ライフサイエンスコーパス: midline

1 al frame of reference (i.e., relative to the midline).

2 romedial prefrontal cortex and the posterior midline.

3 ural neurons, which project axons across the midline.

4 all areas, particularly those closest to the midline.

5 magnetic stimulation (TMS) to the cerebellar midline.

6 The effects were stronger at midline.

7 underlying neural circuits along the ventral midline.

8 Collected brains were bisected down the midline.

9 the hands uncrossed or crossed over the body midline.

10 and enhancing; however, it was still in the midline.

11 ment direction is mirror-reversed across the midline.

12 grammed cell death (PCD) along the embryonic midline.

13 plate (FP), a glial structure occupying the midline.

14 patterned head-like outgrowths containing a midline.

15 2 depending on the distance from the ventral midline.

16 , uniting the neural fold tips in the dorsal midline.

17 towards or away from the cells lying at the midline.

18 e and a loss of the desmosomal intercellular midline.

19 to explain the guidance of all axons at the midline.

20 ich fail to condense appropriately along the midline.

21 hrough a defect in the occipital bone in the midline.

22 mp in hypogastric region on the left side of midline.

23 that detect fully automatically the glottal midline.

24 l aspect of this domain, particularly on the midline.

25 tion of repelling growing axons from the CNS midline.

26 sease, and 71% of tumors involved or crossed midline.

27 OMP model of pseudoachondroplasia, increased midline-1 (MID1) expression and mammalian target of rapa

28 cement versus conventional suture closure of midline abdominal surgery.

29 There was a membrane covered, midline, abdominal wall defect at the base of the umbili

30 ting in many more axons failing to cross the midline, although mutations in mud alone have little eff

31 s on high levels of myosin along the ventral midline, although the basis for this localization is unc

32 forces for reaches to targets either side of midline and a minimal grip force for midline movements.

33 predominantly regulated by Ets at the dorsal midline and are expressed in a ring.

34 xons of the PrV barrelette neurons cross the midline and confer the whisker-related patterning to the

35 t, resulting in widening of the neural plate midline and defective neural tube closure.

36 homocysteine between pairs of trial arms at midline and endline, adjusted for baseline homocysteine,

37 /-) mice, many vertebrae are split along the midline and fused across the anterior-posterior axis, su

38 highlight a network centred on the cortical midline and hippocampus that allows us to make prospecti

39 tudies on the functional organization of the midline and intralaminar nuclei are scarce, and this has

40 ere associated with widespread activation of midline and lateral barrel cortex areas following a vibr

41 atial perception, with a linear mapping near midline and more complex relations at lateral locations.

42 EGFR is activated in the ventral midline and neurogenic ectoderm by the Spitz ligand, whi

43 as in the mesodermal-derived meninges of the midline and paramedian anterior, central, and ventral po

44 tal proliferative compartments: ventricular, midline and parenchymal.

45 wer was suppressed for IC sources in central midline and parietal regions, whereas mean beta band pow

46 tion, it receives dense projections from the midline and posterior intralaminar thalamus, and moderat

47 the cranial neural folds to move toward the midline and results in NTD.

48 tive and repellent cues leading axons to the midline and then directing them to the contralateral hem

49 ocampal areas TH / TF, the ventral posterior midline, and lateral parietal association cortex.

50 n enhanced neural response in fronto-limbic, midline, and occipitotemporal regions to a learned repre

51 Parietal, midline, and prefrontal, but not primary cortical areas,

52 typic transition on their way to the ventral midline, and that this transition is driven in response

53 ation: a polarized AP axis, the pre-existing midline, and the dorsal-ventral median plane.

