ライフサイエンスコーパス: middle age

1 articipants each followed from birth through middle age.

2 1930s, a birth cohort with much lower BMI in middle age.

3 ddle age correlates to better LV function at middle age.

4 e were able to maintain cohorts of mice into middle age.

5 d and predictors of HF stage and symptoms in middle age.

6 n older adults may hold promise for those in middle age.

7 ies are particularly pronounced in young and middle age.

8 have an increased brain amyloid load at late middle age.

9 reduce the risk of incident hypertension in middle age.

10 ccelerates these effects in apoE4-TR mice at middle age.

11 ly determine cardiovascular disease (CVD) by middle age.

12 nces for the development of COPD and ACOS by middle age.

13 urse of functional impairment and decline in middle age.

14 strategy that could reduce deaths and CVD in middle age.

15 1930s, a birth cohort with much lower BMI in middle age.

16 uld occur in males, mostly in adolescence to middle age.

17 st detectable in white adipose depots during middle age.

18 s showing loss of one or more rhythms during middle-age.

19 preclinical Alzheimer's disease during late middle-age.

20 ition in the predominant causes of deaths in middle-age.

21 ain ~60-fold higher than at the start of the Middle Ages.

22 rope, helping to end antiquity and start the Middle Ages.

23 li (Southern Italy) occurred during the Late Middle Ages.

24 HuNox2Tg brains at middle age (11-12 months) already had high levels of ROS

25 nths) mice is, if anything, stronger than in middle-aged (12-14 months) mice.

26 re, randomised controlled trial in young and middle-aged (21-50 years), healthy non-obese (BMI 22.0-2

27 ogress has largely been negated in young and middle-aged (25-49 years) white individuals, and America

28 - 3%; Old: 15 +/- 2%; ACh: Young: 63 +/- 2%, Middle Aged: 34 +/- 3%; Old: 23 +/- 3%, P < 0.05).

29 t/obese (Body Mass Index [BMI] >= 28 kg/m2), middle-aged (35-65 years old) men.

30 Higher proportion of younger (34.9%) and middle-aged (36.2%) patients had multiple metastatic sit

31 age-related, reduction (Flow: Y: 65 +/- 3%; Middle Aged: 36 +/- 3%; Old: 15 +/- 2%; ACh: Young: 63 +

32 d over twofold among young (18-39 years) and middle-aged (40-59 years) adults during the study period

33 15 days to <2 months, or >=2 months) in the middle- (age, 40-59) and late adulthood (age, 60 or olde

34 is observational study was conducted in 5065 middle-aged (44-77 years old) UK Biobank participants wh

35 BMD reduction over a 8-year follow-up of 692 middle-aged (46.7+/-12.3 yrs), low-income BACH/Bone coho

36 Young (18-49 years) and middle-aged (50-64 years) patients were 2 to 8 times mor

37 n SMFAs from Young (27 +/- 2 years, n = 10), Middle Aged (54 +/- 2 years, n = 10) and Old (75 +/- 2 y

38 Participants were predominantly middle-age (64+/-11 years) women (97%).

39 Subjects were predominantly middle-aged (64+/-14 years) women (90%).

40 hrix jacchus) at two time points during late middle age (8 months apart, similar to a span of 5-6 yea

41 e report exacerbated myelin and axon loss in middle-aged (8-10 months of age) compared with young (6

42 ubregion-dependent tracer distribution in 17 middle aged (9-10 months) and 36 old (22-24 months) mice

43 Middle-aged (9-11 months) transgenic animals (both male

44 restored the vasodilatory response to flow (Middle Aged + Adropin: 59 +/- 3%; Old + Adropin: 47 +/-

45 Old + Adropin: 47 +/- 3%, P < 0.05) and ACh (Middle Aged + Adropin: 59 +/- 3%; Old + Adropin: 49 +/-

46 ptimal for infants; older children; young to middle-age adults (including pregnant women); and elderl

47 butor to the burden of ASCVD among young and middle-age adults, but meta-analyses of cohort studies s

48 en with overweight/obesity, young adults and middle-age adults.

49 lts (22.22 +/- 2.20 years, 33% males) and 73 middle-aged adults (53.62 +/- 5.18 years, 48% males).

