for the methylase Tgs1.

262 ermB gene, which encodes a 23S ribosomal RNA methylase that mediates resistance to macrolide, lincosa

263 RlmN is a dual-specificity RNA methylase that modifies C2 of adenosine 2503 (A2503) in

264 t has been demonstrated that it is a protein methylase that symmetrically dimethylates the omega-N(G)

265 d mutations in SET2, which encodes a histone methylase that targets lysine 36 of histone H3 and, like

266 g domain in SahR is related to SAM-dependent methylases that are able to tightly bind SAH.

267 sis, for example, small-molecule kinases and methylases that are expanded independently in the fly an

268 ibed class of S-adenosylmethionine-dependent methylases that convert a phospholipid 18 carbon cis uns

269 mparable to that of the cell cycle-regulated methylases that include Dam and CcrM methylases.

270 acking Sas2 histone acetylase or the histone methylases that modify lysines 4 (Set1) or 79 (Dot1) of

271 of the p65 subunit, carried out by a lysine methylase, the nuclear receptor-binding SET domain-conta

272 e association of Set1 and Set2 (the H3-Lys36 methylase), this association is largely independent of R

273 family, forms a complex with SETDB1 histone methylase to silence transcription at target promoters b

274 t of Set1, the histone H3-lysine 4 (H3-Lys4) methylase, to a highly localized domain at the 5' portio

275 lso illustrated the evolution of the LlaKR2I methylase toward a new and separate cellular function.

276 contributed to the evolution of the LlaKR2I methylase toward a novel role comparable to that of the

277 and most closely resembles the m(2)G10 tRNA methylase Trm11.

278 calculated molecular mass suggests that the methylase undergoes posttranslational cleavage, possibly

279 n-2, these studies show CbiL to be the first methylase unique to the anaerobic pathway, methylating a

280 These Class D methylases, unlike Class A, B, and C enzymes, which use

281 Class A methylases use two cysteine residues to methylate sp(2)-

282 2-aa sequence of an internal fragment of the methylase was determined (GLVPGCGGGYDVVAMANPER FMVGLDIXE

283 Interestingly, the Dam methylase was found in place of the NgoAXI endonuclease

284 trains studied, the average number of active methylases was 8.2 +/- 1.9 with no significant variation

285 In direct competition assays with HPA:II methylase we observe that the mispaired substrate is met

286 nt roles and functional targets for the H3K4 methylases, we have undertaken a genome-wide analysis of

287 4 DNA methyl-transferases and 0 of 3 DNA de-methylases were abundant (TPM >50) in at least one stage

288 To our great surprise, no methylases were found by this method; rather, two small

289 ctive in cap methylation in vitro, yet their methylases were less sensitive to SIN inhibition than th

290 . lactis without the presence of the LlaKR2I methylase, which is required to protect L. lactis from A

291 and polyadenylation factor CPF and the Set1 methylase, which modifies lysine 4 of histone H3 (H3-K4)

292 the viral helicase, papain-like protease and methylase, which suggest a regulatory function for ORF3

293 HOTTIP, members of the MLL/COMPASS-like H3K4 methylases, which regulate chromatin in the Hox/HOX clus

294 that COMPASS family members function as exo-methylases, which we have confirmed by in vitro and in v

295 Our intention was to identify other methylases whose specificities overlapped enough with th

296 SETMAR is a protein methylase with a sequence-specific DNA binding domain.

297 5-bp spacers, and bpm encodes a DNA adenine methylase with unusual site specificity and a homopolyme

298 tides, generated by using bacterial cytosine methylases with four-base recognition sequences, were lo

299 us lactis ssp. lactis consists of a bidomain methylase, with close evolutionary ties to type IIS meth

300 ns nine conserved motifs of N-4 cytosine DNA methylases within the beta group of aminomethyltransfera