54 two regions of the fronto-striatal circuit: midline anterior cingulate cortex (ACC) and left dorsal

55 lateral positions in each hemispace, and the midline area represented by either their overlap or a se

56 Using the developing mouse telencephalic midline as an exemplar, we show that the specific sulfat

57 erval from QRS onset to aortic valve closure midline, as derived for continuous-wave Doppler, and the

58 sulfation catalyzed by the enzyme Hs2st, in midline astroglial development and in regulating FGF pro

59 s required for migration of axons across the midline at the CC, and that their absence results direct

60 es (unilateral, bifrontal and bifrontal with midline bar) and sizes are employed to identify optimal

61 t as a bilateral structure, then crosses the midline between P6 and P12, and subsequently bends to ad

62 d the mesenchyme respectively, causes dorsal midline Bmp signaling to drop at early neural tube stage

63 SDNs, where receptive fields possess a sharp midline boundary, confining responses to a single visual

64 Of the twelve individuals, midline brain malformations were found in five, urogenit

65 omatosensory cortex without any infection of midline brain regions, indicating the virus can move by

66 did not split and subsequent development of midline brain structures stalled.

67 nd in circumventricular organs (CVOs), small midline brain structures that are supplied by high perme

68 of the brain are coordinated by a series of midline-bridging neuronal commissures whose development

69 t VZ-derived Ntn1 directs CAs to the ventral midline by its local actions.

70 s in spindle behavior outside and inside the midline can be recapitulated by corresponding changes in

71 Nuclear protein of the testis (NUT) midline carcinoma (NMC), is a rare and highly aggressive

72 atic mistargeting of active chromatin in NUT midline carcinoma (NMC), we have identified protein inte

73 in the treatment of the genetically defined midline carcinoma and hematopoietic malignancies.

74 ered that BRD4 is hyperphosphorylated in NUT midline carcinoma and identified CDK9 as a potential kin

75 ently repressed by BRD4-NUT, a driver of NUT midline carcinoma.

76 the zippering point at the embryonic dorsal midline causes far-reaching, rapid separation of the ele

77 However, mutant mice did have a large midline cavity originating from the embryonic forebrain

78 hh effector Gli2 fail to produce appropriate midline cell architecture, whereas embryos with expanded

79 Analysis of Drosophila CNS midline cell development provides a useful system for st

80 Disruption of lateral, but not midline, cell remodeling results in exencephaly.

81 Midline cells in the mouse midbrain neuroepithelium are

82 The midline central gray of the pons and nucleus incertus re

83 s, dorsal striatum and ventral striatum, and midline cerebellar vermis and subgenual cingulate cortex

84 greater activation of the right amygdala and midline cerebellar vermis to nonemotional as opposed to

85 uding shorter snout, expansion of the facial midline, cleft lip, extensive exencephaly, and microphth

86 ation of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patt

87 VBW myofibroblasts in orchestrating ventral midline closure by mediating the response to the TGFbeta

88 These cells, which reside in the suture midline, contribute directly to injury repair and skelet

89 ect reinstatement effects within a posterior midline core memory retrieval network during all phases

90 temporal Wnt signaling profile of the dorsal midline cortical hem, which in turn causes gyrification

91 strum core projects predominantly to frontal-midline cortical regions, whereas the dorsal and ventral

92 variants defines the most frequent cause of midline craniosynostosis and has implications for the ge

93 t near BMP2 that is strongly associated with midline craniosynostosis explained nearly all the phenot

94 dings show that DCC is a master regulator of midline crossing and development of white-matter project

95 h on responsiveness to Wnt attraction during midline crossing and turn anteriorly only after exiting

96 In mammals, midline crossing at the level of the hindbrain and spina

97 a Brn3b(Cre) knock-in allele reduced axonal midline crossing at the optic chiasm and optic tract fas

98 pine formation, axon elongation, and pontine midline crossing in a FEZF2-dependent manner.

99 as an axon guidance molecule that regulates midline crossing in the CNS.

100 As expected, Sox11 treatment caused robust midline crossing of CST axons into previously denervated

101 to cause CVM migration defects, particularly midline crossing of the bilateral groups.

102 Partial midline crossing of the PrV axons, in a conditional Robo

103 creased frequency of mushroom-body beta-lobe midline crossing, a metric of axonal guidance.

104 ed in perturbed axonal pathfinding, delay in midline crossing, excess branching of neurites, and axon

105 cement of the Slit response before and after midline crossing, resulting in a switch that reinforced

106 exhibited marked defects in commissural axon midline crossing.

107 lit response in commissural axons upon their midline crossing.

