ライフサイエンスコーパス: microgravity

1 round (normogravity) as compared underwater (microgravity).

2 ty, and gene expression was suppressed under microgravity.

3 d with limb muscles, which were unaltered in microgravity.

4 f fluctuations during transient diffusion in microgravity.

5 shape got rescued to normal one by applying microgravity.

6 ts to ameliorate some effects of exposure to microgravity.

7 mals spending nine days (from P15 to P24) in microgravity.

8 t, has emerged as a possible major impact of microgravity.

9 otein during cardiac adaptation in simulated microgravity.

10 ts were clustered in the subapical region in microgravity.

11 and matrix were measured after activation in microgravity.

12 How cells (might) sense microgravity.

13 reduced silencing (~28 times) of the EGFP in microgravity.

14 orientation of the FN matrix after 27.5 h in microgravity.

15 ease PDGF-BB showed significant responses in microgravity.

16 ctivated osteoblasts even during exposure to microgravity.

17 action data collected from crystals grown in microgravity.

18 n pulmonary function that occur in sustained microgravity.

19 rs from impairments resulting from simulated microgravity.

20 related to cephalad fluid shifts induced by microgravity.

21 ed proprioceptive input and motor control in microgravity.

22 ingression by S. typhimurium under simulated microgravity.

23 -based diagnostics have never been tested in microgravity.

24 be fully elucidated, genome-wide response to microgravity.

25 ed rest, the reference ground-based model of microgravity.

26 space mission or after exposure to simulated microgravity.

27 he mechanisms underlying wound healing under microgravity.

28 and muscle activity, for example bed rest or microgravity.

29 t in females, exposed to long-term simulated microgravity.

30 ow physical movement influences responses to microgravity.

31 on between cancer cells and host immunity in microgravity.

32 ity, and a decrease during the experience of microgravity.

33 vice to control the cell division process by microgravity.

34 hy of astronauts due to the circumstances of microgravity.

35 late the host stress responses under modeled microgravity.

36 uscle and bone mass during the 33 d spent in microgravity.

37 t animal and its symbiont use during modeled microgravity.

38 rnational Space Station for 21/22d or 37d in microgravity.

39 visual impairments in astronauts exposed to microgravity.

40 c reticulum were differentially modulated in microgravity.

41 e observed in the 3D culture under simulated microgravity.

42 microgravity (0 g), and hypergravity (1.8 g).

43 N mRNA synthesis is significantly reduced in microgravity (0-G) when compared to ground (GR) osteobla

44 easured by RT-qPCR, was also up-regulated in microgravity (+12.94, +2.98 and +16.85 fold respectively

45 4 +/- 2 mmHg) and ICP (supine, 17 +/- 2 vs. microgravity, 13 +/- 2 mmHg) were reduced in acute zero

46 oth in normogravity (13.7 5.3 s; n = 20) and microgravity (19.5 6.1 s; n = 20).

47 investigations of trap topologies unique to microgravity(4,5), atom-laser sources(6), few-body physi

48 central venous pressure (supine, 7 +/- 3 vs. microgravity, 4 +/- 2 mmHg) and ICP (supine, 17 +/- 2 vs

49 y (parabolic flight) and prolonged simulated microgravity (6 deg head-down tilt bedrest).

50 tions induced by thermophoretic diffusion in microgravity, a regime not accessible to analytical calc

51 istimulation, and (iii) in the stimulus-free microgravity aboard the Space Shuttle.

52 In addition, microgravity affects virulence, growth kinetics, and bio

53 By in situ observations of microgravity alloy solidification experiments onboard th

54 ntrast, kale showed the greatest response to microgravity alone, while Brussels sprouts responded the

55 signaling, the stress of simulated low-shear microgravity also caused a dysregulation of expression.

