ライフサイエンスコーパス: methylation

1 one post-translational modifications and DNA methylation.

2 d this is magnified when cells also lack DNA methylation.

3 nderstanding of epigenetic regulation by DNA methylation.

4 methylation and inhibits NSD2-mediated H3K36 methylation.

5 ificantly higher in women with positive anal methylation.

6 clear effector of MILI to silence TEs by DNA methylation.

7 This likely occurs via promoter methylation.

8 ng activities by interfering with its lysine methylation.

9 that may function through regulation of m7G methylation.

10 rs COMPASS recruitment to chromatin and H3K4 methylation.

11 bivalent regions is associated with gain of methylation.

12 a greater transcriptional regulator than CG methylation.

13 genous base modifications in the form of DNA methylation.

14 bits DNA methylation and histone H3 lysine 9 methylation.

15 major regulatory sequences controlled by DNA methylation.

16 of H2B ubiquitination in stimulating histone methylation.

17 ng RNAs (siRNAs) that guide RNA-directed DNA methylation.

18 free energies are sensitive to the extent of methylation.

19 , in the absence of mammalian readers of DNA methylation.

20 cificity to an ATPase step essential for DNA methylation.

21 ortex exhibit hemispheric differences in DNA methylation.

22 kappaB axis through PRMT5-mediated YBX1-R205 methylation.

23 allenge: the need to erase and reset genomic methylation(1).

24 hydroxyl group on the ribose at 3'-end (2'-O-methylation, 2'Ome) is critical for miRNA function in pl

25 predominant cytosine modifications, cytosine methylation (5mC) and hydroxymethylation (5hmC).

26 uch functionality plausibly explains why DNA methylation, a well-known mutagen, has been maintained w

27 evolutionary trajectories for SCNAs and DNA methylation aberrations.

28 or CHG-methylated genomes, we show that CHG methylation acts as a greater transcriptional regulator

29 forest, cotranscriptionally acquired histone methylation acts as a memory of prior transcription.

30 structure but only localized changes in DNA methylation, adding another example of the dynamics of D

31 previous associations between predicted DNA methylation age and neurodegenerative phenotypes might r

32 thanol precipitation and analysed by NMR and methylation analyses.

33 size, we performed the first epigenome-wide methylation analysis of whole blood DNA samples from a c

34 breast cancer model to evaluate differential methylation and accessibility between cancerous and nonc

35 target histones and nonhistone proteins for methylation and are critical regulators of muscle develo

36 ules (IgCAMs) as direct substrates, with DNA methylation and chromatin accessibility profiling uncove

37 We produce epigenome maps, including DNA methylation and chromatin accessibility, as well as tran

38 ation of epigenetic mechanisms including DNA methylation and chromatin modifications.

39 We encounter allele-specific TE methylation and demethylation of aberrantly expressed yo

40 ng (for example, PBRM1, BAP1 and SETD2), DNA methylation and DNA damage repair, all of which have bee

41 s have demonstrated associations between DNA methylation and environmental factors with evidence also

42 ibe the cell type-specific functions of this methylation and explore growing evidence that disruption

43 work that learns the association between DNA methylation and expression using both gene- and cell-dep

44 A2 correlated negatively with T cell histone methylation and functional gene signatures.

45 Genome-wide DNA methylation and gene expression are commonly altered in

46 onth, and 3 months of life, and measured DNA methylation and gene expression profiles in upper airway

47 tochastic deterministic relationship between methylation and gene expression within the set of genes

48 We reveal that POL2A inhibits DNA methylation and histone H3 lysine 9 methylation.

49 nificantly affected the patterns of cytosine methylation and hydroxymethylation in the lungs.

50 se fetal gonocytes undergoing de novo genome methylation and identify a previously unknown MIWI2-asso

51 In vitro, H1 promotes PRC2-mediated H3K27 methylation and inhibits NSD2-mediated H3K36 methylation

52 ein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating

53 ential for promoting PRDM9-dependent histone methylation and normal meiotic progress, possibly by fac

54 .75% and 2.01% polymorphic metAFLP loci with methylation and sequence changes, respectively.

