ライフサイエンスコーパス: microsomal

1 ral, mutagenicity was higher with S9 hepatic microsomal activation.

2 g that 4-oxo-atRA formation is mediated by a microsomal alcohol dehydrogenase.

3 tentially, a better choice than caffeine for microsomal and cell studies due to its reported lack of

4 were investigated using human in vitro liver microsomal and cytosolic bioassays.

5 xhibited favorable in vitro ADME properties (microsomal and hepatocyte stability, MDCK permeability,

6 Preliminary human liver microsomal and in vivo rodent studies demonstrated that

7 reconstitution experiments showed that both microsomal and mitochondrial WT CYP2C8 efficiently catal

8 nthesized standards, we identified the major microsomal and plasma metabolites of 230 as products of

9 d had favorable ADME properties but had poor microsomal and plasma stability.

10 tabolites were detectable after gull and rat microsomal assay incubation with solutions 3 or 4, and s

11 lamino)phenyl)propanoates in a MCF-7 CYP26A1 microsomal assay is described.

12 tial metabolites of TBECH were identified in microsomal assays of both the TBECH mixture and beta-TBE

13 The microsomal assays revealed that C.sativa seeds have very

14 In vitro microsomal assays suggested that compounds (R)-1 and (S)

15 Through microsomal assays with ezetimibe and the transport inhib

16 cubation period of solution 1 in gull or rat microsomal assays, there was no significant (p > 0.05) d

17 entatus) and adult male Wister-Han rat liver microsomal assays.

18 e interactions between the soluble domain of microsomal b5 and the catalytic domain of the bifunction

19 In order to design a green microsomal bioreactor on suitably identified carbon elec

20 s probably due to the known accessibility of microsomal carboxylase to water, which reprotonates the

21 l structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P45

22 e brain/free plasma >/= 1 in rat and reduced microsomal clearance along with the ability to increase

23 cterium tuberculosis (Mtb), high mouse liver microsomal clearance, and low aqueous solubility.

24 GPR119 receptor with low unbound human liver microsomal clearance.

25 SRFR1 is localized in both a cytoplasmic microsomal compartment and in the nucleus.

26 that Mi-1.2 and SlSERK1 colocalize only in a microsomal complex.

27 o acid sequence diversity than their type A (microsomal) counterparts, as exemplified by the type B p

28 facilitate determination of the activity of microsomal CYP enzymes in a parallelized system at physi

29 Microsomal CYPs are anchored in the endoplasmic reticulu

30 first structure of full-length rabbit ferric microsomal cytb5 (16 kDa), incorporated in two different

31 Microsomal cytochrome b5 (cytb5) is a membrane-bound pro

32 se (POR) is essential for the functioning of microsomal cytochrome P450 (P450) monooxygenases and hem

33 om drug metabolism to steroidogenesis, human microsomal cytochrome P450 enzymes require the sequentia

34 yt b(5)) is one of the key components in the microsomal cytochrome P450 monooxygenase system.

35 CYPOR) is essential for electron donation to microsomal cytochrome P450-mediated monooxygenation in s

36 f multi-walled carbon-nanotubes (MWCNTs) and microsomal cytochrome P4501A2 (msCYP1A2) on a graphite s

37 ges in the structural studies of full-length microsomal cytochrome-P450 and cytochrome-b5 by solid-st

38 tb5 interaction epitope recognized by ferric microsomal cytP450 (56 kDa).

39 e by hmoDCs, and enhances their stability to microsomal degradation.

40 Twelve full-length genes coding for microsomal Delta12 fatty acid desaturases (FADs) from th

41 tional proteoliposomes, reconstituted from a microsomal detergent extract, lost their activity when m

42 ke accompanied by an increased resistance to microsomal digestion.

43 erved in the crystallographic dimers of some microsomal drug-metabolizing cytochromes P450.

44 , and their subsequent hydrolysis by sEH and microsomal EH.

45 Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that co

46 Analysis of brain microsomal enzymes shows that estrogen 4-hydroxylation i

47 The microsomal epoxide hydrolase (mEH) plays a significant r

48 at oxetanes are hydrolyzed to diols by human microsomal epoxide hydrolase (mEH).

