ライフサイエンスコーパス: microgel

1 nanoparticle-inside-microgel system (Nano-in-Microgel).

2 ydrogen bonding leading to reassembly of the microgel.

3 then added, resulting in "core/double-shell" microgels.

4 rticles are co-assembled with the responsive microgels.

5 d-capped polyacrylamide/gold composite Janus microgels.

6 ion for polyphenols encapsulated in alginate microgels.

7 esulting in the asymmetric morphology of the microgels.

8 domain-tagged target protein in the spidroin microgels.

9 ne-step generation and collection of gelatin microgels.

10 with two different types of thermoresponsive microgels.

11 an a deep penetration of the enzyme into the microgels.

12 hich exclusively form in the presence of the microgels.

13 brication for both uniform and pore-gradient microgels.

14 dly classified by particle size as nanogels, microgels, aerogels, and macrogels.

15 The sequential reconfiguration of the microgels affects the velocity and shape of the active t

16 inner phase to produce spheroid-encapsulated microgels after spheroid formation.

17 njugation and emission confinement on single microgels allow for ultrasensitive miRNA detection.

18 The ultralow cross-linking of the microgels allows the particles to undergo large shape ch

19 The antifouling properties of the microgels also permit the direct measurement of miRNAs i

20 assembling molecules, cells, spheroids, and microgels and achieving bottom-up tissue engineering.

21 endent interaction was confirmed between the microgels and charged bioactives and this binding was im

22 unctions of both osteogenic and vasculogenic microgels and enhanced one another.

23 odel for the pH-dependent association of the microgels and further bioactives (including cationic and

24 marmoset pluripotent stem cells into agarose microgels and identified culture conditions for the deve

25 Protein microgels and in particular silk-based microcapsules hav

26 the interfacial assembly of thermoresponsive microgels and lipogels at the surface of giant unilamell

27 No translocation of the microgels and lipogels through the membrane was observed

28 Overall, the novel protein microgels and the conjugate developed in this study have

29 polymeric rings, single-chain nanoparticles, microgels, and many-arm stars display complex dynamic be

30 here to real data from colloidal particles, microgels, and polymer solutions.

31 switched to coalescence by neutralizing the microgels, and the emulsion can be broken on demand.

32 as a molecular-scale probe of nanostructured microgels are also discussed.

33 Microgels are colloidal polymer networks with high molar

34 The microgels are enzymatically degradable and had a high hy

35 The microgels are functionalized with DNA and become element

36 sed matter science and on applications where microgels are involved, ranging from materials to biomed

37 maintained over a three-day period, that the microgels are mechanically tractable, and that, for micr

38 Thermoresponsive microgels are one of the most investigated types of soft

39 Microgels are soft colloids that show responsive behavio

40 Porous polymer microgels are used as an immobilization matrix to improv

41 In summary, we have developed a tissue-like microgel array for evaluating stem cell differentiation

42 The developed microgel array platform consisted of various microgel en

43 Here, we have developed a new microgel array to address this grand challenge through r

44 Pore-gradient microgel arrays enable thousands of parallel high-resolu

45 robotic printing of complex stem cell-laden microgel arrays.

46 ng the surface fluorescence intensity of the microgels as a function of radius of curvature, the effe

47 We present novel microgels as a particle-based suspension array for direc

48 nally, the potential use of these asymmetric microgels as carriers of cargo molecules is showcased.

49 capabilities of these food-grade whey based microgels as matrices that enable the immobilisation of

50 We demonstrate polymer microgels as promising materials for controlling crystal

51 oids, polyelectrolyte networks, cross-linked microgels as well as block copolymer and dendrimer micel

52 Arrays containing both pNIPAm-co-AAc microgels (as an internal control) and biotinylated pNIP

53 th MgSO(4) abruptly transitioning to a rigid microgel at 30% RH.

54 Soft prolate-shaped microgels at the air-water interface offer an ideal mode

55 ence of poly(N-isopropylacrylamide) (PNiPAm) microgels at the air/water interface.

56 ions, facilitating the sequential molding of microgels at two different temperatures.

