ライフサイエンスコーパス: methylation level

1 bisulfite treatment of DNA reflects the DNA methylation level.

2 DNA methyltransferase by CFK1 to control DNA methylation level.

3 rovides information complementary to the DNA methylation level.

4 tes CLCuMuV infection and enhances the viral methylation level.

5 72 expression and increases histone H3K9 tri-methylation levels.

6 er YKL-40 levels were associated with higher methylation levels.

7 ction and changes in the gene expression and methylation levels.

8 ygous loss in female ESCs leads to male-like methylation levels.

9 be corrected in order to determine accurate methylation levels.

10 and the time since smoking cessation affects methylation levels.

11 d rare variants that are associated with DNA methylation levels.

12 ing upon the predictive power of average DNA methylation levels.

13 oding transcriptomic, metabolomic and genome methylation levels.

14 at3 pollen affected transfer RNA and histone methylation levels.

15 between multiple low frequency variants and methylation levels.

16 ications were found to be most predictive of methylation levels.

17 mprinted genes and a global reduction in DNA methylation levels.

18 biomarkers of chronological age based on DNA methylation levels.

19 1 function in regulating global histone H3K4 methylation levels.

20 eosomes containing specific CpG patterns and methylation levels.

21 variation can be used as predictors of gene methylation levels.

22 tiation by controlling the stability of H3K4 methylation levels.

23 owed the opposite response, increased global methylation levels.

24 ne expression data, lipid concentrations and methylation levels.

25 M-value have been used as metrics to measure methylation levels.

26 l viability parallels baseline FLT3 R972/973 methylation levels.

27 te to large blood-brain correlations for DNA methylation levels.

28 thought to be inversely correlated with DNA methylation levels.

29 cally valid for the differential analysis of methylation levels.

30 ns between prenatal smoking exposure and DNA methylation levels.

31 n at these sites, and estimated differential methylation levels (0-84 %) upon in vitro demethylation

32 early 1 million CpGs possessing intermediate methylation levels (20-80%), termed dynamic sperm CpGs.

33 Global DNA methylation level (%5-mC) was quantified using ELISA met

34 und that Spirodela has the lowest global DNA methylation levels (9%) of any plant species tested.

35 mapping accuracy, methylation call accuracy, methylation level accuracy and space efficiency.

36 irical Bayes method are recommended when DNA methylation levels across CpG loci are independent, whil

37 riate FDR control and the highest power when methylation levels across CpG loci were independent.

38 riate FDR control and the highest power when methylation levels across CpG sites were correlated.

39 ape gbM, we first tested for correlations in methylation levels across orthologues(1,2).

40 g to different correlation structures in CpG methylation levels across the genome while taking into a

41 In colorectal cancer patients, EGFR methylation level also correlated with a higher recurren

42 We identified extensive variation of histone methylation levels among individuals and mapped hundreds

43 assess the association between site-specific methylation level and age- and sex-specific BMI percenti

44 and to broaden the E component by including methylation level and gene expression as promising ways

45 statistically significant imbalances in mean methylation level and methylation entropy, as well as fo

46 To assess the association between methylation level and TNBC risk, logistic regression was

47 to evaluate the causal relationships between methylation levels and 14 cardiovascular disease traits.

48 The Brassicaceae have reduced CHG methylation levels and also reduced or loss of CG gene b

49 tion of the cluster results in decreased DNA methylation levels and altered histone modifications at

50 R bias', causes inaccurate estimation of the methylation levels and calibration methods based on stan

51 Using pre-deployment SKA2 methylation levels and childhood trauma exposure, we fou

52 ek of cast immobilization increased nNOS DNA methylation levels and downregulated nNOS gene expressio

53 ms (SNPs) is important for quantification of methylation levels and for study of allele-specific epig

54 sing features including neighboring CpG site methylation levels and genomic distance, co-localization

55 preferentially from genomic regions with low methylation levels and high recombination rates.

56 et methylome and found a strong link between methylation levels and histone marks.

57 igin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused

58 involving sixmers and their association with methylation levels and other gene level properties.

