ライフサイエンスコーパス: methylation status

1 tematic re-evaluation of the mosquito genome methylation status.

2 Adjacent Motif (PAM) and is sensitive to its methylation status.

3 aintenance of lineage-specific chromatin and methylation status.

4 recise prediction of biological age from DNA methylation status.

5 e-DNA-methyltransferase gene (MGMT) promoter methylation status.

6 the silenced gene with no change in promoter methylation status.

7 ion included clinical factors and tumor MGMT methylation status.

8 GATA1, and USF1) factors was not affected by methylation status.

9 Efficacy did not differ by methylation status.

10 l donor betaine to modulate inflammatory and methylation status.

11 omide for newly diagnosed GBM, regardless of methylation status.

12 nhancer activities in response to changes in methylation status.

13 ethylation, histone acetylation, and histone methylation status.

14 H19) and potentially other genes of unknown methylation status.

15 ghtly coordinated and coupled to target site methylation status.

16 he two sense pancRNAs did not change the DNA methylation status.

17 . coli, irrespective of its dam, dcm, or hsd methylation status.

18 ent gene transcripts without affecting FoxP3 methylation status.

19 on of these genes through changes in histone methylation status.

20 ld be related to the modification of the DNA methylation status.

21 ance of miR-4516 was retained including MGMT methylation status.

22 ical pathways or genomic properties like DNA methylation status.

23 ponents such as cellulose content and pectin methylation status.

24 score, secondary structure and promoter DNA methylation status.

25 ntified, and O-GlcNAc levels regulated their methylation status.

26 utarate (2HG) can cause changes in chromatin methylation status.

27 activity, independent of the MMP13 promoter methylation status.

28 ffect of PTSD on cortical thickness via SKA2 methylation status.

29 lls, also identifying in the RORC2 and IL17A methylation status a novel tool for their distinction fr

30 oligodendroglial elements, and MGMT promoter methylation status, analysed by intention to treat.

31 s were used to identify associations between methylation status and 21 dietary variables hypothesized

32 The DNA methylation status and a repressive histone modification

33 t epi-allelic haplotypes, annotated with CpG methylation status and DNA polymorphisms, from whole-gen

34 interactions at enhancers, we find that DNA methylation status and enhancer activity during early ze

35 y showing an inverse correlation between DNA methylation status and expression level.

36 genes showed an inverse correlation between methylation status and gene expression.

37 ant association was observed between RASSF1A methylation status and HNSCC risk under a random-effects

38 ism may play an essential role in regulating methylation status and liver injury in Wilson's disease

39 These results also suggest that promoter methylation status and miRNA expression levels represent

40 f the ferT RNA was also regulated by the DNA methylation status and paralleled the expression profile

41 Among the genes whose DNA methylation status and RNA expression were both signific

42 Genome-wide differences in DNA methylation status and RNA expression were demonstrated

43 a methylationEPIC arrays to characterize DNA methylation status and RNAseq to evaluate gene expressio

44 Arg-specific NMR experiment that detects the methylation status and symmetry of each arginine side ch

45 Discrepancies between MGMT promoter methylation status and treatment response in some patien

46 Gene expression levels were opposite to methylation status, and both correlated with birth weigh

47 F (V600E) mutation status, mut-L homologue 1 methylation status, and disease-specific survival in the

48 connect between chromatin accessibility, DNA methylation status, and gene activity.

49 I "PGFRA," RTK II "classic"), MGMT promoter methylation status, and hallmark copy number variations

50 r markers (1p/19q co-deletion, MGMT promoter methylation status, and IDH1/IDH2 mutations).

