ライフサイエンスコーパス: microvilli

1 refractoriness of its 30,000 sampling units (microvilli).

2 (with myelin loops) and at nodal gaps (with microvilli).

3 nd the membrane corrugation (microridges and microvilli).

4 mic F-actin deforms exocytosed membrane into microvilli.

5 d abnormal beating of cilia, blebbing of the microvilli.

6 d reduced body weight and shorten intestinal microvilli.

7 testinal enterocytes and efface brush border microvilli.

8 scaffolding protein NHERF-1 and PLCbeta2 in microvilli.

9 BL) promotes the growth of brush border (BB) microvilli.

10 is essential for localization to actin-based microvilli.

11 +)-dependent adhesion links between adjacent microvilli.

12 lls display a unique apical membrane lacking microvilli.

13 fusion, apical membrane blebs, and disrupted microvilli.

14 s kinetically coupled to the loss of surface microvilli.

15 in the stabilization of apical cargoes into microvilli.

16 lex, lacks the inherent ability to target to microvilli.

17 abdomere, consisting of tens of thousands of microvilli.

18 layer with tightly opposed cells and apical microvilli.

19 after ABCB1a translocates to the tips of the microvilli.

20 nclusions regarding their role in intestinal microvilli.

21 growth delay but surprisingly still develop microvilli.

22 ased 8.6-fold, probably due to the growth of microvilli.

23 ssociates with NHERF2 in opossum kidney cell microvilli.

24 a dramatic increase in the number of apical microvilli.

25 related to alterations in the number of RPE microvilli.

26 of harmonin became colocalized with Cdh23 in microvilli.

27 ng with decreased canalicular and sinusoidal microvilli.

28 eptive membrane derived either from cilia or microvilli.

29 h LPA exhibited enhanced mesothelial surface microvilli.

30 t is preceded by an elongation of RPE apical microvilli.

31 minal web and striking puncta at the tips of microvilli.

32 hat both are required for assembly of apical microvilli.

33 of kinetic Monte Carlo simulation within the microvilli.

34 bodies and disorganization of follicle cell microvilli.

35 by lateral bacterial binding to the sides of microvilli.

36 , enterocytes show large inclusions lined by microvilli.

37 e usually contacted on their shaft by oocyte microvilli.

38 esis to form specialized structures, such as microvilli.

39 ce for the role of cellular protrusions like microvilli.

40 inding protein) also bound preferentially to microvilli.

41 a membrane but instead is highly enriched on microvilli.

42 le in regions of the plasma membrane lacking microvilli.

43 osin-7b (MYO7B) links the tips of intestinal microvilli.

44 creased, largely due to increased binding to microvilli.

45 or (TCR) accumulation selectively stabilized microvilli.

46 in stereocilia and Myo7b/ANKS4B/Harmonin in microvilli.

47 unding sustentacular cells (SCs) with apical microvilli.

48 eton, and a reduction of focal adhesions and microvilli.

49 bsorptive surface of the tube into villi and microvilli.

50 n in epithelial cells at the basal region of microvilli, a localization unlikely to be involved in ac

51 Knockdown of EBP50 decreases the presence of microvilli, a phenotype that can be rescued by EBP50 re-

52 hotoreceptors and retinal pigment epithelium microvilli, a region critical for retinal function and h

53 t for deficits in apical absorption, loss of microvilli, aberrant junctions, and losses in transcellu

54 catch bonds generate responses in which some microvilli almost completely stop, while others move wit

55 YO5B-KD) in CaCo2-BBE cells elicited loss of microvilli, alterations in junctional claudins, and disr

56 ctin network with concomitant loss of apical microvilli, an increase in actin bundles at the basal su

57 e is enriched in apical markers and displays microvilli and a primary cilium; its lumenal space is ri

58 icles that are released from the tips of IEC microvilli and accumulate in the intestinal lumen.

59 he apical marker ezrin, and disrupted apical microvilli and basal infoldings are observed in mutant m

60 cells exhibited a significant loss of apical microvilli and basal infoldings, reduced retinal adhesio

61 inishment of RPE pigments, and retraction of microvilli and basal infoldings.