57 A mixture of thermo-responsive microgels, Au-nanorods colloids and analyte solution is

58 detection limit of this microfluidic porous microgel based assay was 0.9 pg/mL, with only 1+ hour of

59 f a thermoreversibly cross-linked biopolymer microgel based on protein, DNA, and peptide nucleic acid

60 therefore paves the way for employing these microgel-based aqueous lubricant formulations as a novel

61 lacrylamide)-co-acrylic acid (pNIPAm-co-AAc) microgel-based etalon and cause the microgel layer to co

62 Dual pH and temperature sensitive microgel-based etalons were fabricated by sandwiching a

63 These results demonstrate that microgel-based injectable hydrogels can be useful tools

64 The microgel/BChE films were built up on a surface of graphi

65 micrometer-sized poly(N-isopropylacrylamide) microgel beads are promising models for complex, heterog

66 nterpenetrating networks inside the embedded microgel beads depends on their cross-link density: wher

67 ility of dextran tracers inside the embedded microgel beads is hindered compared to those in free bea

68 We investigate the coupling of the microgel beads with the gel matrix and the formation of

69 tected with a shell composed of whey protein microgel/beet pectin complexes.

70 t at determining the pH at which the maximum microgel-bioactive interaction occurred.

71 constructs could be generated by assembling microgel building blocks and performing a secondary cros

72 oporous gel scaffold assembled from annealed microgel building blocks whose chemical and physical pro

73 ion can be quantified in terms of the single-microgel bulk modulus, which thus emerges as the correct

74 increases the proportion of cell-containing microgels by a factor of ten, with encapsulation efficie

75 Topographical analysis of dried microgels by atomic force microscopy verified that micro

76 tion of interpenetrating networks inside the microgels by confocal two-focus fluorescence correlation

77 0(4) EV particles/mL was achieved with these microgels by targeting EV proteins like CD63 and HER2, w

78 Microgels can accommodate compression in suspensions in

79 These multifunctional microgels can be administered minimally invasively and c

80 Suspensions of soft and highly deformable microgels can be concentrated far more than suspensions

81 For this purpose, sequentially patterned microgels can be used to spatially organize either livin

82 We show that the polymer microgels can improve polymorph selectivity significantl

83 elucidate how the interaction of force with microgels can lead to the activation of latent functiona

84 In this paper, we fabricate functional microgel capsules that consist of two miscible yet disti

85 On further polymerization, microgel clusters transition to microspheroids that rese

86 LC-solid interface and further assemble into microgel clusters whose orientation is guided by the LC

87 Only microgels co-encapsulating both KGM60 and quercetin enha

88 Alginate microgels co-encapsulating degraded Konjac glucomannan (

89 Microgels co-encapsulating KGM60 and quercetin increased

90 tate-of-the-art simulations to show that the microgel collapse does not happen in a homogeneous fashi

91 show that in segregated membranes, the soft microgel colloids form closely packed 2D crystals on the

92 Here, we report active microgel compartments (a-MC) containing urease capable o

93 the encapsulation of single cells in gelatin microgel compartments and their subsequent clonal cultiv

94 o urease) microgel compartments, the passive microgel compartments showed increasing orthogonal assem

95 y mixtures of active and passive (no urease) microgel compartments, the passive microgel compartments

96 verlayer to interact with negatively charged microgel confined between Au overlayers.

97 These microgels consist of a polystyrene core surrounded by a

98 Microcapsules and microgels consisting of macromolecular networks have rec

99 The osteogenic microgel containing chitosan, gelatin, and hydroxyapatit

100 opylacrylamide-co-acrylic acid) (pNIPAm-AAc) microgels containing mechanically and thermodynamically

101 On the other hand, the vasculogenic microgels containing only gelatin, enriched endothelial

102 ogels in a pH-dependent manner; for example, microgels containing ovalbumin release 80% of their enca

103 APCs that phagocytosed the acid-degradable microgels containing ovalbumin were capable of activatin

104 Combining the two types of microgels created a hybrid construct that sustained the

105 ts into a 3D culture medium made from packed microgels, creating a mechanically controlled environmen

106 Our combination of microgel culture, single-cell profiling and spatial iden

107 Microgel-cultured cells are encapsulated in individual m

108 a significant [Formula: see text]-dependent microgel deformation.

109 eloped an enzyme-responsive, nanoparticle-in-microgel delivery system.

110 NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, prol

111 ts suggest that control over the kinetics of microgel deswelling events can be accomplished simply by

112 The acid-degradable microgels developed in this article should therefore fin

113 ance between the Au surfaces mediated by the microgel diameter.

114 external energy input, surface tension, and microgel dimensions.

115 In this work, we investigate the drying of microgel dispersions in respect to two reference systems

116 thiocyanate, increased the deformability of microgels during drying.

