ライフサイエンスコーパス: midlife

1 monization, and not investigating factors at midlife.

2 high fat intake during both adolescence and midlife.

3 cognitive sequelae of these risk factors in midlife.

4 , the elderly report less pain than those in midlife.

5 father, and a sibling from childhood through midlife.

6 gain are associated with adult body size in midlife.

7 ly childhood growth with BMI in daughters at midlife.

8 associated with better cognitive function in midlife.

9 socioeconomic mobility between childhood and midlife.

10 al territory, and with increasing age during midlife.

11 edict more pronounced depressive symptoms in midlife.

12 ed ELS in relation to depressive symptoms in midlife.

13 with other physical health problems in early midlife.

14 nd measured coronary artery calcium (CAC) in midlife.

15 es (ACEs) are associated with elevated AL in midlife.

16 0.16-0.64) compared with men with low CRF in midlife.

17 fitness had higher cognitive test scores at midlife.

18 ve effect of cardiorespiratory fitness as of midlife.

19 nd striatal neurons, as well as morbidity in midlife.

20 sk of hyperproliferative disease (cancer) by midlife.

21 le to costly health and social problems into midlife.

22 evaluate men with above-median PSA levels in midlife.

23 o middle adulthood and cognitive function at midlife.

24 with worse gait and cognitive performance in midlife.

25 it scores and cardiovascular disease risk at midlife.

26 ines, was associated with worse cognition in midlife.

27 with intellectual decline from childhood to midlife.

28 midlife with gait and cognitive function in midlife.

29 ith worse indices of LV systolic function in midlife.

30 ith gait, but not with cognitive function in midlife.

31 uggested lower structural brain integrity in midlife.

32 hort study followed 516 young adults through midlife.

33 g adulthood may affect cognitive function in midlife.

34 several cases are still detectable well into midlife.

35 signs of cognitive decline from childhood to midlife.

36 ek to measure dementia-prevention efforts in midlife.

37 Maximum weight and height in midlife (40-65 years of age) were retrospectively ascert

38 portance of monitoring women's health during midlife, a critical window for implementing early interv

39 Although midlife adiposity predicts increased incidence of AD, it

40 Midlife adiposity was derived from BMI data at 50 years

41 later life with cardiorespiratory fitness in midlife after adjustment for cardiovascular risk factors

42 r mixed-effects models, elevated CHD risk in midlife (age 55 years) was associated with lower levels

43 oved Pegboard tasks as children and again at midlife (age = 38 years).

44 paralleled by bioenergetic dysregulation in midlife aging female brain.

45 urity and increases in deaths of despair and midlife all-cause mortality in US counties during 2000-2

46 During 2010-2017, midlife all-cause mortality rates increased from 328.5 d

47 ets and definitions of pain, we show today's midlife Americans have had more pain throughout adulthoo

48 mine whether better cognitive functioning at midlife among more physically fit individuals reflects n

49 cells with a rapid decline in population at midlife and a concomitant increase in peripheral blood b

50 k of developing type 2 diabetes (T2D) during midlife and an elevated risk of developing hypertension

51 oid-beta1-42 levels were already frequent in midlife and APOE genotype strongly affects the levels of

52 40% of variance in the same measure in late midlife and approximately 10% of variance in each of sev

53 Midlife and concurrent cardiovascular risk factors.

54 Midlife and concurrent vascular risk factor associations

55 n ICAD prevalence and the risk factors (both midlife and concurrent) associated with its development

56 mal / preclinical phase of LOAD for women in midlife and highlight therapeutic windows of opportunity

57 relation between habitual dietary intake at midlife and incident PAD over approximately 20 y of foll

58 ate or ideal level of behavioral CVH in both midlife and late life (versus poor level in both midlife

59 with intermediate global CVH metrics in both midlife and late life and 0.14 (0.02, 0.76; p = 0.024) f

60 ns of cardiovascular health (CVH) metrics in midlife and late life in relation to risk of dementia.

