ライフサイエンスコーパス: milestone

1 f the linker has been an early technological milestone.

2 thway regulates a critical CIN developmental milestone.

3 es, and multiplayer poker is a recognized AI milestone.

4 ween complementary feeding and developmental milestones.

5 linically meaningful mobility and upper limb milestones.

6 cal disorder and regression of developmental milestones.

7 ed with disrupted attainment of adult social milestones.

8 ams are now required to rate residents using milestones.

9 teriorates according to agreed-upon clinical milestones.

10 tonia, growth retardation, and delayed motor milestones.

11 ss of motor skills and delayed developmental milestones.

12 olecule techniques that sought to detect its milestones.

13 eurons encounters several activity-dependent milestones.

14 s of managing biographical and developmental milestones.

15 d Stages Questionnaire data on developmental milestones.

16 ion how sleep may impact these developmental milestones.

17 lted in major advances and reached important milestones.

18 d amounts of CFB consumed, and developmental milestones.

19 types and amounts of CFB, and developmental milestones.

20 able decision makers to assess the following milestones: (1) a minimum of 33% reduction of CO2 emissi

21 dination and tracking of key global planning milestones, (2) guidance facilitating development of cou

22 = 0.018), and those who live past the 5-year milestone (46.1%) seem to be cured of disease.

23 Mumbai, India, reached its platinum jubilee milestone (75 years), which was celebrated with conferen

24 differences in age at attaining the pubertal milestones according to intrauterine cumulative (weeks)

25 This review focuses on the most significant milestones achieved to date in the conformational analys

26 tify feeding-associated differences in motor milestone achievement in preterm infants.Our results sug

27 The milestone achievements and recent results by both approa

28 ectrical properties highlighting some of the milestone achievements reported to date but also address

29 mobility and upper limb disease progression milestones across the lifespan as well as reduced risk o

30 which provides criteria for defining optimal milestones, allowing short, independent, cell-constraine

31 I also provide a few milestones along Blood's 70 years of publication, includ

32 sub-states associated to distinct structural milestones along the pore, and how to control residence

33 Intense light fields have facilitated milestones along this way, including the induction of no

34 mographic parameters with reproductive aging milestones (AMH <20 pg/mL or >12 months of amenorrhea).

35 model, an accelerated failure time model, a milestone analysis, and restricted mean survival time ar

36 d with advanced path sampling techniques and milestoning analysis to characterize how mRNA substrate

37 s regression models on the risk of a disease milestone and death were used.

38 cal discoveries that have brought us to this milestone and to explore other targets and immunotherapy

39 in the field, highlighting key psychosocial milestones and accompanying biological changes during de

40 zed by regressive loss of neurodevelopmental milestones and acquired psychomotor deficits.

41 nt most commonly presents with delayed motor milestones and ankle contractures.

42 d timing of attainment of neurodevelopmental milestones and associated behaviours in early childhood

43 lectual disability, delayed speech and motor milestones and autism spectrum disorder.

44 tnatal maternal environment on developmental milestones and behavioral phenotypes.

45 The research milestones and current trends of the immunosensors are r

46 elp to set up achievable malaria elimination milestones and guide the creation of efficient operation

47 ncy that results in failure to achieve motor milestones and in death or the need for mechanical venti

48 Section 2 describes early milestones and key advances in metal-organic magnet rese

49 ished since the year 2000, but including the milestones and key citations of earlier work.

50 walking, pain during exercise, delayed motor milestones and learning disabilities at school.

51 and OS HR but not 9-month PFS or 6-month ORR milestones and OS HR.

52 le periodic table, and discussing historical milestones and recent developments.

53 t, compiling the main fundamental/industrial milestones and remaining challenges facing homogeneous/h

54 ted with a more rapid development of disease milestones and shorter survival in patients with PD.

