ライフサイエンスコーパス: methylation pattern

1 n of DNA, and are associated with a specific methylation pattern.

2 muscle inactivity is independent of the DNA methylation pattern.

3 bred lines, arising from inbred-specific DNA methylation patterns.

4 lease (DSN) to remove excess DNA with normal methylation patterns.

5 per characterisation of the heterogeneity of methylation patterns.

6 etween maternal plasma lipids and infant DNA methylation patterns.

7 failed to reveal any evidence of defined DNA methylation patterns.

8 r cell lines and observed strikingly similar methylation patterns.

9 cell populations by assembling cell-specific methylation patterns.

10 ulatory motifs underlies some human-specific methylation patterns.

11 a good model to study the inheritance of DNA methylation patterns.

12 enomic annotations and with estimation of co-methylation patterns.

13 including both tissue-specific and invariant methylation patterns.

14 ations in urine are a robust predictor of As methylation patterns.

15 ymes in the establishment and maintenance of methylation patterns.

16 rates, relative timing of mutations, and DNA-methylation patterns.

17 (OGT) only in cells that had normal genomic methylation patterns.

18 ltransferases inactivated and thus different methylation patterns.

19 , is a key regulator of EBV latency type DNA methylation patterning.

20 at affect both histone modifications and DNA methylation patterning.

21 nd wild type for growth, gene expression and methylation patterning.

22 s in several driver genes can cause aberrant methylation patterns, a hallmark of cancer.

23 This study provided some evidence that DNA methylation patterns acquired in the founder animal can

24 ultra-long nanopore data, allowed us to map methylation patterns across complex tandem repeats and s

25 Nevertheless, several genes showed variable methylation patterns across gestation, with a general tr

26 In comparison of autosomal DNA methylation patterns across sex, hundreds of differentia

27 ighboring CpGs and the similarities in local methylation patterns across subjects and across multiple

28 odulating PRC2 recruitment and shaping H3K27 methylation patterns across the genome.

29 A) is a protein Ag with a complex C-terminal methylation pattern and is recognized by T cells from hu

30 is cross-talk result in aberrant H3K27/H3K36 methylation patterns and altered transcriptional profile

31 during pregnancy may result in abnormal gene methylation patterns and contribute to developmental pro

32 mals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive.

33 We compared genomic DNA methylation patterns and gene expression in African Amer

34 We compared DNA methylation patterns and gene expression in inner-city c

35 ation system causes changes in site-specific methylation patterns and gene expression patterns that m

36 re purified and analyzed for genome-wide DNA methylation patterns and gene expression profiles.

37 he DNA methyltransferase Dnmt1 maintains DNA methylation patterns and genomic stability in several in

38 owerful tools for estimating variance in DNA methylation patterns and have the potential for detectin

39 can be discriminated based on their genomic methylation patterns and methylation context.

40 Finally, prolonged exercise affected gene methylation patterns and micro-RNA content in the sperm

41 Although altered DNA methylation patterns and mutations in DNMT3A correlate w

42 ne methylation as well as alterations to DNA methylation patterns and noncoding RNA expression throug

43 light the conservation and divergence of DNA methylation patterns and regulatory machinery in plants

44 ions in human DNMT3B disrupt genome-wide DNA methylation patterns and result in ICF syndrome type 1 (

45 the complete genome sequence, as well as DNA methylation patterns and small RNA transcriptomes, was a

46 However, there is a lack of tools coupling methylation patterns and the corresponding methyltransfe

47 the mechanistic basis of human-specific DNA methylation patterns and the interpretation of inter-spe

48 BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary intes

49 retinal ganglion cells restores youthful DNA methylation patterns and transcriptomes, promotes axon r

50 strategies involved in setting up normal DNA methylation patterns and understanding how this stable e

51 aralogs, compared their cytosine and histone methylation patterns, and analyzed the sequence evolutio

52 ography tandem mass spectrometry, histone H3 methylation patterns, and markers of mitochondrial respi

53 a functional role of spatial correlations in methylation patterns, and provide a mean to quantitate s