49 Microsomal epoxide hydrolase (mEH, EPHX1) is a critical

50 ncreased among women AA for rs2234922 in the microsomal epoxide hydrolase gene, EPHX1 (OR = 1.77, 95%

51 However, rat microsomal ER provides a statistically significant, and

52 R was associated with increased levels of ER/microsomal (ER/M) associated alphaS monomers and aggrega

53 CYP3A4 inhibition, hERG inhibition, and rat microsomal extraction ratio (ER).

54 (2+)-dependent kinase (PhK), are elevated in microsomal extracts from MHS patients' muscle.

55 In microsomal extracts, mPGES-1 protein was barely detectab

56 t in both species; in a phylogenetic tree of microsomal FAD enzymes, FADX and FADY formed a unique cl

57 P450 (CYP)-specific bioactivity of the liver microsomal film on the catalytically superior, stable HP

58 ctroactive surface coverage and stability of microsomal films were greater on highly surface defectiv

59 A microsomal fraction containing recombinant LaPT1 prenyla

60 We also found that the TH microsomal fraction content decreases after inhibition o

61 radation was simulated in vitro by using the microsomal fraction of JAWS II cells, followed by liquid

62 specific prenyltransferase activity from the microsomal fraction of peanut hairy roots.

63 a cells, with decreased association with the microsomal fraction, whereas a phospho-mimic mutant, TH1

64 This microsomal fraction-derived resveratrol 4-dimethylallyl

65 Fluorescence imaging and microsomal fractionation studies revealed that SAUR63:GF

66 Metabolic stability is usually assessed in microsomal fractions and only the best compounds progres

67 of DGAT isoforms during seed development in microsomal fractions from two oilseed rape cultivars: ed

68 of all DGAT isoforms in oilseed rape in the microsomal fractions of yeast cells heterologously expre

69 more, in vitro assays of acyltransferases in microsomal fractions prepared from developing seeds of s

70 G6PT transport is the rate-limiting step in microsomal G6P metabolism, this may explain why the trea

71 ls for antioxidant enzymes (lactoperoxidase, microsomal glutathione S-transferase 2 and 3, glutathion

72 level is directly correlated to the level of microsomal GPAT enzymatic activity in seeds.

73 (4)S) and glutathione S-transferases (GSTs) [microsomal GST (mGST)2, mGST3, and GST-mu (GSTM)4] from

74 erfamily but is likely to be present also in microsomal GST-1 based on sequence similarity.

75 tro ADME profile, including plasma and mouse microsomal half-lives, aqueous solubility, cell permeabi

76 can be metabolically degraded, using a model microsomal in vitro assay (Wistar-Han rats liver microso

77 e concentrations increased over the 0-60 min microsomal incubation period.

78 Rat liver microsomal incubations from eight test compounds were an

79 Microsomal incubations using NADPH concentrations below

80 inhibitor was subjected to a series of liver microsomal incubations, which generated a number of meta

81 efflux, but it was rapidly cleared in liver microsomal incubations.

82 to 130% of the parent compound added to the microsomal incubations.

83 nd 5-136 were formed atropselectively in all microsomal incubations; however, the direction and exten

84 The participation of the microsomal isoform (CYB5A) in N-reduction could be exclu

85 Higher microsomal levels of 7-ethoxycoumarin-O-deethylase activ

86 Most derivatives strongly inhibited in vitro microsomal lipid and LDL peroxidation, exhibiting potent

87 by significant increases in small intestinal microsomal lovastatin-hydroxylase activity and systemic

88 tion is typically catalyzed by an LPAT2 from microsomal LPAT class A that has high specificity for C1

89 ntly increases VLDL lipidation in hepatocyte microsomal lumina, and also VLDL secretion into the plas

90 Rat liver microsomal lysoplasmalogenase was solubilized with octyl

91 It is unknown whether microsomal (m) prostaglandin (PG) E synthase (S)-1, a ta

92 Microsomal (m) prostaglandin (PG) E(2) synthase (S)-1 ca

93 dant in Arabidopsis tissues and present in a microsomal membrane fraction.

94 d mobilized Ca(2+) stored in sperm (and from microsomal membrane preparations).

95 nal domain located in the lumen of the rough microsomal membranes (topologically equivalent to the ex

96 Topology mapping in microsomal membranes also indicates that TM1 does not in

97 topologies of mouse Astn1 and Astn2 in rough microsomal membranes and found that Astn2 has a cleaved

98 sicle formation assays involve incubation of microsomal membranes and purified COPII proteins with nu

99 ption/translation systems in the presence of microsomal membranes and with detergent phase separation

100 logically relevant P450-P450 interactions in microsomal membranes continues to grow.

