ライフサイエンスコーパス: microenvironment

1 cluding effector CD8+ T cells from the tumor microenvironment.

2 al centre B cells and ASCs within the tumour microenvironment.

3 the same way by the local pressurized CO(2) microenvironment.

4 WAF1/CIP1) overexpression and protumorigenic microenvironment.

5 MCTs), supporting the formation of an acidic microenvironment.

6 as the specific source of FGF1 in the tumor microenvironment.

7 critical regulator of immunity in the tumour microenvironment.

8 and increased stromal cells within the tumor microenvironment.

9 sidered to be important players in the tumor microenvironment.

10 nformation on spatial position and the local microenvironment.

11 pecific proteases overexpressed in the tumor microenvironment.

12 or cell lineage in reprogramming the stromal microenvironment.

13 and regulatory pathways active in the aortic microenvironment.

14 lie the dual potential of TANs in the tumour microenvironment.

15 tial distributions and interactions with the microenvironment.

16 the ability of cells to interact with their microenvironment.

17 r heterogeneity, and complexity of the tumor microenvironment.

18 ch CXCR4 inhibition affects the tumor immune microenvironment.

19 hat host Wnt5a promotes an immunosuppressive microenvironment.

20 e to fluorescence quenching in the digestive microenvironment.

21 ithin the context of a disrupted bone marrow microenvironment.

22 stance and immunomodulation within the tumor microenvironment.

23 u) that leads to a highly vascularized tumor microenvironment.

24 -primed exhausted CD8 + T-cells in the tumor microenvironment.

25 well as the formation of a tumor-permissive microenvironment.

26 in diverse cell types that compose the tumor microenvironment.

27 ve despite nutrient limitations in the tumor microenvironment.

28 characterize the differences in their tumor microenvironment.

29 ct on angiogensis, a key factor in the tumor microenvironment.

30 populations reshape the immunological tumor microenvironment.

31 t hematopoietic cell type in the solid tumor microenvironment.

32 key characteristics and functions of in vivo microenvironment.

33 T regulatory cell distribution in the tumor microenvironment.

34 ing in small electrical changes in the tumor microenvironment.

35 neficial effects on the ovarian tumor immune microenvironment.

36 a proinflammatory and TGF-beta-low cytokine microenvironment.

37 of this critical cell type within the tumour microenvironment.

38 es with gene expression of LGP2 in the tumor microenvironment.

39 rveillance and sustain the suppressive tumor microenvironment.

40 osmotic pressures are altered in the tumour microenvironment.

41 which overcomes the immunosuppressive tumor microenvironment.

42 y regulation is complex and dependent on the microenvironment.

43 mmunosuppressive mechanisms within the tumor microenvironment.

44 erapy as a result of immunosuppressive tumor microenvironment.

45 ell cultures, thereby disrupting each cell's microenvironment.

46 ted with exclusion of T cells from the tumor microenvironment.

47 cell survival due to the harmful dystrophic microenvironment.

48 ncreased adenosine levels characterize tumor microenvironment.

49 ely create an inflammatory and profibrogenic microenvironment.

50 suggest the development of a malignant tumor microenvironment.

51 assessment of both tumor cells and the tumor microenvironment.

52 enotype of non-neoplastic cells in the tumor microenvironment.

53 te the development of a profibrotic cellular microenvironment.

54 onses in normal tissues as well as the tumor microenvironment.

55 lymphoma B-cells and other cells within the microenvironment.

56 d degree of immune infiltration in the tumor microenvironment.

57 immune suppression associated with the tumor microenvironment.

58 for effector T cell recruitment to the tumor microenvironment.

59 reveal how glioblastoma alters the neuronal microenvironment.

60 g, live lymph node sections and a live tumor microenvironment.

61 mitochondrial activity and the tumor immune microenvironment.

62 metastatic relapse by modulating the immune microenvironment.

63 epigenetic changes, and changes in the tumor microenvironment.