55 onset developmental delay with delayed motor milestones and significant speech delay (50% non-verbal)

56 significantly improved several developmental milestones and spatial olfactory memory in Ts1Cje neonat

57 Time from diagnosis to five disease milestones and survival were calculated to assess diseas

58 We present an overview of key milestones and their significance in the understanding a

59 ially developed psychometric tool, WHO motor milestones and visual tests.

60 The patient achieved normal developmental milestones and was not taking medications.

61 rning to read is a fundamental developmental milestone, and achieving reading competency has lifelong

62 nger survival, superior achievement of motor milestones, and better motor function than in historical

63 ognostic significance of achieving treatment milestones, and the critical importance of molecular mon

64 -corrected visual acuity (BCVA) at treatment milestones, and treatment failures were recorded.

65 ession is more rapid, age-related disability milestones are identical to relapsing-onset disease.

66 To facilitate this aim, reporting milestones are now required across all internal medicine

67 ce requirements and competitive transitional milestones are substantial.

68 Future work is needed to explore how milestones are used to support residents' development an

69 cted, and iOCT was performed during surgical milestones, as directed by the operating surgeon.

70 ported, most of which capture stage-specific milestones, as well as data on graft failure.

71 l requires recapitulation of the sequence of milestones associated with in vivo development of the di

72 s suggests a moderate association between OS milestones at 12 or 9 months and OS HR but not 9-month P

73 l report; observed the attainment of 7 motor milestones at 6, 12, and 18 mo of age; and conducted a c

74 order characterized by loss of developmental milestones at 9-24 months of age followed by seizures, d

75 may inform establishment of the validity of milestone-based assessment.

76 The initial milestone-based evaluations of IM residents nationally s

77 ne residents in the 2013-2014 academic year, milestone-based ratings correlated with RAES ratings but

78 As these milestones become imminent, and if programs are to succe

79 phics, etiology of SJS/TEN, age at treatment milestones, best-corrected visual acuity (BCVA) at treat

80 d with increased median age at loss of three milestones by 2.1-2.7 years in comparison with prednison

81 ith increased median age at loss of mobility milestones by 2.1-4.4 years and upper limb milestones by

82 y milestones by 2.1-4.4 years and upper limb milestones by 2.8-8.0 years compared with treatment for

83 re we color in some details of the lives and milestone contributions of our seven personal heroes of

84 g (Brief COPE), achievement of developmental milestones (Course of Life Questionnaire), and satisfact

85 Such findings suggest that examining early milestone differences and standardized testing results m

86 ectoderm occupying opposite poles-is a vital milestone during human embryo implantation.

87 clinical outcome represents key mechanistic milestones during drug development.

88 ; 3: GD14.5-16.5; 4: GD0.5-16.5) aligning to milestones during human development.

89 e era of contemporary treatment at different milestones during the follow-up.

90 High-adherence patients achieved recovery milestones earlier (vs low adherence), with return of bo

91 ) and fill factor (FF) to 77.19%, yielding a milestone efficiency of 11%.

92 considerably with the achievement of recent milestones encompassing the identification of many loci

93 on of the Archives of Clinical Surgery was a milestone event in the ensuing rise of surgery as a spec

94 Time to all disease progression milestone events was significantly longer in patients tr

95 ney made rich by many interesting scientific milestones, fascinating exploration of all corners of th

96 found impairments in postnatal developmental milestones, fewer inhibitory forebrain neurons, and defi

97 An important milestone for achieving not only such skyrmion materials

98 rolled by induced conformational change is a milestone for de novo protein design, and opens up new a

99 opment of amnion-is a critical developmental milestone for early human embryogenesis and successful p

100 antiretroviral therapy (ART) is an important milestone for efforts to cure HIV-1 infection.

101 rgeable Li metal anode (LMA) is an important milestone for improved battery technology.

102 ty and, if confirmed, they are going to be a milestone for instructing computational models of brain

103 ad of using cryogenic distillation, is a key milestone for molecular separations because of the multi

104 erefore, pEFS24 is an appealing and relevant milestone for patient counseling and could be a surrogat

105 ing mobile phone microscopy, achieving a new milestone for tele-medicine technologies.