101 Microsomal membranes from immature peanut seeds were sol

102 pable of acylating monoacylglycerol from the microsomal membranes of developing peanut cotyledons.

103 NPC6 is associated with the chloroplasts and microsomal membranes, and hydrolyzes phosphatidylcholine

104 proteins Bik, Bim, Noxa, Bmf, and Puma into microsomal membranes.

105 ation of human CYP3A4, CYP3A5, and CYP2E1 in microsomal membranes.

106 f a light-emitting ruthenium metallopolymer, microsomal metabolic enzymes, and DNA to detect potentia

107 ethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable

108 following oral dosing at 4 x 30 mg/kg, with microsomal metabolic stability data suggesting that this

109 hat improved the human/rodent correlation in microsomal metabolic stability.

110 a selectivity window over cytotoxicity, and microsomal metabolic stability.

111 -TB while retaining low toxicity with higher microsomal, metabolic, and plasma stability.

112 ing low cytotoxicity, increased stability to microsomal metabolism, and also revealed striking enanti

113 nly limitation currently being their rate of microsomal metabolism.

114 Here, we identify the microsomal metabolite and describe synthesized analogues

115 on immunoblottings performed with cytosolic, microsomal, mitochondrial, and nuclear proteins from rat

116 Rates of microsomal NA bioactivation and the effects of an anti-C

117 largely controlled by the activities of the microsomal omega-6 and omega-3 fatty acid desaturases, F

118 Although some human microsomal P450 enzymes can instead accept the second el

119 e (CPR), the essential electron donor to all microsomal P450 enzymes, in either liver or intestine, l

120 ccurs throughout the cell, as expected for a microsomal P450, but CYP4G16 localizes to the periphery

121 c transplantation, PDE3A1 mRNA abundance and microsomal PDE3 enzyme activity were increased by 1.7-fo

122 methylesterification, coupled with decreased microsomal pectin methyltransferase activity.

123 ed cell-wall methylesterification levels and microsomal pectin methyltransferase activity.

124 versions were also localized to cytosol and microsomal pellets.

125 EP3 and microsomal PG synthase type 1 play a role in decreasing

126 ase, highlights the role of cyclooxygenase-2/microsomal PGE synthase 1/PGE2 signaling in hypertension

127 Microglial cyclooxygenase-2, microsomal PGE synthase, and PGE2 expression were increa

128 cytofluorescence, we detected both COX-2 and microsomal PGE synthase-1 (mPGES-1) but not COX-1 in the

129 Microsomal PGE synthase-1 (mPGES-1) is an inducible enzy

130 LPS exposure induced expression of microsomal PGE synthase-1 (mPGES-1), a key enzyme in PGE

131 ) production primarily through inhibition of microsomal PGE synthase-1 (mPGES-1), not COX-2.

132 d WT mice have increased levels of COX-2 and microsomal PGE synthase-1 (mPGES-1).

133 IL-6 coinduced Cox-2 and microsomal PGE synthase-1, and inhibited the expression

134 or-kappaB-dependent thromboxane synthase and microsomal PGE(2) synthase was down-regulated by seleniu

135 d the development of disease in mice lacking microsomal PGE(2) synthase-1 (mPGES1), which converts CO

136 nerated by dust mite priming of mice lacking microsomal PGE2 synthase (ptges(-/-) mice), shows a simi

137 landin E2 (PGE2) through inducible COX-2 and microsomal PGE2 synthase 1 (mPGES-1) (1).

138 s of prostaglandin E2 (PGE2)-forming enzymes microsomal PGE2 synthase 1 (mPGES1) and COX2.

139 The main source of inducible PGE2, microsomal PGE2 synthase-1 (mPGES-1), has emerged as an

140 We demonstrate that microsomal PGE2 synthase-1 null mice develop a remarkabl

141 because mice lacking the genes encoding the microsomal PGE2 synthase-1 or the EP2 receptor were prot

142 Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced incre

143 o 4 hrs; whereas the increased expression of microsomal PGES (mPGES)-1 and a myeloid cell transcripti

144 We found that microsomal PGES1 (mPGES1), mPGES2, and cytosolic PGES (c

145 Microsomal PGES1 may be a potential target to prevent or

146 amagnetic microparticles bearing recombinant microsomal phase I cytochrome P450 or phase II conjugati

147 This is explained by an increase in microsomal phospholipids containing polyunsaturated fatt

148 three parent compounds was dependent on the microsomal preparation used and followed the rank order

149 heptachlor epoxide differed depending on the microsomal preparation.