108 ceptors do not bind Slit ligands and promote midline crossing.

109 urning of commissural axons before or during midline crossing.

110 ent pathway that acts in parallel to promote midline crossing.

111 wed anterior-posterior guidance errors after midline crossing.

112 e they became sensitized to these cues after midline crossing.

113 ch that reinforced robust regulation of axon midline crossing.

114 ogenic progenitor cells does not manifest in midline defects.

115 oscopy, by fully automating segmentation and midline detection.

116 d via redundant genetic regulation of dorsal midline development and signaling.

117 terns that highly correspond to the cortical midline DMN subsystem.

118 F signaling steers cardiomyocytes toward the midline during cardiac fusion.

119 commissural neuron axon guidance to the CNS midline during development.

120 Ipsilateral gastrulation was lost by midline ECM and PCD inhibition but restored with exogeno

121 t promotes juxtaposition of cells across the midline enabling fusion propagation.

122 k whole-embryo FAIRE peak overlap with known midline enhancers and provide a useful predictive tool f

123 ogous auditory nuclei, on either side of the midline, enhances the precision of sound localization.

124 cific epithelial progenitor cell population (midline epithelial cells [MECs], Isl1+ Nkx2.1+ Sox2+) lo

125 and presentations on the screen's horizontal midline (Experiments 1-2) and in the upper and lower vis

126 el due to a large, well-characterized set of midline-expressed genes and in vivo validated enhancers.

127 ared a large dataset of fragments that drive midline expression in vivo with the FAIRE data.

128 srupted in tok mutants and can be rescued by midline expression of Slit-N, suggesting that Slit is th

129 on of Six1 in Six2 (-/-) embryos resulted in midline facial cleft and frontal bone agenesis.

130 ngle mutants, including skull bone agenesis, midline facial cleft, and syngnathia.

131 Mllt10 knockout mutants (Mllt10-KO) exhibit midline facial cleft.

132 ind that regions of the genome with a strong midline FAIRE peak and weak whole-embryo FAIRE peak over

133 At the embryonic mouse telencephalic midline, FGF/ERK signaling drives astroglial precursor s

134 ral axons from dorsal spinal cord to ventral midline floor plate (FP). FP cells produce a chemoattrac

135 roglia morphology over 28 days following rat midline fluid percussion injury (mFPI) as a first step i

136 lt male C57BL/6 mice received diffuse TBI by midline fluid percussion or were sham-injured.

137 ripe of two or three cells along the ventral midline, followed by progressive expansions into more la

138 sing from maxillary prominences, fuse at the midline, forming the hard and soft palate.

139 Greater non-midline fractures among anthropoids suggest that fusion

140 The latter population expands along the midline from anterior to posterior until the esophagus-g

141 icting trajectories moved towards the visual midline from the other eye.

142 onstrated that a node within MDC, located in midline frontal cortex, becomes active during the early

143 on tensor imaging and increase resting-state midline frontal theta activity.

144 ty showed a shift from anterior to posterior midline functional coupling in the naturalistic conditio

145 Thalamic midline fusion during early postnatal development was al

146 system, where it localizes to the axons and midline glia.

147 high grade tumors, including H3K27M diffuse midline glioma (H3K27M DMG), remain poor.

148 BACKGROUNDPatients with diffuse midline gliomas (DMGs), including diffuse intrinsic pont

149 enes are characteristic of pediatric diffuse midline gliomas (DMGs).

150 Diffuse midline gliomas and posterior fossa type A ependymomas c

151 nonical oncohistone, occurring frequently in midline gliomas but also identified in haematopoietic ma

152 The majority of diffuse midline gliomas, including more than 70% of DIPGs, harbo

153 ir absence results directly or indirectly in midline gliosis, increased Slit2, and complete CC agenes

154 dies identify a parallel pathway controlling midline guidance in Drosophila and highlight a novel rol

155 Netrin-1 (Ntn1) emanating from the ventral midline has been thought to act as a long-range diffusib

156 -Attenuated Inversion Recovery) crossing the midline (Hazard Ratio; HR = 1.30 [1.21-1.87], P < 0.001)

157 rst extracted separately on each side of the midline in brainstem nuclei that project to the ICs.