55 ed factor, SPOCD1, that is essential for the methylation and silencing of young transposable elements

56 t is essential for piRNA-directed TE de novo methylation and silencing.

57 show that LPS treatment induces Socs1 m(6)A methylation and sustains SOCS1 induction by promoting Ft

58 programmed through the global erasure of DNA methylation and the exchange of histones with protamines

59 The much smaller effects of 1'-, 3'-, and 5'-methylations and the greater effects of 2'- and 4'-methy

60 es of mRNA expression, miRNA expression, DNA methylation, and histone acetylation from ASD and contro

61 somatic copy number alterations (SCNAs), DNA methylation, and point mutations in lung cancer driver g

62 taset consisting of histone acetylation, DNA methylation, and RNA transcription data from human corti

63 ation, become de-methylated during global de-methylation, and then become re-methylated.

64 -29.18], P = .02) and with positive cervical methylation (aOR, 6.49 [95% CI, 1.66-25.35], P = .007),

65 matin remodelling activities and the de novo methylation apparatus through SPOCD1.

66 e find that kinetic constants of maintenance methylation are correlated among neighboring CpG sites.

67 e finding that heterochromatin and genic DNA methylation are highly variable among 725 A. thaliana ac

68 e processes involved in Hg(II) biouptake and methylation are not well understood.

69 Taken all together, KRAS-mediated DNA methylation are stochastic and independent of canonical

70 enchymal stem cells (MSCs) by Infinium 450 K methylation array.

71 and FAT intakes as exposures and cg00574958 methylation as the mediator.

72 In adjusted models, methylation at 20 CpGs was associated with urinary As af

73 or memory-related nuclear factor-kappaB RELA methylation at lysine 310 and associated increases in H3

74 Methylation at one DMP (cg18587484), annotated to the ge

75 nts with DNMT3 mutations exhibit reduced DNA methylation at regions that are hypomethylated in Dnmt3

76 The non-CpG DNA methylation at telomere fits a binomial model and may re

77 DNA methylation at the 5-position of cytosine (5mC) plays vi

78 DNA methylation at the INSR and IGF2 gene promoter regions w

79 showcase the successful application of cfDNA methylation- based cancer detection to two highly challe

80 ology and mutation classification as well as methylation-based classification of gliomas.

81 e high methylation levels prior to global de-methylation, become de-methylated during global de-methy

82 Methods for quantifying the imbalance in CpG methylation between alleles genome-wide have been descri

83 Wetlands are common sites of active Hg methylation by anaerobic microbes; however, the amount o

84 evaluate the impact of lossy compression on methylation calling accuracy and observe that this impac

85 DNA modifications as methylation can modulate the information coded by the se

86 Thus, direct regulation of DNA methylation can prevent/reverse diabetic retinopathy by

87 Furthermore, genome-wide loss of DNA methylation caused a loss of O-GlcNAc from multiple tran

88 on, and support a model in which genome-wide methylation changes are transduced to differentiation sk

89 ion in chondrocytes we characterised the DNA methylation changes during chondrogenesis of mesenchymal

90 e subtle effects of symmetric and asymmetric methylation changes in regenerants were identified.

91 Future research should explore whether DNA methylation changes mediate associations between prenata

92 KRAS knockdown resulted in unique methylation changes with limited overlap between each ce

93 Moreover, in spite of the methylation changes, we observed no profound alterations

94 ilistically associated with larger values of methylation changes.

95 th massive epigenetic alterations on the DNA methylation, chromatin accessibility and histone modific

96 on information, with new developments in DNA methylation classification.

97 on a recently published brain tumor 450k DNA methylation cohort of 2,801 samples with 91 diagnostic c

98 late cycle at the expense of transfer to the methylation cycle.

99 COCOA is the first such tool for DNA methylation data and can also analyze any epigenetic sig

100 s virtual microdissection of bulk tissue DNA methylation data at single cell-type resolution for any

101 ocol for reference-free deconvolution of DNA methylation data comprising: (i) data preprocessing, con

102 ed whole-genome, whole-transcriptome and DNA methylation data for 208 pairs of tumour tissue samples

103 Multiple ChIP-seq data and DNA methylation data generated from brain were used for iden

104 Human DNA methylation data have been used to develop biomarkers of

105 stimates for precision diagnostics using DNA methylation data.

