ライフサイエンスコーパス: microsatellite

1 ult from the expansion of a disease-specific microsatellite.

2 llite status was determined by genotyping of microsatellites.

3 enzyme impedes transcription across expanded microsatellites.

4 st to existing methods that rely on observed microsatellites.

5 pervised hidden Markov models to discovering microsatellites.

6 Microsatellites-a class of short tandem repeat-are estab

7 tation rate in protein-coding mononucleotide microsatellites, allowing a full cataloging of the true

8 CRCs exhibiting elevated microsatellite alterations at selected tetranucleotide r

9 While the microsatellite analyses did not identify significant gen

10 Microsatellite analyses indicate that this cancer phenot

11 ion was performed on all nests together with microsatellite analyses of different life stages found i

12 Based on microsatellite analyses three groups could be distinguis

13 Our data revealed that, contrary to the microsatellite analyses, the eruption was associated wit

14 H), comparative genomic hybridization (CGH), microsatellite analysis (MSA), multiplex ligation-depend

15 oid males were found in many UK nests, while microsatellite analysis showed that nests had low geneti

16 We analysed temporal stability at neutral microsatellite and adaptive MHC genetic variation over f

17 ations across a broad geographic range using microsatellite and mitochondrial DNA loci.

18 Both the microsatellite and SNP analyses identified patterns of g

19 ight into methodological differences between microsatellite and SNP markers including potential trade

20 Africa to Asia, by analyzing variation at 18 microsatellites and 9 DNA (1 mitochondrial and 8 nuclear

21 3 genetically diverse progeny by typing with microsatellites and 9230 single-nucleotide polymorphisms

22 Array length variants are common among microsatellites and affect gene expression; but, efforts

23 ection within an artificial population using microsatellites and allele-specific quantitative PCR.

24 are characterized by sequence alterations in microsatellites and can accumulate thousands of mutation

25 ng of major histocompatibility complex-borne microsatellites and HLA-DPB1 alleles using DNA obtained

26 ive-based functional trade-offs, we used DNA microsatellites and metabarcoding to quantify the diet,

27 , a method for simultaneously capturing both microsatellites and methylation-informative cytosines to

28 ifs along the neo-X, including expansions of microsatellites and transposable element (TE) insertions

29 Microsatellites are a tract of repetitive, short DNA mot

30 e to cells via loss-of-function mutations in microsatellites are called MSI target genes.

31 Clinically, genomic GGAA-microsatellites are highly variable and polymorphic.

32 1-FLI1 can induce target genes by using GGAA-microsatellites as enhancers.Here, we show that EWSR1-FL

33 eq-based estimates approached those based on microsatellites as more loci with more missing data were

34 emonstrate its utility: a mononucleotide (A) microsatellite at the BAT-26 locus and a dinucleotide (C

35 ip affect coalitionary dynamics, we combined microsatellite based genetic inferences with long-term g

36 (b)) over the hatchery production cycle with microsatellite-based parentage of natural, mass- and con

37 fusion) showed low affinity for smaller GGAA-microsatellites but instead significantly increased its

38 We detected high allelic diversity in microsatellites, but surprisingly poor geographical stru

39 We found higher F ST using microsatellites, but that RAD-Seq-based estimates approa

40 present the Comparative Analysis of Germline Microsatellites (CAGm): a database of germline microsate

41 We further coupled microsatellite capture with single-cell reduced represen

42 We cover methods that have been applied to microsatellite, common variant, targeted resequencing an

43 n patterns for mitochondrial DNA but not for microsatellites, compatible with the environmental heter

44 usually involves three steps: (1) obtaining microsatellite-containing sequences, (2) primer design,

45 We examined microsatellite data from a quarter of the total populati

46 We use a microsatellite data set to test hypotheses of population

47 of ribosomal genes and Hox paralogs and with microsatellite data, brings a closer look at results of

48 Based on microsatellite data, STRUCTURE analyses identified two (

49 PCR-capillary electrophoresis using nine microsatellites demonstrates the accuracy of the fingerp

50 ntal variation, geographic distribution, and microsatellite-derived host population structure and het

51 The ease of microsatellite development and ability to adapt markers

52 bility of cold-pressed hazelnut oil based on microsatellite DNA markers.