56 of this study were to identify if simulated microgravity alters intestinal epithelial barrier functi

57 Overall, microgravity alters specific pathways for optimal immuni

58 Exposure to microgravity alters the distribution of body fluids and

59 esults reported here indicate that simulated microgravity alters the expression of miRNAs and genes i

60 Microgravity alters the vestibular processing of head ti

61 Head down-tilt bed rest (HDBR) serves as a microgravity analog because it mimics the headward fluid

62 Microgravity and 3D culture can profoundly modulate cell

63 rmogravity followed by the I-GEL (90% during microgravity and 95% during normogravity).

64 indlimb unloading (HU) is an animal model of microgravity and bed rest.

65 rcadian timing of crews exposed to prolonged microgravity and confinement.

66 8 to 23.30 muM Fe(2+)/100 g dw), enhanced by microgravity and darkness conditions.

67 ycolysis pathways in osteocytes subjected to microgravity and discovered a set of mechanical sensitiv

68 is crucial to protecting human health under microgravity and elevated oxidative stress.

69 Spaceflight stressors - such as microgravity and galactic cosmic radiation - and other m

70 closing volume was approximately the same in microgravity and in normal gravity, emphasizing the impo

71 which can negatively impact skeletal health: microgravity and ionizing radiation.

72 LM and LT and was 100% both during simulated microgravity and normogravity followed by the I-GEL (90%

73 he bioleaching of REEs from basaltic rock in microgravity and simulated Mars and Earth gravities usin

74 The payload was designed to operate in microgravity and to withstand mechanical stress, such as

75 Exposure to microgravity and treatment with the soluble receptor eac

76 Microgravity and unloading are known to cause osteoclast

77 ht, quiescent osteoblasts were launched into microgravity and were then sera activated with and witho

78 All astronauts had previous exposure to microgravity and, thus, control data were not available

79 ing conditions in a submerged setting (pool, microgravity) and on ground (normogravity).

80 rful tool for on-site genetic diagnostics in microgravity, and can be further utilized for long-term

81 eton as an active site of rapid bone loss in microgravity, and indicate that this loss is not limited

82 h in experiments using vibrated grains under microgravity, and we describe novel predicted spatiotemp

83 t influence the iron metabolism responses to microgravity; and 2) iron metabolism parameters, especia

84 howed for the first time, a way to integrate microgravity as a physical signal within biochemical pro

85 rogravity responsive device, which integrate microgravity as a signal within biochemical and cellular

86 olutions to human space travel must consider microgravity as an important component.

87 covery points to a reduced CSF resorption in microgravity as the underlying cause.

88 ich simulates the headward fluid shifting in microgravity, as spaceflight analogues.

89 g centrifuged or ground controls, confirmed microgravity-associated apoptosis.

90 uous extravehicular activities or to monitor microgravity-associated changes in musculoskeletal anato

91 In adapting to acute plethora in microgravity, astronauts' red-cell mass falls too rapidl

92 The intervention consisted of time in microgravity at the ISS.

93 h suggest that exposure of healthy humans to microgravity augments arterial pressure and sympathetic

94 ouse islets cultured in stationary dishes or microgravity bioreactors were transplanted to streptozot

95 f amyloplasts per cell remained unchanged in microgravity but decreased on the clinostat, and (iii) t

96 oes not plateau during 12 weeks of simulated microgravity but is mitigated by concurrent exercise tra

97 at individual amyloplast volume increased in microgravity but remained constant in seedlings grown fo

98 hat pulmonary function is greatly altered in microgravity, but none of the changes observed so far wi

99 d trabecular bone surfaces also increased in microgravity by 170% (p = 0.004), indicating osteoclasti

100 enetic circuit in E.coli, which responded to microgravity by changing the expression of a target enha

101 urrent density improvements of up to 240% in microgravity by exploiting the magnetic polarization of

102 Cell growth was stimulated in microgravity by increasing serum concentration.

103 e To investigate the intracranial effects of microgravity by measuring combined changes in intracrani

104 cephalogram (EEG) arousals also decreased in microgravity (by 19%), and this decrease was almost enti