62 dling protein espin was targeted to CL4 cell microvilli and caused microvillar elongation, whereas es

63 The photoreceptors bear both microvilli and cilia and express proteins that are ortho

64 psin in eye photoreceptor cells bearing both microvilli and cilia in larva of the annelid Malacoceros

65 N2 KO enterocytes exhibit reduced numbers of microvilli and defects in the microvillar ultrastructure

66 ANX A13) localizes to the tips of intestinal microvilli and determined the crystal structure of the A

67 os depleted of Arp2/3 form apical actin-rich microvilli and electron-dense apical junctions.

68 y developed for functional imaging of kidney microvilli and enables detection of dynamic physiologica

69 L. rhamnosus treatment also increased microvilli and enterocyte lengths and decreased lipid dr

70 ecialized plasma membrane structures such as microvilli and filopodia.

71 d a complex surface topography with numerous microvilli and filopodia.

72 ctor of two the amount of membrane stored in microvilli and folds.

73 gest that ingression drives unfolding of the microvilli and incorporation of microvillar membrane int

74 calizes to the tips of adherent brush border microvilli and is essential for intermicrovillar adhesio

75 n-binding site, retains specific proteins in microvilli and is necessary for microvillar biogenesis.

76 Both kinases were enriched in microvilli and locally activated there.

77 Thus, CDHR2 functions to elongate microvilli and maximize their numbers on the apical surf

78 ane matches the excess membrane contained in microvilli and membrane folds, as determined using scann

79 These sensors include actin-based microvilli and microtubule-based cilia that extend from

80 and protected the structure of cell membrane microvilli and mitochondria after cold storage preservat

81 The strength of adhesion between RPE apical microvilli and photoreceptor outer segments also decline

82 are essential for the growth and function of microvilli and stereocilia.

83 well as the disappearance of ependymal cell microvilli and the development of periventricular edema.

84 apices of RPE cells, at the roots of the RPE microvilli, and at the base of RPE cells next to the Bru

85 ad (Caudiverbera caudiverbera) OSN cilia, SC microvilli, and glycolytic enzymes in rat cilia.

86 roducing P. timonensis resulted in elongated microvilli, and increased MUC3 and MUC4 expression.

87 E3), distribution of NHE3 at the base of the microvilli, and less abundant expression of Na(+)/Pi cot

88 rastructural changes, including reduction of microvilli, and marked increases in secretory vesicle fo

89 EBP50 is not necessary for mitotic cell microvilli, and PKC activation causes a rearrangement of

90 rich processes like filopodia, lamellipodia, microvilli, and stereocilia requires the coordinated act

91 pid bilayer that lead to contractions of the microvilli, and suggest that the resultant mechanical fo

92 plus the loss of apical cytoskeleton, apical microvilli, and the columnar epithelial shape of clone C

93 sence of junctional complexes/desmosomes and microvilli, and the production of membrane-associated mu

94 Ectopic expression of Cobl shortens apical microvilli, and this requires functional WH2 domains.

95 Microvilli are actin-based protrusions found on the surf

96 Because membranes of the furrow and microvilli are contiguous, we suggest that ingression dr

97 Apical microvilli are critical for the homeostasis of transport

98 in linkages between adjacent stereocilia and microvilli are essential for mechanotransduction and mai

99 ithelial tissues such as the kidney and gut, microvilli are length-matched and assembled into tightly

100 Microvilli are membrane extensions on the apical surface

101 cal events occurring in cilia, flagella, and microvilli are of fundamental importance for the functio

102 ce microscopy of glioma cells confirmed that microvilli are present.

103 Following each bump, individual microvilli are rendered briefly (~100-200 ms) refractory

104 rhabdomere structure is disorganized and the microvilli are short and occasionally unraveled.

105 In the absence of CDHR2, microvilli are significantly shorter, and exhibit disord

106 Actin-rich structures, like stereocilia and microvilli, are assembled with precise control of length

107 ules deposited in retinal pigment epithelium microvilli area and an abnormal response on electroretin

108 ss the lumen surface of the small intestinal microvilli as cuprous ion by Ctr1.