53 chinensis based on COI and EF-1a genes, and microsatellite DNA.

54 The database provides advanced searching for microsatellites embedded in genes and functional element

55 Myotonic dystrophy type 1 (DM1) is a CTG microsatellite expansion (CTG(exp)) disorder caused by e

56 translation is found in a growing number of microsatellite expansion diseases, but the mechanisms re

57 suggesting convergence of pathomechanisms in microsatellite expansion disorders and RBP proteinopathi

58 Microsatellite expansion disorders are pathologically ch

59 n is emerging as a driver of pathogenesis in microsatellite expansion disorders.

60 CNBP, the gene containing an intronic CCTG microsatellite expansion in DM type 2 (DM2), is coordina

61 is sequestered in nuclear RNA foci by C(C)UG microsatellite expansions in myotonic dystrophy (DM), is

62 captures local transmission, we genotyped 26 microsatellites from 106 samples collected from index (n

63 crosatellites (CAGm): a database of germline microsatellites from 2529 individuals in the 1000 genome

64 rom low-coverage next-generation sequencing, microsatellites from noninvasive samples) suffer from a

65 low-coverage next-generation sequencing and microsatellites from noninvasive samples.

66 Microsatellite gene flow from G. fortis into G. scandens

67 a population genetic analysis of 18 nuclear microsatellite genotypes from 402 samples and 565 mitoch

68 sex-biased dispersal was detected using the microsatellite genotypes.

69 hat were concordant with the distribution of microsatellite genotypes.

70 Microsatellite genotyping demonstrated a common founder

71 Microsatellite genotyping showed relatively high P. viva

72 We used microsatellite genotyping to assess genetic relatedness.

73 , understudied repetitive DNA regions called microsatellites have been identified as genetic risk mar

74 tumor programmed death-ligand 1 expression, microsatellite-high and/or mismatch repair deficient (MS

75 e the critical role of an EWS/FLI-bound GGAA-microsatellite in regulation of the NR0B1 gene as well a

76 at the BAT-26 locus and a dinucleotide (CA) microsatellite in the coding region of FGFRL1.

77 ed uniparental genetic markers and autosomal microsatellites in DNA samples from 114 cattle breeds di

78 iate need for an accurate tool for detecting microsatellites in newly sequenced genomes.

79 the introduction of linear amplification of microsatellites in order to reduce in vitro amplificatio

80 Simple tandem repeats, microsatellites in particular, have regulatory functions

81 ated from naturally occurring DSBs at (GAA)n microsatellites in Saccharomyces cerevisiae These data g

82 ify variations in the repeat content, beyond microsatellites, in proteomes and genomes directly from

83 Autosomal microsatellites indicate that Creoles occupy an intermed

84 These cancers exhibit hypermutability with microsatellite instability (MSI) and differ from microsa

85 Microsatellite instability (MSI) and mismatch-repair def

86 The relationship between microsatellite instability (MSI) and response to neoadju

87 clinical evidence showing that the degree of microsatellite instability (MSI) and resultant mutationa

88 Microsatellite instability (MSI) and/or mismatch repair

89 Tumors with microsatellite instability (MSI) are caused by a defecti

90 Mismatch repair (MMR) deficiency (MMRD) and microsatellite instability (MSI) are prognostic for surv

91 onger disease-free survival in patients with microsatellite instability (MSI) cancers, but no such co

92 Microsatellite instability (MSI) caused by mismatch repa

93 specific mutations in DDR genes and elevated microsatellite instability (MSI) levels support the impo

94 analysis identified a cancer cell-intrinsic microsatellite instability (MSI) signature, which was ef

95 ation series lack complete information about microsatellite instability (MSI) status and pathology as

96 Tumor mutation burden (TMB) and microsatellite instability (MSI) status were also assess

97 ynthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hype

98 s were analyzed for the presence of fusions, microsatellite instability (MSI), and RAS/BRAF mutations

99 rs underwent MMR immunohistochemistry (IHC), microsatellite instability (MSI), and targeted MLH1-meth

100 heterogeneous disease, with factors such as microsatellite instability (MSI), cancer subsite within