105 exposure to simulated spaceflight, combining microgravity (by hindlimb unloading) and radiation expos

106 w that scant test samples can be measured in microgravity, by a trained astronaut, using a miniature

107 e, a combination of 3D culture and simulated microgravity can be used to efficiently generate highly

108 a possible physiological explanation for how microgravity can cause symptoms similar to those seen in

109 bjective of this study was to investigate if microgravity can create deformations or movements of the

110 Also, microgravity can reduce brain activity and affect cerebr

111 Exposure to microgravity can result in a spectrum of intraorbital an

112 Microgravity can significantly alter cell behavior and f

113 These data support our conclusion that in microgravity cardiomyocytes attempt to maintain mitochon

114 Myofibril force measurements revealed that microgravity caused a 3-fold decrease in specific force

115 Microgravity combined with darkness caused 2-fold increa

116 Previous studies showed that microgravity compromises the human immune system and inc

117 Microgravity condition decreases immunogenicity and sign

118 s was changed significantly in the simulated microgravity condition including miR-150, miR-34a, miR-4

119 tionally, lycopene production using AF under microgravity conditions achieved levels comparable to th

120 Under microgravity conditions and at steady-state, non-equilib

121 fety issues unique to production of crops in microgravity conditions and suggest microgravity may dra

122 is work, we show that environments mimicking microgravity conditions can harness the size and shape o

123 ant (P < 0.05) suppression of 85 genes under microgravity conditions compared to normal gravity sampl

124 RNA-Seq analysis of squid exposed to modeled microgravity conditions exhibited extensive differential

125 Human bladder 5637 cells cultivated under microgravity conditions formed organoids that displayed

126 Additionally, stomatal dynamics under microgravity conditions need further elucidation.

127 The crystals were grown under microgravity conditions on Space Shuttle mission STS-67.

128 getables and human bacterial pathogens under microgravity conditions present in spaceflight are unkno

129 remedy these problems we cultured islets in microgravity conditions to improve their function and to

130 sharing and dominant strains under modelled microgravity conditions were determined by counting ligh

131 R2, ETS1, and c-REL was altered in simulated microgravity conditions.

132 NA (miRNA) and related genes under simulated microgravity conditions.

133 Beyond Earth, where microgravity, cosmic radiation, and oxidative stress acc

134 urnal reductions in intracranial pressure in microgravity creates a low but persistent pressure gradi

135 st 24 h of activation using both spaceflight microgravity culture and a ground-based model system tha

136 hibition of T cell proliferative response in microgravity culture is a result of alterations in signa

137 nvolvement was confirmed with a ground-based microgravity culture model.

138 lation of purified T cells with Bead-Leu4 in microgravity culture resulted in the engagement and inte

139 uble anti-CD3 (Leu4) in clinorotation and in microgravity culture shows a dramatic reduction in surfa

140 en T cells were stimulated with Bead-Leu4 in microgravity culture, they were able to partially expres

141 only partial expression of CD25 occurred in microgravity culture.

142 Cells from simulated microgravity cultures also had improved Ca(2+) transient

143 g improved metabolic maturation in simulated microgravity cultures compared with cultures under norma

144 Prolonged periods of simulated microgravity did not cause progressive elevations in ICP

145 Microgravity directs monocyte inflammatory parameters, a

146 Microgravity does not significantly alter the volume of

147 Exposure to microgravity during space flight and to simulated microg

148 The microgravity environment during space flight imposes num

149 demonstration of the advantages offered by a microgravity environment for cold-atom experiments and v

150 little is known regarding the effects of the microgravity environment of space flight upon the action

151 oncern for humans in space, where the unique microgravity environment poses challenges to the natural

152 re, a corresponding 24-hour average TLCPD in microgravity environment was simulated to be 6.7mmHg.

153 To simulate the microgravity environment, host squid and symbiosis-compe

154 did not occur while the animals were in the microgravity environment.

