ライフサイエンスコーパス: microfluidic

1 he composites was controlled through droplet microfluidics.

2 nologies of artificial intelligence (AI) and microfluidics.

3 ly split into aliquots by the built-in paper microfluidics.

4 uch as flow lithography or multiple-emulsion microfluidics.

5 transcription/translation and droplet-based microfluidics.

6 e, we present an automated, high-throughput, microfluidic 3D organoid culture and analysis system to

7 o applications ranging from drug delivery to microfluidics and from ablation to fabrication.

8 adopted by researchers with no experience in microfluidics and may find applications in a range of fi

9 red tumor models, which have benefitted from microfluidics and mechanical engineering, creating a par

10 d microscope that retains compatibility with microfluidics and open-source software for image acquisi

11 Using microfluidics and pharmacological and genetic studies, w

12 Using microfluidics and time-lapse microscopy, we quantitative

13 Facilitated by the use of robotics, microfluidics, and improved approaches to super-resoluti

14 In microfluidic applications, tips can be made to eject fin

15 liquids on solid surfaces is fundamental for microfluidics applications.

16 A paper microfluidic approach allowed us to expose the entire ro

17 lass slides of embryos mounted manually, our microfluidic approach greatly increases throughput.

18 Compared to transwell assays, microfluidic approaches could offer several advantages,

19 of more advanced, more effective paper-based microfluidic aptasensors for POC disease markers diagnos

20 Over the past ten years, paper-based microfluidic aptasensors have emerged as a class of crit

21 e articles in the development of paper-based microfluidic aptasensors.

22 The microsystem monolithically integrates microfluidics as well as a potentiometric detection syst

23 We therefore used our novel biomimetic microfluidic assay (bMFA) to determine whether the respo

24 Here, we show that a microfluidic assay for the quantification of cell migrat

25 In this study, we developed a microfluidic assay that can measure cellular ROS respons

26 replication across the genome as revealed by microfluidic-assisted replication track analysis.

27 hes, we compared Drop-seq and DroNc-seq, two microfluidic-based 3' RNA capture technologies that prof

28 Here, we present a microfluidic-based platform for non-invasive diagnosis w

29 This droplet microfluidics-based method enables high-throughput chemi

30 Microfluidics-based methods have enabled single-cell mec

31 e viability of such a potential in automated microfluidic Brownian dynamics experiments using hologra

32 in the 90's has revolutionized the field of microfluidics by almost eliminating the need for a clean

33 o shift the landscape of single-cell droplet microfluidics by expanding the repertoire of current nuc

34 ly demonstration of how 3D printed and paper microfluidics can be hybridized into versatile lab-on-ch

35 Microfluidics can help address this issue by allowing a

36 gradient cation exchange chromatography and microfluidic capillary electrophoresis using the ZipChip

37 uccessfully developed microsecond XFMS using microfluidic capillary flow and a microfocused broadband

38 The microfluidic cartridge is operated through a dedicated c

39 (PLA) as a replacement material to PDMS for microfluidic cell culture and OOC applications.

40 SC-derived networks are separated by a novel microfluidic cell culture device that allows controlled

41 inting and rapidly prototyping of PDMS-based microfluidic cell handling arrays in different geometrie

42 mely broad application space in the field of microfluidic cell separation.

43 l concept is integrated into a lab-on-a-chip microfluidic cell that allows for a high sample throughp

44 les assembled from artificial centrosomes in microfluidic chambers of defined size are amenable to hi

45 w that the culture of animals in pillar-less microfluidic chambers reduces lifespan and introduces ph

46 r electrodes projecting into one side of the microfluidic channel and is easily integrated with upstr

47 biosensor, sample, buffer fluid and even the microfluidic channel can be modified in this model.

48 d particles with various shapes in a shallow microfluidic channel via stop flow lithography.

49 as demonstrated that the interaction between microfluidic channel walls and travelling surface acoust

50 to 6.3 mum, in a polydimethylsiloxane (PDMS) microfluidic channel with a rectangular cross-section.