59 e observed relation between decreases in DNA methylation levels and PTSD symptoms at genomic regions

60 PTEN promoter in BM-MSCs exhibits higher DNA methylation levels and repressive mark H3K9Me2 enrichmen

61 ls, frontal cortical Th total percentage DNA methylation levels and serum corticosterone levels, wher

62 en applied to a study of association between methylation levels and smoking status of individuals.

63 -coding genes, lncRNAs showed overall higher methylation levels and their expression was less affecte

64 We found no evidence for association between methylation levels and TNBC overall (P = 0.062).

65 ng of NbAGO4 inhibits TGS, reduces the viral methylation level, and enhances CLCuMuV DNA accumulation

66 ultiple CpG sites, as well as their starting methylation levels, and estimates the age of each indivi

67 with their ancestral functions, dynamic DNA methylation levels, and histone modification abundances.

68 e robust CHH methylation, similar CG and CHG methylation levels, and minimal cross-talk between CG an

69 G sites with the largest absolute changes in methylation level, approximately 30% correlated with gen

70 We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of l

71 ne promoters enriched for CpG sites at which methylation levels are associated with leukocyte telomer

72 ne promoters enriched for CpG sites at which methylation levels are associated with telomere length i

73 bump hunting method is recommended when DNA methylation levels are correlated across CpG loci.

74 We previously showed that H3K79 methylation levels are induced at T3 target genes during

75 the current methods for studying global DNA methylation levels are invasive and require sample prepa

76 me by silencing repetitive elements when DNA methylation levels are low.

77 Additionally, CHH methylation levels are reduced in regions near genes and

78 wever, nerve injury had no effect on the DNA methylation level around the Panx1 promoter in the DRG.

79 tive enough to detect changes in genomic DNA methylation levels as a function of growth phase in Esch

80 lly, we show that the genomic loci whose DNA methylation levels associate most strongly with expressi

81 assays as well as the quantification of the methylation level at every cytosine from the raw peak in

82 y release, concomitantly with changes in the methylation level at specific lysine residues of histone

83 panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated wit

84 Methylation levels at 1308 GAD1 regulatory network-assoc

85 Associations between 68 CHI3L1 SNPs, methylation levels at 14 CHI3L1 CpG sites in whole-blood

86 ificantly associated with alterations in DNA methylation levels at 17 genomic positions and 12 genomi

87 ation450 Bead Chips, we measured genome-wide methylation levels at 482,397 CpG loci in umbilical cord

88 ISIS) method with elastic net penalty to DNA methylation levels at 484,548 CpG markers from 659 human

89 Methylation levels at 52 CpG (cytosine-phosphate-guanine

90 stry were each significantly associated with methylation levels at 916 and 194 CpGs, respectively, an

91 We sought to determine (1) whether methylation levels at CHI3L1 CpG sites mediate the assoc

92 built a random forest classifier to predict methylation levels at CpG site resolution using features

93 ed us to develop a classifier to predict DNA methylation levels at CpG site resolution with high accu

94 In contrast, neither SNPs nor methylation levels at CpG sites in CHI3L1 were associate

95 an passive demethylation to establishing low methylation levels at distal enhancers.

96 also observed a modest parental bias in DNA methylation levels at every CpG analyzed across approxim

97 lood glucose and insulin resistance; (v) DNA methylation levels at five CpG sites, mapping to three w

98 Furthermore, famine significantly increased methylation levels at four CpG sites.

99 The balance of methylation levels at histone H3 lysine 4 (H3K4) is regu

100 SD1) is responsible for maintaining balanced methylation levels at histone H3 lysine 4 (H3K4).

101 We examined whether methylation levels at identified sites also showed an as

102 ICON, a high-throughput method measuring DNA methylation levels at imprinted regions with base-pair r

103 DNA methylation levels at individual CpG sites generated fro

104 rest of the group in having highly disrupted methylation levels at many CpG sites.

105 (SNPs) are associated with differential DNA methylation levels at multiple CpG sites (P<5 x 10(-8)),

106 ieves 92% prediction accuracy of genome-wide methylation levels at single-CpG-site precision.