109 teractors confirmed by their localization to microvilli, as well as a significant class of proteins t

110 s, EBP50 is a critical factor that regulates microvilli assembly and whose activity is regulated by s

111 n vitro and in vivo rapidly depolarize their microvilli at the wound edge.

112 during morphogenesis of the rhabdomere, the microvilli-based photosensitive organelle of Drosophila

113 of the vertebrate photoreceptor cell and the microvilli-based rhabdomere of the invertebrate photorec

114 hat Cobl is localized to the basal region of microvilli both to participate in length regulation and

115 and stochastically adjusting availability of microvilli (bump production rate: sample rate), whereas

116 ins, suggesting they are all anchored in the microvilli but to different extents.

117 nositol 4,5-bisphosphate-binding protein) in microvilli, but only lactaderin-C2 expression reduced br

118 ASAP1 is recruited to the base of microvilli by binding the COBL domain through its SH3.

119 und that NM2C controls the length of growing microvilli by regulating actin turnover in a manner that

120 a accumulated at the tips of espin-elongated microvilli, by analogy to its location in stereocilia, w

121 ors, we show how adaptive sampling by 30,000 microvilli captures the temporal structure of natural co

122 0, but not E3KARP, shows rapid exchange from microvilli compared with its binding partners.

123 by the number of its photon sampling units (microvilli), constituting its light sensor (the rhabdome

124 rane by photoreceptor nuclei and Muller cell microvilli could minimize the light reflection.

125 We show that cell and microvilli deformation, and hydrodynamic drag contribute

126 vitro led to increased apoptosis and reduced microvilli density and length.

127 inal uterine epithelium, including increased microvilli density and maintenance of apical cell polari

128 in-binding protein villin drives both apical microvilli disassembly in vitro and in vivo and promotes

129 EBP50/NHERF1 in the formation of interphase microvilli, E3KARP S303D cannot.

130 r's light sensor, the rhabdomere, has 30,000 microvilli, each of which stochastically samples incomin

131 ining crypts, enterocytes build thousands of microvilli, each supported by a parallel bundle of actin

132 Brush border microvilli enable functions that are critical for epithe

133 hered midbody remnants dancing across apical microvilli, encountering the centrosome, and beckoning f

134 Microvilli establishment required interaction between RA

135 Strikingly, we found that individual microvilli exhibit persistent active motility, transloca

136 Microvilli exhibited high density of antigen-presenting

137 Single microvilli extend and retract in approximately 20 s, whi

138 e microdomains such as the neck of caveolae, microvilli/filopodia and intraluminal vesicles of multiv

139 orin, which was detected within the glioma's microvilli/filopodia, indicating these structures can re

140 Air-dried gliomas revealed nodes within the microvilli/filopodia.

141 ickening, interstitial fibrin deposition and microvilli flattening or disappearance on days 14, 21 an

142 EM revealed irregular stunting of microvilli, foci of indistinct tight junctions, and area

143 Functionally this resulted in reduced microvilli formation and impaired transendothelial migra

144 , PDZK1 can provide a function necessary for microvilli formation normally provided by EBP50.

145 emokines stimulate endothelial filopodia and microvilli formation, leading to their presentation to l

146 membrane as well as augment EBP50's role in microvilli formation.

147 e associated with CXCL8-stimulated filopodia/microvilli formation; these included tropomyosin, fascin

148 ming bundle is defined by the 'bare zone', a microvilli-free sub-region of apical membrane specified

149 In combination, these data show that microvilli function as vesicle-generating organelles, wh

150 For decades, enterocyte brush border microvilli have been viewed as passive cytoskeletal scaf

151 The parallel actin bundles that support microvilli have their pointed-end rootlets anchored in a

152 of molecules and a realistic distribution of microvilli heights was matched to the data, and the fits

153 ssion of WT MYO5B in MYO5B-KD cells restored microvilli; however, expression of MYO5B-P660L, a MVID-a

154 photon sampling units in the cell structure (microvilli), (ii) sample size (QB waveform), (iii) laten

155 image representations, with more and faster microvilli improving encoding.

156 To test the role of microvilli in bacterial adhesion and uptake, we develope

157 Myo7b is highly enriched at the tips of microvilli in both kidney and intestinal brush borders,

158 differentiated cells to apical membranes and microvilli in differentiated monolayers.

