ライフサイエンスコーパス: microchip

1 ment and finally piloted on an ISFET enabled microchip.

2 in an effective length of 7 cm in a plastic microchip.

3 cate a two-dimensional ion-trap lattice on a microchip.

4 response and impedimetric measurement on the microchip.

5 pray supercharging) using a dual-sprayer ESI microchip.

6 w cells, inside the capillary column or on a microchip.

7 ng the fabricated liquid chromatography (LC) microchip.

8 ed voltage control in a miniaturized polymer microchip.

9 ectly from the corner of a rectangular glass microchip.

10 and wireless telemetry unit, all on a single microchip.

11 rescence (SAF) microlens array embedded in a microchip.

12 rophoretic separation integrated on a single microchip.

13 wn the size of electrodes in electroporation microchips.

14 lly integrated light-sources on conventional microchips.

15 ostructured Fabry-Perot interferometer (FPI) microchips.

16 added advantage of these PEG-functionalized microchips.

17 proteins and peptides with the PEG-modified microchips.

18 paration in poly(methyl methacrylate) (PMMA) microchips.

19 rials to construct capillary electrophoresis microchips.

20 t and fluidically complex multilayer polymer microchips.

21 ntages over similar experiments performed on microchips.

22 complished using these new polymeric microCE microchips.

23 (dimethylsiloxane) capillary electrophoresis microchips.

24 ltifunctional windows for biofilm diagnostic microchips.

25 The microchip, a commercial surface acoustic wave resonator,

26 replacing native PDMS microchips with hybrid microchips allowed the achievement of a 6-fold increase

27 measured for solutions introduced on a PDMS microchip allowing determination of forward and reverse

28 ble membranes has great potential to enhance microchip analysis of biomolecules.

29 e to fouling were obtained even after 1 h of microchip analysis with RSD values of </=4% and </=9% (n

30 vitro molecular imaging system comprising a microchip and a beta-particle imaging camera permitted r

31 n a poly(dimethylsiloxane) (PDMS) fabricated microchip and a common dc power supply.

32 MCA) system composing of a wax-printed paper-microchip and a self-made smart analysis equipment for t

33 le single-cell system that is comprised of a microchip and an adjustable clamp, so on-chip operation

34 In addition, we compared microchip and capillary electrophoresis under similar se

35 omechanical system fabricated from a silicon microchip and comprising a micromechanical resonator cou

36 SI-MS sensitivities were achieved using both microchip and conventional fused silica capillary emitte

37 et, which is generated by a heated nebulizer microchip and directed toward the mass spectrometer inle

38 thylsiloxane (PDMS)/glass chronoimpedimetric microchip and its removal in the same LOC system through

39 erature sensor was integrated into a silicon microchip and occupied 0.15 mm(2) of area.

40 The EWOD microchip and optimized synthesis method in combination

41 We used microChIP and qPCR assays of FACS-purified cells to trac

42 es with the simplicity of disposable polymer microchips and easy setup.

43 s with commercial microchips, wire imprinted microchips, and microchips from LIGA molding devices is

44 in DNA, wrote a 5.27-megabit book using DNA microchips, and read the book by using next-generation D

45 dentical spray geometries with both lamps in microchip APPI mass spectrometry (muAPPI-MS) and desorpt

46 Implementing our new streamlined microchip approach, we could directly visualize BRCA1 ge

47 As microchips are promising technical tools for a robust si

48 he results of designing and producing such a microchip array.

49 n which monomeric alphaSyn is incubated with microchips arrayed with tethered compounds, we identifie

50 substance in plasma negatively affected the microchip assays and the effects could be minimized by d

51 simplicity, rapidity, and sensitivity of the microchip-assisted DNA extraction process.

52 The analytical performance of the microchip based assay was compared to that in the well p

53 were used to demonstrate the efficacy of the microchip based DNA extraction process.