51 a late step of reprogramming associated with methylation status, and implicated a secondary set of pl

52 levels, anti-ADI-PEG20 antibody titer, ASS1 methylation status, and metabolic response by 18F-fluoro

53 ion negatively correlated with XAF1 promoter methylation status, and negatively correlate with GBM pa

54 lical structure facilitates sampling of H3K4 methylation status, and proffers H3K9 and other residues

55 regardless of its sequence, CpG content, or methylation status, and required signaling through the a

56 IL-4, INF-gamma and Foxp3 gene promoter DNA methylation status, and their correlation with final cha

57 Based on the potential use of global DNA methylation status as a biomarker of disease status and

58 eded to investigate the potential of DNA-(de)methylation status as a predictor for BF as well as for

59 To enable monitoring of methylation status as it changes over time, we establish

60 I IFN-alpha/beta protein levels with the DNA methylation status as well as the expression profiles of

61 Our data comprises the methylation status at 12 CpGs near the 5' end of the CpG

62 However, it is presently unclear how methylation status at individual genes is targeted for m

63 abled quantitative measurement of single CpG methylation status at relatively low cost and sample inp

64 cing (WGBS), with its ability to interrogate methylation status at single CpG site resolution epigeno

65 tion imparts differential maintenance of DNA methylation status at Tet1 targets, ultimately contribut

66 A gradual change in methylation status at the boundaries of hypomethylated r

67 sequencing has been used to characterize DNA methylation status at the genome scale, but suffers from

68 ylation and changes in the H3K27 acetylation/methylation status at the Il13 locus.

69 dependently established the correct cytosine methylation status at the target CG of each molecule tes

70 d that there was a strong correlation on the methylation status between different generations in the

71 Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that

72 nia, together with the stable inheritance of methylation status between generations, suggests either

73 transcript levels (by quantitative PCR), DNA methylation status (by bisulfite pyrosequencing), and GA

74 a classification-based procedure, called the methylation status calling (MSC) procedure, to make bina

75 mate that Q40 values (0.01% error rates) for methylation status calls could be achieved by reading si

76 sfactory in applications that require binary methylation status calls.

77 atus calling (MSC) procedure, to make binary methylation status calls.

78 ular phenotypes, such as gene-expression and methylation status, can be leveraged to functionally ann

79 No DNA methylation status changes were detected upon Ureaplasma

80 ed or had no significant change in their DNA methylation status compared with normal pregnancy.

81 methylguanine-DNA methyltransferase promoter methylation status, contrast enhancement, initial treatm

82 e brain, and mutation in H67D perturbs redox-methylation status, contributing to GABAergic dysfunctio

83 Finally, gene methylation status determines the expression of several

84 as validated by quantification of global DNA methylation status following treatment of cells with the

85 Changes in histone lysine methylation status have been observed during cancer form

86 gulatory T cell-specific demethylated region methylation status in 1-month biopsy samples revealed a

87 By measuring reelin expression and promoter methylation status in 39 primary breast tumors, as well

88 ations establish a link between SAMe and DNA methylation status in a defined biological system, provi

89 chronological profile of the genome-wide DNA methylation status in a human myoblast differentiation m

90 n levels were negatively associated with the methylation status in beef cattle (P < 0.05).

91 thylViewer can simultaneously query cytosine methylation status in bisulfite-converted sequences at a

92 enous Bt toxins, Bt-transgene expression and methylation status in Bt rice exposed to two levels of C

93 The specific importance of the DNA methylation status in CD4(+) T cells could be confirmed

94 were then selected for analysis of promoter methylation status in cell lines and primary RCC.

95 itors allow unprecedented control of the DNA methylation status in cells and will lead to further adv

96 ixed cell population, the change in promoter methylation status in chronic periodontal disease sugges

97 dy, we investigated gene copy number and CpG methylation status in CRPC to gain insight into specific

98 put and comprehensive platform for measuring methylation status in EWASs.

99 Methylation status in individual CpG sites correlated wi

100 eatment followed by pyrosequencing confirmed methylation status in juvenile DM and other IIMs.

101 Promoter methylation status in long interspersed nucleotide eleme

102 CpG methylation status in normal cells points to locally act

103 rmed DNA bisulfite sequencing to compare the methylation status in postmortem retina pigment epitheli

104 inting but is a strong factor in determining methylation status in preimplantation embryos, suggestin

105 stered these profiles according to their DNA methylation status in primary normal and tumor tissues.

