ライフサイエンスコーパス: milieu of

1 ncy-associated shifts in the transcriptional milieu of a cell may impact HML-2 activity.

2 These findings indicate that the cytokine milieu of a tissue can dramatically influence the develo

3 and to incorporate new neural cells into the milieu of a traumatic spinal cord injury.

4 ory effect of an unstable tissue oxygenation milieu of a tumor is likely to contribute to treatment r

5 nduced transcription in vitro in the complex milieu of a whole cell extract.

6 pro-fibrotic and pro-adipogenic with a rich milieu of activated immune cells responding to microbial

7 nderstanding of how the chronic inflammatory milieu of adipose tissue in obesity prevents thermogenic

8 ting that PVs can influence the inflammatory milieu of adjacent airways.

9 Thus, the proinflammatory milieu of advanced atherosclerotic lesions may be promot

10 lates the leukocyte infiltrates and cytokine milieu of advanced human tumors.

11 nosaccharides available in the extracellular milieu of Agrobacterium tumefaciens can be transported i

12 esent findings demonstrate that the internal milieu of an animal can modify ingestion analgesia, and

13 nfected but were exposed to the inflammatory milieu of an infected lung, pigs were infected with a PR

14 ng, and fighting, all depend on the hormonal milieu of an organism.

15 tes CRC progression to adenocarcinoma in the milieu of APC(Delta14/+), a phenomenon not found with wi

16 complement activation demonstrated a various milieu of ApoE & FH vs C5a & TCC in COVID-19 patients.

17 ions modified to reflect the intrasinusoidal milieu of arginine (RPMI-1640 media with 10 or 100 micro

18 es of RNA may contribute to the inflammatory milieu of arteriosclerosis.

19 mitations: it is a poor mimic of the in vivo milieu of bacterial infections, requires multiple days t

20 h micromolar dissociation constant (Kd) in a milieu of bacterial proteins with minimal sample prepara

21 Platelet-rich plasma (PRP) is a milieu of bioactive factors, including platelet derived

22 are assembled and modified through a complex milieu of biotic and abiotic factors.

23 Whether renal recovery was impacted by the milieu of brain death and/or microvascular injury remain

24 metastasis by modulating the local chemokine milieu of cancer cells in the TME.

25 re, epigenetic reprograming of the metabolic milieu of cancer cells is among the most crucial determi

26 Here we consider how the dynamic metabolic milieu of cancer cells regulates their DNA damage repair

27 For a long time, the external milieu of cancer cells was considered to be of secondary

28 and organellar dynamics within the cellular milieu of cardiomyocytes.

29 mensional analyses to understand the complex milieu of cell types that comprise the tissue microenvir

30 xpressed and purified from the extracellular milieu of cells as an SDS-soluble, nonaggregated protein

31 terized and involve a local pro-inflammatory milieu of cellular and soluble immune mediators.

32 infectivity of sporozoites delivered into a milieu of changes induced by cutaneous hypersensitivity.

33 Exactly how the complex milieu of chemical and mechanical signals interact in th

34 While the focus here is on the extracellular milieu of CHO cell cultures, this methodology is general

35 ediated liver regenerative response within a milieu of chronic inflammation links partial hepatectomy

36 The milieu of chronic kidney disease has associated factors

37 al features of the WT grafts immersed in the milieu of circadian malfunction were normal and absent o

38 Cells exist within complex milieus of communicating factors, such as cytokines, tha

39 compartments in which they occur, and in the milieu of competing proteins.

40 vely, these data indicate that TB provides a milieu of continuous cellular activation and irregularit

41 lators are tuned to optimize the hemodynamic milieu of critically ill patients.

42 olarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment.

43 On inhabitation of the extracellular milieu of cultured cells by infective trypomastigotes, t

44 s (BMSCs), inhibits the production in the BM milieu of cytokines (interleukin-6 [IL-6], vascular endo

45 r subsets is controlled in large part by the milieu of cytokines present during their initial encount

46 s and thermoregulatory dysfunction against a milieu of decreasing estradiol concentrations during men

47 l deposition within the disordered metabolic milieu of developing atherosclerotic plaque.