54 lthough there are some approaches to develop microchip based pesticide detection platforms, there is

55 However, it has been challenging to realize microchip-based calorimeters possessing both high sensit

56 The microchip-based extraction is also performed in a closed

57 Microchip-based field asymmetric waveform ion mobility s

58 study, we introduce a novel method to couple microchip-based free-flow electrophoresis with mass spec

59 We utilized a novel microchip-based immunoaffinity capillary electrophoresis

60 ing the sensitivity and reproducibility of a microchip-based immunoassay by using isotachophoresis to

61 rophotonics"; it combines recent advances in microchip-based integrated photonic and electronic circu

62 demonstrates the potential of incorporating microchip-based lipid extraction into cellular lipidomic

63 on, cytotoxicity, and contact dynamics using microchip-based live cell imaging.

64 RNA was purified using the microchip-based method from neat semen, a mock semen sta

65 DNA recovered was compatible with downstream microchip-based PCR amplification.

66 n capability, the arrayed nanostructured FPI microchip-based platform could provide an ideal technica

67 The microchip-based POC diagnostic demonstrated is applicabl

68 rived N-linked glycans with their subsequent microchip-based separation and mass-spectrometric (MS) m

69 -based extraction of DNA, we describe here a microchip-based solid-phase extraction method for purifi

70 Herein, we present the first example of microchip-based supercritical-fluid chromatography (SFC)

71 our knowledge, this is the first report of a microchip-based system that couples microdialysis sampli

72 Here, we report a simple and low-cost microchip-based TB ELISA (MTBE) platform for the detecti

73 Here, we present a microchip-based technology to facilitate structural stud

74 Using a microchip-based, time-lapse imaging approach allowing th

75 ion mobility separations coupled with MS and microchip-based-proteome measurements combined with MS i

76 a testimony to the potential utility of PeT microchips beyond separations and presents a promising n

77 etric interference spectroscopy (RIfS) based microchip biosensor for the detection of circulating tum

78 tegrate an internal standard (ISTD) into the microchip by adding it to the background electrolyte (BG

79 compared to uninfected B cells and DEP-based microchips can be potentially used for sorting latently

80 Oligonucleotides from DNA microchips can reduce costs by at least an order of magn

81 as oligonucleotides that were separated via microchip capillary electrochromatography (mu-CEC).

82 ns for microfabricated column structures for microchip capillary electrochromatography is presented.

83 OA), a portable instrument for the sensitive microchip capillary electrophoresis (CE) analysis of org

84 ation, and injection method is developed for microchip capillary electrophoresis (CE) and used to per

85 The Mars Organic Analyzer (MOA), a portable microchip capillary electrophoresis (CE) instrument deve

86 A microchip capillary electrophoresis (CE) separation with

87 A microchip capillary electrophoresis (MCE) system has bee

88 o improve point-of-care quantification using microchip capillary electrophoresis (MCE), the chip-to-c

89 ed photopolymerized capture gel injector for microchip capillary electrophoresis (microCE).

90 ion, and injection of dsDNA for quantitative microchip capillary electrophoresis analysis.

91 Furthermore, we present experimental microchip capillary electrophoresis measurements of inte

92 f trace amounts of amines and amino acids by microchip capillary electrophoresis on the Mars Organic

93 A dual-channel sequential injection microchip capillary electrophoresis system with pressure

94 ass transport of short interacting ssDNAs in microchip capillary electrophoresis.

95 of selenium oxoanions, we present the first microchip capillary zone electrophoresis (MCE) separatio

96 The device performance was evaluated using microchip capillary zone electrophoresis (mu-CZE) of ami

97 A hybrid microchip/capillary electrophoresis (CE) system was deve

98 es used in capillary electrophoresis (CE) to microchip CE (MCE) in order to improve concentration sen

99 his work, we demonstrate the utility of this microchip CE-ESI device for HX MS.

100 he results indicate the potential utility of microchip CE-ESI for HX MS.

101 The device has been used to perform microchip CE-MS analysis of peptides and proteins with e

102 ugation, the ADC was analyzed using the same microchip CE-MS method.

103 ions demonstrating the facile engineering of microchip-CE platforms for the analysis of a wide variet

104 cy measured by chromatin immunoprecipitation-microchip (ChIP-chip) and ChIP-sequencing analyses.