117 cytes in vitro, as quantified by single cell microgel electrophoresis of nuclei ("cardiac comets") as

118 Conversely, the polymeric properties of the microgels enable them to spread and flatten at the liqui

119 ifferent transition temperatures for the two microgels enable three distinct dynamical states corresp

120 ed to trigger the drug release from alginate microgels encapsulated with drug-loaded poly(lactic-co-g

121 Microgels encapsulated with quercetin with or without KG

122 linsella levels were exclusively promoted by microgels encapsulating KGM60 with or without quercetin,

123 The ability of microgel encapsulation to sustain MSC survival and incre

124 ent paper by Murthy et al. demonstrates that microgels engineered on the nano-scale and designed to d

125 microgel array platform consisted of various microgel environments that where composed of native-like

126 nce the stability of DOC polymers and reduce microgel equilibrium sizes in concentration as low as 1

127 r to as topological hydrogels or topological microgels (examples including core-shell or Janus microb

128 lly, we use poly(ethylene glycol) diacrylate microgels, excellent reactant carriers, as an experiment

129 Recipients of SA-FasL microgels exhibited normal liver and kidney metabolic fu

130 The microgels fabricated demonstrated extended circulation i

131 The microgels feature a flexible molecular architecture, ant

132 porous hydrogel, made of crosslinked gelatin microgels, for the encapsulation and delivery of human m

133 Our experimental data suggests that the microgels form a corona around the microspheres and indu

134 The reduction of marine microgel formation induced by CB could lead to a decreas

135 Aggregation and microgel formation were relatively increased in the pres

136 to investigate the impact of CNPs on marine microgel formation, a critical shunt between DOC and par

137 the heat-induced formation of protein-based microgels from beta-lactoglobulin-pectin complexes were

138 ategy for generating asymmetric tubular-like microgels from reconstituted silk fibroin; a major compo

139 We report a proof-of-concept to construct microgels from the protein Bovine Serum Albumin (BSA) wi

140 However, in existing techniques, the microgel gelation is often achieved through harmful reac

141 nesis were up-regulated in the low-cell-dose microgel group, providing a mechanistic insight of pathw

142 his, flow curves of three complex fluids - a microgel (hand sanitizer), foam (Gillette), and biopolym

143 The resulting microgels have a highly porous internal structure and an

144 lacrylamide-co-acrylic acid) (pNIPAm-co-AAc) microgels have been synthesized via free-radical precipi

145 isopropylacrylamide (p-NIPAm) nanoparticles (microgels) have been synthesized by seed and feed precip

146 es are physically trapped in the thus formed microgel in the membrane.

147 albumin is released from the acid-degradable microgels in a pH-dependent manner; for example, microge

148 Recognition of the role of planktonic microgels in aquatic biofilm formation can have applied

149 and ecological roles of these polysaccharide microgels in aquatic systems were extensively investigat

150 n mainly relies on self-assembly of hydrogel microgels in combination with chemical gold film deposit

151 ting, accounts of the behavior of individual microgels in compressed suspensions.

152 NA (ssDNA) allows for forming protocells and microgels in multicomponent systems.

153 ross-linking is a key step for manufacturing microgels in numerous applications, including drug deliv

154 o evaluate the detection capabilities of the microgels in sandwich-assay formats that utilize both ap

155 this challenge through the use of core-shell microgel ink to decouple cell microenvironments from the

156 as a stimulus for promoted drug release from microgels integrated with drug-loaded polymeric nanopart

157 able of autonomously directing two different microgels into transient and self-regulating co-assembli

158 ncapsulating KGM60 and quercetin in alginate microgel is effective in modulating human gut microbiota

159 The gelation of these microgels is achieved via the nucleophilic Michael addit

160 at the radius of curvature of the asymmetric microgels is correlated to the wall shear stress.

161 The chemical design of these microgels is such that they degrade under the mildly aci

162 ed from 4-8mum, enzymatic degradation of the microgels is within 30min, and in vitro macrophage phago

163 plant proteins into physically cross-linked microgels, it is possible to improve their lubricity rem

164 ere fabricated by sandwiching a "monolithic" microgel layer between two semitransparent, Au layers.

165 -co-AAc) microgel-based etalon and cause the microgel layer to collapse.

166 The rapid cleavage of the microgels leads to phagosomal disruption through a collo

167 ny pairwise physical cross-links, leading to microgel-like aggregates.