54 We characterize genome-wide DNA methylation patterns, and show that correlation among Cp

55 ironmental stressors may have on genome-wide methylation patterns, and to what extent epigenetics may

56 Aberrant DNA methylation patterns are a common theme across all cance

57 Alterations in global DNA methylation patterns are a major hallmark of cancer and

58 ms which recognise heterogeneous outlier DNA methylation patterns are able to identify many sites in

59 yltransferases (DNMTs) and disruption of DNA methylation patterns are associated with carcinogenesis

60 methylation in angiosperms and show that DNA methylation patterns are broadly a reflection of the evo

61 Such mtDNA methylation patterns are conserved across different spec

62 Genomic methylation patterns are dynamically maintained, with DN

63 Mammalian DNA methylation patterns are established by two de novo DNA

64 In plants, DNA methylation patterns are faithfully inherited over many

65 The vast majority of genic CG methylation patterns are faithfully transmitted over nin

66 We provide evidence that such DNA methylation patterns are generated by OxyR binding.

67 A and DNMT3B specificity suggesting that DNA methylation patterns are guided by the sequence preferen

68 increasing number of disease conditions, DNA methylation patterns are inappropriately distributed in

69 that genome-wide cancer hyper- and hypo- DNA methylation patterns are independent processes, controll

70 DNA methylation patterns are initiated by de novo DNA methyl

71 eg lineage development and stability and how methylation patterns are maintained during lineage self-

72 that, with the exception of cerebellum, DNA methylation patterns are more homogeneous between differ

73 Hemispheric differences in DNA methylation patterns are prevalent in neurons and may af

74 To gain insight into how genomic DNA methylation patterns are regulated during iAs-mediated c

75 n DNA methylation showed that changes in DNA methylation patterns are required for the accurate regul

76 DNA methylation patterns are set up in a relatively fixed pr

77 Following establishment, genomic methylation patterns are transmitted through S-phase by

78 In addition, great tit neuronal non-CpG methylation patterns are very similar to those observed

79 DNA methylation patterns are well known to vary substantiall

80 c datasets and disentangles heterogeneity in methylation patterns arising from replication-associated

81 cts of changes in leukocyte fractions on CpG methylation patterns as well as the potential importance

82 ly a minority of mTECs, independently of DNA-methylation patterns, as small inter-chromosomal gene cl

83 es featuring all of the reported acetylation/methylation patterns associated with Bp and Bm LPS O-ant

84 We show distinct methylation patterns associated with each phenotype.

85 The proportion of genes and DNA methylation patterns associated with gbM are restricted

86 DNA methylation patterns associated with habitual diet have

87 Our analyses indicate that DNA methylation patterns associated with the susceptible and

88 ction associate with subsequent distinct DNA methylation patterns at 52 weeks after surgery.

89 covered characteristic accessibility and DNA methylation patterns at DNase hypersensitive sites (DHSs

90 or carry-out a joint statistical analysis of methylation patterns at four CpG sites producing unrelia

91 of survivors revealed that treatment-related methylation patterns at genomic sites linked to meta-GWA

92 vides a simple explanation for non-canonical methylation patterns at some loci or in certain COMPASS

93 DNA methylation patterns at specific cytosine-phosphate-guan

94 We discovered aberrant DNA methylation patterns at specific genomic regions in frag

95 in subchondral bone and identified different methylation patterns at the late stage of OA.

96 e two mutant subpopulations exhibit distinct methylation patterns at their imprinting control regions

97 Alteration in DNA methylation patterns becomes particularly important in t

98 hylation in both strains; however, the basal methylation pattern between strains shows striking diffe

99 rmation derived from the similarity of local methylation pattern between tissues, the methylation inf

100 ach methylation context showed very distinct methylation patterns between cell types and in response

101 Here, we compare genome-wide methylation patterns between isogenic ESC and EGC lines

102 pluripotent stem cells (iPSCs) show variable methylation patterns between lines, some of which reflec

103 Among these methylation patterns, bipolar patterns are important as

104 out of DNMT3A alone perturbed mtDNA regional methylation patterns, but not global levels, and altered

105 , including a locus that itself controls DNA methylation patterns, but with most of the changes affec

106 s have been shown to have unique genomic DNA methylation patterns (called "episignatures").