105 c even for linear flow rates over the packed microchip column in a range of up to 20 mm.s(-1).

106 Higher regression values obtained using microchip confirmed better quality and integrity of the

107 The E. coli reporter strain was filled in a microchip containing 16 independent electrochemical cell

108 Acrylate-based polymeric microchips containing a separation column (12.5 mm lengt

109 The instrument uses a four-layer microchip, containing eight CE analysis systems integrat

110 Each microchip contains an array of discrete reservoirs from

111 R analysis and allows a compact, inexpensive microchip design.

112 lves a two-stage process to create the final microchip design.

113 We describe a microchip designed to quantify the levels of a dozen cyt

114 re demonstrated on the noted multireflection microchip device for assessing West Nile viral IgM antib

115 The microchip device presented here is particularly suitable

116 ng capillary electrophoresis (CE) and hybrid microchip electrophoresis (hybrid-MCE) as alternatives t

117 A home-made microchip electrophoresis (MCE) device was used to quant

118 Using droplet-interfaced microchip electrophoresis (MCE) techniques, we have deve

119 cs to couple multiwell plate-based assays to microchip electrophoresis (MCE) to screen enzyme modulat

120 Microchip electrophoresis (ME) is ideally suited for thi

121 that integrates microdialysis (MD) sampling, microchip electrophoresis (ME), and electrochemical dete

122 in other device materials commonly used for microchip electrophoresis analysis.

123 tem that couples microdialysis sampling with microchip electrophoresis and electrochemical detection.

124 We applied microchip electrophoresis and MALDI-TOF-MS-based glycomi

125 th its unique capability to resolve isomers, microchip electrophoresis can yield complementary analyt

126 d by end-channel detection for capillary and microchip electrophoresis detection.

127 port is the first to describe a multichannel microchip electrophoresis device with integrated contact

128 onstrates for the first time the creation of microchip electrophoresis devices with ~50 mum cross-sec

129 Limits of detection for microchip electrophoresis in 3D printed microfluidic dev

130 We demonstrated for the first time microchip electrophoresis in a 3D printed device of thre

131 Microchip electrophoresis is an emerging analytical tech

132 being developed to reduce sequencing costs, microchip electrophoresis is the only new technology rea

133 immunoaffinity purification step with rapid microchip electrophoresis separation in a laser-induced

134 nclusions about the role of order during the microchip electrophoresis separation of short DNA molecu

135 We have developed a microchip electrophoresis system that can automatically

136 ntervention; however, long-term operation of microchip electrophoresis systems has received little at

137 reveal the surprisingly powerful ability of microchip electrophoresis to provide ultrafast Sanger se

138 y between contact conductivity detection and microchip electrophoresis was developed.

139 equencing up to 600 bases in just 6.5 min by microchip electrophoresis with a unique polymer matrix/a

140 dysplasia, and esophageal adenocarcinoma by microchip electrophoresis with laser-induced fluorescenc

141 Microchip electrophoresis with two-photon excited fluore

142 l and a triple-negative charge, separated by microchip electrophoresis, and detected by laser-induced

143 ole-cell catalyzed on-chip syntheses, chiral microchip electrophoresis, and label-free detection of e

144 ability of contact conductivity detection in microchip electrophoresis, and similar designs may have

145 an serum, we report a strategy that combines microchip electrophoresis, standard addition, enzymatic

146 With microchip electrophoresis, we are able to distinguish th

147 Through MS and microchip electrophoresis-based glycomic methods, severa

148 ive detection of these glycoproteins using a microchip electrophoresis-electrochemical detection (ME-

149 ampling for sequential injection analysis by microchip electrophoresis.

150 luding the narrow microchannels required for microchip electrophoresis.

151 2 nm for label-free analyte determination in microchip electrophoresis.

152 matically performs the PCR amplification and microchip electrophoretic (ME) separation for rapid fore

153 The in-house fabricated microchips, electrophoretic protocols, and solution matr

154 A microchip electrospray emitter with a magnetic bead trap

155 A microchip electrospray ionization source was coupled wit

156 the metabolism of mitoxantrone is studied by microchip electrospray ionization-mass spectrometry.