51 electrodes are embedded into the disposable microfluidic channel, and the other in which the disposa

52 odes on a glass substrate embedded in a PDMS microfluidic channel, is used in conjugation with immuno

53 individual probe spheres as they flow down a microfluidic channel.

54 n cylindrical microwells located on top of a microfluidic channel.

55 matic liquid crystal, and contained within a microfluidic channel.

56 ities of cells for separation in transparent microfluidic channels and implements label-free imaging

57 ing probes embedded in paper substrates, and microfluidic channels consisted of cotton threads to har

58 Absorbance detection is often prohibited in microfluidic channels due to the limited optical path le

59 lectric field, migration of particles inside microfluidic channels exhibits intricate focusing dynami

60 ction clogging while capable of operating in microfluidic channels filled entirely with highly conduc

61 trate enhanced absorbance detection in glass microfluidic channels using a commercial microplate read

62 Our device is essentially a set of microfluidic channels, each with a nanoconstriction at o

63 r by a stand-alone laser during flow through microfluidic channels, trigger contents release with spa

64 ping water across a single microcapillary or microfluidic channels.

65 l integrity and functionality of HUVEC-lined microfluidic channels.

66 dy cocktails, nanostructured substrates, and microfluidic chaotic mixers.

67 In this work, we develop a microfluidic chip formed by HGPS-SMCs generated from ind

68 A dual-layer paper microfluidic chip was developed as a quicker, low-cost,

69 before the introduction of the sample in the microfluidic chip) and with high compatibility with deve

70 The SERS sensor is integrated into a microfluidic chip, achieving one-step multiplex analysis

71 On the microfluidic chip, droplets were perfused with different

72 tegrated Coulter sensors, distributed over a microfluidic chip, provide rapid and reliable detection

73 g Cas12-gRNA, reporters, and target within a microfluidic chip.

74 In this report, we demonstrate microfluidic ChIPmentation (mu-CM), a microfluidic techn

75 material that is promising for constructing microfluidic chips (lab-on-a-paper) for diagnostics and

76 nting methods most frequently adopted by the microfluidic community.

77 that were exploited here using an iDEP-based microfluidic constriction sorter device for length-based

78 d fluorescence microscopy indicated that the microfluidic control of the stimuli (changes in pH or io

79 We present here a microfluidic coplanar Coulter counter device design that

80 gulates neuritic transport of APP, we used a microfluidic corticocortical neuronal network-on-a-chip

81 enables an alternate modality for a suite of microfluidic CRISPR-based diagnostic assays.

82 h microchannels of a human lung small airway microfluidic culture device, mimicking how lung cells ma

83 Human organ-on-a-chip (Organ Chip) microfluidic culture devices that recapitulate tissue-ti

84 , respectively, exceeding typical lengths of microfluidic designs.

85 This innovative microfluidic device and its associated instrumentation s

86 Using a glass capillary microfluidic device as the printhead, we dispersed dropl

87 Here, we demonstrate that a biomimetic microfluidic device consisting stenosed and tortuous art

88 This study presents a microfluidic device containing an array of spheroid trap

89 Thus, this tortuosity activated microfluidic device could lead to a more quantitative an

90 Herein an integrated microfluidic device for AB diagnosis utilizing a new dua

91 A microfluidic device for simultaneous analysis of total f

92 (RCA) bioassay and an (2) agarose bead-based microfluidic device for the affinity chromatography-base

93 t a self-partitioning SlipChip (sp-SlipChip) microfluidic device for the slip-induced generation of d

94 In this study, we report a microfluidic device for the whole-life culture of the ne

95 e miniaturization of SPE within a 3D printed microfluidic device further allows for fast and simple e

96 d dielectrophoresis (iDEP) integrated into a microfluidic device has the potential to separate SWNTs

97 The 3D microfluidic device is a photoactive polyacrylamide gel

98 Here, using an in-house microfluidic device mimicking the pulmonary capillary be

99 in an HLF-laden, fibrin-based ECM within our microfluidic device optimally (1) enhances the sprouting