50 A total of 480,940 middle-aged adults (median age of 58 years [range 38-73]

51 escents (n = 21; age = 14 +/- 2.1 years) and middle-aged adults (n = 22; age = 36.6 +/- 5 years) afte

52 wer risk of developing future diabetes among middle-aged adults after adjusting for body mass index (

53 ity in diabetes risk between black and white middle-aged adults after adjustment for biological, neig

54 dent disability could benefit from including middle-aged adults and adding NT-proBNP and IL-6 as inte

55 Similar reductions were found in children to middle-aged adults and in clinically relevant subgroups,

56 a hospitalizations in children and young and middle-aged adults did not vary substantially across low

57 This study included 11,715 middle-aged adults in the ARIC (Atherosclerosis Risk In

58 The proportion of cases in middle-aged adults increased steadily from 41% (55 of 13

59 ides, organ system diseases) among young and middle-aged adults of all racial groups, with an onset a

60 age of 20%), whereas estimates for young and middle-aged adults varied by country and were potentiall

61 inally, higher baseline amyloid burden among middle-aged adults was related to changes in vocabulary,

62 tial overuse of chemotherapy among young and middle-aged adults with colon cancer.

63 We tested 60 healthy middle-aged adults with varying doses of APOE4 - 20 APOE

64 ese previously sedentary, otherwise healthy, middle-aged adults, 2 years of high-intensity exercise t

65 hese previously sedentary, otherwise healthy middle-aged adults, a 2 year programme of high-intensity

66 fficient of Variation in children, young and middle-aged adults, respectively.

67 Among middle-aged adults, we observe a 13-kg gradient in weigh

68 h a low-dairy diet (LDD) on BP in overweight middle-aged adults.

69 nd electric remodeling in sedentary, healthy middle-aged adults.

70 ith a disproportionate increase in young and middle-aged adults.

71 oid dysfunction largely come from studies of middle-aged adults.

72 culties with daily functioning are common in middle-aged adults.

73 on muscle metabolism, mass, and function in middle-aged adults.

74 OPSCC) has been reported predominantly among middle-aged adults.

75 tive function in a community-based cohort of middle-aged adults.

76 s regarding the efficacy of GATT in young to middle-aged adults.

77 60 years while increasing at a lower rate in middle-aged adults.

78 ar lean mass (ALM) in a population of 85,750 middle-aged (aged 38-49 years) individuals from the UK B

79 d protein expression in the brains of young, middle aged, aged, and elderly male and female C57BL/6J

80 A decreasing BMI from early to middle age and a low BMI in middle age may be positively

81 We aimed to study the association of CAC in middle age and change in CAC from early adulthood to mid

82 ificantly accelerated in schizophrenia up to middle age and plateaued thereafter.

83 Obesity in the middle aged and elderly is associated with a reduction i

84 mposition and faecal metabolomic profiles in middle aged and elderly women.

85 Adropin incubation in the Middle Aged and Old SMFAs restored the vasodilatory resp

86 pression with adropin incubation only in the Middle Aged and Old SMFAs; (ii) eNOS blockade ablating b

87 mptomatic H1N1pdm infection, primarily among middle aged and older adult women (5-unit BMI increase O

88 or End-Stage Liver Disease score compared to middle aged and older adults (>=60 years).

89 For middle aged and older adults with obesity there was also

90 Studies in middle-age and older (masters) athletes with atheroscler

91 ween 1964 and 1973 when the individuals were middle-aged and 1996 and 2015 when participants were in

92 Twenty-six individuals (10 young, 9 middle-aged and 7 older individuals) participated in thi

93 rum bilirubin levels and incident T2D in the middle-aged and elderly adults; instead, direct bilirubi

94 iated with increased risk of incident CHD in middle-aged and elderly Chinese populations.

95 We analysed cross-sectional data from 10,837 middle-aged and elderly Chinese rural adults who complet

96 ip between smoking behaviours and BMI in the middle-aged and elderly Chinese rural population.

97 alth in a population-based cohort of healthy middle-aged and elderly men.