150 lically stable in both human and mouse liver microsomal preparations and has a plasma t(1/2) of 50 h

151 ation studies and analysis of nascent XyG in microsomal preparations demonstrated that this glycosylh

152 Microsomal preparations from leaves of these mutants sho

153 Microsomal preparations from Pichia cells expressing AtG

154 ere confirmed with in vitro assays utilizing microsomal preparations from yeast overexpressing the re

155 chiral and formed enantioselectively by all microsomal preparations investigated.

156 lites showed considerable differences across microsomal preparations obtained from different species.

157 in yeast and characterized biochemically in microsomal preparations of the cells.

158 oxidation of PCB 51 and PCB 102 by different microsomal preparations results in the formation of chir

159 t that functional abnormalities of the COX-2/microsomal prostaglandin (PG)E2 synthase-1 system may un

160 Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is

161 examined whether PPI treatment affects NOX5, microsomal prostaglandin E synthase (mPGES)-1 and induci

162 By contrast, deletion of microsomal prostaglandin E synthase 1 (mPGES-1) confers

163 Global deletion of microsomal prostaglandin E synthase 1 (mPGES-1) in mice

164 Microsomal prostaglandin E synthase 1 (mPGES-1) is a key

165 Microsomal prostaglandin E synthase 1 (mPGES-1) is an al

166 namely IL-1 type I receptor (IL-1RI), COX-2, microsomal prostaglandin E synthase 1 (mPGES-1), and EP

167 of the enzymes cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase 1 (mPGES-1).

168 A2 (cPLA(2)), cyclooxygenase 2 (COX-2), and microsomal prostaglandin E synthase 1 (mPGES1).

169 An x-ray study indicated that microsomal prostaglandin E synthase type 2 (mPGES2) is a

170 neuroblastoma tumors express high levels of microsomal prostaglandin E synthase-1 (mPGES-1) and elev

171 y consisting of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) by a yet

172 Microsomal prostaglandin E synthase-1 (mPGES-1) in myelo

173 more, injection of a virus vector expressing microsomal prostaglandin E synthase-1 (mPGES-1) into the

174 Microsomal prostaglandin E synthase-1 (mPGES-1) is a key

175 Microsomal prostaglandin E synthase-1 (mPGES-1) is a rat

176 vious studies in rats have demonstrated that microsomal prostaglandin E synthase-1 (mPGES-1) is induc

177 itions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an

178 e associated with altered PGE(2) metabolism, microsomal prostaglandin E synthase-1 (mPGES-1), prostag

179 he expression of cyclooxygenase 2 (COX2) and microsomal prostaglandin E synthase-1 (mPGES-1), which a

180 duces the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 and reduces 15-hyd

181 Inhibiting COX-2 or microsomal prostaglandin E synthase-1 suppressed the 6-O

182 e downstream of COX-1 that synthesizes PgE2 (microsomal prostaglandin E synthase-1) depends criticall

183 Cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1, key components of

184 RNAi knockdown of microsomal prostaglandin E synthase-1, the rate-limiting

185 Thus, we hypothesized that inhibiting microsomal prostaglandin E(2) (PGE2) synthase-1 (mPGES-1

186 Microsomal prostaglandin E(2) synthase-1 (mPGES-1), enco

187 Microsomal prostaglandin E2 synthase (mPGES)-1 is respon

188 Microsomal prostaglandin E2 synthase type 1 (mPGES-1) is

189 Dual inhibition of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-l

190 Microsomal prostaglandin E2 synthase-1 (mPGES-1) is know

191 crophages followed by sustained elevation in microsomal prostaglandin synthase 1 (mPGES-1) expression

192 d astrocytes, LPS strongly induced COX-2 and microsomal prostaglandin-E(2) (PGE(2)) synthase-1, media

193 o 96 pmol/mg protein in liver and intestinal microsomal protein digests.

194 eveloped protocol consumes only about 15 mug microsomal protein per assay.