155 s an adaptation of the flight animals to the microgravity environment.

156 for subject and operator to facilitate US in microgravity environment.

157 of connective tissue might be impaired in a microgravity environment.

158 photosynthetic functions are affected by the microgravity environment.

159 ial barrier disruption upon removal from the microgravity environment.

160 known, particularly for the spaceflight (SF) microgravity environment.

161 controlled supply of precursors in simulated microgravity environments and the physical constraints i

162 Astronauts in microgravity experience multi-system deconditioning, imp

163 ed time under conditions of minimal gravity (microgravity) experience an array of biological alterati

164 ndividing human fibroblast cells in culture, microgravity experienced in space has little effect on g

165 Ground-based simulated microgravity experiments utilizing the NASA rotating-wal

166 ower in sponges from animals with 10 days of microgravity exposure (P<0.01, ANOVA) and further reduce

167 and results published earlier indicate that microgravity exposure augments sympathetic, and diminish

168 during early microgravity exposure, fell as microgravity exposure continued, and descended to prefli

169 during early microgravity exposure, rose as microgravity exposure continued, and drifted back to pre

170 nable to adequately replicate the changes in microgravity exposure highlighting the importance of spa

171 Microgravity exposure is associated with loss of muscle

172 le landing was degraded after a few weeks of microgravity exposure, and longer-term exposure has the

173 R intervals) rose significantly during early microgravity exposure, fell as microgravity exposure con

174 preflight levels: pressure fell during early microgravity exposure, rose as microgravity exposure con

175 on and identify changes, if any, provoked by microgravity exposure.

176 16-week-old female C57BL/6J mice (n = 8) to microgravity for 15-days on the STS-131 space shuttle mi

177 ture environment has also been used to model microgravity for ground-based studies regarding the impa

178 In microgravity grown sprouts, the 50 to 80 % increase in a

179 In comparison with static 1 x g, microgravity has been shown to alter global gene express

180 ased animal models simulating the effects of microgravity have shown that decrements in cerebral perf

181 Actual microgravity, however, has been shown to either increase

182 mune response was suppressed under simulated microgravity; however, there was an acceleration of bact

183 This Review focuses on the effects of microgravity, hypergravity and cosmic radiation.

184 ed to be addressed, including the effects of microgravity, hypergravity and space radiation on the ma

185 It is unclear, however, how microgravity impacts those cellular interactions between

186 y, we tested the hypothesis that exposure to microgravity impairs autonomic neural control of sympath

187 , and tested the hypothesis that exposure to microgravity impairs sympathetic as well as vagal barore

188 Simulated microgravity impairs vagal baroreceptor-cardiac reflex f

189 Following culture under simulated microgravity in a random positioning machine for 7 days,

190 , we found that these macrophages adapted to microgravity in an ultra-fast manner within seconds, aft

191 However, weak buoyancy effects and microgravity in avionics and numerous space systems oper

192 in spinal cord tissue from animals reared in microgravity in comparison with 1G-reared controls.

193 iron metabolism could differently respond to microgravity in females.

194 On the other hand, microgravity in ISS significantly induced the loss of bo

195 h either in the rotating condition to model microgravity in space or in the static condition as a co

196 res) or the experiments must be performed in microgravity in space(4-7).

197 ng cultured cells will sense the presence of microgravity in space.

198 Consistently, simulated microgravity increased mitochondrial respiration in 3D h

199 uts, including exposure to cosmic radiation, microgravity, increased gravity (hypergravity), psycholo

200 The surprisingly ultra-fast adaptation to microgravity indicates that mammalian macrophages are eq

201 In conclusion, simulated microgravity induced an underlying and sustained suscept

202 In a time course experiment microgravity-induced muscle loss on the ISS showed MuRF1

203 herefore, this study offers new evidence for microgravity-induced osteocytic osteolysis, and CDKN1a/p

204 Microgravity is associated with immunological dysfunctio

205 ts face a unique set of stressors, including microgravity, isolation, and confinement, as well as env

206 that while HDBR can simulate some aspects of microgravity, it may not serve as a model for all centra

207 in a clinostat to produce a vector-averaged microgravity-like environment.