64 ven within a highly immune-suppressive tumor microenvironment.

65 different environments such as hypoxic tumor microenvironments.

66 for lung cancer pulmonary and the lung tumor microenvironments.

67 ation of localized biomolecular networks, or microenvironments.

68 the hemodynamic landscape within angiogenic microenvironments.

69 e mediated by interactions with the neuronal microenvironment(1,2).

70 The commuting microenvironment accounts for a large part of students'

71 actors in the formation of the premetastatic microenvironment after resection of primary tumours.

72 ion, we show that increased stiffness of the microenvironment also induces phosphorylation of gammaH2

73 The cage's microenvironment also promotes high diastereoselectivity

74 hibition of NAMPT modulates the tumor immune microenvironment and acts cooperatively with anti-PD-1 c

75 nd biophysical characteristics of the tumour microenvironment and aim to enable studies of cancer, an

76 link between lipid utilization in the tumor microenvironment and anti-tumor immunity in obese mice.

77 ator of global T-cell responses in the tumor microenvironment and as a negative regulator of T-cell t

78 her shown to induce a pro-inflammatory tumor microenvironment and boost anti-tumor T cell activity.

79 has a physiological role in the intratumoral microenvironment and cancer drug resistance.

80 s in the accumulation of LMW-HA in the tumor microenvironment and cancer-related inflammation and ang

81 ying TGFbeta signalling in tumours and their microenvironment and discuss approaches to inhibit these

82 We discuss the influence of the microenvironment and driver mutations on TPCs formation

83 ypical normal host cell from the lung cancer microenvironment and found no effect of field exposure o

84 represent an abundant cell type in the tumor microenvironment and have been linked to poor outcomes a

85 of the physiological features of the tumour microenvironment and have been shown to be far superior

86 mmarizes current understandings of the tumor microenvironment and intercellular communications in CCA

87 s, and describe the composition of the tumor microenvironment and its putative role in tumorigenesis.

88 igated type 2 inflammation in the metastatic microenvironment and mediated recruitment of eosinophils

89 myeloid and fibroblastic cells in the tumour microenvironment and ongoing immune surveillance(4-6).

90 HCs evolve during healthy pregnancy and how microenvironment and ontogeny impact phenotype and funct

91 in beta-thalassemia induced by an altered BM microenvironment and provide novel and relevant insight

92 in the transcriptional control of the tumor microenvironment and suggests use of a synthetic LXR ago

93 ensive reprogramming of the pancreatic tumor microenvironment and that patients who progress on gemci

94 Detailed understanding of the tumor microenvironment and the personalized design of upconver

95 under the oxidizing conditions of the tumour microenvironment and the reducing intracellular conditio

96 f B cell progenitors in the bone marrow (BM) microenvironment and their progression through the pre-B

97 Here, we discuss the properties of the tumor microenvironment and transport considerations for intrat

98 hed light on interactions between the tumour microenvironment and tumour genotype are highlighted, pr

99 Recent studies using engineered microenvironments and phagocytic targets have demonstrat

100 is characterized by an extensive and complex microenvironment, and is resistant to both chemotherapy

101 ve distinct gene expression profiles, immune microenvironments, and outcomes following immunochemothe

102 use with bystander neural cells in the tumor microenvironment; and cancer cell fusion is a direct rou

103 elopmental, metabolic, epigenomic) and tumor microenvironment (angiogenesis, checkpoint regulation).

104 ance, ability to provide a distinct internal microenvironment (apparent local pH, RNA partitioning),

105 d its role in biofilm biology, function, and microenvironment are being revealed.

106 transporters, or components of complex tumor microenvironment are under intense investigation as pote

107 r, and average dwell times in the respective microenvironments are determined from the cell trajector

108 ith increased immune activation in the tumor microenvironment as well as decreased adenovirus-reactiv

109 ntify biologic processes related to the bone microenvironment as well as tumor cells.