100 This microfluidic device provides a rapid and straightforward

101 Collectively, our microfluidic device shows several advantages over tradit

102 ch, it is of particular interest to design a microfluidic device that can be tuned and adjusted to se

103 etails of the design and implementation of a microfluidic device that can be used to model human embr

104 This study reports an integrated microfluidic device that was capable of executing rapid

105 Here, we used a specially designed microfluidic device to study thermotaxis of Escherichia

106 further development of the vacuum-compatible microfluidic device used in in situ liquid SIMS provides

107 rfacial tension (IFT) and wettability in the microfluidic device was simulated using a phase-field mo

108 The latter microfluidic device was successfully used for the determ

109 nsor concept experimentally, we fabricated a microfluidic device with 10 distributed Coulter sensors

110 designed interior structures to fabricate a microfluidic device with high surface area and fluid flo

111 nt bacteria can be realized on an integrated microfluidic device within 6 h.

112 o-electron microscopy (trEM) using a modular microfluidic device, featuring a 3D-mixing unit and vari

113 l migration through confined spaces within a microfluidic device, subcellular photoactivation of Rac1

114 s cells inside the capturing chambers of the microfluidic device, where the hydrodynamic force then i

115 zing is demonstrated using a custom-designed microfluidic device, which relieves contraction of the m

116 achieved in the DAMR system using 3D-printed microfluidic device.

117 ia the neuromuscular junction (NMJ) within a microfluidic device.

118 rapid in-line separation using an open space microfluidic device.

119 ls), can be robustly recapitulated using the microfluidic device.

120 te actuators in various applications such as microfluidic devices and biomimetic microrobots.

121 Because the design geometries of paper-based microfluidic devices are not standardized, conventional

122 In microfluidic devices CLR01 reduced alpha-synuclein aggre

123 rdware, which is amenable to deployment with microfluidic devices for point-of-care diagnostics.

124 esults can be further exploited in design of microfluidic devices for rare cells immunocapture.

125 Droplet-based microfluidic devices have become widely used to perform

126 ow how to immobilize receptors inside closed microfluidic devices in <30 s using bead lane modules in

127 The PETG-based microfluidic devices integrated with electrochemical sen

128 ehensive understanding of particle motion in microfluidic devices is essential to unlock additional t

129 These microfluidic devices often are designed to operate with

130 Cell immunocapture microfluidic devices represent a rapidly developing fiel

131 t step toward designing stretchable inertial microfluidic devices that can be implemented for a wide

132 a a Reservoir-on-a-Chip approach, which uses microfluidic devices to mimic the oil reservoir.

133 Here, we used microfluidic devices to physically isolate these two neu

134 veness of these SPE monoliths and 3D printed microfluidic devices was tested using a panel of nine pr

135 reservoir pores, the inner channels of glass microfluidic devices were coated with thin layers of cal

136 fied polyethylene terephthalate (PETG)-based microfluidic devices with embedded channels and gold fil

137 We manufactured microfluidic devices with narrow channels (60-mum(2) rec

138 phase flow will benefit the design of future microfluidic devices, allowing spatiotemporal control of

139 r integration into flow-injection analyzers, microfluidic devices, and lab-on-a-chip systems.

140 crylate-based monolith, formed in 3D printed microfluidic devices, which can selectively retain pepti

141 Tau propagation from neuron to neuron using microfluidic devices.

142 urther support the rapid prototyping of PDMS microfluidic devices.

143 chnique has merits toward the fabrication of microfluidic devices.

144 for counting the separated cells within the microfluidic disc.

145 Droplet microfluidics disrupted analytical biology with the intr

146 eveloped a new methodology, based on digital microfluidics (DMF), for rapid determination of individu

147 Microfluidic droplet generation affords precise, low vol

148 Microfluidic droplet sorting enables the high-throughput

149 search, and industrial interest, opening the microfluidic droplet technologies for adaptation in thes

150 ne synthesized by only a few living cells in microfluidic droplets via mass spectrometry.