106 sease (AD) and Down syndrome (DS), using DNA methylation datasets from public sources (Gene Expressio

107 Reciprocal changes in histone lysine methylation/demethylation of M(LPS + IFN-gamma)/M(IL-10)

108 The identification of methylation differences that predate islet autoimmunity

109 In adults, deviations from the DNA methylation (DNAm) age prediction are correlated with se

110 d and smoking exposures with human blood DNA methylation (DNAm) profiles.

111 ses summary-level data from cohort-based DNA methylation (DNAm) quantitative trait locus (mQTL) studi

112 Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A) are fr

113 essential for establishment of mammalian DNA methylation during development.

114 milar Dnmt3b isoforms facilitate de novo DNA methylation during embryonic development and in somatic

115 dding another example of the dynamics of DNA methylation during plant development.

116 consequences of failure to reprogram histone methylation during three crucial epigenetic reprogrammin

117 ion, but the functions of repressive histone methylation dynamics during inflammatory responses remai

118 units within SEs typified by distinctive CpG methylation dynamics in embryonic stem cells (ESCs).

119 ecent understanding of the regulation of DNA methylation dynamics in mammalian germ lines and early e

120 e most kinases upstream of the yeast histone methylation enzymes remain unknown, we model the possibl

121 s the number of published syndromes with DNA methylation episignatures and, most significantly, opens

122 r and elucidate the discordance between MGMT methylation, expression, and patient outcome, which curr

123 the end of their reproductive lifespan, DNA methylation fidelity is lost at a number of CpG islands

124 ow consistent association directions for the methylation-gene expression-PrCa pathway.

125 9 di-methylation (H3K9me2) and lysine-27 tri-methylation (H3K27me3) are linked to repression of gene

126 Elevated levels of histone H3 Lysine27 tri-methylation (H3K27me3) were observed at the Avr1b locus

127 H3K9 methylation (H3K9me) specifies the establishment and mai

128 Histone H3 lysine-9 di-methylation (H3K9me2) and lysine-27 tri-methylation (H3K

129 Our findings indicate that cytosine methylation has a broader mutational footprint than is c

130 Arginine methylation has been recognized as a post-translational

131 of studies have reported that bacterial DNA methylation has important functions beyond the roles in

132 s of Ewing sarcoma samples, we show that DNA methylation heterogeneity provides information complemen

133 iles of central epigenetic regulators of DNA methylation, histone modifications and RNA methylation i

134 These include DNA methylation, histone modifications, and regulation of tr

135 Epigenetic mechanisms, including DNA methylation, histone post-translational modifications, a

136 istone deacetylase complex (HDAC) by H3K4 di-methylation, histone sumoylation directly recruits the S

137 maternal SMCHD1 does not alter germline DNA methylation imprints pre-implantation or later in gestat

138 DNA methylation in a fungal pathogen has persisted for milli

139 A methylation, histone modifications and RNA methylation in adult F1 male testes.

140 significant age-associated erosion of LINE-1 methylation in cfDNA suggesting that the threshold of hy

141 Increased DNA methylation in Ppargc1a promoter had a fetal origin; ele

142 Altered methylation in promoters, enhancers, and gene bodies, as

143 y, exposed fish exhibited differences in DNA methylation in selected genes, across all three generati

144 hylation to act in redundancy with symmetric methylation in silencing transposons and to regulate the

145 mediated through differential SMAD3 promoter methylation in TAFs and provide new mechanistic insights

146 mutants with an essentially complete loss of methylation in the CG and non-CG contexts.

147 alcohol use is associated with differential methylation in the glucocorticoid system that might infl

148 The results suggest an important role of DNA methylation in the normal homeostasis of cardiomyocytes

149 In conclusion, our data suggest a role for methylation in the regulation of gene expression underly

150 ach to studying the epigenetic mechanism CpG methylation in tissue samples is to identify regions of

151 feed-forward fashion to promote aberrant DNA methylation in UC.

152 atin model demonstrates that a block of H3K9 methylations in the epigenetic sequence determines the c

153 patients potentially mediated by 365,307 DNA methylations in the TCGA lung cancer cohort.