110 is due to the formation of a neuroinhibitory microenvironment at injury sites, which includes neuroin

111 ive inhalation exposure assessment of indoor microenvironments at six commercial printing centers in

112 T cells are susceptible to the low arginine microenvironment because of the low expression of the ar

113 e-assessment approach for studying the tumor microenvironment before or shortly after treatment initi

114 Tumor stroma resembles a fibrotic microenvironment, being characterized by the presence of

115 uppression and inflammation within the tumor microenvironment but is difficult to achieve due to the

116 PHOS function might also influence the tumor microenvironment by alleviating hypoxia and improving th

117 nd maintains vascular integrity in the tumor microenvironment by contributing to the recruitment of p

118 Cancer cells respond to hypoxic microenvironments by activating the transcription factor

119 , and GPR68) regulate signaling in acidified microenvironments by sensing protons (H(+)).

120 impaired immune system and inhibitory tumor microenvironment can further complicate the prospects fo

121 Blocking CD73 activity in the tumor microenvironment can have a beneficial effect on tumor e

122 y behaviors of lymphocytes within the tissue microenvironment can provide valuable insight into their

123 Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-s

124 ulation abundances were quantified using the microenvironment cell population-counter package and com

125 368 patients (DNA sequencing set) and tumour microenvironment characteristics were assessed in 507 pa

126 d extracellular acidity while they grow in a microenvironment characterized by increasing acidity and

127 d that immune-cell-excluded and inflammatory microenvironments coexist within the same individuals an

128 aits of cancer cells and of associated tumor microenvironment components have been shown to promote a

129 nkles, laxity, impaired wound healing, and a microenvironment conducive to cancer.

130 The tumor microenvironment contributes significantly to tumor prog

131 sis, partly because of the immunosuppressive microenvironment created by tumor-associated macrophages

132 obile hematopoietic cells within specialized microenvironments created by sessile stromal cells.

133 he engrafted HSPC population and bone marrow microenvironment degradation caused by pre-transplantati

134 Furthermore, deletion of Vegfc from the microenvironment delayed hematopoietic recovery after tr

135 eraction between genomic alterations and the microenvironment determines disease course.

136 This microenvironment develops during the progression of prem

137 The immunosuppressive state of the tumor microenvironment diminishes the efficacy of dendritic ce

138 fluoresce in the acidic extracellular tumor microenvironment due to the mechanism of nanoscale macro

139 Besides, changes in protein microenvironment due to the presence of saponin was obse

140 ated in macrophages exposed to TB-associated microenvironments due to tunneling nanotube (TNT) format

141 ly characterized the whole bone marrow (WBM) microenvironment during premalignant, baseline, on treat

142 in establishment of the M1-like shift in the microenvironment during primary tuberculosis.

143 erestingly, MFP treatment reshaped the tumor microenvironment, enhancing the production of proinflamm

144 survival and migration and affect the immune microenvironment, especially macrophages in clearing dyi

145 tion, and survival, the compartmentalized pH microenvironment favors cancer development.

146 FGF2 is induced in the tumour microenvironment following fractionated radiation in mur

147 ) as the substrate to construct a mechanical microenvironment for cardiomyocytes.

148 ions for understanding the role of the tumor microenvironment for macrophage activation.

149 loit the unique characteristics of the tumor microenvironment for precise targeting have been designe

150 ents with chronic hepatitis, which creates a microenvironment for the growth of hepatic progenitor ce

151 brane vesicles, which may provide a tailored microenvironment for viral RNA synthesis in the infected

152 e of treatment induces an immune stimulatory microenvironment harboring more tumor infiltrating lymph

153 mpact of NAD(+) depletion on the brain tumor microenvironment has not been elaborated.

154 ver and decreases heterogeneity of the tumor microenvironment, hence PI3Kbeta inhibition may be a use

155 ing tumour-specific antigens into the tumour microenvironment highlights the potential for mCD40L as

156 response, are a key regulator of intestinal microenvironment homeostasis.