106 clinical trials in 2013 marked an important milestone for the clinical validation of AXL as an antic

107 A major milestone for this research would be that one day we cou

108 heory of insular zoogeography', was a recent milestone for this theme.

109 urvival and overall survival, supporting new milestones for optimal response in patients with early C

110 rving as challenge problems, benchmarks, and milestones for progress.

111 Finally, key remaining milestones for the protometabolic hypothesis are highlig

112 viors is demonstrated, representing critical milestones for the use of SiO2-based materials in future

113 and polyminimyoclonus) and seven disability milestones (frequent falls, use of urinary catheters, wh

114 in order to stay below 550 ppm by 2100 (this milestone goes up to 46% in the case of delayed policies

115 utD increased the risk of reaching the first milestone (hazard ratio, 0.86; 95% CI, 0.83-0.89; P < .0

116 ation Council for Graduate Medical Education Milestones help define competent trainees and practition

117 x to mitigate climate change and meet policy milestones; however, the extent that solar energy develo

118 We describe key synthetic milestones, identify synthetic opportunities, and highli

119 ol into living cells represents an important milestone in achieving the full potential of synthetic b

120 in perennial species, PeachRefPop provides a milestone in an international collaborative project for

121 blished data, and it represents an important milestone in an ongoing collaborative effort to examine

122 and polymerase functionalities, represent a milestone in antiviral therapy.

123 metastatic breast cancer represents a major milestone in cancer therapeutics.

124 manized telomerase gene in mice, achieving a milestone in creating a mouse model with humanized telom

125 The structure of Tra1 is a key milestone in deciphering the mechanism of multiple coact

126 veness in the target population is a crucial milestone in developing IPV-Al.

127 nals (P < 5 x 10(-8)) for age at menarche, a milestone in female pubertal development.

128 This marked a milestone in global polio eradication and was a public h

129 ejection fraction, marking an important new milestone in heart failure treatment.

130 The "tail approach" has become a milestone in human carbonic anhydrase inhibitor (hCAI) d

131 ANCE STATEMENT The ability to use tools is a milestone in human evolution.

132 ntation of the blastocyst is a developmental milestone in mammalian embryonic development.

133 a single neuron, which would be an important milestone in neuroscience.

134 and the plain black-glazed ware represent a milestone in our material culture due to their aesthetic

135 ributions and collectively mark an important milestone in our understanding of both familial and spor

136 issue, Distefano et al. provide yet another milestone in our understanding of regulated necrosis as

137 A potential milestone in personalized nuclear medicine is theranosti

138 mbryonic control is a critical developmental milestone in preimplantation development.

139 cing delta-catenin mutations is an important milestone in prostate cancer metabolic adaptation by mod

140 The use of CE-C(4)D represents an important milestone in quantitative DBS analysis since the detecti

141 Reverse vaccinology (RV) is a milestone in rational vaccine design, and machine learni

142 These findings constitute an important milestone in realizing low-voltage polymer transistors f

143 Persons with Disabilities (CRPD) is a major milestone in safeguarding the rights of persons with dis

144 onucleotide therapy for SMA was an important milestone in SMA research; however, effective next-gener

145 ics and collective behaviour is an important milestone in systems chemistry, soft matter bioengineeri

146 This validation is a critical milestone in the advancement of this technology for futu

147 ixtures of HS oligosaccharides, an essential milestone in the analysis of structure-function relation

148 ordable, consumer-oriented 3-D printers is a milestone in the current "maker movement," which has bee

149 n reflectivity measurements represents a key milestone in the deduction of the interfacial structure

150 This vaccine represents an important milestone in the development of a vaccine against cCMV.

151 Therefore, these studies represent a major milestone in the development of attenuated rVSIV, and li

152 high energy-transfer efficiency represents a milestone in the development of plasma wakefield acceler

153 e models of tinnitus; our results serve as a milestone in the development of precision medicine in th

154 adiolabeled somatostatin analogs represent a milestone in the development of theranostic compounds.