61 ife and late life (versus poor level in both midlife and late life) was significantly associated with

62 Compared with those who were normotensive in midlife and late life, only participants with midlife hy

63 ompared with poor global CVH metrics in both midlife and late life, the fully adjusted HR of dementia

64 Studies have linked midlife and late-life cardiovascular risk factors (CVRFs

65 We estimated associations of midlife and late-life elevated CHD risk with cognitive t

66 95% CI, 1.69-2.32 per 100 person-years); for midlife and late-life hypertension (n = 1030), 2.83 (95%

67 Participants in the midlife and late-life hypertension group (hazard ratio [

68 ion and late-life hypotension, compared with midlife and late-life normal BP, were associated with in

69 between duration of elevated CHD risk during midlife and levels (but not trajectories) of later-life

70 post-intervention surveys for this sample of midlife and older adults new to smartphone technology.

71 3.5 million individuals providing support to midlife and older adults.

72 , postmenopausal estrogen deprivation during midlife and older age has a detrimental impact on metabo

73 n early educational experiences exists among midlife and older US adults.

74 ress, diabetes, head trauma, hypertension in midlife and orthostatic hypotension) and 9 with Level B

75 tigated whether duration of diabetes in late midlife and poor glycaemic control were associated with

76 etabolic health-related changes accompanying midlife and the MT.

77 s Risk in Communities (ARIC) participants in midlife and to explore associations between midlife vasc

78 life and fish-oil consumption in early life, midlife, and late life with osteoporotic fracture risk.

79 ly recorded ELS, but not stressful events in midlife, and the mean BDI score (average of time 1 and t

80 panics; black non-Hispanics and Hispanics at midlife, and those aged 65 and above in every racial and

81 se results suggest that healthy behaviors in midlife are a good target for frailty prevention.

82 ow to moderate, and stable heavy drinking in midlife are not associated with lesser and greater cogni

83 0, as well as improvements in behaviors over midlife, are associated with a lower risk of frailty lat

84 nges in memory circuitry that occur in early midlife, as a function of sex and women's reproductive s

85 er levels of NT-proBNP may identify those in midlife at risk of accelerated physical decline.

86 Our findings support an association between midlife atherosclerosis and development of vascular deme

87 mentia (CAIDE) study, who were followed from midlife (baseline from1972 to 1987; mean age 50.4 years;

88 rly and possibly reciprocally with age, with midlife being a critically vulnerable period in life.

89 We investigated whether midlife biomarkers of heart and kidney damage capturing

90 Associations between midlife BMI and brain amyloid burden approached statisti

91 We find that each unit increase in midlife BMI predicts earlier onset of AD by 6.7 months (

92 Thus, higher midlife BMI was also associated with greater fibrillar a

93 Higher midlife BMI was associated with greater Braak neurofibri

94 We examined the association of midlife body composition with successful aging, defined

95 dy aims to examine the relationships between midlife body mass index (BMI) and (1) AAO of AD (2) seve

96 Greater decline is found with higher midlife BP in whites than in African Americans.

97 Those with older midlife brainAGEs tended to have poorer cognitive functi

98 Midlife hypertension and elevated midlife but not late-life systolic BP was associated wit

99 w that induction of mitochondrial fission in midlife, but not in early life, extends the health and l

100 een apoB in young adults and the presence of midlife CAC independent of baseline traditional CVD risk

101 In midlife, cases had higher body mass index (mean differen

102 In midlife, cases had higher body mass index than controls

103 lifetime systolic blood pressure burden and midlife cognitive function was accounted for by LV mass

104 in childhood/adolescence is associated with midlife cognitive function, leveraging data from the Car

105 vities accounted for little variance in late midlife cognitive functioning in men age 56-66 (n = 1009

106 iation between cardiorespiratory fitness and midlife cognitive functioning.

107 ntia risk by examining its associations with midlife cognitive performance and cognitive decline from

108 ects of these risk factors from childhood on midlife cognitive performance are unknown.