106 ntial of these sensors in monitoring histone methylation status in response to histone methyltransfer

107 DNA methylation status in the AMP promoter regions was also

108 se expression is modulated by an altered DNA methylation status in VSMCs, and among the hits, we sele

109 ations and epimutations (changes in cytosine methylation status) in mutation accumulation (MA) lineag

110 ioids, can influence neuronal-cell redox and methylation status including DNA methylation.

111 long-term influence of morphine on redox and methylation status (including DNA methylation levels) in

112 )-MeG)-DNA methyltransferase (MGMT) promoter methylation status is accepted as a prognostic and promi

113 Altered DNA methylation status is associated with human diseases and

114 ation at both K4 and K79, indicating that H3 methylation status is not solely dependent on H2B ubiqui

115 This methylation status is reflected in the methylation patte

116 The methylation status is stably maintained even after CpG-f

117 )-methylguanine-DNA methyltransferase (MGMT) methylation status may be an important determinant of tr

118 drocytes, consistent with the differences in methylation status observed in vivo in normal and human

119 The methylation status of > 485,000 CpG loci was interrogate

120 In the present work, the methylation status of >145,000 CpGs from 5,472 promoters

121 We have used this method to determine the methylation status of >275 million CpG sites in human an

122 The methylation status of 1,421 autosomal CpG sites located

123 The methylation status of 13 candidate genes (CDO1, CNRIP1,

124 Methylation status of 17 CpG sites in PLAC8 negatively c

125 The methylation status of 2 of these candidate genes, BCL-2

126 We have examined the methylation status of 27 578 CpG dinucleotides in 72 CdL

127 Activation changed the methylation status of 466 CpGs and 18 RDMs in Naive but

128 Using Sequenom MassARRAY we measured the methylation status of 68 CpGs 5' from five candidate gen

129 The method was scaled to interrogate the methylation status of 77,674 CpGs in the promoter region

130 4 levels was observed to be dependent on the methylation status of a miR-494 promoter-associated CpG

131 get poorly transcribed loci by "reading" the methylation status of a particular lysine residue of his

132 In contrast, measurement of the DNA methylation status of a region within the FOXP3 locus th

133 However, monitoring the methylation status of a specific cytosine biomarker is o

134 This enabled the methylation status of a specific cytosine to be accurate

135 lity in liver tissue, based on comparing the methylation status of adjacent CpG sites on long sequenc

136 bisulfite sequencing studies to address the methylation status of Arabidopsis thaliana telomeres.

137 expression of regulatory markers, and FOXP3 methylation status of blood TFR is comparable with tonsi

138 ction in CaM KMT revealed a link between the methylation status of CaM and root length.

139 We sought to elucidate whether the methylation status of CaM plays a role in CaM-mediated s

140 nstitutive and T-cell activation-induced DNA methylation status of CCR5 cis-regulatory regions (cis-r

141 Methylation status of CCR5 intron 2 explains a larger pr

142 Methylation status of CDKN2A, PTEN, and RASSF1A gene pro

143 Measuring the methylation status of cell-free DNA (cfDNA) in plasma ho

144 f single CpG sites are representative of the methylation status of corresponding regions of interest.

145 thod applicable to WGBS data, to resolve the methylation status of CpG dyads into unmethylated, hemi-

146 sferase in mouse and human and regulates DNA methylation status of CpG island-associated promoters in

147 lopment of allergic disease, we examined the methylation status of CpG loci within the promoter regio

148 The methylation status of CpG sites close to the trinucleoti

149 mplantation development by ensuring that the methylation status of CpGs is maintained.

150 for the multiplexed interrogation of the DNA methylation status of cytosine-guanine dinucleotide isla

151 iSA is also tunable for analyzing the methylation status of cytosines in any sequence context.