107 tly altered at enhancer regions and that the methylation levels at specific enhancers predict overall

108 Our method uses smoothing to impute methylation levels at strain-specific sites, thereby all

109 n 24-nucleotide siRNA levels also affect DNA methylation levels at such loci and inversely correlate

110 ng in a PEV model by modulating histone H3K9 methylation levels at the heterochromatin-euchromatin bo

111 owever, the suvh1 mutation did not alter DNA methylation levels at the LUC transgene or on a genome-w

112 First, the methylation levels at the MM and UM motifs are respectiv

113 anMX silencing and decreased repressive H3K9 methylation levels at the transgene.

114 files showed an increased variability of DNA methylation levels at these AE-related X-linked genes.

115 The sum of DNA methylation levels at these sites weighted by their regr

116 s significant (p < 10(-7)) associations with methylation levels at three loci: near PEX14 (p = 9.3 x

117 They found that methylation levels, at 5 loci, mediated smoking exposure

118 many samples, computationally predicting DNA methylation levels based on 450K data would be valuable

119 analyzing the changes that occur at the DNA methylation level between primary cancer cells and metas

120 f CpGs displaying significant differences in methylation levels between fimbrial and proximal fallopi

121 s and differences in gene expression and DNA methylation levels between livers, kidneys, hearts, and

122 Genic CG methylation levels, but not CHG or CHH levels, are corre

123 Using this method, the methylation levels can be quantitatively determined by m

124 growing body of evidence indicates that DNA methylation levels can change rapidly; for example, in i

125 usually exist a large number of genes whose methylation level cannot be accurately estimated due to

126 ntimate relationships between TF binding and methylation level changes around the binding sites.

127 These changes are also accompanied by DNA methylation level changes in several imprinted domains,

128 Second, these DNA methylation level changes were further confirmed manuall

129 sperm, and F0-Extinguished-Lyral sperm have methylation levels comparable to F0-Exposed-Lyral sperm.

130 Over half of the regions show methylation levels consistent with cis inheritance, wher

131 Certain gene bodies with the highest methylation levels correlate with lower expression level

132 he HLA-A promoter region where increased DNA methylation levels correlated significantly with reduced

133 -like behavior to investigate how neural DNA methylation levels differ in these animals and how such

134 oriasis (Wilcoxon ranked PBonferroni < 0.01; methylation level difference > 0.10).

135 MRs as sites where the maternal and paternal methylation levels diverge significantly from the bipare

136 e evaluated genomic regions altered in their methylation level due to maternal stress based of WGBS d

137 gulates H3K4me3 and both H3K4me2 and H3K4me3 methylation levels during vegetative and pathogenic deve

138 found an inverse correlation between the DNA methylation levels (especially in the promoter regions)

139 The TET2 defect elevates blood DNA methylation levels, especially at active enhancers and c

140 We show that our method provides accurate methylation level estimates and accurate detection of di

141 Modeling of the methylation levels for a CpG site in the AHRR gene indic

142 677C > T polymorphism, and site-specific DNA methylation levels for a total of 915 white women and 33

143 Methylation levels for exposed parents and their offspri

144 (Zea mays) inbred lines found that while DNA methylation levels for more than 99% of the analyzed gen

145 hms have been developed to estimate absolute methylation level from read coverage generated by affini

146 was realized with the ability to distinguish methylation levels from a mixture at 0.1%.

147 TET1 methylation levels from DNA derived from nasal airway ep

148 easurements, demonstrating that the receptor-methylation level has only minor effects on receptor coo

149 The genome-wide investigation of DNA methylation levels has been limited to reference transpo

150 disease risk are mediated by changes in DNA methylation levels has not been systematically explored.

151 ntake of these nutrients and genome-wide DNA methylation levels have not been studied comprehensively

152 label, this method could detect as low as 5% methylation level in 50 ng of total DNA input.