107 DNA methylation patterns can also serve as potential biomark

108 Here we show that in vivo and in vitro DNA methylation patterns can be horizontally transferred int

109 e, and showed that horizontally acquired DNA methylation patterns can increase or decrease cell fitne

110 True representation of methylation patterns can only be fully characterised by

111 That is, horizontally acquired DNA methylation patterns can result in the selection for and

112 is considered a stable epigenetic mark, yet methylation patterns can vary during differentiation and

113 Specific and distinct DNA methylation patterns characterize subtypes of AML and ly

114 d that Natur-IVF embryos have expression and methylation patterns closer to in vivo blastocysts.

115 method provides kilobase pair-scale genomic methylation patterns comparable to whole-genome bisulfit

116 The third subtype did not have changes in methylation pattern, compared with control tissue, but h

117 nerve sheath tumors based on genome-wide DNA methylation patterns.CONCLUSIONThese findings uncover a

118 We find that expression and DNA methylation patterns correlate with distinct accessibili

119 Their methylation pattern correlates much stronger than promot

120 Abnormal methylation pattern could contribute to the pathogenesis

121 Detection of aberrant methylation pattern could serve as an excellent diagnost

122 rly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenanc

123 hical method to cluster cells based on local methylation patterns, discovering patterns of epigenetic

124 Finally, we found that de novo methylation patterning does not strictly require implant

125 ey mediator of inheritance of epigenetic DNA methylation patterns during cell division and is a putat

126 n, which results in faithful transmission of methylation patterns during cell division and, at least

127 se 1) is responsible for propagating the DNA methylation patterns during DNA replication.

128 hanges, alternative splicing events, and DNA methylation patterns during nodule formation, developmen

129 In mammals, faithful inheritance of genomic methylation patterns ensures proper gene regulation and

130 lidated thousands of EGR1 binding sites with methylation patterns established during postnatal brain

131 tion resistance driven by the mismatching of methylation patterns following uptake of commensal-deriv

132 llel, permitted determination of genome-wide methylation patterns for all strains.

133 ysis of aged and cancerous cell-specific DNA methylation patterns for diagnostic and prognostic purpo

134 We not only revealed genome-wide methylation patterns for psoriasis but also identified s

135 We also observed that the allelic methylation patterns for the vast majority of the cis-re

136 The control of DNA methylation pattern formation by replication dependent a

137 e that predicts histone modification and DNA methylation patterns from DNA motifs.

138 encing data and incorporates allele-specific methylation patterns from heterozygous individuals to en

139 hpat", that extracts and displays clonal DNA methylation patterns from massively parallel sequencing

140 sing this approach, we identify critical DNA methylation patterns from previously inaccessible cohort

141 mus of F1 mice due to the inheritance of DNA methylation patterns from the paternal generation.

142 ing/quality control/methylation calling with methylation pattern generation and visualization.

143 Individuals harboring this methylation pattern had a more aggressive clinical cours

144 tanding the delineation of genome-wide H3K27 methylation patterns has been the focus of intense inves

145 reliable detection of disease-associated DNA methylation patterns has major potential to advance mole

146 The alterations in DNA methylation pattern have been identified as one of the m

147 transferases or demethylases, yet discordant methylation patterns have also been observed, which are

148 Aberrant DNA methylation patterns have been widely observed in tumori

149 studies examining RNA transcription and DNA methylation patterns have revealed profound insights in

150 is strikingly better on chromosome X, where methylation patterns have unique inter-tissue variabilit

151 The analysis of DNA methylation patterns helps researchers understand epigen

152 ome genomic loci may demonstrate bipolar DNA methylation pattern, i.e. hypermethylated in one cell su

153 g a DNA amplification efficiency of 70% with methylation patterns identical to the respective bulk DN

154 ally, we show that the regional differential methylation patterns identified on sparse array data are

155 ic drug treatment in vitro We found that DNA methylation patterns identify divergent patient subgroup

156 in DNA methylation, whereas well-structured methylation patterns imply deterministic methylation eve

157 cument the expression of lncRNAs and the DNA methylation pattern in calcific aortic valve disease.