152 e high level of accuracy for identifying the methylation status of cytosines in DNA, could find broad

153 Our integrated analysis demonstrates that methylation status of different genomic regions may play

154 arate-dependent dioxygenases that modify the methylation status of DNA by successively oxidizing 5-me

155 We fit a mixed model with the methylation status of each CpG as the dependent variable

156 The global CpG methylation status of eel liver was determined by means

157 This study provides evidence for utilizing methylation status of gene candidates to define late-sta

158 the downregulation, we examined the promoter methylation status of GPC5 gene.

159 e that showed JARID2 binds to and alters the methylation status of histone H3 lysine 27 in the promot

160 Therefore, PP2A directs the methylation status of histones by regulating the phospho

161 date, a small number of enzymes that control methylation status of histones have been identified as c

162 In this study, we analyzed the methylation status of human promoters in rheumatoid arth

163 The DNA methylation status of human X chromosomes from male and

164 We conclude that the DNA methylation status of IEGs plays a crucial role in FS-in

165 p between maternal PAH exposure and promoter methylation status of IFNgamma and IL4.

166 Therefore, the methylation status of immune synapse genes reflects tumo

167 Many studies have reported the methylation status of individual genes with known involv

168 egulated expression of BRCA1 by altering the methylation status of its promoter.

169 When the methylation status of key immune synapse genes was inter

170 Together, these findings show that the methylation status of m(6)Am in the 5' cap is a dynamic

171 We determined the methylation status of miR-137 CpG island in a panel of s

172 Here, we examined the methylation status of MMP13 promoter and report the deme

173 healthy control livers were analyzed for the methylation status of more than 14,000 genes.

174 Although the methylation status of most CpG dinucleotides in the geno

175 ethod can reliably and accurately detect the methylation status of multiple target sites in each sing

176 ion content and a reduced correlation in the methylation status of neighboring cytosine--phosphate--g

177 rences) but were only weakly affected by the methylation status of neighboring cytosines.

178 ociated with decreases in both the redox and methylation status of neuronal cells, as defined by the

179 Aberrations in the methylation status of noncoding genomic repeat DNA seque

180 identified 10-base periodicities in the DNA methylation status of nucleosome-bound DNA and found tha

181 To test this, we analyzed the methylation status of over 27,000 CpGs mapping to promot

182 We have analyzed the methylation status of over 28,000 CpG islands and 18,000

183 Here, we evaluated the DNA methylation status of patients with tuberculosis (TB) an

184 entiation of epiblast cells to PGCs, how DNA methylation status of PGCLCs resembles the dynamics of 5

185 To understand the mechanism DNA methylation status of POLG1 promoter was investigated by

186 Recent reports indicate that the methylation status of promoter proximal CpG dinucleotide

187 as single-CpG resolution and can address the methylation status of repeated sequences.

188 ethod, we characterized the landscape of the methylation status of repetitive elements, such as LINEs

189 sponse and characterization of molecular and methylation status of responders were secondary objectiv

190 Interestingly, the DNA methylation status of resting cells was highly predictiv

191 function had a clear impact not only on the methylation status of RhoA but also RhoA activation and

192 ates with male infertility, we evaluated the methylation status of RHOX genes in sperm from a large c

193 Here we show that the methylation status of rRNA differentially influenced the

194 iR-200b) and pyrosequencing to determine CpG methylation status of selected genes (Aph1a and Dkk4) in

195 Associated with this was an increased methylation status of several CpG dinucleotides in the p

196 This suggests that the DNA promoter methylation status of some steroid responsive genes in t

197 RUNX2 gene transcription is regulated by the methylation status of specific CpG sites in the promoter

198 tudy aimed to determine the influence of the methylation status of specific CpG sites in the RUNX2 pr

199 drocytes is controlled by changes in the DNA methylation status of specific CpG sites of the proximal

200 U.S. population, to have effects on the DNA methylation status of specific genes in the placenta and

201 memory and imprinting by regulating the CpG methylation status of specific promoter regions.

202 argets by two rounds of PCR to determine the methylation status of target sites.

