ライフサイエンスコーパス: microfilariae

1 nerate an annotated cell expression atlas of microfilariae.

2 f the parasite: adult female, adult male and microfilariae.

3 sons with high levels of circulating Loa loa microfilariae.

4 ost of whom (67.5%) had no detectable L. loa microfilariae.

5 ively but a third correlated negatively with microfilariae.

6 e, the majority of the mice remained free of microfilariae.

7 intracorneal binding complex or live Brugia microfilariae.

8 st antigens from adult female worms and skin microfilariae.

9 examined them by microscopy for W bancrofti microfilariae.

10 eatment, we examined blood samples again for microfilariae.

11 ating filarial antigen and, if positive, for microfilariae.

12 We successfully cryopreserved M. ozzardi microfilariae, advancing the prospects of rearing infect

13 Parasitic extracts prepared from B. malayi microfilariae and adult worms were incubated with recomb

14 ycle stages that live in the mammalian host (microfilariae and adult worms).

15 Brugia malayi microfilariae and adults were exposed in vitro to 0.75 t

16 al level, between infection with O. volvulus microfilariae and bilateral blindness was examined, by u

17 C57BL/6 mice immunized with killed B. malayi microfilariae and challenged intravenously with live mic

18 itability estimates suggested that levels of microfilariae and circulating adult worm antigen, as wel

19 nfection status as determined by blood-borne microfilariae and filarial antigenemia.

20 The morphologic similarities of the microfilariae and their infrequency in clinical specimen

21 from doxycycline-treated patients contained microfilariae, and 97% of those patients were without mi

22 male, adult female, blood-borne and uterine microfilariae, and infective L3 larvae.

23 treatment groups in community prevalence of microfilariae at 12 months or individual clearance at 24

24 extended to mosquitoes that were exposed to microfilariae but did not support larval development.

25 iced leader sequence SL1 and is expressed in microfilariae but not in third-stage larvae or adult wor

26 t dependent on the appearance of circulating microfilariae, but may be due to initial low levels of p

27 y response is associated with the release of microfilariae by female worms.

28 A B. malayi microfilariae cDNA library was immunoscreened with antis

29 Finally, we introduce a microfilariae cell culture model to enable future functi

30 At 12 months, microfilariae clearance was achieved in 72 of 111 partic

31 divided into an early phase with killing of microfilariae, clinical symptomatology, increases in pla

32 ssion and/or pathology (directed toward skin microfilariae) could provide the necessary 'final punch'

33 ls treated with ivermectin in 2015 had L loa microfilariae density below the level associated with ne

34 Our molecular methods revealed that microfilariae emerging from skin snips collected from hi

35 ariae and challenged intravenously with live microfilariae exhibit many of the characteristics of hum

36 he parasite, with high levels of circulating microfilariae, few clinical symptoms, and diminished fil

37 h high concentrations of circulating Loa loa microfilariae (>20 000 microfilariae per mL) developing

38 Birds with microfilariae had elevated heterophil to lymphocyte rati

39 Microfilariae harboring Wolbachia organisms were injecte

40 ich are used mostly in combination to reduce microfilariae in blood (lymphatic filariasis) and skin (

41 -friendly diagnostic tool to quantify L. loa microfilariae in peripheral blood, enables rapid, point-

42 diagnosis mainly relies on the detection of microfilariae in skin or blood.

43 ce the concentration of Wuchereria bancrofti microfilariae in the blood for months to years.

44 n in individuals with high levels of Loa loa microfilariae in the blood preclude onchocerciasis elimi

45 Children with high concentrations of microfilariae in the blood were admitted to hospital and

46 c filariasis drugs is only effective to kill microfilariae in the bloodstream, but is often ineffecti

47 chia in O. volvulus is effective in clearing microfilariae in the skin of onchocerciasis patients wit

48 dium spp.) and parasitic filarial nematodes (microfilariae) in wild birds (New Caledonian Zosterops s

49 ee main stages of the B. pahangi life cycle: microfilariae, infective larvae and adults.

50 s suppressed basophils in vitro, transfer of microfilariae into mice did not result in basophil suppr

51 h of the cDNA libraries when compared to the microfilariae, L2, and both adult stages of the parasite

52 For microfilariae, median inhibitory concentrations (IC50 va

53 Patients without circulating microfilariae (MF negative) not only had a higher likeli

54 a worms in subcutaneous tissues, circulating microfilariae (mf) and presence of filarial biomarkers i

55 icity of Loa loa, as people with high L. loa microfilariae (mf) density can develop serious adverse e

56 , led to the clearance of Brugia malayi (Bm) microfilariae (mf) from infected jirds.