48 The brain is composed of a highly complex milieu of different cell types and few methods exist tha

49 nervous system and play complex roles in the milieu of diseases including the primary diseases of mye

50 Here, we characterized the immunological milieu of dystrophic muscle in mdx mice, a model of DMD,

51 ould be individualized to address the unique milieu of each implementation setting.

52 Thus, our study suggests that ligand in the milieu of EGFRvIII-expressing GBM cells is likely to inf

53 se toremifene prevented prostate cancer in a milieu of elevated blood free testosterone levels with n

54 persist for several months within a diverse milieu of endemic host lineages.

55 tory cells including mast cells (MCs), and a milieu of enriched cytokines.

56 mune responses are regulated by the specific milieu of environmental factors, cytokines, and other si

57 a dynamic process that depends on the local milieu of enzymes, sugar precursors and organelle struct

58 il to closely mimic the Th2 and inflammatory milieu of eosinophilic esophagitis (EoE) and assessed al

59 ulation is complemented by a tissue-specific milieu of external, systemic and niche inputs that modul

60 utions are obfuscated by the complex in vivo milieu of factor redundancy and indirect effects.

61 t and co-factor dependent, contingent on the milieu of factors that are present at different stages o

62 des (PMOs) have been well established in the milieu of FDA-approved oligonucleotide-based drugs in th

63 esion and clot stiffening/contraction in the milieu of fluid flow.

64 maturation of naive human B cells within the milieu of germinal centers.

65 the potential to favourably alter the immune milieu of glioblastoma.

66 proteins to the surface and/or extracellular milieu of Gram-negative bacteria, are members of a large

67 tors generated within the local inflammatory milieu of hALX mice showed diminished ability to activat

68 To determine definitively the intracellular milieu of HGPRT in these pathogens, polyclonal antiserum

69 um (ER) stress both in the complex metabolic milieu of high-fat feeding as well as in the setting of

70 ich their presence in the microenvironmental milieu of high-risk breast tissue could play a determini

71 Biofilm formation occurs within a complex milieu of host factors and other members of the human mi

72 asitize, where they must sort through a rich milieu of host proteins and nucleic acids to gather toge

73 ally bind to amyloid deposits in the complex milieu of human brain or whether amyloid binding was ove

74 owth in acidic conditions, the intracellular milieu of human cells, and abscesses in mice.

75 rage of signals present in the extracellular milieu of human immunodeficiency virus-infiltrated brain

76 se-dependent reduction of hypertrophy in the milieu of hyperglycemic culture media.

77 or probing its interactions with the complex milieu of immune response proteins present in human seru

78 V-1 target cells within the complex cellular milieu of infected tissues.

79 e alterations result in an enrichment of the milieu of infection with EVs carrying signatures from in

80 undernutrition, as well as the inflammatory milieu of infectious diseases, can complicate nutritiona

81 RANKL and OPG production in a cytokine-rich milieu of inflamed joints.

82 inflammation, literature characterizing the milieu of inflammatory cytokines and lipid mediators in

83 hostile extrinsic environment composed of a milieu of inhibitory factors.

84 The therapeutic milieu of inpatient services was an important mediator o

85 Thus, the inflammatory milieu of insulitis may skew the autoimmune response tow

86 strates metabolic alterations and supports a milieu of interactions among various cell types within t

87 e applied generically to explore the diverse milieu of interactions that comprise the connectome.

88 transported over a long range in the aqueous milieu of interstitial spaces.

89 small group of self-proteins among the total milieu of intracellular self-proteins.

90 exerts its antioxidant effect in the aqueous milieu of LDL.

91 how that Mtb creates a replication-conducive milieu of lipid droplets in hepatocytes by upregulating

92 rant AR re-activation and CRPC growth in the milieu of low androgen.

93 mportance of FRCs in shaping the suppressive milieu of lymphoid organs during homeostasis.

94 at reside and multiply within the hydrolytic milieu of mammalian macrophage phago-lysosomes.