168 In this article, an acid-sensitive microgel material is synthesized for the development of

169 NA lipid nanoparticle (LNP)-incorporated NHC microgel matrix, termed LiNx, by incorporating LNPs load

170 Here, we firstly explain microgel mechanical properties and how these are measure

171 properties of the beams and the surrounding microgel medium, we explore the mechanical behaviours ex

172 This underscores the pivotal role of microgel morphology and the forces they exert on liquid

173 Additionally, we show that microgel morphology could be controlled by varying the d

174 ical modelling reveal that these non-lipidic microgels not only decrease boundary friction by an orde

175 We demonstrate this behavior by embedding microgel NPs in agarose gels.

176 eloped a method to synthesize highly swollen microgels of precise size with near-neutral surface char

177 cus on the formulation of cell-encapsulating microgels of small "dimensionalities": "0D" (particles),

178 These plant protein microgels offer a much-needed platform to design the nex

179 olymeric nanospheres, orientation-controlled microgels, or microspheroids via single-step polymerizat

180 formed using pea protein isolate (PPI), PPI microgel particles (PPIMP), a mixture of PPIMP and sodiu

181 cately tied to the nature of the stabilizing microgel particles - whether they are more polymeric or

182 Microgel particles and capsules which consist of multipl

183 Microgel particles capable of bulk degradation have been

184 mulated by functionalizing highly deformable microgel particles composed of ultralow cross-linked pol

185 imulated poration electrically in individual microgel particles immobilized and manipulated with a mi

186 c volume phase transition temperature of the microgel particles results in a reversible melting of th

187 lopment that emphasizes the critical role of microgel particles such as TEPs and protobiofilm in faci

188 iruses as model rod-like colloids and pnipam microgel particles to induce thermo-sensitive depletion

189 e synthesized by combining highly deformable microgel particles with molecular-recognition motifs ide

190 e genaration of biofunctionalized, synthetic microgel particles with precise control over particle si

191 Ovalbumin was encapsulated in microgel particles, 200-500 nm in diameter, prepared by

192 the properties of the lipid membrane and the microgel particles, it is possible to control the adsorp

193 radial phase coexistence that exists in the microgel particles, which arises from a similarly radial

194 ctions to fabricate monodisperse, cell-laden microgel particles.

195 t properties of emulsions stabilized by soft microgel particles.

196 is demonstrated in stimuli-responsive 100-nm microgel particles.

197 nsically correlated with the collapse of the microgel particles.

198 erapeutic efficacy at a low cell dose in the microgel platform is a promising clinical route that wou

199 r 96 h on a three-dimensional (3D) ECM-based microgel platform.

200 Marine microgels play an important role in regulating ocean bas

201 -(3-(N,N-dimethylamino)propylmethacrylamide) microgel (poly(NIPAM-co-DMAPMA), MG) for the gentle inco

202 Compounds prepared using the described microgel polymer supports were obtained in similar yield

203 Thus, a chemically functionalized microgel polymer was synthesized, and the utility of thi

204 A series of soluble microgel polymers have been synthesized using solution-p

205 The advantage of the microgel polymers produced was that they exhibited solut

206 Mixed microgel populations of varying stability provide a furt

207 We find that microgels predominantly change shape and mildly shrink a

208 ges and unique multiresponsivity achieved in microgels prepared via this approach illustrate the pote

209 We systematically vary the microgel properties through the use of PEG linkers with

210 Remarkably, irrespective of the single-microgel properties, and whether the suspension concentr

211 The colloidal properties of the microgels provide the foundation for the long-term stabi

212 oach for the directed assembly of cell-laden microgels provides a powerful and highly scalable approa

213 on of BChE within the dangling chains of the microgel rather than a deep penetration of the enzyme in

214 rine model, we also show that the osteogenic microgels regenerate bone in a critical-sized defect wit

215 A patented, microgel-reinforced hydrogel-based aqueous lubricant, pr

216 As the core of the microgel remains liquid but the shell has gelled, this a

217 Crucially, the core of the microgels remains liquid, while the surface has fully ag

218 avors the electron-transfer processes in the microgels resulting in the enhanced ECL emission.

219 In many scenarios either the microgel's mechanical properties or its interactions wit

220 Furthermore, microgels shared between two emulsion droplets in floccu

221 In addition, the nanoparticle-carrying microgels showed little uptake by macrophages, indicatin

222 tching on the battery, the thermo-responsive microgels shrink, which immobilizes the analyte and driv

223 At even higher packing fractions, microgels solely shrink.

224 Diameter-tunable microgel spheres are self-assembled into a buckled trian

225 al structures made from thermally responsive microgel spheres.

226 We demonstrate that shape-controlled microgels spontaneously assemble within multiphase react

227 This unusual feature of the microgel-stabilized emulsions offers fascinating opportu

228 ion of mouse embryonic stem cells in agarose microgels stabilizes the naive pluripotency network and

229 hich addresses the challenges in traditional microgel synthesis.