157 l metabolism in cells residing in low-oxygen microenvironments (hypoxia) such as in the liver, spleen

158 unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of bone turnover

159 We also assessed the tumour immune microenvironment in a prospective cohort of patients who

160 iocrine" gatekeeper roles, controlling their microenvironment in an instructive manner.

161 ew role for Notch3 in manipulating the tumor microenvironment in bone metastases.

162 Our data identify that the neonatal microenvironment in combination with STAT5 is critical f

163 f novel approaches to re-engineer the tumour microenvironment in favour of effective anticancer respo

164 ins of the programmed-death ligand 1 (PD-L1) microenvironment in live lymphocytes and selectively lab

165 Numerous studies support a role of the microenvironment in maintenance of the leukemic clone, a

166 CTGF is also involved in the tumor microenvironment in most of the nodes, including angioge

167 apy and shed light on the role of the immune microenvironment in response to HER2-targeted agents.

168 mokine cascade, which will favour the tumour microenvironment in terms of distant metastasis.

169 tudies show that the adventitia is a dynamic microenvironment in which adventitial and perivascular a

170 ration of antiviral resistance reflected the microenvironment in which the virus population replicate

171 RNA expression correlate with altered immune microenvironments in human ccRCC.

172 has been designed where the stiffness of the microenvironment, in 3D culture, has been set at either

173 es profound changes in the pancreatic cancer microenvironment, including elevated TGFbeta signaling a

174 es profound changes in the pancreatic cancer microenvironment, including increased numbers of tumor-i

175 sential in the development of protumorigenic microenvironment induced by NCOA5 deficiency and metform

176 Yet it remains unclear how the microenvironment influences cell processes, especially w

177 BC; (2) non-neural functions related to cell-microenvironment interactions and intracellular damage p

178 ication with important implications in tumor microenvironment interactions, tumor growth, and metasta

179 readouts, which may be useful to probe cell-microenvironment interactions.

180 An emerging tumor microenvironment is a complex and continuously evolving

181 tate of the preexisting T cells in the tumor microenvironment is a key determinant for effective anti

182 Since the MM microenvironment is hypoxic, we assessed if hypoxia and/

183 ternal genetic programming, but the external microenvironment is increasingly recognized as a signifi

184 This highly regulated microenvironment is made possible by two unique features

185 en pancreatic epithelium and the surrounding microenvironment is pivotal for pancreas formation and d

186 The glioblastoma immune microenvironment is recognized as highly immunosuppressi

187 ar that disruption of the normal bone marrow microenvironment is sufficient to promote leukemic trans

188 creased hyaluronan and collagen in the tumor microenvironment, leading to an extensive remodeling of

189 s stimulate myofibroblasts in the pericystic microenvironment, leading to fibrosis in ADPKD.

190 Within the tumor microenvironment, macrophages exist in an immunosuppress

191 At the implantation microenvironment, macrophages usually fuse into multinuc

192 g networks operating within the local tissue microenvironment may enhance malignant tumor progression

193 ruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the

194 Changes within the obese breast microenvironment may increase breast cancer risk.

195 tightly regulated by their bone marrow (BM) microenvironment (ME).

196 chaperone that, translocated to the external microenvironment, mediates crucial host-parasite interac

197 nding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance

198 ll RCC tumour and peritumoral adipose tissue microenvironment might have clinical relevance and warra

199 physicochemical characteristics of the tumor microenvironment, namely, acidic pH, redox reactants, an

200 We observe that these self-induced hypoxic microenvironments not only contribute to filamentous fun

201 ular signaling system that uses the confined microenvironment of a giant vesicle, derived from a livi

202 lagen fibrils - potentially important in the microenvironment of actively dividing cells, such as can

203 layers that shape the cellular and proteomic microenvironment of AD.

204 ibroblasts, a cell population present in the microenvironment of almost all tissues.