109 m childhood/adolescence associate with worse midlife cognitive performance independent of adulthood e

110 ood were independently associated with worse midlife cognitive performance, especially memory and lea

111 /adolescence cardiovascular risk factors and midlife cognitive performance.

112 djusted MD = -0.03 (95% CI: -0.18, 0.11)) in midlife compared with stable never-drinking were not ass

113 but not education, was associated with late midlife cortical surface area (n = 367).

114 There is an inverse association between midlife CRF and incident lung and colorectal cancer but

115 High midlife CRF is associated with lower risk of cause-speci

116 implicated economic insecurity in increasing midlife death rates and "deaths of despair," including s

117 The analysis focused on midlife deaths (ages 25-64 years), stratified by sex, ra

118 ning, and TPI identified an increased BTP in midlife depressed patients, suggesting early and subtle

119 ate-life depression but poorly documented in midlife depression.

120 oes not allow the detection of subtle CVD in midlife depression.

121 subtle changes in brain vascular function in midlife depression.

122 25-74 years at baseline) from the survey of Midlife Development in the United States.

123 Midlife development of obesity, a major risk factor of i

124 Interventions aimed at reducing midlife disparities in physical capability should target

125 gy is required for the anti-aging effects of midlife Drp1-mediated mitochondrial fission.

126 rom demographics and the APOE genotype, only midlife dyslipidemia was associated with amyloid deposit

127 eptible to amyloid pathology modification by midlife EE.

128 These findings suggest that midlife elevated CHD risk is associated with lower cogni

129 ere at higher risk of poor (lowest quartile) midlife episodic memory and associative learning (relati

130 he early phase of the study corresponding to midlife, even when chronic/recurring, do not increase th

131 n early adulthood were associated with worse midlife executive function and processing speed.

132 Midlife exposure to these factors may be most important

133 cancer, exploring the influence of early and midlife exposures will further advance our understanding

134 ting Drp1-mediated mitochondrial fission, in midlife, facilitates mitophagy and improves both mitocho

135 l, 1.1-1.6) higher respective odds of having midlife FCR.

136 fies how early-life exposures impact on both midlife FEV1 and FVC.

137 Associations between midlife fitness and hospitalizations for heart failure a

138 lder with high midlife fitness than with low midlife fitness in both men($7,569 vs. $12,811; p < 0.00

139 Higher midlife fitness levels seem to be associated with lower

140 articipants aged 65 years or older with high midlife fitness than with low midlife fitness in both me

141 ational and occupational attainment in early midlife for female respondents was not affected by their

142 of intake of several flavonoid subclasses at midlife had greater odds of healthy aging.

143 e confounding in studies of fetal growth and midlife health outcomes.

144 The relations between body composition at midlife, health-related quality of life (HRQoL) in old a

145 Epidemiological studies identify midlife hearing loss as an independent risk factor for d

146 able risk factors (less childhood education, midlife hearing loss, hypertension, and obesity, and lat

147 ut it is unclear whether flavonoid intake in midlife helps to maintain good health and wellbeing in a

148 lerance and slightly increased locomotion at midlife, however, only soma-specific knockdown of nsun-1

149 low intake in adolescence to high intake in midlife (HR = 0.71, 95% CI: 0.54, 0.93).

150 Midlife hypertension and elevated midlife but not late-l

151 Midlife hypertension and hyperlipidemia were associated

152 with late-life ICAD in blacks only, whereas midlife hypertension and hyperlipidemia were associated

153 CI, 1.68-2.54 per 100 person-years); and for midlife hypertension and late-life hypotension (n = 389)

154 o [HR], 1.49 [95% CI, 1.06-2.08]) and in the midlife hypertension and late-life hypotension group (HR

155 idlife and late life, only participants with midlife hypertension and late-life hypotension had highe

156 ion in midlife to late life and a pattern of midlife hypertension and late-life hypotension, compared

157 Midlife hypertension confers increased risk for cognitiv

158 2) of several variables except job score and midlife hypertension in predicting exceptional aging wit