158 vision perform well on detecting the glottal midline in glottis segmentation data, but are outperform

159 he rounded fluctuant mass was present in the midline in occipital region covered with alopecic skin w

160 ng, symphyseal breakage always occurs at the midline in taxa with unfused conditions, further indicat

161 However, CAs still grow towards the midline in the absence of the floor plate (FP), a glial

162 ntral nerve cord, many axons still cross the midline in the absence of the Netrin genes (NetA and Net

163 its loss affects growth cone guidance at the midline in the CNS, also an actin-dependent process.

164 pinal commissural axon navigation across the midline in the floor plate requires repulsive forces fro

165 at information of a target moving toward the midline in the left eye is fused with information of the

166 oblate spheroid with a straightened ventral midline in the mature form can be accounted for by spati

167 formation of the target moving away from the midline in the right eye.

168 itro and project ipsilaterally at the chiasm midline in vivo, and Plexin-A1 and Nr-CAM expression in

169 liver graft implantation using a preexisting midline incision.

170 ects in commissural axon trajectories at the midline intermediate target.

171 red with normative data despite crossing the midline into the blind hemifield in 11 of 12 eyes.

172 LAMPOON traversal and midline laceration was successful in 100%.

173 e abdominal aortic aneurysm repair through a midline laparotomy (Clinical.Trials.gov: NCT00757133).

174 A standardized procedure of closing the midline laparotomy by using a "small steps" technique of

175 The standardized procedure of closing the midline laparotomy by using a "small steps" technique of

176 ipigs underwent pancreatic duct ligation via midline laparotomy for the induction of exocrine pancrea

177 All patients had a midline laparotomy in an emergency setting.

178 romuscular mesh-augmented reinforcement of a midline laparotomy in patients with abdominal aortic ane

179 Burst abdomen after midline laparotomy is associated with increased morbidit

180 ective surgery, it is well documented that a midline laparotomy should be closed with a slowly absorb

181 scheduled for any gastrointestinal emergency midline laparotomy were included until October 2015.

182 rtality compared with operations requiring a midline laparotomy.

183 bdominal cavity was explored from the middle midline laparotomy.

184 nsverse measurement used (midvertebra vs off-midline level).

185 derive from the rostral diencephalic ventral midline, lie above the prechordal mesendoderm and expres

186 Second, we detect no midline localization of Slit during brain development.

187 f cell-cell adhesions are both necessary for midline lumen opening and contribute to later maintenanc

188 orsal thalamic nuclei located at or near the midline, mainly from the central medial (CMT), and parav

189 ay to express the T-box transcription factor midline (mid).

190 grip force was minimal, appropriate for the midline movement, and not the average of the large grip

191 side of midline and a minimal grip force for midline movements.

192 of a posterior wnt1+ signaling center within midline muscle cells.

193 ricular layer (dVL) cells adjacent to dorsal midline Nestin(+) radial glia (dmNes+RG) down-regulate a

194 ression in the organizer and along the axial midline, neural tube closure defects (NTDs) arose and do

195 mx1a and Lmx1b, selectively expressed in the midline neuroepithelium and the mesenchyme respectively,

196 he central complex (CX) comprises a group of midline neuropils in the insect brain, consisting of the

197 anscranial magnetic stimulation of a frontal midline node of the cingulo-opercular MDC affected learn

198 equencing of 291 parent-offspring trios with midline NSC revealed 15 probands with heterozygous damag

199 experience on synaptic transmission from the midline nuclei of the thalamus (mThal) to the NAc have y

200 eration, immature desmosomes lacking a dense midline observed via electron microscopy, and impaired i

201 ventral visual regions, only signals in the midline occipital cortex could be used to distinguish ta

202 ogenitors were specified at the pre-existing midline of regenerating fragments, even when this locati

203 ed in the avascular region around the dorsal midline of the developing midbrain.

204 The primitive streak marks the midline of the future embryo.

205 The mechanical model represents the midline of the larva as a set of point masses which inte

206 sural neurons project their axons across the midline of the nervous system to target neurons on the o

207 by distinct mesenchymal cells at the dorsal midline of the neural tube.