230 requirements by using a nanoparticle-inside-microgel system (Nano-in-Microgel).

231 We leveraged the microgel system to functionally interrogate the signalli

232 However, so far microgel systems have almost exclusively been studied in

233 rium concepts have not been implemented into microgel systems.

234 cturing using visible light and microfluidic microgel templating, facilitating numerous biomedical ap

235 mer particles (TEPs) are planktonic, organic microgels that are ubiquitous in aqueous environments.

236 (TGFbeta-1) and crosslinked hyaluronic acid microgels that drive formation of filament bundles, a hi

237 ompartmental striped, cylindrical, and cubic microgels that encapsulated fluorescent polymer microsph

238 Here, we report the CuS-enclosed microgels that not only help enrich EVs carrying specifi

239 constructs using chitosan and gelatin-based microgels that promote osteogenesis of human mesenchymal

240 tmentalizing microbial consortia in separate microgels, the collective bioprocessing capability of th

241 twork is created using ultralow cross-linked microgels, the colloidal suspension displays viscous beh

242 cular concentration surrounding cells in the microgels, the proangiogenic phenotype of hMSCs can be t

243 isopropylacrylamide hydrogel microparticles (microgels); these crystals display sharp Bragg diffracti

244 rophil elastase-responsive polymeric Nano-in-Microgel to show the versatility of the system in easily

245 The ability of cold-set whey protein microgels to function as pH-sensitive immobilisation mat

246 pproach to direct the assembly of cell-laden microgels to generate tissue constructs with tunable mic

247 islets and streptavidin (SA)-FasL-presenting microgels to the omentum under transient rapamycin monot

248 used micrometer-scale Matrigel beads, termed microgels, to culture individual murine superior cervica

249 loping a microfluidic workflow for producing microgels using visible light-driven photochemical cross

250 or the preparation of enzyme- or drug-loaded microgels via the in situ encapsulation, which also disp

251 ginate-arginine-glycine-aspartic acid (-RGD) microgel was demonstrated, with enhanced osteogenic diff

252 The complexation of BChE with the microgel was found to be safe and effective, as confirme

253 d counterion pressure with elasticity of the microgel, we show that there is a threshold value of a c

254 ated mixtures and associated sizes of formed microgels were increased with up to 75 mmol kg(-1) ionic

255 chemiluminescence of thermoresponsive redox microgels were investigated.

256 els by atomic force microscopy verified that microgels were smallest in the presence of sulphate salt

257 The softest microgels were tested at a low cell dose (5 x 10(4) cell

258 rnal control) and biotinylated pNIPAm-co-AAc microgels were then used to detect multivalent binding o

259 To achieve this structure, pNIPMAm microgels were used as templates in the synthesis of an

260 ons (VPTs) for poly(methacrylic acid) (PMAA) microgels, where the collapsed hydrophobic state can be

261 idely used poly(N-isopropylacrylamide)-based microgels, where the constituent monomers are neutral bu

262 results from the soft colloidal structure of microgel, which allows them to interpenetrate, deform, a

263 ved by surface-specific functionalization of microgels, which are jammed to form microporous hydrogel

264 characterize the internal structure of these microgels, which were found to have a fractal dimension

265 -DNA hybrid, resulting in dissolution of the microgel, while cooling restores the hydrogen bonding le

266 assembly of micron-scale cell aggregates and microgels will be described and discussed.

267 The small mesh size of the microgel with respect to the size of BChE results in a p

268 nker allows for swelling of the particles to microgels with a desired size and deformability.

269 , we demonstrate the construction of protein microgels with controllable and uniform dimensions.

270 vior of compressed suspensions consisting of microgels with different architectures at a variety of p

271 Thanks to simulations of microgels with different cross-linker concentrations, ch

272 Since the interaction of microgels with force is a multiscale and multidisciplina

273 in DHEA produced multiresponsive core/shell microgels with independent cores.

274 y of monomers and enables the fabrication of microgels with tunable chemical structures and variable

275 report the use of a novel material, polymer microgels with tunable microstructure, for controlling p

276 cell spheroids and hydrogel microparticles (microgels) with varied hydrolytic stability to fabricate

277 g in bulk conversion of liquid droplets into microgels within minutes to hours.

278 In contrast, animals receiving microgels without SA-FasL under the same rapamycin regim

279 d was developed for spontaneous synthesis of microgels without use of confined emulsion, additional i

280 rganic pool assembled faster and with higher microgel yields than at other latitudes.