98 Free thyroxine levels in middle-aged and elderly subjects were positively associa

99 resonance (MR) images in community-dwelling middle-aged and elderly subjects without dementia and wi

100 ctric measure of sleep wake cycles in young, middle-aged and old CBA mice, a strain capable of melato

101 d younger adults (>=17 years), two recruited middle-aged and older adults (>=45 years), and two recru

102 In total, 231 middle-aged and older adults (167 women [72.3%] and 64 m

103 All participants were middle-aged and older adults (aged >/=55 years) who rece

104 Middle-aged and older adults (n = 116; 35 with a history

105 Among middle-aged and older adults in the United States, highe

106 n animals and a short-term clinical trial in middle-aged and older adults support the potential memor

107 OSA) is linked to increased glaucoma risk in middle-aged and older adults.

108 years compared with a dichotomous measure in middle-aged and older adults.

109 A reductase inhibitor (statin) therapy than middle-aged and older adults.

110 rden and cognitive decline was present among middle-aged and older adults.

111 verity of SDB in a community-based cohort of middle-aged and older adults.

112 ebo-controlled trial of pomegranate juice in middle-aged and older adults.

113 f pomegranate juice on memory in nondemented middle-aged and older adults.

114 ralizable to broader populations, especially middle-aged and older adults.

115 coronary atherosclerosis in athletes who are middle-aged and older and aims to contribute to the unde

116 poral trends in serum PFAS levels among 1257 middle-aged and older California women (ages 40-94) duri

117 IADL disability occurs frequently among middle-aged and older HIV-infected adults on effective a

118 These structural changes in a group of middle-aged and older individuals may represent adaptive

119 re associated with gray matter changes among middle-aged and older individuals.

120 e arterial stiffness in previously sedentary middle-aged and older men and postmenopausal women.

121 major stroke risk factor, blood pressure, in middle-aged and older men from eastern Finland and wheth

122 r disease (AD), and cognitive performance in middle-aged and older men from Eastern Finland.

123 t dementia and with cognitive performance in middle-aged and older men in the prospective, population

124 riathlon are not rare; most have occurred in middle-aged and older men.

125 d for the management of glycaemic control in middle-aged and older people with type 2 diabetes with e

126 s to the variation in the number of teeth in middle-aged and older populations using a population-bas

127 al study tested these hypotheses directly in middle-aged and older suicide attempters representative

128 Blacks have lower NP levels than middle-aged and older white adults.

129 Recruited were 328 middle-aged and older women from a community health cent

130 associated with increased hospital costs for middle-aged and older women in England across a broad ra

131 artery calcification, among athletes who are middle-aged and older.

132 d importantly affects tooth loss in both the middle-aged and the older populations.

133 "younger"), 35% were 55 to 65 years of age ("middle-aged"), and 24% were 66 to 75 years of age ("olde

134 s decline in fitness from young adulthood to middle age, and achieving increased fitness from young a

135 he beacon task is sensitive to impairment in middle age, and distinct gene profiles are observed in n

136 by a factor of 1.5 from the Neolithic to the Middle Ages, and increased again only during the Early M

137 erbils of either sex, divided between young, middle-aged, and old gerbils.

138 m four tissues and one cell type from young, middle-aged, and old mice-yielding 143 high-quality data

139 e was 1.4% for 18- to 49-year-olds, 1.0% for middle-aged, and only 0.4% for >= 60-year-old recipients

140 ge was 1.4% for 18 to 49 year olds, 1.0% for middle-aged, and only 0.4% for >=60-year-old recipients

141 nes correlated with beacon discrimination in middle-age animals.

142 r gp91phox revealed that the upregulation in middle-aged animals occurred primarily in microglia and

143 ng increased fitness from young adulthood to middle age are associated with less decline in lung heal

144 phy (LVH) and elevated cardiac biomarkers in middle age are at high risk for the development of heart

145 ctional impairment and decline are common in middle age, as are transitions from impairment to indepe

146 The substantial cognitive decline from middle age associated with having both smaller and large

147 cal relevance of coronary atherosclerosis in middle-aged athletes and describe strategies for the cli

148 cial disparity in diabetes incidence between middle-aged black and white individuals.