208 d, the CM fascicles from the two sides cross midline on dorsal surface and continue as sling/oblique

209 ial for ensuring that they cross the ventral midline only once.

210 ease, tumour size >5 cm, tumour crossing the midline, or neurological symptoms), and without known HI

211 djunctive PN may provide greater relief from midline pain and a similarly low rate of operative compl

212 n which surgery failed to adequately resolve midline pain) and the frequency of operative and postope

213 ials with two targets located either side of midline, participants initially reached straight ahead.

214 Holoprosencephaly (HPE), a defect in midline patterning of the forebrain and midface, arises

215 pathway activity, with consequent effects on midline patterning.

216 re observed crossing the ventral floor plate midline perpendicularly at about 20 microns/h and in a m

217 Average midline pituitary height decreased from 5.9 to 5.3 mm (P

218 specify germ layer fate in two basal tailbud midline progenitor populations.

219 he axial push drives the lateral movement of midline PSM cells to maintain PSM growth and cell motili

220 omplex, A5, rostral ventral medulla, A1, and midline raphe, as well as sympathetic preganglionic neur

221 d ROBO2 isoforms are disinhibited to prevent midline reentry and to guide postcrossing commissural ax

222 e early-stage PGCs randomly migrating in the midline region of human embryos before initiation of the

223 inically significant inattention centered on midline regions of the DMN in both MEG and fMRI, boostin

224 responses in frontal, temporal and posterior midline regions, while callous-unemotional traits were p

225 The Slit protein is a major midline repellent for central nervous system (CNS) axons

226 lit-UC) that cannot be cleaved revealed that midline repulsion is still present but longitudinal axon

227 rosophila tok mutants lacking Slit cleavage, midline repulsion of axons occurs normally, confirming t

228 trol physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signallin

229 y mutations and arise in the hemispheres and midline, respectively.

230 ic nuclei such as anterior and ventromedial, midline, reticular, and posterior thalamic nuclei were a

231 As commissural axons navigate across the CNS midline, ROBO-mediated repulsion has traditionally been

232 tations contributing to common non-syndromic midline (sagittal and metopic) craniosynostosis, we perf

233 x, CT findings (compressed basal cistern and midline shift >=5 mm), presence of hypoxia, systemic hyp

234 Significant radiologic predictors included midline shift (OR, 6.8; 95% CI, 3.4-13.8), depressed sku

235 gow Coma Scale, duration on vasopressors and midline shift at septum.

236 eft parietal intracranial hemorrhage without midline shift or hydrocephalus.

237 Lower GCS score, midline shift, depressed skull fracture, and epidural he

238 There was no difference in presence of midline shifts, Injury Severity Score, Glasgow Coma Scor

239 This proposal was based on small, midline stab SCI.

240 ation of Aurora B kinase to the midzone (the midline structure located between segregating chromosome

241 ads to desmosomal remodeling and loss of the midline structure.

242 of infiltrating H3K27M DMG cells into other midline structures and cerebral lobes.

243 it2 at the glial wedge and indusium griseum, midline structures required for CC formation.

244 t processing of associative memory traces in midline structures that are involved in later memory ret

245 osely associated to a distributed network of midline structures that modulate hippocampal theta activ

246 P is reciprocally interconnected mainly with midline structures, including the MnR/DRC, nucleus incer

247 stablishes foxQ2 as a key regulator of brain midline structures, which distinguish the protocerebrum

248 ty between several frontostriatal seeds, and midline subcallosal cortex and left paracingulate gyrus

249 al responses and uncovers new players in the midline switch in Slit responsiveness of commissural axo

250 Figure 1: Sagittal midline T1-weighted 1.5-T MR image (repetition time msec

251 NT Growing evidence suggest that the ventral midline thalamic nuclei (reuniens and rhomboid) might pl

252 rtex, retrosplenial cortex, cingulate gyrus, midline thalamic nuclei and prefrontal cortex were inten

253 n both lateral entorhinal cortex and ventral midline thalamic nuclei of neonatal rats.