154 ith the level of iCGI transcription in a DNA-methylation independent manner.

155 Protein-lysine methylation is a common posttranslational modification (

156 DNA methylation is a major silencing mechanism of transposab

157 DNA methylation is a ubiquitous chromatin feature, present i

158 Thus, RNA cap methylation is an attractive target for antiviral discov

159 DNA methylation is an epigenetic mark with important regulat

160 DNA methylation is an epigenetic modification that specifies

161 d result in lower KIF3A expression, and this methylation is associated with increased transepidermal

162 Strikingly, this methylation is asymmetric in vivo, detected almost exclu

163 methylmercury produced varies greatly, as Hg methylation is dependent upon both the availability of H

164 of PD patients, hemispheric asymmetry in DNA methylation is greater than in controls and involves man

165 For example, DNA methylation is known to regulate transcription factor bi

166 LUAD samples show substantial SCNA and methylation ITH, and clonal architecture analyses presen

167 ther, our work unveils a genome-scale map of methylation kinetics, revealing highly variable and cont

168 e genome, but variation and evolution of the methylation landscape during maize domestication remain

169 The methylation level of cytosines located at CG sites was h

170 rovides information complementary to the DNA methylation level.

171 an passive demethylation to establishing low methylation levels at distal enhancers.

172 gulates H3K4me3 and both H3K4me2 and H3K4me3 methylation levels during vegetative and pathogenic deve

173 However, a subset of TEs exhibit variable methylation levels in genetically identical individuals,

174 disordered N-terminus of Set2p affect H3K36 methylation levels in vivo, illustrating the functional

175 ng the global re-methylation phase have high methylation levels prior to global de-methylation, becom

176 f-lives of per-site recovery of steady-state methylation levels ranging from shorter than ten minutes

177 psis thaliana and a mutant defective in mRNA methylation (m(6)A).

178 s from repression via repelling PRC2 and DNA methylation machineries.

179 DNMT3L and DNMT3A, components of the de novo methylation machinery, as well as with constituents of t

180 le and context-specific activity for the DNA methylation machinery.

181 table epimutations originate mainly from DNA methylation maintenance errors during mitotic rather tha

182 Using the top 100 asthma-associated methylation markers as classifiers from each dataset, we

183 Mediation analysis with high-dimensional DNA methylation markers is important in identifying epigenet

184 RC2) installs and spreads repressive histone methylation marks on eukaryotic chromosomes.

185 DNA methylation may be involved in development of type 1 dia

186 h evidence also supporting the idea that DNA methylation may modify the risk of environmental factors

187 our findings suggest that variations in DNA methylation mediate the differential expression of a nov

188 We conclude that m(6)A methylation-mediated SOCS1 induction is required to main

189 used two-step MR to investigate whether DNA methylation mediates the effect of smoking on FEV(1).

190 tive and chemoselective oxidative C(sp(3))-H methylation method that is compatible with late-stage fu

191 on microarrays (GSE20347, GSE38129) and gene methylation microarrays (GSE52826) from the Gene Express

192 The methylation motif CACNNNNNTAC was only found in isolates

193 Bu(4)NI-catalyzed regioselective N(2)-methylation, N(2)-alkylation, and N(2)-arylation of tetr

194 d T2DM, and 754 gene expression and 101 gene methylation nodes that were connected to both AD and T2D

195 ized in a sequential order, in which histone methylations occur first in prometaphase, histone acetyl

196 Among those 759 CpG sites, methylation of 42 is associated with expression of 28 ad

197 This results in deficits in promoter methylation of activity-dependent genes, as well as syna

198 itranscriptomic RNA modifications, including methylation of adenine and cytidine residues, are now re