159 Thus, although midlife hypertension is a risk factor for late-life deme

160 Midlife hypertension was also associated with larger pla

161 k factors (eg, physical inactivity, smoking, midlife hypertension, midlife obesity, and diabetes) and

162 f an association with the disease (diabetes, midlife hypertension, midlife obesity, physical inactivi

163 0.14 (0.02, 0.76; p = 0.024) for those with midlife ideal and late-life intermediate global CVH metr

164 Higher SM% at midlife in 1985/1986 was associated (P < 0.05) with high

165 option and mental health-related outcomes in midlife in 243,797 UK Biobank participants (n adopted =

166 were incrementally lower per MET achieved in midlife in men (6.8% decrease in costs per MET achieved;

167 ist actigraphy among 426 participants in the Midlife in the United States Study (31% AA; 69% EA; 61%

168 RIH2 mRNA levels significantly decrease from midlife in vastus lateralis muscles and highly correlate

169 Being in the highest SM% quartile at midlife increased (adjusted OR: 2.32; 95% CI: 1.53, 3.53

170 Already, before midlife, individuals who were aging more rapidly were le

171 preceding the imaging markers, and early to midlife intellectual enrichment to predict longitudinal

172 0.174) and 0.52 (0.29, 0.93; p = 0.027) for midlife intermediate and ideal levels (versus poor level

173 0.03 to 0.26; p < 0.05), whereas people with midlife intermediate and late-life ideal biological CVH

174 inAGE as a potential surrogate biomarker for midlife intervention studies that seek to measure dement

175 at impaired lung function or lung disease in midlife is associated with greater risk of incident deme

176 Exposure to higher BP levels from young to midlife is associated with worse gait and cognitive perf

177 OSA, assessed in midlife, is independently associated with higher levels

178 e find that short-term induction of Drp1, in midlife, is sufficient to improve organismal health and

179 Conclusions: Midlife lung disease and reduced lung function were asso

180 Midlife may be a critical period for initiating treatmen

181 proportions of plasma phospholipid VLSFAs in midlife may be associated with less 20-y cognitive decli

182 A healthy BMI at midlife may delay the onset of AD.

183 clusion, maintaining healthy lifestyle since midlife may help reduce cognitive decline in aging.

184 usion, maintaining a healthy lifestyle since midlife may help reduce cognitive decline in aging.

185 Diabetes prevention and glucose control in midlife may protect against late-life cognitive decline.

186 he associations of overweight and obesity at midlife (mean age, 50 (standard deviation, 4.7) years) w

187 High adiposity in midlife might increase risk for late-life brain patholog

188 ogy and mortality in mammals when applied in midlife.Mitochondrial fission and fusion are important m

189 the hypothesis that high body mass index in midlife modulates the risk for dementia.

190 on-Hispanics were paralleled by increases in midlife morbidity.

191 her rates of deaths of despair and all-cause midlife mortality at baseline but similar rates of incre

192 The increase in midlife mortality during 2010-2017 was associated with a

193 (95% confidence interval: 1.36, 1.47) higher midlife mortality rates at baseline and a rate of increa

194 The largest relative increases in midlife mortality rates occurred in New England (New Ham

195 Rising midlife mortality rates of white non-Hispanics were para

196 The midlife mortality reversal was confined to white non-His

197 By 2014, midlife mortality was increasing across all racial group

198 y at older ages or a slowdown in declines in midlife mortality.

199 rs and cognitive deficits in a predominantly midlife multiethnic population-based sample.

200 a population-based cohort study of women at midlife (n = 396).

201 e rate for participants with normotension in midlife (n = 833) and late life was 1.31 (95% CI, 1.00-1

202 cline in longitudinal data from childhood to midlife (N = 869).

203 Midlife negative and positive aspects of close relations

204 95% CI, 1.00-1.72 per 100 person-years); for midlife normotension and late-life hypertension (n = 155

205 95% CI, 2.40-3.35 per 100 person-years); for midlife normotension and late-life hypotension (n = 927)

206 f these results, gathered in a population of midlife northeast American adults, hold in the general p

207 l inactivity, smoking, midlife hypertension, midlife obesity, and diabetes) and depression.