155 effect in HgTe quantum wells is considered a milestone in the discovery of topological insulators.

156 an important but almost completely forgotten milestone in the evolution of case-control studies and o

157 Transcriptomic analysis has been a milestone in the field and has recently been enhanced by

158 These approvals marked a major milestone in the field of cell and gene therapies.

159 This constitutes a major milestone in the field, yielding a generation of microme

160 The presented findings represent a milestone in the fields of porphyrinoid chemistry and su

161 y graphene production can be considered as a milestone in the graphene field and is highlighted in th

162 The acyl-enzyme intermediate is a central milestone in the hydrolysis reaction catalyzed by these

163 We previously reported a milestone in the optimization of NBD-11021, an HIV-1 gp1

164 This result serves as a key milestone in the quest for two-electron transformations

165 of flaked stone artifacts represents a major milestone in the technology of the human lineage.

166 A major milestone in this direction arose via the completion of

167 A key milestone in this field will be when a universal quantum

168 ered drug delivery vehicle s is an important milestone in treating cancer.

169 n segmentation clock represents an important milestone in understanding human developmental biology.

170 cause for X-linked agammaglobulinemia was a milestone in understanding the genetic basis of primary

171 rgement and traverses a set of morphological milestones in 3D.

172 fant feeding and time to achieve major motor milestones in a US cohort.The Upstate New York Infant De

173 Clinical milestones in ALS progression were defined by loss of in

174 be our own scientific journey, reviewing the milestones in attaining this understanding of the brain-

175 has provided a unique opportunity to achieve milestones in automated image analysis.

176 humans share similar precocial developmental milestones in cardiovascular anatomy and physiology.

177 review critically discusses recent clinical milestones in complement drug discovery, providing an up

178 in biological samples are therefore critical milestones in diagnostics.

179 land (SMG), which recapitulate developmental milestones in differentiation.

180 establishment, Israel has achieved important milestones in health.

181 y life but the link to adverse developmental milestones in humans is unknown.

182 protocol that recapitulates several of these milestones in order to differentiate human pluripotent s

183 In addition to the latest milestones in our pathway collection and curation effort

184 to this phenomenon, a brief history of major milestones in our understanding of NPQ, definitions, and

185 protein is associated with delayed clinical milestones in patients with DMD mutations.

186 relative redox staticity has achieved great milestones in terms of TM-like reactivity.

187 Our study identifies intellectual milestones in the applications of DECT in abdominal radi

188 In this article we review key milestones in the development of our current understandi

189 a historical timeline overviewing the major milestones in the development of wearable electrochemica

190 Here, we review the important milestones in the discovery of these RTKs and their liga

191 Here we present milestones in the establishment of a new biotrophic mode

192 f animals remains one of the most mysterious milestones in the evolution of life.

193 Here, we review key milestones in the field of imprinting and discuss mechan

194 etter function) in the two cohorts and motor milestones in the high-dose cohort with scores in studie

195 m's Cave (Gibraltar), being one of the first milestones in the so-called "Anthropocene".

196 In this Review, we highlight recent milestones in these areas and some key scientific challe

197 es (in months) at attaining various pubertal milestones, including Tanner stages, per 10 daily cigare

198 ided information on a wide range of pubertal milestones-including Tanner stages, axillary hair growth

199 o CD1 dams accelerated several developmental milestones independent of genotype, and induced earlier

200 molars (SPMs) is an important developmental milestone influencing caries risk and the timing of seal

201 gressive microcephaly, delayed developmental milestones, intellectual disability, and, in two out of

202 A prior milestone is the evaluation of the analytical performanc

203 In this review, I focus on one theory: Milestoning is a theory and an algorithm that offers a h

204 age of acquisition of certain developmental milestones, it did not affect our assessments of motor,

205 Here, we provide a timely review of the milestones leading to our current understanding of PRMT5

206 ecently celebrated reaching the $1000 genome milestone, making affordable DNA sequencing a reality.