153 the cross-sectional association between DNA methylation level in obesity-related genes and body mass

154 Furthermore, berberine enhances DNA methylation level in whole genome but reduces that in pr

155 hermore, this method has been used to detect methylation levels in a collection of DNA samples taken

156 ound that Gadd45b downregulation changes DNA methylation levels in a phenotype-, gene-, and locus-spe

157 t under conditions of high and physiological methylation levels in a tetracycline-inducible knock-in

158 Epigenome-wide DNA methylation levels in AECs, NECs and PBMCs were measured

159 may have confounded analyses of genome-wide methylation levels in aging cells.

160 as DNMT1 is essential for maintaining global methylation levels in all cell types.

161 throughout the genome that regulate histone methylation levels in an allele-specific manner.

162 Consistent with the increased DNA methylation levels in atrophic Sol, the gene expression

163 enine and N(4) -methylcytosine revealed high methylation levels in both genes and transposable elemen

164 he susceptible line exhibited reduced global methylation levels in both protein-coding genes and tran

165 normal cells, but frequently shows elevated methylation levels in cancer samples.

166 Next, we quantified CDH1 promoter methylation levels in CDH1 mutation-positive families, i

167 Among them, 2 and 3 increase H3K4 and H3K9 methylation levels in cells and cause growth arrest and

168 Additionally, global DNA methylation levels in cells exposed to CNPs at 0.1 mg/L

169 t 1 N level, and it also increased transgene methylation levels in codingregion (P2), and in total of

170 CHH methylation levels in cotyledons changed greatly from 6%

171 (K4M) mutant, which reduces endogenous H3K4 methylation levels in ES cells, decreases the protein st

172 However, a subset of TEs exhibit variable methylation levels in genetically identical individuals,

173 osure to O3 was associated with higher LINE1 methylation levels in newborn blood spots.

174 type-specific differences in chloroplast DNA methylation levels in plus versus minus mating type game

175 e light-controlled to reduce genome-wide DNA methylation levels in proliferating cells.

176 ss, total soluble protein content, transgene methylation levels in promoterregion (P1), and in total

177 The transgene methylation levels in promoterregion and codingregion we

178 dinal changes of blood-based genome-wide DNA methylation levels in relation to trauma-focused psychot

179 Here, we characterize DNA methylation levels in six different tissues from 3 speci

180 ek of cast immobilization increased nNOS DNA methylation levels in Sol, although only a minor change

181 ability, even with limited changes in global methylation levels in the de novo knockouts.

182 Global DNA methylation levels in the ESR subpopulation are lower th

183 We explicitly show that methylation levels in the internal and terminated invert

184 Adults with ASD showed higher OXTR methylation levels in the intron 1 area compared with ne

185 HD is accompanied by profound changes of DNA methylation levels in three mammalian species.

186 sis and age at blood draw revealed increased methylation levels in TNBC cases compared with controls

187 entified 1,194 target loci showing different methylation levels in tumors compared with controls.

188 disordered N-terminus of Set2p affect H3K36 methylation levels in vivo, illustrating the functional

189 re we estimate the total heritability of DNA methylation levels in whole blood and estimate the varia

190 pecific CG density threshold to predetermine methylation levels in wild-type cells and the magnitude

191 rase protein levels and increased global DNA methylation levels) in the early postnatal amygdala of L

192 trolling global N(6)-methyladenosine (m(6)A) methylation levels, including the m(6)A methylation of H

193 They impose intermediate DNA methylation levels incognizant of functional genomic ele

194 of the myoblasts proceeded, their global DNA methylation level increased and their methylation patter

195 Elevated methylation level is associated with increased disease s

196 omputational prediction of CpG site-specific methylation levels is critical to enable genome-wide ana

197 melanomas, which also corresponded with DNA methylation levels isolated from tissue samples.

198 ression modulated by structural variants and methylation levels likely leads to the differential expr

199 t smoking status was associated with the DNA methylation levels (M values) of cg03636183 in the coagu

200 clocks comprise a set of CpG sites whose DNA methylation levels measure subject age.