208 the disease (diabetes, midlife hypertension, midlife obesity, physical inactivity, depression, smokin

209 ocioeconomic markers (height, education, and midlife occupation categorized as low, intermediate, and

210 15, and 26 years, for height, education, and midlife occupation, respectively.

211 ic circumstances, early-adulthood education, midlife occupational stress, and late-life social networ

212 was strongly associated with baseline PSA in midlife: odds ratios (95% CIs) comparing PSA in the > 90

213 y extensive loss of striatal neurons and the midlife onset of debilitating and progressive chorea, de

214 functioning in healthy menopausal women with midlife onset of executive difficulties include modulati

215 , a neurodegenerative disorder with frequent midlife onset, encompasses developmental components.

216 Herein we describe Japanese siblings with a midlife-onset, slowly progressive type of cerebellar ata

217 l behavioral CVH metrics in particular, from midlife onwards is associated with a reduced risk of dem

218 nerative disease, with symptoms appearing in midlife or decades after exposure.

219 The authors examined midlife outcomes of childhood bullying victimization.

220 -up of 26.2 (standard deviation, 4.9) years, midlife overweight and obesity were not associated with

221 In conclusion, midlife overweight predicts earlier onset of AD and grea

222 the shift to interventional studies from the midlife period.

223 tive lipid-lowering efforts during the early midlife period.

224 s study include the lack of data on diet and midlife plasma glucose, high rate of attrition, as well

225 the memory pool early in life followed by a midlife plateau to the ease of learning salient features

226 Prostate-specific antigen (PSA) level in midlife predicted future prostate cancer (PCa) mortality

227 to determine if a baseline PSA level during midlife predicts lethal PCa in a US population with oppo

228 otein that promotes mitochondrial fission-in midlife, prolongs Drosophila lifespan and healthspan.

229 on-based sample of individuals with NAFLD in midlife, prospectively assessed alcohol use is not assoc

230 Risk-stratified screening on the basis of midlife PSA should be considered in men age 45 to 59 yea

231 is study, we investigated the association of midlife quality of close relationships with subsequent c

232 demographics, APOE, intellectual enrichment, midlife risk factors (physical inactivity, obesity, smok

233 Understanding how midlife risk factors influence age at onset (AAO) of Alz

234 1, and 134 had 2 or more; a higher number of midlife risk factors was associated with elevated amyloi

235 ablished, controversial and novel modifiable midlife risk factors.

236 ing blood pressure from early adulthood into midlife seems to be associated with increased WMHV and s

237 ted biomechanical exposure and job strain in midlife separately and jointly predicted back and degene

238 l health and prolong lifespan, and observe a midlife shift toward a more elongated mitochondrial morp

239 Midlife smoking and diabetes were associated with increa

240 Midlife smoking and diabetes were strongly associated wi

241 ed linear models examined the association of midlife social contact between 45 and 55 years and cogni

242 Cardiovascular risk factors in midlife (specifically elevated blood pressure, physical

243 Higher intake of flavonoids at midlife, specifically flavones, flavanones, anthocyanins

244 PSA levels in midlife strongly predict future lethal PCa in a US cohor

245 alidated contributors: early life education, midlife substantive work complexity, late life leisure a

246 Further, ovariectomy unexpectedly promotes midlife survival of female mice lacking hepatic mTORC2,

247 eters, such as mitochondrial respiration and midlife survival, increases functional healthspan of the

248 In midlife, the prevalence of overweight was 39% and that o

249 In midlife they reported low life satisfaction.

250 , and physical activity between groups, from midlife through 1 year preceding the cognitive sub-study

251 , and physical activity between groups, from midlife through 1 year preceding the cognitive substudy.

252 From midlife through later life, compared with controls, case

253 etary factors present during adolescence and midlife to be associated with pancreatic cancer.

254 nteract with the psychosocial environment of midlife to contribute to perimenopausal depression risk.