195 level in human liver, kidney, and intestinal microsomal protein was determined by extrapolation from

196 Isolated microsomal proteins appeared to also be involved in the

197 Piperidine-derived analogues showing minimal microsomal reactive metabolite formation were discovered

198 The microsomal retinol dehydrogenase (RDH11) and cytosolic s

199 T2B protein levels in a panel of human liver microsomal samples (n = 62).

200 ere the real product ions of DRM detected in microsomal samples from IDA, SWATH, and MS(All) methods,

201 hree independent approaches: an experimental microsomal Sec61 translocon assay, a biophysical (spectr

202 not block the translocation of a full-length microsomal secretory protein and was cleaved as part of

203 vigera var. pulcherrima (CpuLPAT2a) encoding microsomal, seed-specific class A LPAT2s and a cDNA from

204 igera var. pulcherrima (CpuLPATB) encoding a microsomal, seed-specific LPAT from the bacterial-type c

205 ficity and saturated acyl-CoA selectivity of microsomal sn-1 acyltransferase(s) and reveal its partic

206 organelle clustering into a two-dimensional microsomal spread and 2) identification of TGN and post-

207 The log D values, plasma stabilities, and microsomal stabilities of selected compounds were found

208 he 18 compounds further assessed showed high microsomal stabilities, although in the acute infection

209 splayed low off-target activity (>500x), and microsomal stability (T(1/2) > 30 min).

210 suitable physiochemical characteristics and microsomal stability (t1/2 > 4 h for human and mouse) to

211 An empirical approach to improve the microsomal stability and CYP inhibition profile of lead

212 l)-3,5-dimethy lisoxazole (31) has excellent microsomal stability and good oral pharmacokinetics in r

213 xazepine 1, an EP2 antagonist possessing low microsomal stability and potent CYP3A4 inhibition.

214 od-stage growth with improved solubility and microsomal stability and reduced hERG binding.

215 This substitution also increased the microsomal stability and the free fraction of compounds

216 reover, JG-231, a JG-98 analog with improved microsomal stability effectively suppressed the xenograf

217 metabolism study of 4f showed its high human-microsomal stability in comparison with that of iso-CA-4

218 Compound 14 presented a good microsomal stability in mouse and human microsomes and p

219 Addressing P2X7 affinity and liver microsomal stability issues encountered with this templa

220 that further optimization of solubility and microsomal stability of the series could provide a stron

221 e basis of their improved blood, plasma, and microsomal stability profiles compared with the parent n

222 Microsomal stability studies demonstrated that 14 was mo

223 ere complemented with in vitro human and rat microsomal stability studies.

224 ibitor compound 3, a strategy to improve the microsomal stability was pursued resulting in the identi

225 ssessed desirable properties in terms of its microsomal stability, and CYP and hERG inhibition, along

226 for CCR1 over other CCR-family members, high microsomal stability, and good pharmacokinetics in mice.

227 lectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable.

228 aadamantane 22, which has a good solubility, microsomal stability, and selectivity for sEH, was selec

229 Structure-property relationships including microsomal stability, cell permeability, and in vivo pha

230 1 and 75 displayed excellent microsomal stability, intrinsic clearance, and hepatic e

231 several optimization cycles, we improved the microsomal stability, potency, and kinase selectivity.

232 e properties in vitro and in vivo, including microsomal stability, tolerated toxicity, and blood-brai

233 and TM90-C2B, as well as the improvement of microsomal stability.

234 the EP2 receptor and significantly improved microsomal stability.

235 o solubility and permeability, and excellent microsomal stability.

236 against W2 and TM90-C2B as well as improved microsomal stability.

237 feration, solubility, CYP450 inhibition, and microsomal stability.

238 ties, including high solubility and moderate microsomal stability.

239 ovement of both the water solubility and the microsomal stability.

240 istance, low cytotoxicity, and high in vitro microsomal stability.

241 boptimal physicochemical properties and poor microsomal stability.

242 ison and exhibit good solubility, metabolic (microsomal) stability, and promising cytotoxicity in thr

243 idant, anti-inflammatory, and anti-apoptotic microsomal stress protein, migrates to the nucleus in a

244 Mouse and human microsomal studies of analogue 2b show it to have excell

245 Moreover, microsomal studies showed convenient metabolic stability

246 pids that have been transferred to the ER by microsomal TG transfer protein (MTP), inducing ER stress

247 nt induction of the VLDL lipidation proteins microsomal TG transfer protein and transmembrane 6 super

248 Both lomitapide, a microsomal transfer protein inhibitor (MTPI), and mipome

249 In addition, we established a microsomal translation/translocation/O-mannosylation sys

250 ing or genetic or pharmacologic reduction in microsomal triglyceride transfer protein (MTP) activity,