199 We devote particular attention to N (6)-methylation of adenosine and attempt to place the knowle

200 As in other eukaryotes, N (6)-methylation of adenosine is the most abundant and best s

201 Microbially-mediated methylation of arsenic (As) plays an important role in t

202 Methylation of carbon-5 of cytosines (m(5) C) is a post-

203 Cytosine methylation of DNA is a widespread modification of DNA t

204 Extensive aberrant methylation of DNA is broadly documented in early UC, co

205 Therefore, posttranslational methylation of flagellin facilitates adhesion of Salmone

206 Methylation of histone H3 lysine 27 (H3K27) is widely re

207 Methylation of histone H3K4 is a hallmark of actively tr

208 Methylation of iAs by arsenic methyltransferase (AS3MT)

209 Methylation of miRNAs at the 2'-hydroxyl group on the ri

210 e bisulfite-sequencing, we find that CHH DNA methylation of most 24-PHAS loci is increased in meiotic

211 ategy is based on combining the preferential methylation of open chromatin regions by DNA methyltrans

212 and carbon-11 into the desired compounds via methylation of pharmaceutical precursors bearing aryl an

213 l-types in a tumor, can be inferred from DNA methylation of surgical specimens.

214 otrophic factor (BDNF) and total percent DNA methylation of Th and Bdnf genes in the frontal cortex a

215 Methylation of the CpG7 site mediated 32.0% (95% CI 5.0-

216 Remarkably, methylation of the second exon of HR4 is not only reduce

217 Methylation of the ubiquitous antioxidant glutathione by

218 roper mtLSU maturation by securing efficient methylation of two 16S rRNA residues, and ultimately ser

219 and highlight a differential impact of m(4)C methylation on prokaryotic ribosomes and eukaryotic mito

220 mechanics methods, and compute the effect of methylation on protein-protein binding free energies.

221 verted methylated guanosine and a unique 2'O-methylation on the ribose of the penultimate nucleotide.

222 ations and the greater effects of 2'- and 4'-methylations on nicotine alpha7 nAChR interaction might

223 ultra-long nanopore data, allowed us to map methylation patterns across complex tandem repeats and s

224 retinal ganglion cells restores youthful DNA methylation patterns and transcriptomes, promotes axon r

225 Genomic methylation patterns are dynamically maintained, with DN

226 A and DNMT3B specificity suggesting that DNA methylation patterns are guided by the sequence preferen

227 Our analyses indicate that DNA methylation patterns associated with the susceptible and

228 hanges, alternative splicing events, and DNA methylation patterns during nodule formation, developmen

229 ysis of aged and cancerous cell-specific DNA methylation patterns for diagnostic and prognostic purpo

230 evealed that these segments are comprised of methylation patterns specific to either prostate cancer

231 Gene methylation patterns were similar to those in mammals, a

232 lly segregate into 2 groups according to DNA methylation patterns, related to normal MBC and PC profi

233 y transcription factors during the global re-methylation phase have high methylation levels prior to

234 DNA methylation plays a critical role in regulating gene exp

235 Protein methylation plays a vital role in cell processing.

236 ther, our findings indicate that dynamic RNA methylation plays an important regulatory role in oligod

237 uggest that HSI2- and HSL1-dependent histone methylation plays critical roles in regulation of seed d

238 ogical age differences, we also examined DNA methylation predictors of smoking, alcohol, body mass in

239 We find that removal of methylation probes which are correlated with confounder

240 could have a role in the altered genome-wide methylation profile: the long noncoding RNA ephemeron, w

241 We associated blood DNA methylation profiles from 581 MDD patients at baseline w

242 Using recently published DNA methylation profiles of Ewing sarcoma samples, we show t

243 dentified evolutionary divergence in the DNA methylation profiles of populations derived from the spr

244 ve these components without the need for DNA methylation profiles of purified cell types.

245 All DMB/MBEN assessed by DNA methylation profiling belonged to the SHH-INF subgroup.

246 xt-generation sequencing and array-based DNA methylation profiling to determine the clinically action

247 genetic dysregulation, including altered DNA methylation, promotes PAH.

248 ntioxidant capacity, biochemicals related to methylation, protein glycosylation, extracellular matrix

249 SD GWAS data with fetal brain expression and methylation quantitative trait loci, given the early ons

250 and a [4Fe-4S] cluster to catalyze iterative methylation reactions: a cyclopropylcarbinyl rearrangeme

251 gens has demonstrated that global changes in methylation regulate the expression of multiple genes.

252 ne, growth, and apoptotic pathways among the methylation-regulated genes.