207 This milestone marked the beginning of a new era in the field

208 rence, -0.9; 95% CI, -1.0 to -0.8; P < .001; milestone medical knowledge 1 difference, -0.3; 95% CI,

209 icant similarity for growth or developmental milestone metrics, 10/28 (35.7%) showed similarity in HP

210 We use Markovian milestoning molecular dynamics (MD) simulations on a tes

211 onitored the acquisition of 11 developmental milestones monthly by maternal report; observed the atta

212 uals except 1 had normal cognitive and motor milestones, neuroimaging, and interictal neurological st

213 l Prize work; however, the latest efficiency milestone of 5.0% was more than 30 years ago.

214 After passing the milestone of 50% urbanisation, humanity is rapidly becom

215 inatal cannabinoid exposure retards an early milestone of development, delaying the trajectory of GAB

216 By reaching the key milestone of magnetic coupling above 77 K, these results

217 Recently, the milestone of sequencing and assembling a human genome on

218 A milestone of the year was the Ebola outbreak.

219 A major milestone of this effort was the publication in Cancer R

220 This review recounts the milestones of CD19 CAR therapy and summarizes lessons le

221 It briefly covers the milestones of qualitative changes in the field of electr

222 Seven progressive stages with milestones of success are defined for reporting on uteru

223 ovulatory cycle are important developmental milestones of the reproductive system.

224 ccumulation of genetic alterations providing milestones of tumor initiation, progression, disseminati

225 We outline milestones on the roadmap for the future development of

226 nd evaluating conservation targets is to use milestones, or interim targets linked to specific ecolog

227 WHO Motor Milestone outcomes, adherence, and morbidity were monito

228 ose group, incremental achievements of motor milestones (p<0.0001), improvements in CHOP-INTEND motor

229 reward from antibiotic sales through prizes, milestone payments, or insurance-like models in which in

230 two assessments of motor function: the motor milestones portion of the Hammersmith Infant Neurologica

231 To explore milestone rate, a proposed intermediate end point for im

232 Milestone rates may be useful as a complementary tool to

233 This analysis of milestone rates suggests a moderate association between

234 Trial-level milestone ratios for milestone rates were calculated for overall response rat

235 comes and Measures: Correlations of RAES and milestone ratings by training year; correlations of medi

236 Of the 26 PGY-3 residents with milestone ratings indicating deficiencies on either of t

237 Evidence of validity of milestone ratings is needed.

238 Milestone ratings may better detect problems with profes

239 Results: Corresponding RAES ratings and milestone ratings showed progressively higher correlatio

240 red more between PGY-1 and PGY-3 years using milestone ratings than the RAES (all P values <.001).

241 alism with residents' lowest professionalism milestone ratings was 0.44 (95% CI, 0.43 to 0.45; P < .0

242 on improvement." However, when subcompetency milestone ratings were used, 861 residents (12.8%) who s

243 velopmental rating scale, with developmental milestone ratings.

244 es: Program director ratings on the RAES and milestone ratings.

245 sociations were observed between 9-month PFS milestone ratio and OS HR (R2 = 0.19; 95% CI, 0.03-0.49)

246 R2 = 0.80; 95% CI, 0.63-0.91) and 9-month OS milestone ratio and OS HR (R2 = 0.67; 95% CI, 0.49-0.82)

247 association was observed between 12-month OS milestone ratio and OS HR (R2 = 0.80; 95% CI, 0.63-0.91)

248 ression model evaluated associations between milestone ratios and hazard ratios (HRs).

249 Trial-level milestone ratios for milestone rates were calculated for

250 data and pooled data to compare trial-level milestone ratios with conventional end points.