151 arget by performing digital amplification in microfluidic droplets.

152 ling of a micromotor-based immunoassay and a microfluidic electrochemical detection was explored as a

153 -edge technologies including nanotechnology, microfluidics, electronic engineering, and material scie

154 Microfluidic encapsulation and barcoding was used to per

155 The microfluidics engineering is central to achieve a contro

156 such requirements, and its performance in a microfluidic environment further offers the potential fo

157 With the feasibility of 3D printed microfluidics established, we look ahead at trends in 3D

158 rescence correlation spectroscopy (FCS), and microfluidic experiments.

159 y in low sample volumes) and electrochemical microfluidic (flow-controlled ultraminiaturized electroc

160 difference in diffusivities within parallel microfluidic flows.

161 ), widely applied water-in-oil droplet-based microfluidics for single cell analysis met problems.

162 This metasurface integrated with microfluidics further enhances the light-matter interact

163 For achieving this, a microfluidic glass chip incorporating a monolithic separ

164 st decade, extensive research on paper-based microfluidics has accumulated a large number of scientif

165 Studying the basic phenomenon in microfluidics has also generated new knowledge, which co

166 Inertial microfluidics has been proven to be a powerful tool for

167 Microfluidics have many potential applications including

168 th different sizes concurrently flowing in a microfluidic Hele-Shaw channel.

169 The microfluidic human embryo model is compatible with high-

170 Here we describe a method that combines microfluidics, hydrogels, and Xenopus laevis egg extract

171 rfaces of cancer cells using multi-frequency microfluidic impedance cytometry.

172 However, the current obstacle of inertial microfluidics in biological applications is the broad si

173 s of SCD mice in vivo and SCD human blood in microfluidics in vitro.

174 s of SCD mice in vivo and SCD human blood in microfluidics in vitro.Conclusions: These results are th

175 le also removing some troublesome aspects of microfluidics including the use of surfactants and the c

176 er was realized by using a vacuum compatible microfluidic interface and time-of-flight secondary ion

177 onent that has so far been overlooked in the microfluidics literature-the fuse-is a passive safety de

178 Our FCS and microfluidic measurements also highlight the key role sh

179 at are simply unattainable with conventional microfluidic methods, namely the elimination of exterior

180 te in the mechanism of liposome formation by microfluidic mixing in the channel with "herring-bone" g

181 e final size of formed liposomes prepared by microfluidic mixing of an ethanol solution of lipids and

182 Introduction of microfluidic mixing technique opens a new door for prepa

183 Our microfluidic model advances current tumor invasion assay

184 In this article, we develop a microfluidic model in which tumor spheroids are embedded

185 In the present study, we introduce a microfluidic model of the solid tumor-vascular interface

186 we construct and characterize a 3D in vitro microfluidic model that supports the growth of patient-d

187 Proof-of-concept of the applicability of the microfluidic modulator chip is demonstrated in a heart-c

188 The microfluidic modules discussed here broadly map function

189 n transfer the purified bacterial DNA to our microfluidic nanoarray to amplify 16S rRNA using dPCR an

190 of particles and fluids through multichannel microfluidic networks is influenced by details of the ch

191 Automated microfluidics offers advantages in high-throughput and p

192 stic technologies, including nanotechnology, microfluidics, -omics science, next-generation sequencin

193 upled to thin layer Au-based electrochemical microfluidics operating at -0.20 V under controlled flui

194 This study employed the use of a microfluidic paper-based analytical device (uPAD) to det

195 ions of electrochemical detection methods in microfluidic paper-based analytical devices (muPADs) has

196 inally, we detail the design and assembly of microfluidic paper-based devices that use Cas12a-sensiti

197 mbining an affinity-based method and passive microfluidic particle trapping.

198 roenvironment supplied by a vasculature-like microfluidic perfusion.