208 eviously demonstrated that low-shear modeled microgravity (LSMMG) under optimized rotation suspension

209 transitions from a 1 g linear force field to microgravity (<1 g); however, it appears that the three-

210 logical perturbations in cardiac function in microgravity may be a consequence of alterations in mole

211 crops in microgravity conditions and suggest microgravity may dramatically reduce the ability of PGPR

212 The stress of microgravity may expose the most critical components of

213 rrelationships can occur as a consequence of microgravity-mediated perturbations in cellular architec

214 that bull sperm swim with higher velocity in microgravity (microG) than at 1 G.

215 ound-based studies of the effects of modeled microgravity (MMG) on cell-mediated immunity.

216 rica serovar Typhimurium grown under modeled microgravity (MMG) were more virulent and were recovered

217 the analogous immune suppression observed in microgravity, MMG, and aging, further investigation may

218 We also analyzed the effects of microgravity (mostly 0G) and artificial produced 1G in I

219 We previously showed that simulated microgravity (muXg) using the NASA developed rotary cell

220 Microgravity, obtained during parabolic flight aboard NA

221 Lack of immune response in microgravity occurs at the cellular level.

222 ve) cells of Zea mays seedlings grown in the microgravity of outer space allocate significantly less

223 Given that microgravity of space and SMG also compromise human immu

224 tested the hypothesis that adaptation to the microgravity of space impairs sympathetic neural respons

225 gravity during space flight and to simulated microgravity on Earth disrupts spermatogenesis and testi

226 However, the effects of microgravity on epithelial barrier function are poorly u

227 few studies have investigated the effects of microgravity on female reproduction, with findings of di

228 Some of the observed effects of microgravity on head and arm movement control appear to

229 Here we investigated the effect of simulated microgravity on hiPSC-CM maturation.

230 Despite the observed severe effects of microgravity on mammalian cells, many astronauts have co

231 otion; therefore, we examined the effects of microgravity on mouse shoulder muscles for the 15-d Spac

232 nature of their pathologies, the effects of microgravity on pathophysiology, and the alterations in

233 We have investigated the effects of microgravity on root nodule formation, with preliminary

234 ould yield new information on the effects of microgravity on the biological activities of various cla

235 the first to report the effects of simulated microgravity on the expression of miRNA and related gene

236 een conducted in space or by using simulated microgravity on the ground have focused on the growth or

237 In this study, we examine the impact of microgravity on the interactions between the squid Eupry

238 trast, MuRF1 KO mice subjected to 21 days of microgravity on the International Space Station (ISS) we

239 We examined the impact of simulated microgravity on the timeline of bacteria-induced develop

240 ture during flight, rather than an effect of microgravity on uropontin synthesis.

241 xamined the effects of a stressor, simulated microgravity, on beneficial bacteria behaviours when col

242 neonatal cardiomyocytes exposed to simulated microgravity or normal gravity.

243 or 2 weeks either in the absence of gravity (microgravity) or at 1G.

244 Microgravity, or an altered gravity environment differen

245 Removal of loading via microgravity, paralysis, or bed rest leads to rapid loss

246 al volume was unexpectedly reduced by 18% in microgravity, possibly because of uniform alveolar expan

247 erstand the unique environmental stress that microgravity presents to diverse cell types.

248 Continued loading in microgravity prevents atrophy, but masticatory muscles h

249 Intestinal cells grown in microgravity produce a three-dimensional tissue assembly

250 We confirmed experimentally that in microgravity protein synthesis was decreased while apopt

251 Microgravity provides unique, though experimentally chal

252 se interactions occur in a confined space in microgravity, providing ample opportunity for heavy micr

253 ut experienced presyncope after the mission, microgravity provoked major changes.