149 Higher BMI in middle age, BMI at age 18 years, and waist circumference

150 Herewith we report an unusual case of a middle-aged clinically and biochemically euthyroid woman

151 med multiplex cytokine analysis in a healthy middle-aged cohort with family history of AD (n = 68) an

152 ndialdehyde immunoreactivity in lesions from middle-aged compared with young mice.

153 Being free of CAC from young adulthood to middle age correlates to better LV function at middle ag

154 sponders (N = 97) of overweight non-diabetic middle-aged Danes to two earlier reported dietary trials

155 on Age Ingrian (500 BC-450 AD) (IngIA) and 7 Middle Age Estonian (1200-1600 AD) (EstMA) individuals t

156 Case Report: A middle-aged female patient presenting with a history of

157 We hereby report a case of a middle-aged female who was subsequently diagnosed with l

158 s identified by TPI, between three groups of middle-aged females matched for age: patients with depre

159 eater weight gain and glucose intolerance in middle-aged females than males.

160 t and a wider array of cognitive deficits in middle-aged females than males.

161 a correlated with spatial memory deficits in middle-aged females, but not males.

162 Here, the authors report that middle-aged flies have more elongated, or 'hyper-fused'

163 risk factors measured at study entry (i.e., middle age for most participants).

164 rtance of avoiding excess weight gain before middle age for preventing this highly fatal cancer.

165 rtance of avoiding excess weight gain before middle age for preventing this highly fatal cancer.

166 ors in a well-characterized cohort of 20,625 middle-aged French workers who were followed from the 19

167 The middle age group had higher ankle plantar flexor moment

168 Additionally, the middle age group had higher knee flexion angle at ground

169 ovelty seeking did not change markedly until middle age (> 3-6 years), then showed a steady linear de

170 Within the Alzheimer's disease continuum, middle-age health factors likely do not greatly influenc

171 ealthy subjects (22.8 +/- 5.3 years) and ten middle age healthy subjects (50.7 +/- 6.0 years) engaged

172 ng moderate calorie restriction in young and middle-aged healthy individuals, and they offer promise

173 ously acquired resting-state fMRI data in 22 middle-aged healthy subjects.

174 During Europe's Middle Ages, honey and wax became important commodities

175 e model mimicking the liver Cd deposition in middle-aged human population to determine whether the en

176 nonalcoholic fatty liver disease (NAFLD) in middle-aged human population, but biological evidence is

177 ears or younger than 12 years as compared to middle-aged human subjects.

178 chronologically younger individuals than in middle age individuals, with a diminution of that effect

179 Recolonizing the gut of middle-age individuals with bacteria from young donors r

180 sms of this impaired exercise response in 20 middle-aged individuals at high risk of developing type

181 Many CVRF-free middle-aged individuals have atherosclerosis.

182 Arterial inflammation is highly prevalent in middle-aged individuals with known subclinical atheroscl

183 Middle-aged individuals with physician-diagnosed COPD an

184 levels of 10 mU/L or higher or for young and middle-aged individuals with subclinical hypothyroidism

185 subjects that is distinct from that in young/middle-aged individuals, but also a novel set of taxa co

186 In these middle-aged individuals, HIV infection was independently

187 in around 1% of normal colorectal crypts in middle-aged individuals, indicating that adenomas and ca

188 ns boost non-neutralizing H3N2 antibodies in middle-aged individuals, potentially leaving many of the

189 pnic hypoxia were measured in a cohort of 82 middle-aged individuals.

190 lthy, lean, or slightly overweight young and middle-aged individuals.

191 rn Europe, with lower growth during the Late Middle Ages into the Early Modern Period.

192 ght to determine whether exposure to TRAP in middle age is associated with allergic sensitization, cu

193 Conclusions Higher CAC in middle age is associated with higher LV mass and volumes

194 in favorable cardiovascular health in early middle age live a longer, healthier life free of all typ

195 offsets age-related dendritic retraction in middle-aged (MA) rats.

196 iscrimination task to characterize young and middle-age male F344 rats, followed by a spatial referen

197 sion in the CA1 region of the hippocampus of middle-aged male mice using a viral vector rejuvenates h

198 entially affect the host immune phenotype in middle-aged males and females.