157 e, and subsequently quantified the EVs via a microchip ELISA.

158 This attribute of the microchip emitter should simplify electrospray optimizat

159 000 nL/min) and applied potentials using the microchip emitters.

160 rescence (SAF) microlens array embedded in a microchip enabled quick and accurate detection of low le

161 cated in the electric field-free region of a microchip, enabled the separation of six nitroaromatic a

162 In microchip EuNP immunoassay (microENIA) of inactivated in

163 nfluenza microENIA enhanced using the hybrid microchips even surpassed that of a commercial laborator

164 to approximately 25% of that obtained using microchips fabricated without MMA.

165 Microchip fabrication and integration of these pH sensor

166 Our microchip fabrication is simple and mass-producible as w

167 The microchip facilitated in-flow coating of chitosan on the

168 The poly(methyl methacrylate) (PMMA) microchips feature integral in-plane contactless conduct

169 t-of-detection of current nanostructured FPI microchip for f-PSA is about 10 pg/mL and the upper dete

170 Here, we report a microchip for rapid (<1h) detection of P. aeruginosa (62

171 pment of a dual electrochemical immunosensor microchip for simultaneous detection of insulin (I) and

172 substrates have been used for fabrication of microchips for DNA extraction, PCR amplification, and DN

173 onstrate the effectiveness of multilayer PeT microchips for dynamic solid phase extraction (dSPE) and

174 rane arrays in poly(dimethylsiloxane) (PDMS) microchips for label-free analysis of lipid-protein inte

175 a route to the creation of three-dimensional microchips for memory and logic applications.

176 l microchips, wire imprinted microchips, and microchips from LIGA molding devices is presented.

177 To fabrication through-hole microchips from this alternative material for microfluid

178 The concept can be extended to other microchip functions and stimuli-responsive materials and

179 a robust, high-performance, stainless-steel microchip gas-chromatography (GC) column that is capable

180 le alternative platform for portable, robust microchip GC that is capable of high-temperature operati

181 old reduction in peak width in the following microchip gradient LC separation.

182 A microchip has been fabricated to perform the analysis.

183 ynthesis methods harnessing the power of DNA microchips have recently been demonstrated.

184 ns combined with the appropriate design of a microchip holder to suitably position the microchannels

185 SA tryptic digest are demonstrated using the microchip HPLC system.

186 ntegrate the nanoporous-junction into a PDMS microchip in a leak-free manner with excellent repeatabi

187 buffers to all 40 reservoirs situated on the microchip in only five pipetting steps using an 8-channe

188 gh quality DNA rapidly, we have fabricated a microchip in poly(dimethyl siloxane) (PDMS) by soft lith

189 s a performance bottleneck for semiconductor microchips in modern computer systems--from mobile phone

190 ent multielectrochemical electrode arrays on microchips in order to automate measurement of quantal e

191 and mechanical resonator formed in a silicon microchip, in which radiation pressure from a laser is u

192 ch to the rapid fabrication of rigid plastic microchips including the narrow microchannels required f

193 volumes could be achieved by using the PDMS microchip injector.

194 ay variation was clearly reduced when hybrid microchips instead of native PDMS microchips were used i

195 The microchip integrates this precolumn derivatization, cont

196 Efficient microchip integration of these processes enables the sen

197 a robust, integrated poly(dimethylsiloxane) microchip interface for ESI-MS using simple and widely a

198 This microchip is adaptable to all commercial TEM holders.

199 The microchip is capable of robust local temperature control

200 The fastHDX thiol-ene microchip is fabricated entirely using thiol-ene photoch

201 The paper-microchip is heated at 120 degrees C for 20 min to cause

202 The microchip is made of two bare gold electrodes and PDMS m

203 Development of affordable microchip laser sources has the potential to substantial

204 des using titanium dioxide incorporated in a microchip liquid chromatography device was used to analy

205 e same chip has proved challenging, owing to microchip manufacturing conflicts between electronics an

206 icrofluidic cell culture device created with microchip manufacturing methods that contains continuous

207 ly cleaved from the antibody and analyzed by microchip MEKC.