201 oci (cis-meQTLs) using SNP genotypes and DNA methylation levels measured across the IREB2-HYKK-PSMA4-

202 elated with DNA methylation with the highest methylation levels measured in both haploid gametophytes

203 rsed nuclear elements (LINE1) and AluYb8 DNA methylation levels measured in newborn blood spot tests,

204 Here we show that DNA methylation levels, measured by the Infinium HumanMethyl

205 Ke and colleagues found that m(6)A methylation levels negatively correlate with transcript

206 It also provides accurate predictions of the methylation levels not considered in the controlled expe

207 This enables more precise modeling of the methylation levels observed in the standard controls.

208 The calibration of the methylation levels obtained by MethylCal allows a cleare

209 Here, we correlated the mean methylation level of 12 CpG sites within the L1 gene, to

210 The methylation level of cytosines located at CG sites was h

211 The methylation level of GPC5 was negatively correlated with

212 These findings reveal that modulating the methylation level of phospholipid headgroups is a simple

213 traction from membranes by the change of the methylation level of phospholipid headgroups.

214 The methylation level of several CpG modules, specifically t

215 ion is associated with significantly altered methylation level of the CpGs in the neighbor regions.

216 significantly associated with higher overall methylation level of the INSR gene (d = 3.6%; 95% CI 1.2

217 50) of 54 +/- 4 nM) decreases the N-terminal methylation level of the regulator of chromosome condens

218 AC3B dysfunction does not alter promoter DNA methylation level of the transgene d35S::LUC, although t

219 The initial overall DNA methylation level of the two de novo regions was at a lo

220 Although the overall methylation level of these two histone marks did not cha

221 In a pilot study (n = 266), the blood methylation levels of 3 genes (Wif1, PENK, and NPY) were

222 d with differential peripheral leukocyte DNA methylation levels of 30 CpGs, most of which were also a

223 We profiled peripheral blood DNA methylation levels of 384 CpGs in promoter regions of 82

224 de association study begun in 2008 using DNA methylation levels of 456513 CpG loci measured on the In

225 blood tissues heterozygous for IGF2 and H19 methylation levels of 48 placentas.

226 We find that the methylation levels of 65 probes are associated with the

227 urve acquisition on droplets to discriminate methylation levels of a tumor suppressor gene, CDO1, on

228 entified >100 TRs associated with expression/methylation levels of adjacent genes.

229 ally and empirically that cell-type-specific methylation levels of an individual can be learned from

230 roach can be used to sensitively analyze the methylation levels of cancer-related genes, which might

231 The DNA methylation levels of cg03636183 in F2RL3 were associate

232 leukin-18 levels through the decrease in DNA methylation levels of cg03636183 in F2RL3.

233 of MAADP and ADP% were also associated with methylation levels of CpG 11 and CpG 12 + 13.

234 R, ERL1 and ERL2 Stomatal phenotypes and DNA methylation levels of ER genes in ibm1 and edm2 mutants

235 We compared the DNA-methylation levels of FTD cases (n = 128), and of FTD ca

236 Significantly elevated methylation levels of GCK CpG4 methylation were observed

237 This reduction markedly decreases methylation levels of histones, resulting in dramatic al

238 The comparison of mouse data with DNA methylation levels of incident T2D cases from the prospe

239 Most studies are limited to the average DNA methylation levels of individual CpGs and thus neglect h

240 We analyzed DNA methylation levels of inflammasome-related genes in pati

241 Moreover, as methylation levels of neighboring CpG sites are known to

242 Dynamic methylation levels of scUMCs correlate with the intensit

243 mples and cell models demonstrated increased methylation levels of several CpG nucleotides upstream o

244 how our covariate model accurately predicts methylation levels of the Foxp3 locus.

245 lytic responses that are proportional to the methylation levels of the gene locus in the presence of

246 placentas not associated with differences in methylation levels of the H19ICR.

247 In addition, methylation levels of two CpG loci within the putative G

248 s independently of global alterations of DNA methylation levels or changes in H3K27me3 profiles.

249 methylated groups, profiling the average DNA methylation level over user-specified genomics regions,

250 igher proportion of ALS patients with a high methylation level (P = 0.09).

251 ores were inversely correlated with IL-4 DNA methylation levels (P<.0002) and positively correlated w

252 lated with IFN-gamma and Foxp3 gene promoter methylation levels (P<.0011) (P<.0165).