203 analyzed complementary DNA and evaluated the methylation status of the androgen receptor gene.

204 resistance was associated with an increased methylation status of the catalytic subunit of protein p

205 performed the first systematic survey of DNA methylation status of the CpG islands of the PEG3 (Pater

206 ly recording the haplotype, copy number, and methylation status of the disease-associated, highly rep

207 racterizing the functional links between the methylation status of the DNA and of two particularly im

208 We subsequently studied the DNA methylation status of the Eph/ephrin family by bisulfite

209 ansferase and demethylase enzymes to set the methylation status of the epigenome for proper control o

210 associated variants are correlated with the methylation status of the FNDC1 gene (cg05678571, P=1.43

211 ry sclerosing cholangitis controls), and the methylation status of the four best performing markers w

212 re in all AML blasts irrespective of the DNA methylation status of the gene.

213 ha (3-fold; P = 0.035) without affecting the methylation status of the gene.

214 Through its SET domain, WHSC1 regulates the methylation status of the histone H4 K20 residue and is

215 n, we determined the effects of GRHL2 on the methylation status of the hTERT promoter.

216 Assessment of the DNA methylation status of the identified genes could contrib

217 (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in

218 In addition, we evaluated methylation status of the IFNgamma promoter in cord whit

219 Anti-IL-1beta did not alter the methylation status of the IL-1beta promoter.

220 oss of methylation at a CpG depends upon the methylation status of the immediately preceding CpG.

221 Expression of p57 is regulated by the DNA methylation status of the imprinting control region 2 (I

222 The DNA methylation status of the iNOS promoter and enhancer reg

223 also observed significant differences in the methylation status of the insertion sites among MITE fam

224 These data also show that the DNA methylation status of the intronic CpG island affects tr

225 i and performed manually-curated matching of methylation status of the key regulatory sequences (prom

226 f normal and tumor tissues revealed that the methylation status of the majority of CpG sites adjacent

227 e-implantation development, we find that the methylation status of the majority of CpGs genome-wide i

228 Retrospectively, the methylation status of the methyl-guanine methyl transfer

229 f MITF did not alter the expression level or methylation status of the MITF pathway genes.

230 Therefore, we determined the methylation status of the MSH2 gene in 268 CRC tissues,

231 y, however, the results indicated that the O methylation status of the OPS antigens was also affected

232 We aimed to investigate whether the methylation status of the P2Y12 promoter has effects on

233 t target of miR-128 and able to modulate the methylation status of the pivotal VSMC gene myosin heavy

234 ethylesterase-1 (PME-1), thus preserving the methylation status of the PP2A catalytic subunit.

235 The methylation status of the promoter of O(6)-methylguanine

236 Thus, changes in the DNA methylation status of the PRTN3 promoter may predict the

237 he brain of Xenopus embryos, we analyzed the methylation status of the RASSF10-associated 5'-CpG isla

238 f these CpG sites, we also evaluated the DNA methylation status of the rDNA promoter in prostate canc

239 eaction (PCR) was performed to determine the methylation status of the SOCS1 promoter in 45 saliva sa

240 etylation and methylation as well as the DNA methylation status of the TEs.

241 bisulfite Sanger sequencing to determine the methylation status of the Treg-specific demethylated reg

242 , we show that MSRE-qPCR can distinguish the methylation status of the TSDR in populations of cells c

243 tion sequencing approach for determining the methylation status of the TSDR, our MSRE-qPCR results we

244 and quantitative PCR (qPCR) to determine the methylation status of the TSDR.

245 that involves random transitions in the DNA methylation status of the VWF promoter.

246 hout their juvenile phase can affect the DNA methylation status of their oocytes during gonad maturat

247 We also show that the methylation status of these genes can cluster important

248 cAMP response elements, suggesting that the methylation status of these loci could serve as a mechan

249 The methylation status of these regions was obtained from th

250 The methylation status of these sites had a significant impa

251 ated CpG island, binds GLI2 depending on the methylation status of this CpG island, and physically in

252 onstrated by quantifying differences in TSDR methylation status of Tregs treated with and without rap

253 this method, we present data on the regional methylation status of two CpG clusters located in the EN

254 rom blood (n = 42) and saliva (n = 20) using methylation status of X-linked polymorphic repeats.