208 posomal and polymeric nanoparticles, wafers, microchips, microparticle-based nanoplatforms and cells-

209 retic separation performance attainable from microchips molded by masters fabricated using convention

210 rtant limitations of nonsilicon and nonglass microchips, namely, resistance to nonpolar solvents and

211 , demonstrating the potential of this unique microchip nanoparticle assay in clinical diagnosis of in

212 Here, we present a microchip nanopipet with a narrow chamber width for sort

213 es of a new, high-repetition-rate (36.6 kHz) microchip Nd:YAG laser.

214 Through miniaturization into microchips, new techniques have been realized that would

215 We demonstrate microchip nonaqueous capillary electrophoresis (muNACE)

216 The successive connection of multiple microchip outlets to the electrospray ionization source

217 surements were evaluated indicating that the microchip packed with fresh silica beads is capable of b

218 quality was maintained when integrated with microchip PCR.

219 under similar separation conditions, and the microchips performed as well as the capillaries.

220 (2020) optimized a three-dimensional microchip perfusion system that augments growth, maturat

221 t was found that detection capability of the microchip platform could be readily improved using Europ

222 Meanwhile, use of the microchip platform effectively reduced sample/reagent co

223 Here, we present scFTD-seq, a microchip platform for performing single-cell freeze-tha

224 n and incubation time, were optimized in the microchip platform for the lowest limit of detection, hi

225 we continued to miniaturize this assay to a microchip platform for the purpose of converting the ben

226 We have also evaluated the microchip platform with discarded, de-identified HIV-inf

227 ased DNA detection technology scalable for a microchip platform, we describe a simplistic, low-cost m

228 e successfully tested using muENIA on hybrid microchip platforms, demonstrating the potential of this

229 The microchip process was accomplished in sub-90 min compare

230 es obtained from the data suggested that the microchip process was reproducible.

231 e region II amplicon was introduced into the microchip, purified, concentrated, and injected, generat

232 the need for additional sample manipulation, microchip redesigns, and/or system expansions required f

233 in the downstream, field-free region of the microchip, resulting in a stationary-phase monolith with

234 further validated our assay by comparing our microchip results with the standard culture-based method

235 consists of a poly(dimethylsiloxane) (PDMS) microchip sample injector featuring a pneumatic microval

236 low, permitting inertial collection into the microchip sample reservoir.

237 Here we use high-fidelity DNA microchips, selective oligonucleotide pool amplification

238 Applying two-photon excitation microchip separations and label-free detection could als

239 e block copolymers specifically designed for microchip separations to achieve accurate DNA size calli

240 ms relative to the existing state-of-the-art microchip source and demonstrate its utility for creatin

241 The microchip subassays were optimized to deliver results co

242 Escherichia coli using a highly error-prone microchip-synthesized oligo pool (479 oligos) without pr

243 ach for engineering a synthetic pathway with microchip-synthesized oligonucleotides (oligo).

244 nomical de novo gene synthesis methods using microchip-synthesized oligonucleotides has been limited

245 e high-quality DNA from oligos, particularly microchip-synthesized oligonucleotides.

246 ults indicate that the prototype growth tube-microchip system (termed aerosol chip electrophoresis, A

247 rrent paradigm of capillary electrophoresis, microchip systems promise to reduce sequencing costs dra

248 uantifying the extent of interaction in this microchip technique may prove powerful for exploration o

249 Here we developed a microchip technology (the Cluster-Chip) to capture CTC c

250 uNWs approach, enhancing the maturity of the microchip technology and opening new avenues for future

251 We evaluated the microchip technology by detecting and quantifying multip

252 -art complementary metal-oxide-semiconductor microchip technology for nucleic acid amplification dete

253 We used a microchip technology that facilitates quantification of

254 By using an integrated microchip that can programmably control the solution pH

255 ntegrated selective enrichment target (ISET) microchip that improves the sample preparation step for