254 nucleus reuniens (Re) is the largest of the midline thalamic nuclei.

255 spatial working memory (SWM) and the ventral midline thalamic reuniens and rhomboid nuclei (Re/Rh) ha

256 ventricular nucleus of the thalamus (PVT), a midline thalamic structure that is increasingly being re

257 s is mediated by the nucleus reuniens of the midline thalamus (RE).

258 The nucleus reuniens (RE) is part of the midline thalamus and one of the major sources of thalami

259 (Re) and rhomboid (Rh) nuclei of the ventral midline thalamus are reciprocally connected with the hip

260 s provides electrophysiological evidence for midline thalamus as a site of complex information integr

261 These data highlight midline thalamus as an important node integrating multip

262 tinct roles of entorhinal cortex and ventral midline thalamus for the functional development of prefr

263 re, we show that the nucleus reuniens of the midline thalamus gates mPFC control of VTA DA neuron fir

264 Midline thalamus is implicated in linking visceral and e

265 entricular thalamus, a nucleus of the dorsal midline thalamus, in the arbitration of appetitive and a

266 the thalamus (PVT), a nucleus of the dorsal midline thalamus, in this interaction.

267 entricular thalamus, a nucleus of the dorsal midline thalamus, is integral to this behavioral competi

268 The nucleus reuniens (Re), a nucleus of the midline thalamus, is part of a cognitive network includi

269 irect source of metabolic information to the midline thalamus, our results support a growing body of

270 behaviours, such as the ventral striatum and midline thalamus.

271 on by directed interactions with the ventral midline thalamus.

272 d that softer sounds are perceived closer to midline than louder sounds, favoring rate-coding models

273 organizing center from stem cells at the old midline that directs head patterning and outgrowth.

274 absence of active beta-catenin at the dorsal midline, the DNA-binding protein TCF binds and actively

275 rsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilatera

276 editation has been shown to modulate frontal midline theta (FMT) and alpha oscillations that are link

277 Rather, near the midline, this lower quadrant map continued directly into

278 support to a continuous allocation model of midline tissue formation in zebrafish, and provide an em

279 2(+) callosal axons also failed to cross the midline to form the corpus callosum.

280 nferior defects advance above the horizontal midline to involve the superior VF.

281 fusion of the paired palatal shelves at the midline to separate the oral cavity from the nasal cavit

282 m (CNS)-organizing activity from the ventral midline to the neurogenic ectoderm.

283 palate, hyoid and mouth floor, squeezing the midline tongue base and food bolus back into the orophar

284 the trial was to determine if 2 widely used midline-traction and bilateral-thrust OA designs differ

285 in a randomized crossover trial using either midline-traction with restricted mouth opening (MR) or b

286 terior lateral plate mesoderm to the ventral midline, undergoing a mesenchymal-to-epithelial transiti

287 Ectopic midline vascularisation in endothelial Nrp1 and Vegfa(18

288 ly, the neurogenic ectoderm, not the ventral midline, was found to be the dominant source of EGF patt

289 puncture samples were collected at baseline, midline (week 5), and endline (week 12) to measure plasm

290 cess originating at the telencephalic dorsal midline, where levels of secreted Bmps are maintained by

291 do so in elongated cells within the crowded midline, where tension is low, or in regions that have b

292 n the early embryo fold directly towards the midline, where they meet and fuse to create the primitiv

293 re responsive to FGF signaling at the dorsal midline, whereas 'horseshoe' genes are predominantly reg

294 dorsal VZ highly disrupts CA guidance to the midline, whereas the deletion from the FP has little imp

295 to the egocentric representation of our body midline which allows us to perceive and adjust the posit

296 e to decode target positions on the vertical midline, which cannot be achieved using standard N2pc me

297 utant axons from R-neurons fail to cross the midline, which is indicative of an aberrant composition

298 ce of netrin1 directing axons to the ventral midline, while local VZ-supplied netrin1 is required for

299 em cell niche that centers around the dorsal midline with high expression of neural crest genes, plur

300 during development in a row along the dorsal midline, with rows of new feather buds added sequentiall