ライフサイエンスコーパス: methyltransferase

1 how that Ocr physically associates with BrxX methyltransferase.

2 adenosylmethionine-dependent carboxylic acid methyltransferase.

3 to be a protein (i.e. actin) histidine-N(3) methyltransferase.

4 ot for the chromatin binding of Trr, the MLR methyltransferase.

5 sphatase and tensin homolog and thiopurine S-methyltransferase.

6 the ability to interact with NSD1, an H3K36 methyltransferase.

7 evelopment of bisubstrate inhibitors for any methyltransferases.

8 potent and selective inhibitors for protein methyltransferases.

9 rtook a systematic screen to uncover new RNA methyltransferases.

10 as the genome does not encode any other DNA methyltransferases.

11 dentify that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Pontin chromatin-

12 n and acetylation of STAT3 that targeted DNA methyltransferase 1 (DNMT1) in a sequential manner.

13 ells displayed altered expression of the DNA methyltransferase 1 (DNMT1) isoform.

14 that a clonal population of DNA (cytosine-5)-methyltransferase 1 (DNMT1)-only cells produces a hetero

15 isubstrate analogues with protein N-terminal methyltransferase 1 (NTMT1) were examined to probe the m

16 Protein arginine methyltransferase 1 (PRMT1) is a key regulator of hepati

17 Here, we show protein arginine methyltransferase 1 (PRMT1), a key enzyme that catalyzes

18 Both oxidants inhibited DNA methyltransferase 1 activity, but only chloramine deplet

19 n in MCT-RVfib reflected increased DNMT (DNA methyltransferase) 1 expression, which was associated wi

20 DNA methyltransferase 2 (DNMT2), known to efficiently cataly

21 Precise regulation of DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2), the de novo Arabidopsis DNA

22 oups by multiple complexes of histone lysine methyltransferase 2 (KMT2) family proteins.

23 tions in the histone-modifying enzyme lysine methyltransferase 2D (KMT2D).

24 In addition, DNA methyltransferase 3A (DNMT3A) activity is modulated by s

25 Mutations in the DNA methyltransferase 3A (DNMT3A) gene are the most common c

26 DNA methyltransferase 3A (DNMT3A) is the most commonly mutat

27 DNA methyltransferase 3a and 3b are the enzymes capable of e

28 topoiesis driven by mutations of DNMT3A (DNA methyltransferase 3a) is associated with increased incid

29 ession in mice inhibits lipogenesis in a DNA methyltransferase-3a (DNMT3A)-dependent manner.

30 Here we report that DNA methyltransferase 3B (DNMT3B) is induced at distant meta

31 Moreover, we identify DNA methyltransferase 3ba (Dnmt3ba) as the primary enzyme re

32 Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetric dimethyl

33 Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-m

34 Here we demonstrate that protein arginine methyltransferase 5 (PRMT5) functions as an epigenetic a

35 The aberrant expression of protein arginine methyltransferase 5 (PRMT5) has been associated with mul

36 Protein arginine methyltransferase 5 (PRMT5) is the major methyltransfera

37 between NF-kappaB, YBX1 and protein arginine methyltransferase 5 (PRMT5).

38 Protein arginine methyltransferase-5 (PRMT5) is overexpressed in aggressi

39 Protein arginine methyltransferase 6 (PRMT6) plays important roles in sev

40 al models, we showed that protein arginine N-methyltransferase 6 (PRMT6) regulates aerobic glycolysis

41 is a regiospecific 1-benzylisoquinoline 6-O-methyltransferase (6OMT) accepting both R- and S-substra

42 S-substrates, whereas NnOMT5 is mainly a 7-O-methyltransferase (7OMT), with relatively minor 6OMT act

43 2L and DPY30 are required for efficient H3K4 methyltransferase activities of all KMT2CoreCs except ML

44 yribonucleotidyltransferase and cap-specific methyltransferase activities(2,3).