57 in which an allergic response is induced to microfilariae (Mf) in the lungs.

58 ing live infective-stage larvae (L3) or live microfilariae (Mf) of Brugia malayi, a causative agent o

59 on of human monocytes, cells were exposed to microfilariae (mf) of Brugia malayi, and their phenotypi

60 individuals, we examined the effect of live microfilariae (mf) on expression and function of TLRs in

61 MDA, the stop-MDA decision is made based on microfilariae (mf) prevalence in adults.

62 l measures where onchocerciasis was endemic, microfilariae (MF) prevalence rates were 82.8% and 65.1%

63 ation of (skin-dwelling) Onchocerca volvulus microfilariae (mf) using the skin snip technique (SST).

64 ght patients who had skin snips positive for microfilariae (Mf) were studied 120 days after receiving

65 nting cell function and is most specific for microfilariae (MF), the parasite stage found in large nu

66 om elutriated monocytes were exposed to live microfilariae (mf), the parasite stage that circulates i

67 indicate that Bm-spn-2 is expressed only by microfilariae (Mf), which are the long-lived blood-dwell

68 in Ghana and included 272 participants with microfilariae (MF), who were randomly assigned to 4 trea

69 for point-of-care quantification of Loa loa microfilariae (mf).

70 filarial antigens (CFAs) and 44 who also had microfilariae (MF).

71 re correlated with the number of circulating microfilariae (mf).

72 d macrophages, were exposed in vitro to live microfilariae (mf).

73 embryogenesis, waning of circulating larvae (microfilariae [mf]), and gradual cure of adult infection

74 lation between optic density (OD) values and microfilariae (mfs) loads.

75 tin, suggesting that the loss of circulating microfilariae, not the reduction of Wolbachia bacteria,

76 Among all five villages with a prevalence of microfilariae of 2 to 38%, the probability of transmissi

77 Finally, live microfilariae of B. malayi were able to downregulate cel

78 We have shown that live microfilariae of Brugia malayi induce caspase-dependent

79 n response to live infective-stage larvae or microfilariae of Brugia malayi, we found significant imp

80 Although excretory/secretory products from microfilariae of L. sigmodontis suppressed basophils in

81 Microfilariae of some species exhibit temporal separatio

82 ive-stage larvae of Brugia malayi but not to microfilariae of this parasite.

83 oa microfilarial density greater than 20,000 microfilariae per milliliter of blood, who were consider

84 aign, a higher exclusion threshold of 26 000 microfilariae per mL or less was used.

85 with a L loa microfilarial density of 20 000 microfilariae per mL or less were offered treatment; in

86 f circulating Loa loa microfilariae (>20 000 microfilariae per mL) developing serious adverse events

87 manifestations of human onchocercal disease, microfilariae-positive Ghanaian subjects with inflammato

88 ulating cell-free DNA (ccfDNA) from 48 of 53 microfilariae-positive patients.

89 vity of the test with serum samples from 106 microfilariae-positive subjects was 90.6%.

90 flammatory ocular disease were compared with microfilariae-positive subjects without ocular disease.

91 ete symbionts, block embryogenesis, and stop microfilariae production.

92 gs efficiently to the bloodstream, where the microfilariae reside, while also targeting drug to the l

93 Blood-borne Brugia malayi microfilariae survived for significantly longer time per

94 19) had significantly higher levels of skin microfilariae than children of uninfected mothers (n = 1

95 sis (river blindness), including the larvae (microfilariae) that migrate into the cornea.

96 was isolated from the sheath of W. bancrofti microfilariae through ultrafiltration, followed by chrom

97 Exposure of microfilariae to nicotinamide alters intramosquito migra

98 Importantly, co-occurrence patterns with microfilariae varied in direction among avian malaria sp

99 osquitoes rapidly destroy invading B. malayi microfilariae via a defense response known as melanotic

100 roduction of TNF-alpha after chemotherapy of microfilariae was also only detected in LPS-responsive C

101 ortion of children who remained positive for microfilariae was significantly lower in the ivermectin

102 om adult female worms, adult male worms, and microfilariae, we find variability in N-glycosylation at

103 i adult males, adult females, L3 larvae, and microfilariae were assessed using a wide dose range (0-1

104 Microfilariae were more sensitive to the action of CaGC

105 Ivermectin has controlled transmission of microfilariae, with an African Program elimination targe

106 ctor control and drug treatment to eliminate microfilariae, with no means available to prevent infect