199 Here, we present a microfluidic pipeline for large-scale smFISH imaging of

200 oscale fluid manipulation method, composable microfluidic plates (cPlate), which are comprised of min

201 In sum, our microfluidic platform can quantify spatiotemporal parame

202 iquid interface, and one-stop protocol, this microfluidic platform can simplify the fabrication proce

203 We present a portable microfluidic platform containing carbon nanotube arrays

204 , highly sensitive, and specific paper-based microfluidic platform for fast multiplexed detections of

205 We developed a microfluidic platform for measuring electrical impedance

206 Here, we present a high-throughput microfluidic platform that enables the quantitative, sin

207 pithelium and vasculature, we introduce a 3D microfluidic platform that juxtaposes a human mammary du

208 Here, we developed a one-stop microfluidic platform to assemble and culture human cere

209 We develop a droplet microfluidic platform to increase the concentration of a

210 This microfluidic platform was used to investigate MB enhance

211 We recently developed a simple and robust microfluidic platform, DropMap, to measure simultaneousl

212 nterfaces between two immiscible fluids in a microfluidic platform, we discover that the system can a

213 ngle-cell precision could be achieved in the microfluidic platform, which could have clinical utility

214 erein we report the development of a droplet microfluidic platform, which enables high-throughput rea

215 portable, high-throughput and user-friendly microfluidic platform.

216 obilization and amperometric biosensing in a microfluidic platform.

217 Finally, we used a microfluidics platform to assess the timing of parkin re

218 ated a 3D-bioprinted perfused drug screening microfluidics platform.

219 The integration of SCADA substrates into microfluidic platforms will provide a practical tool tha

220 effective integration of THz spectroscopy in microfluidic platforms.

221 a-middle T virus or primary human IDC) in 3D microfluidic platforms.

222 py with a focus on its implementation within microfluidic platforms.

223 the design and performance of an integrated microfluidic probe (iMFP) for nano-DESI MSI.

224 High throughput microfluidic protocols in single cell RNA sequencing (sc

225 siloxane (PDMS), an elastomer widely used in microfluidic prototyping, but posing a number of challen

226 mmunication between single cells isolated by microfluidics provided evidence for only one Stochastic

227 Herein, we introduce a microfluidic redox-neutral electrochemistry (muRN-eChem)

228 Now, a microfluidic-regulated tandem process of supramolecular

229 We have developed a fully automated microfluidic RT-qPCR system for rapid quantitative detec

230 nsitive top-down platform by incorporating a microfluidic sample preparation system, termed nanoPOTS

231 In this study, we develop a microfluidic screening method as a useful tool in the pr

232 The microfluidic sensing device operates in the range of 0.1

233 ultiple sensing functions in one paper-based microfluidic sensing platform.

234 system that consists of a constriction-based microfluidic sensor with embedded electrodes that can de

235 hich allows this technology to also act as a microfluidic sequential ChIP-seq system.

236 ld-effect transistor (EGOFET) with a 6.5 muL microfluidics set up capable to provide an assessment of

237 vidual single cells; a glass capillary-based microfluidic setup is used to extract each desired singl

238 dwich immunoassays on microtiter plates, our microfluidic setup offers a 25-50-fold reduction of samp

239 cent assay in real time (BART), with droplet microfluidics, should enable high-throughput, low copy,

240 r (CMOS) compatible thin film waveguides and microfluidics shows great promise toward highly integrat

241 The large-scale microfluidic single-bead trapping permits massively mult

242 In this research we explore the use of microfluidic single-cell impedance spectroscopy in the f

243 devices based on biochemical extraction and microfluidic solutions typically require high concentrat

244 present a new channel design for an inertial microfluidic sorting device by embedding microsquares to

245 ain-wide calcium imaging in combination with microfluidic stimulation to map out, at cellular resolut

246 Using a time-delayed microfluidic strategy fabricated on paper, an automated

247 The microfluidic strategy presented here answers this challe

248 c membrane, we developed an oil-free passive microfluidic system (OFPMS) that consists of alternating

249 Our proposed microfluidic system can enumerate micron-sized spheres i

250 We describe a microfluidic system for high-throughput sorting of nanol

251 In addition, we designed a microfluidic system to recapitulate the shear rate condi

252 g photochemical injury in an endothelialized microfluidic system under flow.