45 ects DNA methylation by reducing de novo DNA methyltransferase activity at increasing PBB153 concentr

46 trations as well as reducing maintenance DNA methyltransferase activity at the lowest tested PBB153 c

47 SETD5 lacks histone methyltransferase activity but scaffolds a co-repressor

48 des a dominant-negative protein that reduces methyltransferase activity by ~80% in cells with heteroz

49 tional active site that is distinct from its methyltransferase activity catalyzes the final two steps

50 erivatives mutated at residues essential for methyltransferase activity failed to rectify the defect,

51 However, a clear in vitro methyltransferase activity for METTL21C remains yet to b

52 nd disruption of this interaction blunts its methyltransferase activity in cells and in vivo.

53 ow that Cfp1 only modestly activates COMPASS methyltransferase activity in vitro.

54 y cold exposure and that Dot1l and its H3K79 methyltransferase activity is required for thermogenic g

55 An important subunit known to regulate SET1 methyltransferase activity is the CxxC zinc finger prote

56 exposure alters the epigenome by disrupting methyltransferase activity leading to defects in imprint

57 ally silenced during BLCA progression by the methyltransferase activity of EZH2.

58 s can be altered by oxidants that target DNA methyltransferase activity or deplete its substrate, the

59 impairing its ubiquitination independent of methyltransferase activity or PRC2, thereby facilitating

60 ant CHD7 retains the ability to recruit H3K4 methyltransferase activity to its targets.

61 ic ENZ-PRO mutants lack binding affinity and methyltransferase activity toward the substrate protein

62 apeutic target with inhibitors targeting its methyltransferase activity under clinical investigation.

63 zh2) also bound to this region; however, its methyltransferase activity was required for Stat3 methyl

64 the domains of MtBzaC and reconstituted its methyltransferase activity with the predicted substrate

65 ent for antigen processing and presentation, methyltransferase activity, cell adhesion, and cell junc

66 is likely a direct target of ASH1L's histone methyltransferase activity.

67 Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase activity.

68 First, methyltransferase allele-methylome mapping corrected met

69 , heterogeneity analysis of partially active methyltransferase alleles revealed that intracellular st

70 ppears to occur with the Type II M.HinfI DNA methyltransferase and an ortholog of CcrM, BabI, but not

71 nt epigenetic therapy that uses low-dose DNA methyltransferase and histone deacetylase inhibitors, 5-

72 yl-transfer reaction catalyzed by catechol O-methyltransferase and modeled by hybrid QM/MM methods ar

73 First, the NS5 methyltransferase and RNA-dependent RNA polymerase (RdRP

74 osynthesis by inhibiting demethylmenaquinone methyltransferase and the stimulation of protein secreti

75 ures transiently interacting factors such as methyltransferases and demethylases, as well as previous

76 ry, uniquely and as opposed to other histone methyltransferases and histone marks, maternal DOT1L dep

77 racked the evolutionary history of RNA m(4)C methyltransferases and identified a difference in substr

78 Cytosine DNA bases can be methylated by DNA methyltransferases and subsequently oxidized by TET prot

79 - the COMPASS family of histone H3 lysine 4 methyltransferases and the SWI/SNF family of chromatin r

80 The recently characterized mammalian writer (methyltransferase) and eraser (demethylase) of the DNA N

81 n two proximal genes: FTSJ3, encoding an RNA methyltransferase, and GH1, encoding growth hormone.

82 rRNA N (6,6)-dimethyladenosine (m(2) (6,6)A) methyltransferase, and results obtained with a catalytic

83 case EcoGII, an N(6)-methyladenosine (m(6)A) methyltransferase, and the ability of nanopore sequencin

84 nterplay between the knot, activation of the methyltransferase, and the implications in RNA interacti

85 berellin biosynthesis and inactivation using methyltransferases are found in all land plant lineages.