253 ng the global re-methylation phase have high methylation levels prior to global de-methylation, becom

254 uencing of the two feeding groups found that methylation levels progressively diverged with age, with

255 howed global methylome patterns with overall methylation levels ranging from 17% to 84%.

256 f-lives of per-site recovery of steady-state methylation levels ranging from shorter than ten minutes

257 fite sequencing, and for 92.0% of CpG sites, methylation levels ranging over [0,1] were in concordanc

258 tion was reduced in suvh1; in contrast, H3K9 methylation levels remained unchanged.

259 that accounts for the spatial correlation of methylation levels, sequence depth and biological variat

260 Cytosine methylation levels showed a gradual decrease within appr

261 th CAPS treated with anti-IL-1 drugs display methylation levels similar to those of healthy control s

262 PMDs are hypervariable in methylation level, size and distribution, and display el

263 educed chromatin accessibility and increased methylation levels specifically at these enhancers, indi

264 HARDEN allows for higher targeted DNA methylation levels than a dCas9-DNMT3a fusion protein co

265 ntify stocks with stronger reductions in DNA methylation levels than provided by single gene mutation

266 d exons that demonstrate significantly lower methylation levels than their surrounding introns.

267 namic alterations to histone acetylation and methylation levels that are largely reversible upon read

268 als that, while dispensable for global H3K27 methylation levels, the non-core PRC2 subunits are colle

269 We found methylation levels to be significantly higher in the pen

270 genetic biomarker of aging based on host DNA methylation levels to study accelerated aging effects du

271 epigenome of cancer cells, direct global DNA methylation levels toward a hypomethylated state, and im

272 3' regions of genes, which show overall low methylation levels, underwent differential methylation i

273 It then compares methylation levels using beta-binomial hierarchical mode

274 nfants were interrogated for genome-wide DNA methylation levels using the Infinium Human MethylationE

275 Interestingly, most histone methylation level variation was trans-linked and the mos

276 k including proteins encoded by GSTP1, whose methylation level was shown previously to be associated

277 sociation between SAM/SAH ratio and high H19 methylation levels was detected among infants with low B

278 The greatest impact on global methylation levels was observed in DNMT3-deficient cells

279 gical mechanisms behind the condition at the methylation level, we conducted an epigenome-wide associ

280 DNA methylation levels were assessed by pyrosequencing of th

281 d between beta values and M values only when methylation levels were correlated across CpG loci.

282 or false discovery rates, changes in the DNA methylation levels were found in 42 genes.

283 Moreover, decreased methylation levels were found in the promoters of Myh7,

284 5'-region is enriched with CpG sites, whose methylation levels were markedly reduced by 5-Aza-dC.

285 oteomics showed that cellular global histone methylation levels were not significantly affected by SM

286 Mass spectrometry demonstrated that DNA methylation levels were several orders of magnitude belo

287 In vivo tRNA methylation levels were stimulated by growth of cells in

288 eased nNOS gene expression, whereas nNOS DNA methylation levels were unchanged, suggesting that downr

289 The overall methylation levels (%) were compared using FASTmC method

290 , and long interspersed nucleotide element 1 methylation level) were available for a subset of cases.

291 study YKL-40 levels, but not CHI3L1 SNPs or methylation levels, were associated with childhood asthm

292 were linked to developmental genes and have methylation levels which are associated with development

293 TT genotype was associated with reduced DNA methylation levels, while MTHFR c. 1298A > C AC genotype

294 omic regions that, along with differences in methylation levels with respect to normal colon tissue,

295 Taken together we have associated DNA methylation levels with the chondrocyte phenotype.

296 transcript behavior by jointly analyzing DNA-methylation levels with the presence of mutations in a G

297 ratio of X chromosomes to autosomes dictates methylation levels, with female hybrids being hypomethyl

298 Indeed, we detected stark differences in methylation levels within promoters and regulatory regio

299 th local extremes of gene expression and DNA methylation levels within the population.

300 Next, coMethDMR tests association between methylation levels within the sub-region and phenotype v