101 RC by major molecular pathological features: microsatellite instability (MSI), CpG island methylator

102 All the studies collected information on microsatellite instability (MSI), CpG island methylator

103 ding 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator

104 omarkers, including major mutational events, microsatellite instability (MSI), epigenetic features, p

105 d the cases of 32 NADC patients, focusing on microsatellite instability (MSI), genetic mutations, CpG

106 lly clinically relevant genotypes, including microsatellite instability (MSI), homologous recombinati

107 ociation with tumor mutational burden (TMB), microsatellite instability (MSI), programmed cell death

108 r mechanisms in colorectal cancer (CRC) with microsatellite instability (MSI), somatic mutations accu

109 roximately 15% of colorectal cancers exhibit microsatellite instability (MSI), which leads to accumul

110 ips, we queried dependencies in cancers with microsatellite instability (MSI), which results from def

111 was 63.6% (30.8% to 89.1%) in patients with microsatellite instability (MSI)-high tumors (n = 11) an

112 The high microsatellite instability (MSI-H) is frequently observe

113 al/family history of cancer or polyps, tumor microsatellite instability [MSI], mismatch repair [MMR]

114 e oncogene for human colorectal cancers with microsatellite instability and as a predictive indicator

115 reatment of patients whose tumours have high microsatellite instability and larotrectinib and entrect

116 with low BER/SSBR gene expression show high microsatellite instability and neoantigen production.

117 n a tissue-agnostic approach: pembrolizumab [microsatellite instability and tumor mutational burden (

118 given its normal role in protecting against microsatellite instability and while MLH3 does have an a

119 Tumor testing for microsatellite instability and/or mismatch repair-defici

120 predicts colon cancer molecular subtypes and microsatellite instability based on broad CNA scores and

121 Microsatellite instability determines whether patients w

122 herapy, and mismatch repair gene defects and microsatellite instability have been associated with res

123 dations for germline and somatic testing for microsatellite instability high/mismatch repair deficien

124 eover, although bulk analyses did not detect microsatellite instability in MMR-deficient gliomas, sin

125 ) CRIS-A: mucinous, glycolytic, enriched for microsatellite instability or KRAS mutations; (ii) CRIS-

126 etastatic endometrial cancer (unselected for microsatellite instability or PD-L1), had an Eastern Coo

127 several gene signatures representing HPV and microsatellite instability remained significant in multi

128 ignatures for radiosensitivity, hypoxia, and microsatellite instability revealed significant underlyi

129 MIRMMR predicts microsatellite instability status in cancer samples usin

130 Recruitment of patients with high microsatellite instability was capped at 5%.

131 Microsatellite instability was independently associated

132 efective DNA repair, chromosome instability, microsatellite instability, and alterations in the serra

133 ade, including high tumor mutational burden, microsatellite instability, and an apolipoprotein B mRNA

134 int inhibitors are used to treat tumors with microsatellite instability, and anti-angiogenic agents m

135 BRAF- and KRAS-mutation status, microsatellite instability, and CpG island methylator ph

136 mutations and molecular pathways, including microsatellite instability, epigenetics, microbiota, and

137 Microsatellite instability, MLH1 promoter hypermethylati

138 ns and inference of tumor mutational burden, microsatellite instability, mutational signatures and so

139 Except for tumor samples with microsatellite instability, RNAIndel robustly predicts 8

140 icrosatellite-stable tumors from tumors with microsatellite instability, thus potentially improving c

141 e (WRN) as a novel specific vulnerability of microsatellite instability-high (MSI-H) cancer cells.

142 hypermethylation status of MLH1 (MLH1ph) in microsatellite instability-high (MSI-H) colorectal carci

143 Microsatellite instability-high (MSI-H) tumors are chara

144 In patients with microsatellite instability-high (MSI-H) tumors, longer O

145 ell infiltration and increased glycolysis in microsatellite instability-high (MSI-H) tumors, suggesti

146 tivity of pembrolizumab in Hodgkin lymphoma, microsatellite instability-high tumours, and melanoma.

147 immunotherapy, mismatch-repair-proficient or microsatellite instability-low (pMMR-MSI-L) tumors have

148 t in tumours from multiple cancer types with microsatellite instability.