158 We find a remarkably consistent, abnormal methylation pattern in insulinomas.

159 s demonstrate that EHS leads to a unique DNA methylation pattern in monocytes and altered immune and

160 ing healthy controls revealed a distinct DNA methylation pattern in psoriasis compared with controls.

161 aim of the present study was to evaluate the methylation pattern in the suppressor of cytokine signal

162 ll cycle progression and perturbs global DNA methylation patterning in the genome.

163 l epigenetic bias, here we have profiled DNA methylation patterns in a cohort of 57 individuals with

164 an visualise the diversity of epiallelic DNA methylation patterns in a sample.

165 we show that Epiclomal discovers sub-clonal methylation patterns in aneuploid tumour genomes, thus d

166 Furthermore, we have shown that genome-wide methylation patterns in Arabidopsis thaliana are highly

167 We analyzed DNA methylation patterns in blood samples of pediatric patie

168 hyl-donor availability influenced global DNA methylation patterns in both adult mice and their offspr

169 tive studies reveal efficient replication of methylation patterns in C. neoformans, rare stochastic m

170 NMT1 and DNMT3b and, in turn, changes in DNA methylation patterns in cancer cells.

171 Their results show aberrant DNA methylation patterns in CD4-enriched T cells from periph

172 ell death in humans based on tissue-specific methylation patterns in cfDNA.

173 We have shown that genome-wide DNA methylation patterns in CLL are strongly associated with

174 IL-13 altered global DNA methylation patterns in cultured AECs and were significa

175 and control animals highlighted differential methylation patterns in Daphnia upon exposure to Microcy

176 We profiled genome-wide DNA methylation patterns in DNMT3A c.2312G > A; p.(Arg771Gln

177 tic changes, and we find early maturation of methylation patterns in DS brain and lymphocytes.

178 e find that sex rather than cell type drives methylation patterns in ESCs and EGCs.

179 ct roles of DNMT1-dependent and -independent methylation patterns in genome stability and regulation

180 llomavirus (HPV) infection distinctly alters methylation patterns in HPV-associated cancer.

181 of DNMT3B are highly correlated with non-CpG methylation patterns in human cells.

182 To evaluate the transgenerational DNA methylation patterns in human, we analyzed the DNA methy

183 Several studies show alterations in DNA methylation patterns in iAs-mediated pathogenesis, but t

184 d comprehensive update on the involvement of methylation patterns in inflammatory skin disease.

185 Thus, we show that DNA methylation patterns in JMML are predictive of outcome a

186 tes the establishment and maintenance of DNA methylation patterns in mammalian cells.

187 s suppressive effect but identified aberrant methylation patterns in MYD88 wild-type patients.

188 s into the diversity and dynamics of RMS and methylation patterns in N. gonorrhoeae.

189 hat ecRNAs are fundamental regulators of DNA methylation patterns in neuronal systems, and reveal a p

190 ssiveness of individual PC foci based on DNA methylation patterns in primary PC foci and matched lymp

191 ed in genome-wide association studies of DNA methylation patterns in relation to environmental exposu

192 of lifelong physical activity on global DNA methylation patterns in skeletal muscle of healthy aged

193 tudy to examine global transcription and DNA methylation patterns in specific immune cell populations

194 Here, we interrogate cytosine methylation patterns in sperm obtained from mice consumi

195 We have also analysed the changes in methylation patterns in the chloroplast DNA as the rice

196 Here, we focus on genome-wide methylation patterns in the microcrustacean Daphnia magn

197 OpvAB(ON) cell lineages display opposite DNA methylation patterns in the opvAB regulatory region: (i)

198 We examined genome-wide DNA methylation patterns in the prefrontal cortex (PFC, BA10

199 DNA methylation patterns in the preimplantation embryo are d

200 model and investigated the transgenerational methylation patterns in these animals.