86 Erythromycin-resistance methyltransferases are SAM dependent Rossmann fold methy

87 propose that oncohistones inhibit the H3K27 methyltransferase as chromatin patterns are being duplic

88 ere, we identify Dot1l, the only known H3K79 methyltransferase, as an interacting partner of Zc3h10 t

89 Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification an

90 ani induced the expression of histone lysine methyltransferases Ash1l, Smyd2, and Ezh2 and histone ly

91 We found that ASH1-like histone lysine methyltransferase (ASH1L) is overexpressed in ATC relati

92 occus neoformans, the loss of a cytosine DNA methyltransferase at least 50 million years ago has enab

93 at the Arabidopsis thaliana protein arginine methyltransferase AtPRMT3 regulates pre-rRNA processing;

94 cysteinase (Achy) and betaine-homocysteine S-methyltransferase (Bhmt) mRNA and protein levels followi

95 directly couple the monooxygenase (Bik2) and methyltransferase (Bik3) to efficiently channel intermed

96 ET domain (SETD) proteins are protein lysine methyltransferases, but SETD3 was recently demonstrated

97 F, phosphoribosyltransferase CobT, and three methyltransferases, BzaC, BzaD, and BzaE, that conduct t

98 METTL4, a putative mammalian methyltransferase, can mediate mtDNA 6mA methylation, wh

99 t a small molecule inhibitor of the arginine methyltransferases CARM1 and PRMT6 was able to increase,

100 S-adenosyl-l-methionine dependent methyltransferases catalyze methyl transfers onto a wide

101 dependent radical S-adenosylmethionine (SAM) methyltransferases catalyze methylation reactions at non

102 Caulobacter crescentus Cell Cycle Regulated Methyltransferase (CcrM) is an important epigenetic regu

103 lobacter crescentus cell cycle-regulated DNA methyltransferase (CcrM), the MTA1-MTA9 complex from the

104 y involves a feedback loop involving the DNA methyltransferase, CHROMOMETHYLASE 3 (CMT3), H3K9me2, an

105 methyltransferase MET1 and chromodomain DNA methyltransferases (CMTs).

106 fy ERK-mediated phosphorylation of the m(6)A methyltransferase complex as a regulatory mechanism for

107 )12, encoding a core subunit of the H3K27me3 methyltransferase complex by using CRISPR/Cas9, and obta

108 lized fusions with a modified METTL3:METTL14 methyltransferase complex can direct site-specific m(6)A

109 tes the Slc14a2 gene by recruiting a histone methyltransferase complex to the promoter.

110 L3 (the catalytic subunit of the major m(6)A methyltransferase complex), m(6)A demethylases (ALKBH5 a

111 hic study of the SARS-CoV-2 nsp16-nsp10 2'-O-methyltransferase complex, which methylates Cap-0 viral

112 and is installed by the METTL3-METTL14-WTAP methyltransferase complex.

113 SP5, resulting in stabilization of the m(6)A methyltransferase complex.

114 ins including WDR5, a core component of H3K4 methyltransferase complexes.

115 2 (bmr12) encodes the sorghum caffeic acid O-methyltransferase (COMT) and is one of the key enzymes i

116 ht be modified by variants of the catechol-O-methyltransferase (COMT) gene.

117 Human catechol O-methyltransferase (COMT) has emerged as a model for unde

118 sense mutation in the sorghum caffeic acid O-methyltransferase (COMT) was combined with 35S::SbF5H th

119 st (POI) to the Escherichia coli DNA adenine methyltransferase (Dam).

120 ine candidates using two delivery platforms, methyltransferase-defective recombinant vesicular stomat

121 which catalyzes DSB formation, and in PRDM9 methyltransferase deficient mice reveal that 5hmC is tri

122 , suggesting that NCgl2764/Rv0224c encodes a methyltransferase, designated here as MtrP.

123 g KLRG1, or small-molecule inhibitors of DNA methyltransferases (DMNT) each reduced colony formation.

124 s an unusually specific maintenance-type CpG methyltransferase (DNMT) that mediates long-term epigeno

125 lmark of melanoma, but the expression of DNA methyltransferase (Dnmt)-1 in melanocytic tumors is unkn

126 ng sequence (RFTS) domain of maintenance DNA methyltransferase DNMT1, a module known to bind the ubiq

127 The maintenance methyltransferase, dnmt1, is expressed within the CMZ.

128 Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most

129 DNA methyltransferase DNMT3A is essential for establishment

130 The de novo DNA methyltransferases Dnmt3a and Dnmt3b play crucial roles

131 mediated by direct repression of de novo DNA methyltransferases Dnmt3a and Dnmt3b, leading to transie

132 patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit bot

133 dinucleotide, is installed by two denovo DNA methyltransferases, DNMT3A and DNMT3B.