251 hylomicron and HDL pathways are dependent on microsomal triglyceride transfer protein (MTP) and ATP-b

252 lesterol absorption pathways and the role of microsomal triglyceride transfer protein (MTP) and ATP-b

253 Using a microsomal triglyceride transfer protein (MTP) inhibitor

254 The use of microsomal triglyceride transfer protein (MTP) inhibitor

255 Microsomal triglyceride transfer protein (MTP) is a key

256 Microsomal triglyceride transfer protein (MTP) is a targ

257 Microsomal triglyceride transfer protein (MTP) is a uniq

258 Furthermore, these mice had higher microsomal triglyceride transfer protein (MTP) mRNA and

259 Microsomal triglyceride transfer protein (MTP) plays a k

260 Microsomal triglyceride transfer protein (MTP) plays an

261 Here we demonstrate that microsomal triglyceride transfer protein (MTP), a protei

262 We have shown previously that Clock, microsomal triglyceride transfer protein (MTP), and noct

263 n of IL-10, CD1d, and its critical regulator microsomal triglyceride transfer protein (MTP), as well

264 lipoproteins, a process that is dependent on microsomal triglyceride transfer protein (MTP), can cont

265 Microsomal triglyceride transfer protein (MTP), essentia

266 An intracellular chaperone, microsomal triglyceride transfer protein (MTP), is requi

267 Here, we investigated the role of microsomal triglyceride transfer protein (MTP), required

268 The microsomal triglyceride transfer protein (MTP), the prod

269 rough genetic or pharmacologic inhibition of microsomal triglyceride transfer protein (Mttp) causes h

270 Impaired expression of microsomal triglyceride transfer protein (MTTP) contribu

271 Microsomal triglyceride transfer protein (MTTP) is an en

272 etion of the abetalipoproteinemia (ABL) gene microsomal triglyceride transfer protein (Mttp-IKO), whi

273 Both microsomal triglyceride transfer protein and apolipoprot

274 and/or vit genes, the orthologs of mammalian microsomal triglyceride transfer protein and apolipoprot

275 ry-low-density lipoprotein (VLDL) synthesis (microsomal triglyceride transfer protein and apolipoprot

276 activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcr

277 ates transcription and activity of placental microsomal triglyceride transfer protein as well as expr

278 ol and mitigates atherosclerosis by reducing microsomal triglyceride transfer protein expression and

279 hibits triglyceride secretion and intestinal microsomal triglyceride transfer protein expression in v

280 ed lipoprotein production by down-regulating microsomal triglyceride transfer protein expression.

281 Lipid-lowering was induced by microsomal triglyceride transfer protein gene inactivati

282 reversed by conditional inactivation of the microsomal triglyceride transfer protein gene, were plac

283 Acyl-CoA:Cholesterol acyltransferase 1, and microsomal triglyceride transfer protein in the intestin

284 A microsomal triglyceride transfer protein inhibitor and a

285 med to assess the efficacy and safety of the microsomal triglyceride transfer protein inhibitor lomit

286 second-generation antisense oligonucleotide, microsomal triglyceride transfer protein inhibitors that

287 at physiological levels increased intestinal microsomal triglyceride transfer protein levels and acti

288 l mediates the transcriptional regulation of microsomal triglyceride transfer protein via hepatic nuc

289 /-) mice contain higher levels of intestinal microsomal triglyceride transfer protein, absorb more li

290 in part by transcriptional effects on apoB, microsomal triglyceride transfer protein, and lipogenic

291 ydrogenase 1A1, and catalase, as well as the microsomal triglyceride transfer protein, involved in re

292 Furthermore, we identified microsomal triglyceride transfer protein, which we show

293 ed cellular apoB stability via activation of microsomal triglyceride transfer protein.

294 posttranscriptional effects on the LDLR and microsomal triglyceride transfer protein.

295 was normalized by inactivating the gene for microsomal triglyceride transfer protein.

296 er conditional knockout of the gene encoding microsomal triglyceride transfer protein.

297 decreased expression of Mttp and its product microsomal triglyceride transfer protein.

298 acterized by pathognomonic anti-liver kidney microsomal type 1 (LKM-1) showing a remarkable antigen-s

299 Finally, we showed that microsomal vesicles isolated from mammalian cells contai

300 bited substrate-specific reductions in liver microsomal vitamin E-omega-hydroxylase activity ranging