159 led a substantial increase in the density of microvilli in DIO mice.

160 ing in the morphogenesis of the brush border microvilli in epithelial cells remain unknown.

161 from the nucleus in low confluence cells to microvilli in high confluence cells, and this regulates

162 bserved ablation, blunting, or distortion of microvilli in infected epithelial cells.

163 involved in the assembly and maintenance of microvilli in polarized epithelial cells.

164 mined by the same technique, and toxin bound microvilli in posterior midgut.

165 ry of sectioned larvae, predominately to the microvilli in posterior midgut.

166 cells and is crucial for the maintenance of microvilli in such cells.

167 ressed on its own, this sequence targeted to microvilli in the absence of any direct interaction with

168 for molecules concentrated near the tips of microvilli in the case of L-selectin, and sequestered aw

169 , protein glycosylation, and organization of microvilli in the nodes of Ranvier of peripheral nerves.

170 The microvilli in the R8 rhabdom are not aligned in a unifor

171 vity and highlight the multifaceted roles of microvilli in the spatial distribution of membrane prote

172 folded plasma membrane, and multiple apical microvilli in the taste pore.

173 helial cells create tightly packed arrays of microvilli in their apical membrane, but the fate of the

174 KI mouse model, and in renal epithelial cell microvilli in vitro.

175 um had gross hyperplasia, crypt enlargement, microvilli inclusion, and abnormal epithelial permeabili

176 r, to the formation of kidney and intestinal microvilli, inner ear stereocilia, immune synapses, endo

177 mptive hair cells with numerous disorganized microvilli instead of ordered stereocilia.

178 sion complex (IMAC) to assemble their apical microvilli into an ordered brush border.

179 motor also redistributes along the length of microvilli, into compartments normally occupied by Myo1a

180 Thus, the domain-specific presence of microvilli is a dynamic process requiring a localized ki

181 our results suggest that Myo1a targeting to microvilli is driven by membrane binding potential that

182 their apical membrane, but the fate of these microvilli is relatively unknown when epithelial cell po

183 lls assemble, stabilize, and organize apical microvilli is still developing, investigations of the bi

184 ved in the anchorage of membrane proteins in microvilli, is also mislocalized.

185 rated the growth and increased the length of microvilli; it also led to a redistribution of F-actin f

186 The epithelium exhibited apical vacuoles, microvilli, junctional complexes, and linear basement me

187 environment using a tightly packed array of microvilli known as the brush border.

188 using a densely packed collection of apical microvilli known as the brush border.

189 he intestinal tract build an apical array of microvilli known as the brush border.

190 sporting epithelial cells generate arrays of microvilli, known as a brush border, to enhance function

191 ition, morphological changes in the gut wall microvilli layer were observed.

192 ons of Fas2 expression levels impact on both microvilli length and organization, which in turn dramat

193 tissues, Arp2/3 inhibition led to increased microvilli length on the surface of crypt, but not villu

194 uction, survival, larval growth and gut wall microvilli length were observed with low AC dose (0.5% s

195 ls, we observed a reduction of espin-induced microvilli length, pointing to a potent function of twin

196 uptake and increasing intestinal, villi, and microvilli lengths.

197 ial effectors, mediates antiphagocytosis and microvilli lesions by inhibiting myosin function.

198 SEM images show distinct shedding of microvilli-like features upon treatment with LPA.

199 sound through deflection of stereocilia, the microvilli-like projections that are arranged in rows of

200 It is formed by three rows of stiff microvilli-like protrusions of graduated heights, the sh

201 evealed that CXCL8-stimulated filopodial and microvilli-like protrusions that interacted with leukocy

202 sealed by cell-cell junctions and lined with microvilli-like protrusions.

203 hair bundles, the arrays of mechanosensitive microvilli-like stereocilia crowning the auditory hair c

204 than those in 2D cultures, and they develop microvilli-like structures on the cell membranes as seen

205 The microvilli-like structures on the surface of multicellul

206 interdigitated, actin- and Moesin-positive, microvilli-like structures wrapping the RCs.