254 During space travel, exposure to microgravity, radiation, and stress alter human immunore

255 trast to prevailing theory, we observed that microgravity reduces central venous and intracranial pre

256 We tested the hypotheses that exposure to microgravity reduces sympathetic neural outflow and impa

257 pace medicine, incorporating past studies of microgravity-related conditions and their terrestrial co

258 Immune dysfunction due to microgravity remains a hurdle in the next step of human

259 host health and examining its resiliency in microgravity represents a new frontier for space biology

260 te that the environment created by simulated microgravity represents a novel environmental regulatory

261 The reduction in gravity, or microgravity, represents a novel environment that can di

262 During 6 months in microgravity, resorption was threefold higher than forma

263 acterized the first biochemical and cellular microgravity responsive device using an engineered genet

264 f space bioengineering is to create cellular microgravity responsive device, which integrate microgra

265 Microgravity results in headward fluid shifts, ventricul

266 imb suspension, a claimed surrogate model of microgravity, showed only marginal commonalities between

267 f Escherichia coli under low-shear simulated microgravity (SMG) conditions resulted in enhanced stres

268 culture system, which generates a simulated microgravity (SMG) environment, and then the cells were

269 Culture of the lymphoma cells in simulated microgravity (SMG), and not Static conditions, restored

270 were solely induced by space stressors (e.g. microgravity, space radiation) or in part explained by t

271 In this study, we explored the impact of microgravity stress on key elements of the NFkappaB inna

272 stem can be used for a variety of controlled microgravity studies of cartilage and other tissues.

273 terations of physical phenomena occurring in microgravity, such as bubble formation, surface wettabil

274 regulated in multiple cell types exposed to microgravity suggesting a common, yet to be fully elucid

275 cation of cTnI up-regulated during simulated microgravity suggests a potential role of the NH(2)-term

276 erating deltoid muscle was more sensitive to microgravity than the joint-stabilizing rotator cuff mus

277 ugh the fetal otolith organs are unloaded in microgravity, the fetus' semicircular canals receive hig

278 ntermeasures probably reduced the effects of microgravity, the results support the idea that ground-b

279 stigates the health effects of adaptation to microgravity: the nature of their pathologies, the effec

280 n the absence of the symbiont during modeled microgravity there was an enrichment of genes and pathwa

281 Following exposure to microgravity, there is a reduced ability of astronauts t

282 In microgravity, these mechanisms are altered, leading to f

283 g approaches for the muscles of the spine in microgravity, this study examined the effects of axial l

284 s reflect astronaut's movement adaptation to microgravity, this study highlights the importance of un

285 For the comparison of normogravity and microgravity, time to ventilation was shorter for all de

286 ages and the extended freefall of persistent microgravity to provide high-precision measurement capab

287 Exposure to microgravity (uG) during space flights produces a state

288 in late-osteoblast-to-osteocyte cells under microgravity (uG) have yet to be elucidated.

289 oy a slow-rotating 2-D clinostat to simulate microgravity upon in-vitro lettuce plants following a fo

290 erent airway management devices in simulated microgravity using a free-floating underwater scenario.

291 m cells and exposed the spheres to simulated microgravity using a random positioning machine for 3 da

292 cultured on microcarrier beads in simulated microgravity using a rotating wall vessel (RWV) for 18 d

293 catory and appendicular muscles responses to microgravity, using mice aboard the space shuttle Space

294 Microgravity was associated with a 55% reduction in the

295 ) exposed to short term (25 hours) simulated microgravity, we characterize altered genes and pathways

296 Instead amyloplasts in microgravity were grouped near the cell centers while th

297 In summary, muscle responses to microgravity were muscle-type specific, short-duration S

298 evels of galactic cosmic radiation (GCR) and microgravity which are associated with increased risk of

299 exposes astronauts to unique conditions like microgravity, which may affect brain function, though it

300 the deregulation of HfQ protein in E.coli in microgravity, which was translated through HfQ mediated