253 this transition, the complete picture of DNA methylation remains elusive.

254 siRNA production and reveals RdDM targets of methylation repatterning.

255 Indeed, near-complete DNA methylation reprogramming, as occurs during mammalian em

256 Although activity-related loss of DNA methylation requires the Gadd45 (Growth arrest and DNA-d

257 Local levels of DNA methylation result from opposing enzymatic activities, t

258 We also created a methylation risk score (MRS) to predict MDD status 6 yea

259 Further, three previously proposed DNA methylation scores were applied for comparison.

260 The aim of this study was to adapt a Methylation-sensitive High-Resolution Melting (MS-HRM) a

261 ying whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found al

262 periodontal disease result in unique histone methylation signatures in affected cell populations, inc

263 n cohort data have revealed differential DNA methylation signatures in proxy tissues that are associa

264 iation studies identified the cg00574958 DNA methylation site at the carnitine palmitoyltransferase-1

265 se a novel method, Met-predictor, to predict methylation sites and methylation types using a support

266 chemotaxis, each chemoreceptor has multiple methylation sites that are responsible for adaptation.

267 oking dose) with blood DNAm in 790,026 CpGs (methylation sites) measured with the Illumina Infinium H

268 identify regions of concordant differential methylation spanning multiple CpG sites (differentially

269 bunits, oncogenic histone mutations, and the methylation state of chromatin.

270 In mammalian cells, distinct H3K4 methylation states are created by deposition of methyl g

271 Here, we evaluated the DNA methylation status of patients with tuberculosis (TB) an

272 t target of miR-128 and able to modulate the methylation status of the pivotal VSMC gene myosin heavy

273 bisulfite Sanger sequencing to determine the methylation status of the Treg-specific demethylated reg

274 rom blood (n = 42) and saliva (n = 20) using methylation status of X-linked polymorphic repeats.

275 MGMT promoter methylation status remained prognostic at tumor recurren

276 ent progress in N7-methylguanosine (m7G) RNA methylation studies has focused on its internal (rather

277 MMR-IHC with targeted MLH1-methylation testing was more discriminatory for LS than

278 discriminatory for LS than MSI with targeted methylation testing, with 100% versus 56.3% (16/16 versu

279 and Dnmt3b to contribute to the de novo DNA methylation that governs early steps of ESC differentiat

280 ne expression, alternative splicing, and DNA methylation that may shape transcriptome complexity and

281 remodeler-associated modifications, and DNA methylation) that contribute to relapse to cocaine, amph

282 required for the faithful propagation of DNA methylation throughout the cell cycle.

283 Our data found CHH methylation to act in redundancy with symmetric methylat

284 Our study links DNA methylation to disease endpoints via intermediate proteo

285 that catalyzes histone H3 lysine 27 (H3K27) methylation to mediate epigenetic silencing of target ge

286 In a comprehensive integrated analysis of methylation, transcriptome, and genome profiles of more

287 discuss this phenomenon and propose that DNA methylation turnover might facilitate key lineage decisi

288 -predictor, to predict methylation sites and methylation types using a support vector machine-based n

289 veal that histone modifications, but not DNA methylation, underlie exon-specific transcription of the

290 The 2'-methylation uniquely enhanced binding and agonist potenc

291 DNA methylation valleys exhibit elevated conservation and hi

292 g capabilities are mechanistically linked to methylation variability in mammals, with implications fo

293 specific and that novel and stably inherited methylation variants are of biological significance.

294 to identify introduced and stably inherited methylation variants.

295 1a promoter had a fetal origin; elevated DNA methylation was also detected in neonatal BAT and brown

296 Cytosine methylation was measured in blood using pyrosequencing.

297 oscopy to collect epithelial cells whose DNA methylation was measured using the Illumina 450 K platfo

298 MGMT promotor methylation was quantified using Sanger sequencing of th

299 k can be used directly in alkaline-catalysed methylation, whereas direct transesterification of both

300 Deletion of SNORD42A decreased 18S-U116 2'-O-methylation, which was associated with a specific decrea

301 confirmed strong associations of cg00574958 methylation with metabolic phenotypes (BMI, triglyceride