95 se may be due to differences in the cellular milieu of melanocytes and may have implications for norm

96 e of recreating the physiologically relevant milieu of metastatic colonization may strengthen our gra

97 ovide novel insights into the complex immune milieu of MIBC with inflammation and supports its clinic

98 How are complex milieus of microenvironmental signals interpreted to coo

99 ufficient counterparts within the largely WT milieu of mixed bone marrow chimeras.

100 eothermal fields would resemble the internal milieu of modern cells.

101 We conclude that in a complex milieu of multiple CXC chemokines, CXCR1 functions as th

102 trafficking; (d) oxidative stress; and (e) a milieu of muscle cellular aging in which these changes o

103 r potential to emulate the electromechanical milieu of native tissues or conform well with the curved

104 sis and quantitation of apoptosis within the milieu of necrosis are analytical challenges.

105 Here we show that in the milieu of negative selection on physiological self class

106 Little is known about the internal milieu of NH(4)Ac-containing ESI droplets.

107 ype 1 diabetes, in the diabetes-predisposing milieu of NOD mice in the absence of the endogenous clas

108 can target specific RNAs amidst the cellular milieu of non-target RNAs.

109 diffusing rapidly through the extracellular milieu of nonexpressing cells.

110 to 7.0, whereas the intra- and extracellular milieu of normal cells is 7.4.

111 nd secreted factors promote the inflammatory milieu of obesity, but the transcriptional pathways that

112 an the endocrine, adipokine, or inflammatory milieu of obesity.

113 of the molecular, cellular and extracellular milieu of pancreatic cancer, and discuss them in the con

114 in illuminating a key element of the immune milieu of pancreatic cancer.

115 Yet, how the milieu of pancreatic progenitor cells, including exposur

116 and posttreatment samples, we show a complex milieu of parasites, including variants likely up-select

117 profile the vaginal microbiota and cytokine milieu of participants sampled longitudinally throughout

118 ulmonary microenvironment contains a complex milieu of pattern recognition molecules of the innate im

119 ) for alphaSN spreading in the extracellular milieu of PD.

120 r p62, a protein central to the pathological milieu of PDB, as one of the few noncollagenous human se

121 T cells probe a diverse milieu of peptides presented by molecules of the major h

122 ion early in life can prime the local immune milieu of peripheral tissues, which can cause lasting ch

123 tration require virion exposure to an acidic milieu of pH 6.2 to 6.8, even when furin and TMPRSS2 cle

124 disassembly, at the acidic pH of the tumour milieu, of pH-sensitive positron-emitting neutral copoly

125 DeltaA1-488 bound platelets in the milieu of plasma.

126 parasitemia might be impaired by the type 2 milieu of preexisting helminth infection.

127 critical period in adolescence the hormonal milieu of pregnancy affects the developmental fate of a

128 itor, the composition of their intracellular milieu of proteins changes to appropriately guide their

129 t step we addressed aptamer stability in the milieu of proteins present in these environments.

130 ors may contribute to the overall angiogenic milieu of RCC.

131 In the glucose-rich milieu of red blood cells, asexually replicating malaria

132 sphate crystals are more likely to form in a milieu of reduced PPi concentration.

133 Metazoan genes are embedded in a rich milieu of regulatory information that often includes mul

134 There is accumulating evidence that the milieu of repeat elements and other non-genic sequence f

135 The biological process behind the milieu of SANs to evoke pacemaker rhythm is unknown.

136 embly remain challenging in the dysregulated milieu of SCI because of impaired neurogenesis and neuro

137 , its behavior must be shaped by the complex milieu of sensory stimuli it detects, its previous exper

138 echanisms by which axons convert the complex milieu of signaling molecules into retrograde signals ar

139 igration and to the highly immunosuppressive milieu of solid tumors.

140 hniques is that we can incorporate the whole milieu of soluble factors produced by cells in situ into

141 ile both are exposed to the same circulating milieu of soluble factors.

142 Chronic HCV infection appears to disrupt the milieu of soluble inflammatory mediators even after vira

143 ndage and the left atrial body may produce a milieu of stagnant blood flow within the appendage and b

144 amic nature of the extracellular biochemical milieu of stem cell microenvironments that regulate plur

145 rly-stage disease nodules comprise a complex milieu of stromal and immune cells which interact to pro

146 east tumours and cell lines comprise a large milieu of subclones (7-22) that are organized into a few

147 In a milieu of sustained plasma P4 levels, these reciprocal c

148 enhancers, with a typical gene embedded in a milieu of tens of enhancers.