205 Understanding how HCMV controls the microenvironment of an infected cell so as to favor prod

206 spectra revealed that the tryptophan residue microenvironment of betaLG was affected by the vitamin B

207 n altered the systemic and peritoneal immune microenvironment of mice with endometriosis as demonstra

208 ion with elevated calcium are present in the microenvironment of most solid cancers.

209 cancer-associated fibroblasts (CAFs) in the microenvironment of murine carcinomas, each endowed with

210 eloped a new method to capture the proteomic microenvironment of the neuronal endolysosomal network b

211 Here we report that changes to the microenvironment of the overgrown tissue are important f

212 Targeting the pH indicators to the microenvironment of the presynaptic voltage gated Ca(2+)

213 iposomes could remodel the immunosuppressive microenvironment of triple negative breast cancer and fa

214 Here we characterized the tumor and splenic microenvironment of two syngeneic subcutaneous (NXS2 and

215 A complex microbiota inhabits various microenvironments of the gut, with some symbiotic bacter

216 tion of regular surface cavities with unique microenvironment on graphitic carbon nitride as "subnano

217 with driver mutations generating a conducive microenvironment on the epithelial boundary, which becom

218 activation state of neighboring cells in the microenvironment or within progression of a particular d

219 dely utilized, little is known about how the microenvironment, particularly confined aqueous environm

220 Immune microenvironment plays a critical role in lung cancer co

221 The tumor microenvironment plays a critical role in prostate cance

222 wever, recent studies suggest that the tumor microenvironment plays a key role in the progression and

223 ltrating lymphocytes (TILs) within the tumor microenvironment provides strong prognostic value, which

224 ility to adapt and colonize lipid-rich tumor microenvironments, providing an opportunity for specific

225 The profound impact of the tumour microenvironment, reflected in the efficacy of immune ch

226 drive the immunologically restrictive tumor microenvironment remain poorly understood.

227 ial source of CD73 activity within the tumor microenvironment remains unspecified.

228 In soft microenvironments reminiscent of metastatic sites, breas

229 ion in two-dimensional and three-dimensional microenvironments, respectively.

230 Tumours with an immunosuppressive microenvironment respond poorly to therapy.

231 Currently, photosensitizers (PSs) that are microenvironment responsive and hypoxia active are scarc

232 ent growth and highlights how the metastatic microenvironment restores this malignant property of can

233 PD-L1 expression in the tumor microenvironment significantly correlated with presence

234 infers the emergent network biology of tumor microenvironment spatial domains revealing a spatially-m

235 sembly system that achieves lysosomal acidic microenvironment specifically inducing topological trans

236 We propose that increased tumor microenvironment stiffness leads to stromal cell-mediate

237 and granulocytes, which are often ignored in microenvironment studies.

238 werful when deconvoluting highly specialized microenvironments, such as stem cell (SC) niches.

239 oimmunity, and variable effects on the tumor microenvironment that can limit or worsen tumor progress

240 IL-33 as an orchestrator of the glioblastoma microenvironment that contributes to tumorigenesis.

241 highly stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution and contr

242 Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metast

243 s induce dynamic changes in the tumor immune microenvironment that vary by subtype and pathologic res

244 meostasis and alters both systemic and local microenvironments that impact stem cell plasticity and i

245 cellular organisms relies on specific tissue microenvironments that nurture hematopoietic precursors

246 e areas include the immune system, the tumor microenvironment, the fibrotic response, and stem cell f

247 e interaction between cancer cells and brain microenvironment, thereby inducing brain metastatic comp

248 When exposed to a newborn skin microenvironment, these cells express hair-follicle line

249 ears to establish an immunosuppressive tumor microenvironment through the activation of STAT3, and lo

250 ent cholangiocytes can modify the periductal microenvironment through their ability to secrete variou

251 in inducing immune suppression in the tumor microenvironment, through both targeted inhibition of RA

252 mune systems and regulating the inflammatory microenvironment, thus alleviating the inflammatory resp

253 ued after cell transplantation into a normal microenvironment, thus proving the active role of the BM