251 revisits IMG's original aims, highlights key milestones reached by the system during the past 10 year

252 journey through the major breakthroughs and milestones realized in the area of MOF-based small-scale

253 the long-term effects of glucocorticoids on milestone-related disease progression across the lifespa

254 ualification to identify key experiences and milestones relating to successful employment particularl

255 Key milestones relating to the study of skin in this way are

256 th higher risk of reaching the first disease milestone (respectively, HR: 0.88; 95% CI 0.83 to 0.92;

257 group than in the control group had a motor-milestone response (21 of 51 infants [41%] vs. 0 of 27 [

258 group than in the control group had a motor-milestone response (37 of 73 infants [51%] vs. 0 of 37 [

259 The primary end points were a motor-milestone response (defined according to results on the

260 cement therapy, achievement of developmental milestones, satisfaction of psychological needs, and cop

261 ucted a systematic analysis of developmental milestones, sensory abilities, and motor deficits, follo

262 eat spinal muscular atrophy is a significant milestone, serving to accelerate similar progress in a s

263 A milestone survival analysis was conducted to capture the

264 y body disease took longer to reach multiple milestones than patients with multiple system atrophy.

265 ogenesis represents a remarkable biochemical milestone that is summarized in this review.

266 dvances in retinal imaging mark an important milestone that shifts attention away from anatomy alone

267 We highlight some of the key milestones that allowed improved understanding and manag

268 od Institute (NHLBI) and celebrate important milestones that have been achieved by the Division of Ca

269 technologies for development of SMIRNAs, and milestones that have led to broader acceptance of RNA as

270 In this review, we describe the milestones that have led to this era of global transcrip

271 Here, we look back on the historical milestones that have paved the way for the discovery of

272 Here we summarize the milestones that mark this scientific triumph, discuss di

273 manifest symptoms at specific developmental milestones that suggest an intersection between early se

274 The year 2016 will mark an important milestone - the 35th anniversary of the first reported c

275 have taken the field to its first scientific milestone; the elemental principles of neural repair in

276 vant molecular systems by a method that uses milestoning theory to combine Brownian dynamics simulati

277 ions were conducted in explicit solvent with milestoning theory, making it possible to extract kineti

278 onitoring and tracking of the activities and milestones through dashboards and review meetings were u

279 This is a milestone to better understand their growth mechanism an

280 a species of similar temporal developmental milestones to humans.

281 tion uses the newly developed ACC Curricular Milestones to provide specific, competency-based feedbac

282 Establishing prevalence at birth is a milestone toward assessing years of life lost, years of

283 trical pulses, which represents an important milestone toward electrically driven perovskite lasers.

284 (DRC) was reported in 2001, marking a major milestone toward polio eradication in Africa.

285 s with CF and a CF mouse model, an important milestone toward the development of a clinical rAAV cand

286 We have thus reached a critical milestone toward the development of specific antiviral t

287 induced by tfec will represent an important milestone toward the expansion of HSCs for regenerative

288 sequently, this work represents an important milestone towards the detection of biomarkers in tissues

289 These achievements are a critical milestone towards the development of this micro/nano bio

290 The present approach represents a first milestone towards visualizing magnetization textures of

291 These results represent major milestones towards the goal of creating a significant qu

292 This milestone was one of the key criteria prompting the Glob

293 ween complementary feeding and developmental milestones was restricted by an inadequate amount of evi

294 Time to fixed disability milestones was shorter than in ROMS (Expanded Disability

295 To unravel these milestones we propose a framework, tumor evolutionary di

296 and time from diagnosis to specific disease milestones were calculated to assess disease progression

297 ent of social and psychosexual developmental milestones were related to higher subjective well-being.

298 time in the first reporting period in which milestones were used.

299 m cells, have also contributed to the latest milestones where more relevant tissues or organ-like con

300 ry over the last century by focusing on some milestones within scientific, clinical, and public healt