134 When the function of the de novo DNA methyltransferase DNMT3B is disrupted, as in ICF1 syndro

135 transposon-rich repeats and requires the DNA methyltransferase Dnmt5.

136 CpG methylation by de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for ma

137 DNA generated and maintained by several DNA methyltransferases (DNMTs) with partially overlapping fu

138 DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the two DNMT families, D

139 lized dCas13 fusions with a truncated METTL3 methyltransferase domain and cytoplasm-localized fusions

140 The connector and methyltransferase domains of L are mobile with respect t

141 g evidence has suggested that histone H3 K79 methyltransferase Dot1l has an antifibrotic effect by re

142 Here we show that the histone methyltransferase DOT1L, which marks the nucleosome core

143 We show that the DRM methyltransferase double mutant drm1drm2 also presents e

144 endent recruitment of the SetDB1/Wde histone methyltransferase effector.

145 activation of the histone H3 lysine 9 (H3K9) methyltransferase Ehmt1 and stabilization of the zinc fi

146 Moreover, we show that the specific H3K36 methyltransferase encoded by SDG8 is required for canoni

147 Here, we show that a putative methyltransferase, encoded at the same genetic locus as

148 EDAL binds to the conserved histone methyltransferase enhancer of zest homolog 2 (EZH2) and

149 H3K27me3 (mediated via the polycomb histone methyltransferase, enhancer of zeste homologue 2 [Ezh2])

150 g the first of the TS analogue inhibitors of methyltransferase enzymes to show an affinity in the nan

151 mb Repressive Complex 2 (PRC2), an H3K27 tri-methyltransferase, exacerbated the impairment in differe

152 uman counterpart, phosphatidylethanolamine N-methyltransferase, expressed in yeast) was addressed by

153 role of the murine histone 3 Lys-27 (H3K27) methyltransferases EZH1 (enhancer of zeste 1) and EZH2 i

154 n-dependent kinase 4 (CDK4) and CDK6 and the methyltransferase EZH2 as a valid target for psoriasis t

155 caused by pathogenic variants in the histone methyltransferase EZH2, which encodes a core component o

156 ithin TIL resulting from loss of the histone methyltransferase EZH2.

157 established RNA-binding protein and histone methyltransferase, EZH2 is not known to be a nuclease.

158 cule sequencing method that combines adenine methyltransferase footprinting and single-molecule real-

159 ErmC is an erythromycin resistance methyltransferase found in many Gram-positive pathogens,

160 d the alpha5-alpha6 linker are essential for methyltransferase function, including an aromatic residu

161 protein which possesses ExoN and guanine-N-7 methyltransferase (G-N-7 MTase) activities, responsible

162 oronavirus, as a model, we showed that G-N-7 methyltransferase (G-N-7 MTase) of PEDV nsp14 methylated

163 The presence of the arsenite (As(III)) methyltransferase gene (arsM) in soil microbes has been

164 The approach revealed protein arginine methyltransferase gene 5 (PRMT5) as an effective druggab

165 Inactivation of the methyltransferase gene negatively impacts sporulation, a

166 CM intermediates and repression of glycine N-methyltransferase (Gnmt).

167 The beta class of methyltransferases has a unique multimeric feature, form

168 Opi3 (as well as phosphatidylethanolamine N-methyltransferase) has an N-out C-in topology and contai

169 While individual m(5) C-methyltransferases have been studied, the impact of the

170 c efficiency, the active-sites of viral mRNA methyltransferases have low mutational plasticity, while

171 tBzaC as a SAM:hydroxybenzimidazole-riboside methyltransferase (HBIR-OMT).

172 Defects in histone methyltransferases (HMTs) are major contributing factors

173 onuclease (HsdR, HsdM and HsdS subunits) and methyltransferase (HsdM and HsdS subunits).

174 tural homology with two known protein lysine methyltransferases-human SETD6 and the plant LSMT-but di

175 1) and its DNA methyltransferase partner DNA methyltransferase I (DNMT1) are critical for the restric

176 y combines two existing methods: DNA adenine methyltransferase identification (DamID) and CEL-Seq2.