149 DNA repair genes that are further linked to microsatellite instability.

150 ivolumab) for the treatment of patients with microsatellite instability.

151 damage, increased mutability, and triggered microsatellite instability.

152 and multiplex polymerase chain reaction for microsatellite instability.

153 h has been associated with BRAF mutation and microsatellite instability.

154 sensitivity, HPV status, tumour hypoxia, and microsatellite instability.

155 ts those genetic alterations contributing to microsatellite instability.

156 of genes have been identified in tumors with microsatellite instability.

157 o upstream Wnt inhibitors in cancers without microsatellite instability.

158 ons and neoantigenic peptides as a result of microsatellite instability.

159 es such as the identification of tumors with microsatellite instability.

160 These tumors included both microsatellite instable (MSI) and stable (MSS) phenotype

161 An analysis of microsatellite instable (MSI) cell lines reveals the dys

162 iverse cohort of CRC specimens revealed that microsatellite instable (MSI) samples have a high indel

163 ibition, which improved CTL efficacy against microsatellite instable and microsatellite stable colon

164 tein convertase improves T-cell targeting of microsatellite instable and stable colorectal cancer.

165 responding to anti-PD1 antibody therapy, and microsatellite instable colorectal cancers.

166 This association is well established in microsatellite instable CRC.

167 tion of a successful cohort of patients with microsatellite instable tumours who received nivolumab (

168 d in cancers, most notably those enriched in microsatellite instable-high and KRAS-wild-type colorect

169 Furthermore two tumors were highly microsatellite-instable (MSI-high), in one case associat

170 Short tandem repeat (STR), or "microsatellite", is a tract of DNA in which a specific m

171 tive method for detecting somatic changes in microsatellite length was developed that allowed the par

172 icantly increased its affinity at sweet-spot microsatellite lengths.

173 trol region (n = 302) and for eleven nuclear microsatellite loci (n = 247).

174 Phylogenetic analysis on 12 microsatellite loci and 1715 combined CDSs from whole-ge

175 and Taiwan) were examined using nine nuclear microsatellite loci and three chloroplast microsatellite

176 c variation at the mitochondrial and nuclear microsatellite loci for 148 individuals, we identified t

177 were genetically characterized by a panel of microsatellite loci for P. falciparum (26) and P. vivax

178 uences, (2) primer design, and (3) screening microsatellite loci for polymorphism.

179 distribution of previous studies to identify microsatellite loci for white-tailed deer (Odocoileus vi

180 mapping methods have utilized highly mutable microsatellite loci found within the human genome.

181 Microsatellite loci have been used extensively over the

182 We conducted a genetic survey at 10 microsatellite loci of 482 coyotes originating from 11 e

183 d detection of polymorphic genetic markers - microsatellite loci or simple sequence repeats (SSRs) an

184 Analysis of six chloroplast microsatellite loci revealed no variation.

185 Multilocus genotypes from 7 microsatellite loci suggested that most populations (10

186 ar microsatellite loci and three chloroplast microsatellite loci to characterize molecular diversity

187 We used 12 microsatellite loci to genotype 582 individuals from eig

188 We used 12 highly polymorphic microsatellite loci to identify 50 individual jaguars.

189 Genetic differentiation in microsatellite loci was obvious among the five species.

190 We evaluated nuclear (microsatellite loci) and mitochondrial diversity across

191 istant basins in Chile were genotyped for 13 microsatellite loci, and allocated, through probabilisti

192 sequences (n = 1327) and nuclear markers (17 microsatellite loci, n = 222) from major wintering groun

193 a dataset of 268 individuals genotyped at 19 microsatellite loci, we analyzed genetic structure acros

194 Using nine polymorphic microsatellite loci, we genotyped M. cavernosa colonies

195 ross the United States and China using eight microsatellite loci, which are standard genetic markers

196 Historical studies used only a few microsatellite loci; therefore, our temporal comparisons

197 mposition of African tea based on 23 nuclear microsatellites loci (nSSRs) and three cpDNA intergenic

198 , Avpr1a and Oxtr each contain a polymorphic microsatellite locus located in their 5' regulatory regi