199 ge, condition, and resource holding power as middle-aged males that are in prime physical condition o

200 A middle-age man with EoE since 2004, had a total esophage

201 MI from early to middle age and a low BMI in middle age may be positively associated with ALS risk.

202 ing the progression of cardiac remodeling in middle-age may be a novel therapeutic approach to preven

203 Participants (N=40) were mostly middle-aged (mean age=53 years [SD=9.8]), predominantly

204 tients in both study arms were predominantly middle-aged men (mean age 59 years, male 68.9%) with vir

205 to graded, steady-state eucapnic hypoxia in middle-aged men and women (n = 82) with continuous posit

206 ial proportion (41.5%) of apparently healthy middle-aged men and women, more frequently by peripheral

207 both systolic and diastolic BP in overweight middle-aged men and women.

208 Middle-aged men engaged in competitive or recreational l

209 hickness) in an independent sample cohort of middle-aged men with subclinical cardiovascular disease

210 and coronary artery calcium score (CACS) in middle-aged men.

211 ignificantly associated with increased BP in middle-aged men.

212 t structural abnormalities in developing and middle age mice.

213 ic insults, young C57BL/6 mice (age 3-4 mo), middle-aged mice (age 10-12 mo), and aged mice (age 24-2

214 ducing PERK expression in the hippocampus of middle-aged mice enhances hippocampal-dependent learning

215 tion increased with advancing age, such that middle-aged mice showed much more pronounced differences

216 rom microglia cultures and that treatment of middle-aged mice with indapamide was associated with a d

217 Following lysolecithin demyelination in middle-aged mice, indapamide treatment was associated wi

218 ysolecithin demyelination model in young and middle-aged mice, the latter group developed greater acu

219 Using middle-aged mice, we modeled metabolic disease (obesity/

220 oss various ages, i.e., juvenile, adult, and middle-aged mouse groups.

221 Case Report: Our case is of a middle-aged multiparous female who presented with amenor

222 asured physical activity (PA) in a cohort of middle-aged nonathlete participants in the PESA (Progres

223 By middle age, normal human tissues, including the esophage

224 o determine if dietary NR supplementation in middle-aged, obese, insulin-resistant men affects mitoch

225 nships over five life stages: origin, birth, middle age, old age, and death.

226 owed central visual impairment from early to middle-age onset and progressive macular atrophy.

227 indicate that young mice sleep less than do middle-aged or aged mice, especially during the night, w

228 ittle is known about the eczema phenotype in middle-aged or elderly adults.

229 ber of testosterone prescriptions issued for middle-aged or older men with either age-related or obes

230 The study included 5,269 Danish middle-aged or older twins who provided data on the numb

231 bility or postprandial glucose metabolism in middle-aged overweight subjects.

232 lly among young participants (aged 7-20) and middle aged participants (25-55 years).

233 Towards this end, 175 late middle-aged participants (mean age 55.9 +/- 5.7 years at

234 med a range of analyses in 367,703 unrelated middle-aged participants of European ancestry from UK Bi

235 ilver production-from the Early through High Middle Ages, particularly in northern Europe, with lower

236 ding 850 younger patients (<50 years), 2,540 middle-aged patients (50-69 years) and 1,542 elder patie

237 Of 954 middle-aged patients (57 +/- 10 years, 63% men) with a m

238 Is of hazard ratios included 1 for young and middle-aged patients compared with older patients for al

239 r health (CVH) on health-related outcomes in middle-aged patients is firmly established.

240 In middle-aged patients with COVID-19, FIB-4 may have a pro

241 e risk of progression to critical illness in middle-aged patients with COVID-19.

242 dardized 1-year mortality rates declined for middle-aged patients with heart failure but remained con

243 Middle-aged patients with stage I (odds ratio, 5.04; 95%

244 In addition, middle-aged patients with subclinical hypothyroidism may

245 In this study of middle-aged patients with type 2 diabetes and relatively

246 whether differences exist between young and middle age people.

247 Working in Uganda, he noted that middle-aged people (40-60 years old) had a much lower in

248 wer in older persons who are healthy than in middle-aged persons who are healthy.