255 ng-term follow-up, sustained hypertension in midlife to late life and a pattern of midlife hypertensi

256 ents in, ideal cardiovascular health through midlife to late life are associated with lower CVD preva

257 al and primary prevention efforts throughout midlife to late life as a potential intervention to decr

258 that increasing weight loss per decade from midlife to late life is a marker for MCI and may help id

259 the relationship of CVHS attainment through midlife to late life with CVD prevalence and cardiovascu

260 e associations of composite CVH metrics from midlife to late life with risk of incident dementia.

261 whether such discrepancies are also seen in midlife to late life.

262 percentile of education/occupation score and midlife to late-life cognitive activity), the onset of c

263 his, Apoe-deficient mice were exercised from midlife to old age and in contrast to wild-type (Apoe-su

264 Importantly, long-term aerobic exercise from midlife to old age prevented this age-related neurovascu

265 itive performance and cognitive decline from midlife to old age, including cognitive decline trajecto

266 n (SD) rate of weight change per decade from midlife to study entry was greater for participants who

267 rowth factors with adult BMI in daughters at midlife using quantile, linear, and logistic regression

268 midlife and to explore associations between midlife vascular risk factors and 25-year dementia incid

269 Midlife vascular risk factors are associated with increa

270 To determine if midlife vascular risk factors are associated with late-l

271 cipants without dementia and with nonmissing midlife vascular risk factors at baseline (mean age, 52

272 Place of birth, race, educational level, and midlife vascular risk factors data were collected betwee

273 Midlife vascular risk factors have been associated with

274 An increasing number of midlife vascular risk factors was significantly associat

275 In adjusted models, compared with 0 midlife vascular risk factors, the OR for elevated SUVR

276 t 3 life epochs (childhood, young adulthood, midlife) via questionnaire (2001-2002) and summarized in

277 hort study enrolled 4761 participants during midlife (visit 1, 1987-1989) and followed-up over 6 visi

278 terol, and smoking associated inversely with midlife visual and episodic memory and visuospatial asso

279 Diabetes in midlife was associated with a 19% greater cognitive decl

280 s having cancer at Medicare age, high CRF in midlife was associated with an adjusted 32% (HR, 0.68; 9

281 Higher IMT in midlife was associated with an increased hazard ratio (H

282 More frequent social contact during midlife was associated with better subsequent cognitive

283 e of late-life BP, sustained hypertension in midlife was associated with dementia risk (HR, 1.41 [95%

284 years at baseline, 60% women), higher IMT in midlife was associated with development of small vessel

285 Elevated body mass index in midlife was associated with elevated SUVR (odds ratio [O

286 Daily fish-oil consumption in midlife was associated with lower fracture risk in women

287 ithout an incident CV event, OSA assessed in midlife was independently associated with higher left ve

288 e cohort study, diet quality assessed during midlife was not significantly associated with subsequent

289 the AHEI-2010 (upper vs. lower quintiles) in midlife was related to 34% (95% CI, 9% to 66%; P for tre

290 cognitive function is limited, especially in midlife.We hypothesize that higher intake of these B vit

291 d 9 with Level B weaker evidence (obesity in midlife, weight loss in late life, physical exercise, sm

292 Intakes of 6 major flavonoid subclasses in midlife were ascertained on the basis of averaged intake

293 arge differences in cognitive performance in midlife were attenuated at dementia diagnosis.

294 he most common neurodegenerative disorder of midlife, while Alzheimer's disease (AD) is the most comm

295 Increasing evidence of associations from midlife will guide the shift to interventional studies f

296 ange in the number of healthy behaviors over midlife with future risk of frailty.

297 mulative BP exposure from young adulthood to midlife with gait and cognitive function in midlife.

298 examined the relation of flavonoid intake in midlife with the prevalence of healthy aging.

299 pattern of decreasing depressive symptoms in midlife women, with higher risk before and lower risk af

300 As adults approaching midlife, young suicide attempters were significantly mor