199 In total, 154,586 non-redundant enset microsatellite markers (EMM) were identified and 40 sele

200 screened hundreds of genomic- and EST-based microsatellite markers (SSRs) from previous de novo asse

201 By using microsatellite markers accompanied by the geometric morp

202 Colonies were genotyped using nine microsatellite markers and > 9,000 single nucleotide pol

203 major islands in the Andamans, developed new microsatellite markers and amplified mitochondrial marke

204 rasses were characterized genotypically with microsatellite markers and phenotypically for pathogenic

205 ate Bayesian computation (ABC) approach with microsatellite markers compared the scenarios with gene

206 ere assessed at two scales by genotyping ten microsatellite markers for 356 individual colonies.

207 and identified 157 high-quality, informative microsatellite markers in this oomycete.

208 Microsatellite markers provide evidence for largely tran

209 We use a set of microsatellite markers to characterise the origins of pa

210 We developed new microsatellite markers to genotype I. campana from two l

211 nalyses of the mitochondrial COI gene and 11 microsatellite markers to investigate both past demograp

212 Development of microsatellite markers usually involves three steps: (1)

213 Using microsatellite markers, we assessed historical gene flow

214 Using 15 microsatellite markers, we investigated genetic diversit

215 four main Chinese tea production areas using microsatellite markers, with one Japanese population als

216 d interpretation of genotyping results using microsatellite markers.

217 waii, USA, were genotyped (n = 600) using 12 microsatellite markers.

218 of gene flow and genetic structure using 12 microsatellite markers.

219 ions due to grafting were investigated using microsatellite markers.

220 as clonal and identical to their mother with microsatellite markers.

221 We show that errors in transcription of microsatellites (MS) and mis-splicing of exons create hi

222 Microsatellites (MSs) are tracts of variable-length repe

223 ases in clone frequencies for multiple loci, microsatellite mutation rates in wild-type and Msh2-defi

224 Here, we exploit this relationship to infer microsatellite mutation rates.

225 Microsatellite mutations involving the expansion of tri-

226 eatment hypermutated glioma cells identified microsatellite mutations.

227 ion of pedigrees is largely based on SNPs or microsatellites, obtained from genotyping arrays, whole

228 Indels in microsatellites of coding genes can result in the synthe

229 The analysis revealed 139 microsatellites, of which 71 were in the non-coding regi

230 This study employs 63 de novo developed microsatellite or SSR (Single Sequence Repeat) markers i

231 The properties of the consolidated 11 microsatellite panel suggest that they are applicable fo

232 We reviewed microsatellite panels from 58 previous or ongoing projec

233 The development of broadly-applicable, core microsatellite panels has the potential to improve repea

234 We used microsatellite paternity analysis and hand pollinations

235 three replicated assignments (e.g., PCRs for microsatellites) per genetic sample.

236 utationally pooling Saccharomyces cerevisiae microsatellite profiles, and on samples obtained by pool

237 Here we developed a population-level microsatellite profiling approach, SID (Saccharomyces ce

238 MtDNA-microsatellite profiling combined with relatedness and n

239 nt of the nuclear rhodopsin gene (RH1) and 9 microsatellite regions (SSRs) were amplified and analyse

240 eads to the accumulation of mutations within microsatellite regions.

241 herited human disorder that is caused by CTG microsatellite repeat expansions (MREs) in the 3' untran

242 The presence of microsatellite repeat expansions within genes is associa

243 e observations suggest that transcription of microsatellite repeat-containing RNAs is more sensitive

244 tumors is accumulation of variants targeting microsatellite repeats and the potential for high tumor

245 Transcription of expanded microsatellite repeats is associated with multiple human

246 temic disease caused by expanded CTG or CCTG microsatellite repeats.

247 Genetic tagging (19 microsatellites) revealed 18% of re-sampled individuals

248 tic analyses, based on mitochondrial DNA and microsatellites, revealed considerable genetic structure

249 ory region (the regulatory region-associated microsatellite, RRAM) that likely regulates gene express

250 specific DNA molecules covering the complete microsatellite sequence.

251 Microsatellite sequences have an enhanced susceptibility

252 EWS/FLI binds GGAA-microsatellite sequences in vivo and in vitro.

253 very two consecutive GGAA-repeats on shorter microsatellite sequences.