207 P(2)-enriched apical membrane sac containing microvilli-like structures.

208 erent ionic conditions, we hypothesized that microvilli may augment the mucosal barrier by providing

209 Type I microvilli may be either restricted to the bottom of the

210 icles from microvillar tips, suggesting that microvilli may function as vesicle-generating organelles

211 These microvilli may play multiple roles in glioma biology, su

212 E-cadherin-dependent adhesion organizes the microvilli meshwork and ensures the proper attachment of

213 These brush layers, which consist mainly of microvilli, microridges and cilia, are important for int

214 intracellular vacuolar structures containing microvilli (microvillus inclusion bodies) in epithelial

215 zed intestinal epithelial cells with reduced microvilli ("microvillus-minus," or MVM) but retaining n

216 MVID can be diagnosed based on loss of microvilli, microvillus inclusions, and accumulation of

217 we characterize organization and dynamics of microvilli (MV) and a previously unappreciated actomyosi

218 sease is the loss (effacement) of absorptive microvilli (MV) from the surface of small intestinal ent

219 Within brush border microvilli, Myo1a carries out a number of critical funct

220 This includes severe diarrhea, loss of microvilli, occurrence of microvillus inclusions, and su

221 Moreover, at the same shear stress, microvilli of cells with higher cortical tension carried

222 syndecan-1 was expressed specifically on the microvilli of hepatocyte basal membranes, facing the spa

223 ing scaffolding proteins found in the apical microvilli of polarized epithelial cells.

224 n mammals, peropsin is present in the apical microvilli of retinal pigment epithelial (RPE) cells.

225 is expressed in zebrafish in both i) apical microvilli of the chemosensory cells of taste buds inclu

226 ot aligned in a uniform direction, while the microvilli of the main rhabdom show the typical crustace

227 TRP and TRPL, reside in the light-sensitive microvilli of the photoreceptor's rhabdomere.

228 Immunohistochemistry localized AgAPN2 to the microvilli of the posterior midgut.

229 microscopy to be surprisingly mobile in the microvilli of the renal proximal tubule OK cell line.

230 ssociated with calyceal processes, which are microvilli of unknown function surrounding the base of t

231 and PKC activation causes a rearrangement of microvilli on cells due to phosphorylation-dependent los

232 It has long been supposed that microvilli on T cells act as sensory organs to enable se

233 s an essential regulator of the structure of microvilli on the apical aspect of epithelial cells.

234 avascular taste sensation takes place at the microvilli on the apical side of taste cells after diffu

235 ow treadmilling of the actin core of nascent microvilli on the apical surface of epithelial cells und

236 o the formation of a brush border containing microvilli on the apical surface.

237 d preferential binding of PFO* and ALO-D4 to microvilli on the plasma membrane; lower amounts of bind

238 ncreasing formation and elongation of stable microvilli on the surface of cultured epithelial cells.

239 d AM with a cobblestone appearance, abundant microvilli on the surface, and wide connection with the

240 ch epithelial cells regulate the presence of microvilli on their apical surface are largely unknown.

241 ransporting epithelial cells build arrays of microvilli on their apical surface to increase membrane

242 tinal epithelial cells without effacement of microvilli or cup-and-pedestal formation.

243 These include abnormally tall and numerous microvilli or stereocilia, ungraded stereocilia bundles,

244 ing epithelial cells is crowded with nascent microvilli, persistent motility promotes collisions betw

245 known about how the concerted action of the microvilli population encodes light changes into neural

246 Stereocilia, the modified microvilli projecting from the apical surfaces of the se

247 The active motion of scanning microvilli provides a force-generating mechanism that is

248 zontally (R3, R4, R7) and vertically aligned microvilli (R1, R2, R5, R6).

249 of real-world intensity changes that reduce microvilli refractoriness, these performance gains are s

250 of this hypothesis, showing that enterocyte microvilli release unilamellar vesicles into the intesti

251 to bacterial surface charge, suggesting that microvilli resist binding of microbes by using electrost

252 U251 cells with microvilli resisted the cytolytic actions of different h

253 zed along the full length and to the base of microvilli, respectively.