201 er than stochastic variation, read-level CpG methylation patterns in tissue whole genome bisulfite se

202 ovides the ability to investigate clonal DNA methylation patterns in unprecedented detail and scale,

203 iated, at least in part, through altered DNA methylation patterns in upper airway mucosal cells.

204 G), and explored variation in read-level CpG methylation patterns in whole genome bisulfite sequencin

205 netic information encoded in the genomic DNA methylation pattern is translated by methylcytosine bind

206 Hemispheric asymmetry in neuronal DNA methylation patterns is largely mediated by differential

207 Transmission fidelity of CpG DNA methylation patterns is not foolproof, with error rates

208 DNA transposon, suggesting that the observed methylation pattern may be independent of the mode of in

209 To study whether normal DNA methylation patterns may be restored in ICF1 cells, we c

210 d was further validated by comparing the CpG methylation pattern, methylation profile of CGIs/promote

211 With this system we demonstrated that DNA methylation patterns not only accompany the horizontal t

212 lating tumor content fraction, reflective of methylation patterns observed in biopsy tissues, and was

213 Methylation patterns observed in blood samples from pati

214 on; with treatment, these change to resemble methylation patterns observed in patients without intest

215 This methylation status is reflected in the methylation pattern of ctDNA shed from the primary tumor

216 ble common epigenetic change, we studied DNA methylation pattern of more than 450 000 CpG sites in 44

217 We find that HR modifies the DNA methylation pattern of the repaired segment.

218 utero exposure to BPA altered the global CpG methylation pattern of the uterine genome, subsequent ge

219 control and motivational processes with DNA methylation patterns of 60 candidate genes in boys at ea

220 stable with an epivariation frequency in DNA methylation patterns of at least two orders of magnitude

221 betes and diagnosis of beta-cell death using methylation patterns of circulating DNA.

222 Also, the analysis of methylation patterns of duplicated and single-copy genes

223 st, second and third trimesters to determine methylation patterns of homeobox gene promoters across g

224 ls the first genome-wide analysis of histone methylation patterns of human primary bladder tumours by

225 Methylation patterns of kidneys from patients with CKD s

226 ve analysis, we investigated genome-wide DNA methylation patterns of meningiomas from ten European ac

227 DNA methylation patterns of primary samples are distinct fro

228 gy to properly and unambiguously extract DNA methylation patterns of repetitive, as well as single ge

229 The DNA methylation patterns of some genes and transposons are m

230 dopsis reproduces the strong linker-specific methylation patterns of species that diverged from flowe

231 encing (ChIP-seq) experiments show that H3K4 methylation patterns on active genes are not universal o

232 s ago has enabled the Darwinian evolution of methylation patterns over geological timescales.

233 Changes to DNA methylation patterns over time form the basis of ageing

234 ng the pivotal role aberrant genome-wide DNA methylation patterns play in cancer ontology.

235 t birth, is a potentially rich source of DNA methylation patterns predictive of ASD in the child.

236 Herein, we applied a novel methylation pattern recognition and simulation approach,

237 as demonstrated by widespread changes to DNA methylation patterns, redistribution of histone marks an

238 Highly variable methylation patterns reflect stochastic fluctuations in

239 y cohort data unveils cell type-specific DNA methylation patterns related to HIV-associated CI and pr

240 lly segregate into 2 groups according to DNA methylation patterns, related to normal MBC and PC profi

241 diated co-methylation contributes to the DNA methylation patterns remain unclear.

242 l approach, we observed in the isolated CTCs methylation patterns resembling more those of epithelial

243 ne DNA methyltransferases (Mod) alter global methylation patterns resulting in changes in gene expres

244 al dementia (ALS/FTD) that recapitulates DNA methylation patterns seen in patients, demonstrating tha

245 onstrates that the expression of alternative methylation patterns should be an important consideratio

246 evealed that these segments are comprised of methylation patterns specific to either prostate cancer

247 of pregnancy within our study reveals a CpG methylation pattern that is restricted to female animals

248 pathogen takes up commensal DNA containing a methylation pattern that it does not recognize.