254 We identified 233 microsatellites (simple sequence repeats, SSRs) per Mbp

255 In addition, integration of SNP data and microsatellite (SSR) data resulted in a final map compri

256 and polymorphisms of nuclear and organellar microsatellites (SSRs) for most Juglans genomes have not

257 ts were available for 303 patients (283 with microsatellite stability or low MSI [median age, 62 year

258 ber gain of tyrosine kinases/KRAS genes, and microsatellite stability status.

259 ere classified according to their histology, microsatellite stability, Epstein-Barr virus status, and

260 r a low CpG island methylator phenotype, and microsatellite stability.

261 ively impairs the viability of MSI-H but not microsatellite stable (MSS) colorectal and endometrial c

262 c cancer, allowing the identification, among microsatellite stable (MSS) patients, of a subset of MSI

263 m 283 patients with CRC, comparing MSI-H and microsatellite stable (MSS) patients.

264 Finally, a combined analysis combining all microsatellite stable (MSS) samples demonstrated a clear

265 efficacy against microsatellite instable and microsatellite stable colon cancer cells.

266 ed biopsies of metastases from patients with microsatellite stable colorectal and pancreatic cancer.

267 hod, are an independent prognostic factor in microsatellite stable stage II CRC.

268 but no such correlations were found for the microsatellite stable subtype or late stage colorectal c

269 seven patients with objective responses had microsatellite stable tumors.

270 with colon cancer diagnosed at stage II and microsatellite stable, median age 67, 30% women) and rep

271 In advanced ACC that is microsatellite stable, pembrolizumab provided clinically

272 et dispensable in models of cancers that are microsatellite stable.

273 stage II, CRC tumors, 582 of them confirmed microsatellite stable.

274 n with colorectal cancer risk for cases with microsatellite stable/MSI-low, CIMP-negative, BRAF-wildt

275 osatellite instability (MSI) and differ from microsatellite-stable (MSS) colorectal cancers in both p

276 that would allow high-resolution mapping on microsatellite-stable cells or tissues with RETrace.

277 ems to be stronger than that between BMI and microsatellite-stable CRC.

278 a response against neoantigens expressed in microsatellite-stable gastrointestinal (GI) cancers, and

279 Microsatellite-stable metastatic colorectal cancer is ty

280 s of immune inflammation, such as those with microsatellite-stable metastatic colorectal cancer.

281 and 36.2% (26.5% to 46.7%) in patients with microsatellite-stable tumors (n = 94).

282 tern of MS indels can accurately distinguish microsatellite-stable tumors from tumors with microsatel

283 patients with MSI-H, MSI-indeterminate, and microsatellite-stable tumors, respectively ( P < .001).

284 s classified as MSI-H, MSI-indeterminate, or microsatellite-stable.

285 interaction P < .001 for interaction between microsatellite status and the two arms).

286 pair-deficiency was analyzed by checking the microsatellite status using the five different mononucle

287 Microsatellite status was determined by genotyping of mi

288 Cancer gene mutations (e.g., KRAS, TP53) and microsatellite status were also preserved in the respect

289 Tumors were evaluated for LOH1p/16q by microsatellite testing.

290 romote RNAPII-transcription at these GC-rich microsatellites: the DSIF complex and PAF1C.

291 ts distribution, using mitochondrial DNA and microsatellites to compare its patterns of genetic struc

292 that are known (UGT1A1*28) or likely (HMOX-1 microsatellites) to impact bilirubinemia.

293 I exon 2 and exon 3, and neutral diversity (microsatellites), to study the relative importance of se

294 sex from this study, the LG23 sex-associated microsatellite UNH898 and ARO172, and the recently isola

295 novelty of CAGm is the ability to aggregate microsatellite variation by population, ethnicity (super

296 orts to understand the role and diversity of microsatellite variation has been hampered by several ch

297 Using an existing panel of 15 microsatellites, we estimated allelic diversity in seagr

298 Twenty-six P. falciparum microsatellites were genotyped in 66% of confirmed cases

299 Microsatellites were used to genotype 440 individuals fr

300 progenitors - by binding to an intronic GGAA-microsatellite, which promotes EwS growth in vitro and i