254 ss to epithelial soma through densely packed microvilli rooted on the terminal web (TW) remains uncle

255 ture of cell morphology, e.g., filopodia and microvilli, serving a huge variety of functions.

256 n distinct cytoskeletal processes, including microvilli, stereocilia and filopodia.

257 evealed that hepatocyte apical membrane with microvilli substantially extended into the basolateral d

258 can selectively slow and stabilize scanning microvilli, suggesting a physical mechanism that may con

259 malous diffusion and fractal organization of microvilli survey the majority of opposing surfaces with

260 by cortical tension and considers leukocyte microvilli that deform viscoelastically and form viscous

261 des an elaborate example with tightly packed microvilli that function in nutrient absorption and host

262 ctin-supported membrane protrusions known as microvilli that increases the functional capacity of the

263 ed complex found at the tips of brush border microvilli that mediates adhesion between neighboring pr

264 The microvilli that penetrated 0.4-mum transwell chamber's p

265 ll is crowned by a hair bundle, a cluster of microvilli that pivot in response to sound vibrations, c

266 cells, TMC1 is gated by small deflections of microvilli that produce tension on extracellular tip-lin

267 ing feature is the brush border, an array of microvilli that serves to amplify apical membrane surfac

268 g an apical specialization: a dense array of microvilli that serves to increase membrane surface area

269 nfirmed an almost complete absence of apical microvilli, the appearance of microvillus inclusions, an

270 enrichment at the distal tips of enterocyte microvilli, the site of IMAC function, and is a direct b

271 targeted to the plasma membrane of CL4 cell microvilli, the topological equivalent of stereocilia.

272 f stereocilia and of subsequently regressing microvilli, thus contributing to the early hair bundle s

273 the lamellipod, L-selectin is distributed on microvilli tips along the top of the lamellipodium, wher

274 locally within the apical cortex cause their microvilli to become motile over the dorsal/apical surfa

275 Transporting epithelial cells build apical microvilli to increase membrane surface area and enhance

276 redistribution of Npt2a from proximal tubule microvilli to intracellular compartments and lysosomes a

277 T-cells use microvilli to search the surfaces of antigen-presenting

278 Prior work has shown that restriction of microvilli to the apical aspect of epithelial cells requ

279 regulatory process is necessary to restrict microvilli to the apical aspect of polarized epithelial

280 network forms a passage from the base of the microvilli to the rough endoplasmic reticulum.

281 ized enterocytes harboring actin-rich apical microvilli undergo extensive cell remodeling to drive in

282 inesis in Drosophila embryos, a reservoir of microvilli unfolds to fuel cleavage furrow ingression.

283 from these mice localized PSGL-1 normally in microvilli, uropods, and lipid rafts.

284 COBL localizes to the base of BB microvilli via a mechanism that requires its proline-ric

285 ejuni cells adhered to the tips of host cell microvilli via intimate flagellar contacts and by latera

286 ectin concentrated on the tips of deformable microvilli was cleaved by force exerted on the L-selecti

287 tical plasma membrane-cytoskeletal linker of microvilli, was required to restrict its function to the

288 Anti-adhesive Muc1 protein and microvilli were present on the luminal epithelium of PUG

289 microdomain surrounding AFD receptive ending microvilli, where it regulates K(+) and Cl(-) levels.

290 d EPS8 localize to the barbed ends of motile microvilli, where they control the kinetics and nature o

291 omplexes that localize to the distal tips of microvilli, where they drive physical interactions betwe

292 e formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a indu

293 on of Eps8L1a leads to the formation of long microvilli, whereas its overexpression has the opposite

294 channel 4 (CLIC4) is enriched at apical RPE microvilli, which are interdigitated with the photorecep

295 e in our studies of a scaffolding protein in microvilli, which forced us to reevaluate its contributi

296 id (<10 ms) acidification originating in the microvilli, which is eliminated in mutants of PLC, and t

297 l tract, individual cells build thousands of microvilli, which pack tightly to form the brush border.

298 repel microbes from epithelial cells bearing microvilli, while M cells are more susceptible to microb

299 ressed in epithelial cells induced a loss of microvilli with consequent enhanced microbial binding.

300 kdown cells showed disorganized brush border microvilli with decreases in villin expression.