255 can improve over existing DMR detection (i) methylation statuses of nearby CpG sites are highly corr

256 fite sequencing (scRRBS), to measure the CpG methylation status on the same cell for cell type infere

257 Consistent with this, H4K20 methylation status plays a direct role in recruiting ORC

258 icrosatellite instability status, CpG island methylation status, PTEN loss, EGFR expression, and copy

259 MGMT promoter methylation status remained prognostic at tumor recurren

260 NR3C1 methylation status represents a candidate prognostic bio

261 Analysis of the tumor suppressor gene p16 methylation status revealed a clear reduction in methyla

262 P53INP1, and DDAH1 genes at the level of DNA methylation status, RNA, and protein-level expression.

263 rd, TE insertions are distributed by age and methylation status, such that older, methylated TEs are

264 s at least partially independent on promoter methylation status, suggesting a possible relationship b

265 ncer iHMRs are more variable in sequence and methylation status than any other functional class, cons

266 We identified 195 genes with changes in methylation status that were significantly associated wi

267 Klf10 expression was primarily regulated by methylation status, the Klf10 promoter was examined by m

268 polymorphism in MTHFR influences global DNA methylation status through a direct interaction with fol

269 promoters, are the most dynamic in their DNA methylation status throughout development and differenti

270 e the proportion of such CpGs with preserved methylation status to be 78%.

271 n >/=5% and a 5-95% range >/=10%, we related methylation status to maternal pregnancy diet and to chi

272 r, our results suggest that MTHFD2 links RNA methylation status to the metabolic state of tumor cells

273 cursors induced by their MTA-dependent m(6)A methylation status, together with direct interactions be

274 kely through preserving a particular histone methylation status underlying the transient state of dev

275 r the quantitative measurement of global DNA methylation status using ultra-performance liquid chroma

276 In multivariate analysis, melanoma AIM1 methylation status was a significant prognostic factor o

277 Methylation status was also found to have a role in tran

278 DNA methylation status was altered in IPF.

279 LINE-1 and AIM1 methylation status was assessed in paraffin-embedded arc

280 11p15 methylation status was associated relapse (20% relapse w

281 Higher NR3C1 methylation status was associated with depression and se

282 his study aimed to investigate whether NR3C1 methylation status was associated with the long-term pro

283 Methylation status was categorized as low (fewer than tw

284 The methylation status was confirmed by pyrosequencing.

285 as not affected, but global protein arginine methylation status was decreased (10-35%) in liver and b

286 Methylation status was evaluated for CACNAG1, SOCS1, RUN

287 In addition, global DNA methylation status was not affected, but global protein

288 The pooled results showed that MGMT promoter methylation status was significantly associated with an

289 st this hypothesis, DNA and protein arginine methylation status were assessed in liver, brain, heart,

290 Global DNA and protein arginine methylation status were evaluated as the contents of 5-m

291 Thus, the activity of Dam MTase and methylation status were sensitively converted to the DNA

292 features and outcomes based on PTEN promoter methylation status were then analyzed using SPSS and R.

293 on levels correlated inversely with promoter methylation status, whereas demethylation increased reel

294 etylation and, to a secondary degree, by its methylation status, which aided in the interpretation of

295 pG sites (CpG11 and CpG12 + 13) showed lower methylation status, which correlated with a strong assoc

296 pancreatic cancer is correlated with altered methylation status, which seems to be regulated by DNMT1

297 ybrid offspring, recapitulating the parental methylation status with nearly 100% fidelity, indicating

298 We related these to offspring methylation status within 3 maternally methylated imprin

299 Examination of genome-wide DNA methylation status within 928 TE subfamilies in human em

300 P exposure, adverse health outcomes, and DNA methylation status within human populations.