256 ation, we developed a splittable single-cell microchip that integrates a high-density antibody array

257 oteins are separated by electrophoresis on a microchip that is dragged along a polyvinylidene fluorid

258 ylene glycol) (PEG)-functionalized polymeric microchips that are inherently resistant to protein adso

259 The system employs tunable microchips that can be decorated with switchable adaptor

260 nano-SPEARs provide the core technology for microchips that enable scalable, in vivo studies of neur

261 sis technology, which integrates on a single microchip the synthesis of DNA oligonucleotides using in

262 to most methods used to fabricate polymeric microchips, the photopolymerization-based method used wi

263 ve and passive detection states to allow the microchip to be periodically activated to perform a meas

264 The absence of band broadening from microchip to capillary indicated a minimum dead volume a

265 and fluorescein (FL), were performed on PMMA microchips to demonstrate the feasibility of the fabrica

266 he fabrication technique was tested to build microchips to perform several analyses, including chroma

267 The complete isolation of the DNA using the microchip took 15min as against>2h with a TRIzol method.

268 oped system was very robust, with individual microchips used for up to 2000 analyses with lifetimes l

269 nate (PC)-polydimethylsiloxane (PDMS) hybrid microchip using a simple epoxy silica sol-gel coating/bo

270 ds for fabricating poly(methyl methacrylate) microchips using a novel two-stage embossing technique a

271 n optical fibers, which were placed into the microchip, using guides at the outlet of the flow, incre

272 The microchips utilized consist of a flow-through silicon pl

273 IV-infected patient samples by comparing our microchip viral load measurement results with reverse tr

274 layer and a blank PMMA layer to generate the microchip was achieved by solvent welding.

275 rporation of solid-phase extraction (SPE) to microchip was ensured by facile 3D element integration u

276 interference from the sampling pressure, the microchip was operated isobarically by sealing the buffe

277 DNA extracted using the microchip was pure with absorbance (260/280) ratio of 1.

278 rs, the LOD of influenza microENIA on hybrid microchips was determined to be ~10(4) TCID50 titer/mL a

279 Using temperature transponder microchips, we showed that the core body temperature inc

280 The microchips were characterized with regard to pH sensitiv

281 Resultant improved microchips were evaluated for the separation of fluoresc

282 Four tested microchips were measured to consume only 113 pW with a r

283 horetic separations with membrane-containing microchips were performed on cations, anions, and amino

284 These microchips were used for FFIEF of small molecule markers

285 hen hybrid microchips instead of native PDMS microchips were used in the microENIA tests.

286 nd-channel electrochemical detection on this microchip, where an electrophoretic separation of dopami

287 dripped onto the reaction area of the paper-microchip, which is embedded with two layers of reagents

288 f the assay, a cyclic olefin copolymer (COC) microchip, which was fabricated using hot embossing, was

289 orescently labeled cells were immobilized on microchip window surfaces and visualized in a fluid cell

290 nal CNC machining techniques with commercial microchips, wire imprinted microchips, and microchips fr

291 ting extraction of glycerophospholipids on a microchip with a nanoelectrospray ionization quadrupole

292 Here we show that an endothelialized microchip with controllable permeability can be used to

293 We design and fabricate a microchip with integrated analyte injection and detectio

294 od, a mine waste rock was also tested in the microchip with natural waters.

295 cal sensing of viruses on a flexible plastic microchip with printed electrodes.

296 We evaluated the microchip with spiked samples of PBS with bacteria conce

297 here, we established 61 kV/cm in N(2) using microchips with 35 microm gaps.

298 xperiments were performed using fused silica microchips with and without octadecyltrimethoxysilane co

299 ted influenza viruses, replacing native PDMS microchips with hybrid microchips allowed the achievemen

300 es have progressed on many fronts, servicing microchips with minute amounts of reagents still constit

301 The microchips with the microelectrode array were fabricated

302 Illustrative of the compatibility of PeT microchips with the PCR process, the successful amplific

303 This method utilizes microchip zone electrophoresis for rapid separation (<90