249 rthermore, we identified distinct epigenetic methylation patterns that are conserved across tissues,

250 ssfully employed for characterisation of DNA methylation patterns that are essential for the diagnosi

251 a harbors H3F3A mutations but shows distinct methylation patterns that correlate with anatomical loca

252 le (SWI/SNF) chromatin remodeling and global methylation patterns that may allow for future therapeut

253 ns can be used to decipher mutation-specific methylation patterns that may lead to therapeutic insigh

254 ian randomization to identify changes in DNA methylation patterns that might contribute to the develo

255 ong physical activity is associated with DNA methylation patterns that potentially allow for increase

256 EBV latency types are defined by DNA methylation patterns that restrict expression of viral l

257 Loss of Dnmt3a led to disturbed methylation patterns that were distinct in lymphoid and

258 sts, they had unique gene expression and DNA methylation patterns that were, in part, indicative of t

259 Furthermore, there were differences in methylation patterns that, although not statistically si

260 uggest that DNMT3A maintains a conserved DNA methylation pattern, the erosion of which provides a dis

261 nd late-onset myopia were confirmed with DNA methylation patterns: there were very distinct and stron

262 ent to daughter strands, producing heritable methylation patterns through cell divisions.

263 Dnmt2-dependent methylomes lack defined DNA methylation patterns, thus necessitating a systematic re

264 CG methylation is higher in pollen, allowing methylation patterns to be accurately inherited across g

265 methylated in placentas, suggesting similar methylation patterns to mouse.

266 mation, such as histone modification states, methylation patterns, transcription factor binding sites

267 Yet, studies of methylation patterns under stress could provide crucial

268 20%) were not associated with a specific DNA methylation pattern using an unsupervised approach.

269 Genome-wide analysis of DNA methylation patterns using single molecule real-time DNA

270 e for directly detecting epimutations in DNA methylation patterns using single-cell, locus-specific b

271 Currently, how extensive methylation patterns vary among brain cells is unknown a

272 ies anal cancer and HGAIN with a cancer-like methylation pattern, warrantingvalidation studies to ver

273 d with symptoms (P < 0.05), and baseline DNA methylation pattern was found to be predictive of sympto

274 DNA methylation pattern was reversed at the end of photother

275 Methylation patterns were analysed in buccal cell DNA wi

276 DNA methylation patterns were analyzed in samples collected

277 Genome-wide DNA methylation patterns were determined in whole blood samp

278 We found that DNA methylation patterns were highly conserved between tissu

279 Methylation patterns were identified using Illumina 450K

280 Interestingly, the aberrant histone H3 methylation patterns were predominantly observed within

281 These differential methylation patterns were primarily observed in organell

282 Gene methylation patterns were similar to those in mammals, a

283 Genome-wide DNA methylation patterns were strikingly similar between HCM

284 - treated FAP patient tissue after which the methylation patterns were visualized by Next Generation

285 NA alterations (colonic exome sequencing and methylation patterns) were monitored following human fec

286 ny other genes in these classes have similar methylation patterns, whether the genes are active or re

287 its intermediates are known to alter the DNA methylation pattern, which is a critical regulator of ep

288 DNA methylation patterns, which are critical for gene expres

289 and association with genome-wide cancer DNA methylation patterns, which are largely independent of c

290 enetic background to transcriptional and DNA methylation patterns while controlling for cell line clo

291 iversity Vienna (Vienna, Austria), assessing methylation patterns with an alternative methylation chi

292 teristics, gene expression profiles, and DNA methylation patterns with blastocyst-derived TSCs.

293 ows users to perform integrative analysis of methylation patterns with other genomic features togethe

294 activity of B cells in RA and suggest shared methylation patterns with SLE.

295 both through comparison of nanopore-derived methylation patterns with those from Reduced Representat

296 HGAIN samples revealed heterogeneous methylation patterns, with a subset resembling cancer.

297 Extensive variation of DNA methylation patterns within a species has been uncovered

298 stem in Escherichia coli where different DNA methylation patterns within the cis-regulatory sequence

299 relied only on histone modifications or DNA methylation patterns within the gene body; promoter meth

300 Here, we hypothesized that DNA methylation patterns would help predict disease outcome