149 Although Cannabis contains an overwhelming milieu of terpenoids, only a limited number are currentl

150 abolized, as well as the prevailing hormonal milieu of that tissue.

151 l mechanisms readily overcome the inhibitory milieu of the adult injured spinal cord to extend many a

152 ginate from the environment but adapt to the milieu of the airway of the cystic fibrosis patient and

153 a major role in the immune and inflammatory milieu of the airway.

154 gnaling pathway functions within the complex milieu of the animal intestine.

155 udied the effects of the highly inflammatory milieu of the atherosclerotic plaque on IGF-1 signaling

156 The interstitial milieu of the brain is buffered to an average pH of 7.3,

157 nctional mitochondria into the extracellular milieu of the brain, without affecting the release of he

158 h that 'senses' changes in the intracellular milieu of the cardiac myocyte and responds by preferenti

159 ecreted by multiple bacterial species in the milieu of the catheterized urinary tract can directly im

160 However, in the milieu of the cell, the energy landscape can be modulate

161 Among the molecular milieu of the cell, the membrane bilayer stands out as a

162 cks them from responding to the trans-acting milieu of the cell.

163 elected to function optimally in the crowded milieu of the cell.

164 on their reactivity and occlusion within the milieu of the cellular environment.

165 lar composition, organization, and molecular milieu of the cellular infiltrates in muscle in juvenile

166 steine 474 of OCT2 is exposed to the aqueous milieu of the cleft and contributes to forming a pathway

167 The milieu of the CNS during HIV infection is extraordinaril

168 variation, and differences in environmental milieu of the colon which vary between the sexes.

169 data demonstrate that the altered metabolic milieu of the diabetic pregnancy causes permanent defect

170 s a safe, noninvasive method of sampling the milieu of the distal lung and is sufficiently sensitive

171 Interestingly, the environmental milieu of the draining lymph nodes (DLNs) of the mice im

172 When maintained in the normal ionic milieu of the ear, many bundles oscillated spontaneously

173 -induced conformational change in the acidic milieu of the endosome, resulting in fusion of viral and

174 How the genetic milieu of the epithelial compartment influences tumor an

175 proinflammatory cytokines released into the milieu of the epithelium in patients with Crohn's diseas

176 suggesting that a decline in the estrogenic milieu of the females could be a factor in accelerating

177 We examined unfolding in the milieu of the fusion reaction by conducting experiments

178 The diverse cellular milieu of the gastric tissue microenvironment plays a cr

179 one to degradation in the acidic-proteolytic milieu of the gastrointestinal tract, leading to poor or

180 a complex phenotypic differentiation by the milieu of the germinal center.

181 One of the reasons why the internal milieu of the GI system is poorly investigated is becaus

182 and restrains inflammation in the infectious milieu of the gingiva.

183 Within the milieu of the gut, this represents a novel mechanism by

184 d to be a hallmark of T cells exposed to the milieu of the HBV-infected liver in patients with active

185 greater knowledge of the intricate cellular milieu of the heart is critical to increase our understa

186 ic substrates such as p130Cas in the complex milieu of the host cell has not been fully elucidated.

187 ry morphological defects on the inflammatory milieu of the host mammary fat pad.

188 pathogenic microbes adapt to the nutritional milieu of the host through metabolic reprogramming and n

189 e in serum and multiply in the iron-limiting milieu of the host vertebrate.

190 T cells recently activated by the antigenic milieu of the host, with negligible numbers of residual

191 ctions and is influenced by the inflammatory milieu of the host.

192 hosphacan) and is found in the extracellular milieu of the human brain parenchyma.

193 osal innate immune response in the authentic milieu of the human respiratory tract.

194 rting cells are part of the complex cellular milieu of the human salivary gland, where they play impo

195 thesis that this cytokine was present in the milieu of the inflamed joint, and that it contributed to

196 ly-stage neurons can overcome the inhibitory milieu of the injured adult spinal cord to mount remarka

197 role in the maintenance of the unique ionic milieu of the inner ear fluid.