177 oprecipitation (ChIP-seq) and/or DNA adenine methyltransferase identification (DamID-seq).

178 Set5 is a histone H4 lysine 5, 8, and 12 methyltransferase, implicated in the regulation of stres

179 ly, synaptic NMDARs drive degradation of the methyltransferase in a neddylation-dependent manner.

180 ind that NSUN-4 acts as a dual rRNA and tRNA methyltransferase in C. elegans mitochondria.

181 Thus, we knocked out the main de novo DNA methyltransferase in cardiomyocytes, DNMT3A, in human in

182 protein levels of the principal de novo DNA-methyltransferase in neurons, DNMT3A1, are tightly contr

183 otential and that EZH2 is the dominant H3K27 methyltransferase in NPCs and epithelial descendants.

184 optogenetic control for Set2, the sole H3K36 methyltransferase in yeast, by fusing the enzyme with th

185 ation of lung cancer, experiment using a DNA methyltransferase inhibitor (5-azacytidine, AZA), methyl

186 that treatment of rhabdomyosarcoma with DNA methyltransferase inhibitor (DNMTi) upregulates Hippo ac

187 This lysine methyltransferase inhibitor targets EZH2, the enzymatic

188 The DNA methyltransferase inhibitors (DNMTi) 5-azacytidine and 5

189 k showed that epigenetic drugs including DNA methyltransferase inhibitors and histone deacetylase 6 i

190 ammatory mediators such as NF-kB by means of methyltransferase inhibitors provides another avenue to

191 Using histone acetyltransferase and methyltransferase inhibitors, we showed that this phenom

192 expression after treatment with EZH2 and DNA methyltransferase inhibitors.

193 , and this is reversed by treatment with DNA methyltransferase inhibitors.

194 and could be reversed by treatment with DNA methyltransferase inhibitors.

195 DNA methyltransferases interact with their CpG target sites

196 CysS is a Cbl-dependent radical SAM methyltransferase involved in cystobactamid biosynthesis

197 TrmD (tRNA-(N(1)G37) methyltransferase) is an essential tRNA modification enz

198 FERASE 2 (DRM2), the de novo Arabidopsis DNA methyltransferase, is crucial to maintain DNA methylatio

199 We also find that CMTR1, a human mRNA cap methyltransferase, is required for efficient viral cap s

200 s, Endo-T cells differentially expressed DNA methyltransferase isoforms and had increased levels of I

201 ne deacetylases (HDACs), histone H3 lysine 9 methyltransferase (KMT1/SUV39), and components of nucleo

202 Histone methyltransferase KMT2D (a COMPASS-like enzyme, also cal

203 sylmethionine (SAM)-dependent histone lysine methyltransferases (KMTs), a genuinely important class o

204 the PP2A methylesterase, PME-1, or the PP2A methyltransferase, LCMT-1, altered the sensitivity of mi

205 bisulfite mapping, we demonstrate that human methyltransferase-like 15 (METTL15), encoded by a nuclea

206 We demonstrate that the methyltransferase-like 5 (METTL5) protein catalyzes m(6)

207 Methyltransferase-like protein 21C (METTL21C) is a PKMT

208 he transition of ESCs into epiblast, and the methyltransferase-like protein Dnmt3l, which, during the

209 SMRT sequencing was used to investigate DNA methyltransferases M.BceJIII and M.EcoGIX, using artific

210 ylation (A) domain that contains an internal methyltransferase (M) domain, while maintaining a monoli

211 atterns are dynamically maintained, with DNA methyltransferases mediating inheritance of methyl marks

212 and RNA-independent mechanisms involving DNA methyltransferase MET1 and chromodomain DNA methyltransf

213 ments hypomethylated through mutation of DNA methyltransferase MET1.