249 (idiopathic) etiology, affecting mostly the middle aged population.

250 is a debilitating disease, which affects the middle aged population.

251 rdiovascular prognostic value of TMR in a UK middle-aged population and identify any genetic contribu

252 recordings from 55 222 individuals from a UK middle-aged population undergoing an exercise stress tes

253 bclinical atherosclerosis in an asymptomatic middle-aged population, and investigate interactions amo

254 In a cross-sectional study of a middle-aged population, average LTL and short telomere l

255 associated with cardiovascular risk in a UK middle-aged population, supporting the hypothesis that i

256 enhance risk prediction in a general, white middle-aged population.

257 Study participants were middle-aged, predominantly male with similar cardiometab

258 In young to middle-aged (predominately male) nonsmokers (n = 30) and

259 coincident with the locations of two nearby middle-aged pulsars (Geminga and PSR B0656+14).

260 hysical function impairment was common among middle-aged PWH; greater BMI and physical inactivity are

261 ast 25 years (older trained, OT), and (3) 22 middle-aged (range 35-59 years) untrained women (middle-

262 Middle-age rats showed increased variability in discrimi

263 ampal subregions indicated DEGs in the DG of middle-age rats, linked to synaptic function and neuroge

264 In middle-age, SBP in both races identified risk of inciden

265 quency with age, affecting 4-14% of cells in middle-aged subjects who had never smoked.

266 ased risk of future dementia in asymptomatic middle-aged subjects, two decades before dementia onset.

267 AIDE) risk score and longitudinal atrophy in middle-aged subjects.

268 Problem orientation increased strongly until middle age then showed no marked changes in later age pe

269 0.35 p/100 person-years), and increased from middle age to a second smaller peak in people 80 years o

270 n more than 300,000 individuals ranging from middle age to birth.

271 es in lead pollution observed from the Early Middle Ages to the 1970s industrial peak.

272 Forty-four middle-aged to older adults (68.45 +/- 7.73 years) perfo

273 le-aged (range 35-59 years) untrained women (middle-aged untrained, MU) as a reference control for th

274 compared to similarly aged or even younger (middle-age) untrained women.

275 It is estimated that 87% of middle-aged US adults and 95% of individuals >=60 years

276 iles to pollen allergens in the young vs the middle-aged Uzbek population were associated with replan

277 f these on intestinal epithelium of multiple middle-aged versus old-aged mice highlighted the consist

278 dietary intake from 32 AN and 21 RA healthy middle-aged volunteers before screening colonoscopy.

279 adherence to healthy dietary patterns during middle age was associated with lower risk of CKD.

280 Most patients were middle-aged white men.

281 Majority surgeons' suicides were middle-aged, White males.

282 majority of patients are female of young or middle age with a normal BMI reporting complaints that o

283 ge and change in CAC from early adulthood to middle age with left ventricular (LV) function.

284 2423), spanning childhood or adolescence to middle age, with prospective or family-based data.

285 e the dietary intake and food consumption of middle-aged women and their female and male adult offspr

286 d structural brain characteristics in 12,021 middle-aged women from the UK Biobank, demonstrating tha

287 , on the health and lifestyle of overweight, middle-aged women in primary care.

288 nd vascular cell adhesion molecule-1) in 524 middle-aged women in the Nurses' Health Study II.

289 e of diverse cardiovascular conditions among middle-aged women with and without prior HDP.

290 se cardiovascular conditions in asymptomatic middle-aged women with prior HDP remains unknown.

291 Among postmenopausal middle-aged women, CHIP was independently associated wit

292 In middle-aged women, cirrhosis incidence increases with to

293 ass and strength, but their effectiveness in middle-aged women, or whether there are any additional b

294 In this large prospective cohort of French middle-aged women, participants with greater flavonol, a

295 o be a major public health problem affecting middle-aged women, particularly in less-resourced countr

296 es (ACS) afflicting predominantly younger to middle-aged women.

297 ardiovascular disease risk assessments among middle-aged women.

298 autoimmune liver disease that mainly affects middle-aged women.

299 functional muscle power (stair climbing) in middle-aged women.

300 depression and incident cardiac events among middle-aged workers from the GAZEL cohort.