198 sessing target engagement within the complex milieu of the intracellular environment.

199 their activities respond to a change in the milieu of the intracellular transport pathway.

200 ffector phase of arthritis by regulating the milieu of the joint and serum, and by inducing apoptosis

201 The normal milieu of the kidney includes hypoxia, large osmotic flu

202 ars of Saccharomyces cerevisiae in the cell milieu of the latter despite the facts that the protein

203 eta appears to be localized within the lipid milieu of the lipoprotein particle and not associated wi

204 Whether more iron in the extracellular milieu of the lung associates with distinct clinical phe

205 We propose that the metabolic milieu of the lung, and potentially other tissues, is an

206 acetate to mimic the decidualizing steroidal milieu of the luteal phase and early pregnancy.

207 f the morphological, cellular, and molecular milieu of the mammary gland offers insights into the dri

208 sociated immune cells that shape the complex milieu of the meningioma microenvironment.

209 ggest that IL-7 may function to regulate the milieu of the microenvironment by modulating IL-6 secret

210 ce of TMPRSS2-expressing cells in the acidic milieu of the nasal cavity.

211 to neurons and astrocytes in the post-injury milieu of the neonatal brain injured by HI.

212 ng this we need to consider the multisensory milieu of the newborn infant.

213 by this region were essential in the complex milieu of the nucleus.

214 transfect other cells and that the metabolic milieu of the parental cell decides the quality of exoso

215 f therapies based on the associated clinical milieu of the patient.

216 umran scrolls represent the broader cultural milieu of the period.

217 mine whether the vector would survive in the milieu of the peritoneal cavity, the authors examined th

218 In this study, the normal milieu of the primate spinal cord was disturbed by multi

219 Hence by maintaining the microbial milieu of the proximal small intestine, the clearance of

220 between donor organ quality and the biologic milieu of the recipient.

221 nd display an alteration in the inflammatory milieu of the serum and cerebrospinal fluid.

222 a gatekeeping enzyme regulating the hormonal milieu of the SG.

223 the external environment and/or the internal milieu of the skin can lead to pathological conditions s

224 ery while targeting the immunologically rich milieu of the skin.

225 environmental stresses including the acidic milieu of the stomach and the toxic effects of bile in t

226 +]o, potentially regulated by changes in the milieu of the synaptic cleft during neural activity.

227 ell activation within the highly immunogenic milieu of the transplanted tissue.

228 by cytokines and by the nutrient-restrictive milieu of the tumor microenvironment (TME) to suppress a

229 to synergize with OV to modulate the immune milieu of the tumor microenvironment (TME), thereby impr

230 suppressor mutations can modulate the immune milieu of the tumor microenvironment, and they offer spe

231 plify the acidic signal in the extracellular milieu of the tumor to achieve specific imaging with imp

232 colorectal cancer cells affects the cytokine milieu of the tumors, possibly affecting tumor-stroma in

233 We sought to broadly define the inflammatory milieu of the upper respiratory tract in AERD and to det

234 While folates are absorbed in the acidic milieu of the upper small intestine, the underlying abso

235 or' molecules into the cytoplasm or cellular milieu of their hosts to facilitate colonization.

236 Future research should clarify the temporal milieu of these effects and investigate whether individu

237 Soluble factors in the biochemical milieu of these wounds are sufficient to activate the in

238 irus infection and replication in the airway milieu of this model.

239 inal ganglion cells (RGCs) require a complex milieu of trophic factors to enhance cell survival and a

240 The extracellular milieu of tumors is generally assumed to be immunosuppre

241 rately acidic pH similar to the pericellular milieu of tumors.

242 eriments were carried out in three different milieus of varying fluidity [mixed micelles, 1-palmitoyl

243 We demonstrate that this milieu of vascular growth factors is altered in streptoz

244 ls the cellular machinery behind the complex milieu of vertebrate SANs and opens a new direction for

245 When added as liposomes to the milieus of water-soluble molecules to be delivered throu

246 t to the alcohol content (13.5 vol%), acidic milieu of wine and other ingredients present during the