214 e (m(6) A) mRNA modification by depletion of methyltransferases, Mettl3 and Mettl14, enhanced respons

215 The O-6-methylguanine-DNA methyltransferase (MGMT) is responsible for the direct r

216 While O(6)-methylguanine (O(6)-MeG)-DNA methyltransferase (MGMT) promoter methylation status is

217 The histone methyltransferase mixed-lineage leukemia-4 (MLL4) is a t

218 We previously showed that histone methyltransferases MLL3/MLL4 and associated PTIP are req

219 ine methyltransferase 5 (PRMT5) is the major methyltransferase (MT) catalyzing symmetric dimethylatio

220 The methyltransferase (MTase) domain and the C-terminal doma

221 RNA-dependent RNA polymerase (RdRp) and the methyltransferase (MTase) domain reduced SLA-binding aff

222 rticle, we propose that highly conserved DNA methyltransferases (MTases) represent a unique opportuni

223 tine is demethylated by the newly discovered methyltransferase MtcB, sending one-carbon units into pr

224 tqC and the methylcorrinoid:tetrahydrofolate methyltransferase MtqA, were much more abundant in E. li

225 S-adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) catalyse the methylation of a v

226 The trimethylamine methyltransferase MttB is the first described member of

227 We also demonstrate that both m(6)A methyltransferase mutants and ect2/ect3/ect4 exhibit abe

228 ynthesized from naringenin by naringenin 7-O-methyltransferase (NOMT).

229 Protein N-terminal methyltransferases (NTMTs) methylate the alpha-N-termina

230 e domain formation, which requires SETDB1, a methyltransferase of H3K9me3.

231 Histone methyltransferases of the nuclear receptor-binding SET d

232 ain-containing protein 1 (UHRF1) and its DNA methyltransferase partner DNA methyltransferase I (DNMT1

233 The structure of M.HhaI, the biological methyltransferase partner of HhaI, was determined earlie

234 (CDP-choline) and phosphatidylethanolamine-N-methyltransferase (PEMT) pathways for PC synthesis were

235 The enzyme PROTEIN l-ISOASPARTYL METHYLTRANSFERASE (PIMT) repairs other proteins by rever

236 are >100 known and candidate protein lysine methyltransferases (PKMTs), many of which are linked to

237 Phospholipid N-methyltransferases (PLMTs) synthesize phosphatidylcholin

238 Phenylethanolamine N-methyltransferase (PNMT) is a critical enzyme in catecho

239 The enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) catalyzes the fina

240 t when methionine is abundant, the conserved methyltransferase Ppm1 methylates and alters the activit

241 Here methionine directs the conserved methyltransferase Ppm1 via its target phosphatase PP2A t

242 In most mammals, the methyltransferase PRDM9 guides SPO11 targeting, and the

243 the action of the histone 3 Lys-4 and Lys-36 methyltransferase PRDM9 to ensure successful double-stra

244 CARM1 is a protein arginine methyltransferase (PRMT) that acts as a coactivator in a

245 at blocking the activity of protein arginine methyltransferases (PRMTs), which catalyze the formation

246 0.005) independent of O(6)-methylguanine-DNA-methyltransferase promoter methylation and other strong

247 pyrrolysine characteristic of trimethylamine methyltransferases, raising questions about the activiti

248 Mouse intestinal cells lacking EZH2 methyltransferase reduce H3K27me3 proportionately at all

249 containing an mRNA capping region and a cap methyltransferase region, which are linked by a flexible

250 We further identify HENMT1 as the methyltransferase responsible for 3'-terminal 2'Ome of m

251 te and partially inactivate Dot1l, the H3K79 methyltransferase responsible for placing activating mar

252 We demonstrate that the yeeA gene is a methyltransferase responsible for the presence of m6A mo

253 th Suv39h1, Suv39h2, and SETDB1, the histone methyltransferases responsible for H3K9 trimethylation o

254 e Arabidopsis (Arabidopsis thaliana) histone methyltransferase SET DOMAIN GROUP8 (SDG8) mediates geno

255 We demonstrate that the histone methyltransferase SET-32, methylates H3K23 in vitro.

256 We report that the histone H3K4 methyltransferase Set1, and the histone H3K36 methyltran

257 Overall, our study suggests that the methyltransferases Set1 and Set2 regulate APA induced by

258 visiae, it is controlled by a system of four methyltransferases (Set1p, Set2p, Set5p, and Dot1p) and