253 the development of a disposable paper-based microfluidic system, which unlike its predecessors that

254 ccharomyces cerevisiae cells using a droplet microfluidic system: droplets containing single cells ar

255 chromatographic and electrophoretic systems, microfluidic systems (classical and nonclassical), custo

256 ng PLGA particle sizes produced by different microfluidic systems either individually or jointly merg

257 f sorted or separated cells and particles in microfluidic systems flowing through multiple outlet cha

258 and specially merging the designed system by microfluidic systems for accelerating the analysis time.

259 Extraction methods for samples in microfluidic systems have been limited as this tool is d

260 Despite these advantages, microfluidic systems have yet to be extensively adopted

261 Here, we use microfluidic systems to probe the growth, chromosome cyc

262 While most microfluidic systems use the opening of additional parts

263 high shear rates (> 3,000 s(-1)) through two microfluidic systems with a stenotic section under const

264 m the excess fluorescent label in 3D printed microfluidic systems.

265 ion of particle sizes produced using various microfluidic systems.

266 atic islet structures in both microscale and microfluidic systems.

267 We use a droplet microfluidic technique developed in our lab, Sorting by

268 In the past five years, droplet microfluidic techniques have unlocked new opportunities

269 Using microfluidics techniques, we investigate the influence o

270 Microfluidic technologies are commonly used for the mani

271 Microfluidic technologies are frequently employed as poi

272 response monitoring, but even with advanced microfluidic technologies for rare cell detection the ve

273 Advances in microanalytical and microfluidic technologies have enabled rapid and amplifi

274 Microfluidic technologies offer new platforms for biosen

275 ch represents a continuing trend of adapting microfluidic technology and principles for developing th

276 Our microfluidic technology enabled highly reproducible prod

277 Microfluidic technology is an attractive tool for charac

278 strate microfluidic ChIPmentation (mu-CM), a microfluidic technology that enables profiling cell samp

279 Specifically, we apply state-of-the-art microfluidic technology to demonstrate a one-step immuno

280 ciple demonstration of the capability of our microfluidic technology to study time-resolved single-ce

281 igh-definition single-cell printing, a novel microfluidic technology, is presented here that can accu

282 d-Effect Transistor (EGOFET) integrated with microfluidics that allows for the detection of amounts o

283 extraction (SFNE), a method based on droplet microfluidics that allows multiple liquid-liquid extract

284 intercellular secretion heterogeneity using microfluidics, the challenges in operation of these syst

285 ort in conventional agitation systems and in microfluidics, the latter underpinning many new life sci

286 automated library preparation by centrifugal microfluidics thus offers attractive automation options

287 In this study, we combine microfluidics, time-lapse microscopy, and computational

288 Using microfluidics to control the application of shear, we ge

289 The approach used massively parallel microfluidics to generate libraries of natively paired,

290 ice (DMD), an air-free reaction chamber, and microfluidics to independently control monomer compositi

291 e compactness, high efficiency, and speed of microfluidics to synthesize short-lived radiolabeled com

292 chnologies, and emphasizes opportunities for microfluidic tools to facilitate translation of epigenet

293 This enabled optical access, while microfluidic trapping allowed for online analysis of ind

294 gy for quantitative nucleic acid analysis on microfluidics using a thermometer, which brings fresh in

295 Accordingly, here, a programmable epidermal microfluidic valving system is devised, which is capable

296 Here, by combining paper-based microfluidics with acoustics, we present a rapid and pow

297 Here, we combined microfluidics with single-cell live imaging to monitor S

298 that is readily implemented in standard and microfluidic workflows.

299 The combination of 3D cultures and microfluidics would allow for the production of a dynami

300 The glass microfluidic Y-system with planar immunocapture channel