254 Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in

255 nces in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immunity is

256 er, the degree of heterogeneity of the tumor microenvironment (TME) and its molecular underpinnings r

257 umor progression and remodeling of the tumor microenvironment (TME) by sustaining the calcium transie

258 , metabolic constraints imposed by the tumor microenvironment (TME) can dampen their ability to contr

259 cells are armed to combat tumors, the tumor microenvironment (TME) contains ROS, which suppress NK c

260 Macrophages within the tumor microenvironment (TME) exhibit a spectrum of protumor an

261 y in establishing an immunosuppressive tumor microenvironment (TME) for the support of tumor growth.

262 uelled ongoing efforts to exploit the tumour microenvironment (TME) for therapy, but strategies aimed

263 nature (GES) or high immunosuppressive tumor microenvironment (TME) GES levels at baseline; an immuno

264 The tumor microenvironment (TME) is an essential contributor to th

265 naling within the breast tumor and its tumor microenvironment (TME) is linked to poor clinical outcom

266 The tumor microenvironment (TME) plays a significant role in cance

267 Our understanding of the brain tumor microenvironment (TME) remains limited, and it is unknow

268 Cellular interactions in the tumor microenvironment (TME) significantly govern cancer progr

269 Over 20,000 cancer and tumor microenvironment (TME) single-cell profiles exposed a ri

270 tion, recruitment of NK cells into the tumor microenvironment (TME), blockade of inhibitory receptors

271 l to accurately emulate the volumetric tumor microenvironment (TME).

272 ivable nanomedicines that regulate the tumor microenvironment (TME).

273 eveals important information about the tumor microenvironment (TME).

274 uency of tumor-specific T cells in the tumor microenvironment (TME).

275 ular oncogene activation and a hostile tumor microenvironment (TME).

276 ur cells or indirectly by shaping the tumour microenvironment (TME).

277 ce antitumor immunity by reshaping the tumor microenvironment (TME).

278 ly needed to reverse the ICB-resistant tumor microenvironment (TME).

279 the formation of an immunosuppressive tumor microenvironment (TME).

280 focusing on modulating the pancreatic tumour microenvironment to enhance the efficacy of the immunoth

281 ctivation of GPR81 in cells present in tumor microenvironment to help tumor growth.

282 term gemcitabine administration on the tumor microenvironment to identify potential therapeutic optio

283 e materials can form the basis of artificial microenvironments to promote cell infiltration and repro

284 tified as a function of the stiffness of the microenvironment using BioSig3D.

285 tophagy can play opposing roles in the tumor microenvironment via non-cell-autonomous mechanisms.

286 ces a signal only in the protease-rich tumor microenvironment, was topically applied to 90 specimens

287 gions of tumor heterogeneity and the hypoxic microenvironment were observed based on the spatial dist

288 ed suppressor cells (MDSCs) within the tumor microenvironment, when compared with Lys-SNAs and simple

289 acteristics and key components of the aortic microenvironment, where the first hematopoietic stem cel

290 tion of circulating monocytes into the tumor microenvironment, where they mature into tumor-associate

291 ticularly hindering in geometrically complex microenvironments, where it leads to entanglement and ul

292 pression in multiple cell types of the tumor microenvironment, which could contribute to angiogenesis

293 in the context of its cellular and molecular microenvironment, which includes the nerves.

294 Hypoxia is a common feature of the tumor microenvironment, which is characterized by tissue oxyge

295 enic and exceedingly immunosuppressive tumor microenvironment, which is enriched with dysfunctional a

296 , and lymphangiogenesis in the endometriotic microenvironment, which opens up new horizons in underst

297 s allows us to obtain snapshots of molecular microenvironments with nanometer resolution, facilitatin

298 retion may be intimately linked to a hypoxic microenvironment within keloid tumors and that HIF-1alph

299 a function of the increased stiffness of the microenvironment within the range of MD.

300 The microenvironment within the SVZ stem cell niche controls