259 ethyltransferase Set1, and the histone H3K36 methyltransferase Set2, control choice of pA site in Sac

260 n of protein kinases, telomerase, histone H3 methyltransferase SET7/9, and polypeptide N-acetylgalact

261 results have established the histone lysine methyltransferase SETD1 as a key factor in the opening o

262 study, we have focused on the effect of the methyltransferase SETD1B on histone H3 lysine K4 (H3K4)

263 esponsive genes directly engages the histone methyltransferase SETD2, a component of the active trans

264 previous studies that implicate the N-lysine methyltransferase SETD6 in the activation of nuclear fac

265 monstrated histone lysine (K) methylation by methyltransferase SETDB1 as a common denominator of gene

266 determinants including a novel ribosomal RNA methyltransferase situated in a CRISPR (clustered regula

267 ue to the ASCP genomes, including the lysine methyltransferase SMYD2 and the pancreatic cancer stem c

268 egment is found broadly in N4/N6-adenine DNA methyltransferases, some of which are human pathogens, a

269 ondrial function, delineate the evolution of methyltransferase substrate specificities and modificati

270 Here, we report that ablation of m(6)A methyltransferase subunit METTL14 in myeloid cells exace

271 thylation in yeast is catalyzed by Set1, the methyltransferase subunit of COMPASS.

272 strongly enriched for regions of disorder on methyltransferases, suggesting a role in the modulation

273 histone modification H4K20me3 or the histone methyltransferase SUV420H2 regulates embryonic stem (ES)

274 or application as inhibitors for the protein methyltransferase target PRMT5.

275 SMYD lysine methyltransferases target histones and nonhistone protei

276 he major Trypanosoma brucei protein arginine methyltransferase, TbPRMT1 enzyme (ENZ), requires TbPRMT

277 involved in monosome assembly, and MRM2, the methyltransferase that catalyzes the modification of the

278 omb repressive complex 2 (PRC2) is a histone methyltransferase that methylates histone H3 at Lysine 2

279 teins of unknown function, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group

280 a protein having the activity of BioC, an O-methyltransferase that methylates the free carboxyl of m

281 egmatis gene annotated as encoding Tam, an O-methyltransferase that monomethylates and detoxifies tra

282 ng with SET1 (COMPASS) is a histone H3 Lys-4 methyltransferase that typically marks the promoter regi

283 hromatin (heterochromatin protein 1) and the methyltransferases that affect methyl spreading.

284 Of these, the methyltransferases that contribute to benzimidazole lowe

285 transferases are SAM dependent Rossmann fold methyltransferases that convert A2058 of 23S rRNA to m(6

286 methylate the 2' oxygen is to use viral mRNA methyltransferases that have evolved to escape the host'

287 an ortholog of CcrM, BabI, but not with DNA methyltransferases that lack the conserved C-terminal se

288 e methyl-donor substrate for DNA and histone methyltransferases that regulate epigenetic states and s

289 e pocket of the corresponding histone lysine methyltransferase, thereby inhibiting the respective tra

290 We discuss a family of methyltransferases, those that act on the amino groups o

291 ously on long strands of DNA by applying GpC methyltransferase to exogenously label open chromatin.

292 thylated in the anticodon loop by the METTL2 methyltransferase to form the 3-methylcytosine (m3C) mod

293 oits the large number of naturally available methyltransferases to specifically methylate DNA at a de

294 The RNA methyltransferase TRDMT1 is recruited to DNA damage site

295 Here, we show that a tRNA methyltransferase, TRMT10A, interacts with an mRNA demet

296 ons within the Drosophila enhancer H3K4 mono-methyltransferase Trr and its mammalian homologs, MLL3/4

297 ansferase allele-methylome mapping corrected methyltransferase variant effects previously obscured by

298 lycoside-modifying enzymes and the ribosomal methyltransferases whose widespread presence severely co

299 half of Opi3 and isoprenyl cysteine carboxyl methyltransferases with a solved crystal structure, we i

300 methylation of open chromatin regions by DNA methyltransferases with low sequence specificity, in thi