ライフサイエンスコーパス: mimetic

1 tion that is largely independent of membrane mimetic.

2 chimeric variants of LPL and an LPL peptide mimetic.

3 haride capsule, hydrolyzed a peptide antigen mimetic.

4 hat utilized Matrigel as a basement membrane mimetic.

5 epresent one form of cardiovascular exercise mimetic.

6 genes, demonstrating its action as an FGF21 mimetic.

7 ced myofibroblast differentiation on aligned mimetics.

8 dependent mechanism of sensitization by SMAC mimetics.

9 ive natural products and important glycoside mimetics.

10 food analysis using nanozymes as peroxidase mimetics.

11 ng a new class of small-molecule alpha-helix mimetics.

12 uctures and their interactions with membrane mimetics.

13 s correlated poorly with the activity of BH3 mimetics.

14 ion to explore the physical properties of OM mimetics.

15 c restriction and act as caloric restriction mimetics.

16 oblasts, including FLT-3 inhibitors and SMAC mimetics.

17 ta-glycoconjugates, including C-disaccharide mimetics.

18 ne-4-amine (PP) compounds that are bulky ATP mimetics.

19 trictions and the use of secondary structure mimetics.

20 aid in the development of nanodisc membrane mimetics.

21 l molecular scaffold to design alpha-helical mimetics.

22 and/or DPP4 inhibitors prior to using GLP-1 mimetics.

23 n energy reutilizing strategy based on a bio-mimetic 3D structure.

24 The apolipoprotein A-I (APOA1) mimetic 4F mitigated disease in both the Cox2 MKO/CCHF a

25 Second, an ApoA-1 mimetic, 5A peptide, was demonstrated to modulate the co

26 er 10 000 person-years in 10 684 using GLP-1 mimetics, 6861 of whom were prescribed GTZ and/or DPP4 i

27 Notably, sole treatment with a BDNF mimetic, 7,8-dihydroxyflavone hydrate, significantly res

28 inhibited by administration of Gap19 peptide mimetic, a Cx43 hemichannel-specific inhibitor.

29 derepressed BIM and synergized with the BH3-mimetic ABT-199 in eradicating MLL-rearranged B-ALL cell

30 was blocked with the fluorinated sialic acid mimetic Ac(5)3F(ax)Neu5Ac.

31 d the effects of K326Q and K328Q acetyl (Ac)-mimetic actin on Ca(2+)-dependent, in vitro motility par

32 e use of antibodies and incorporating enzyme mimetic activity in assay systems.

33 ium-gold nanozyme shows excellent peroxidase mimetic activity with O-phenylenediamine in the presence

34 A infusion of adiponectin or the adiponectin mimetic AdipoRon in wild-type mice decreases basal dopam

35 Hypoxia and the hypoxia mimetic agent l-mimosine can increase the production of

36 genin in response to hypoxia and the hypoxia mimetic agent l-mimosine in periodontal fibroblasts.

37 the n-butyl group as an atypical KAc methyl mimetic allowed generation of 31 (GSK6776) as a soluble,

38 ic antibody modality, termed antibody ligand mimetics (ALM), by incorporating complex ligand agonists

39 icrobial peptides and small-molecule peptide mimetics also activate mast cells via MRGPRX2/B2.

40 epcidin synthesis or treatment with hepcidin mimetics ameliorates beta-thalassemia.

41 To this end, we compared mimetic and non-mimetic populations of Echinochloa crus-

42 n reporter, we also demonstrate that phospho-mimetic and nonphosphorylatable point mutations at known

43 ials in ASD children with oxytocin, oxytocin mimetics and additional tentative therapeutics should as

44 the licensed glucagon-like peptide 1 (GLP1) mimetics and dipeptidyl peptidase inhibitors that enhanc

45 We found that combining BH3 mimetics and gamitrinib-TPP blunted cellular proliferati

46 Mfatc) can interact with a range of membrane mimetics and may thereby act as a membrane-anchoring uni

47 at uses a new class of VEGFD-derived peptide mimetics and postinjury nose-to-brain delivery.

48 field of metallo-organic antifreeze protein mimetics and provides insight into the origins of ice-gr

49 oether-linked carbacyclic beta-(1->3)-glucan mimetics and synthesized di-, tri-, and tetramers in an

50 ion between use of DPP4 inhibitors and GLP-1 mimetics and the onset of Parkinson's disease (IRR 0.64;

51 rotein complexes by small molecules, peptide mimetics, and natural products.

52 Acquired resistance to BH3 mimetic antagonists of BCL-2 and MCL-1 is an important c

53 henocopied by an administration of the FGF21-mimetic antibody, consistent with its action to stimulat

54 tes that the antibodies elicited against the mimetic antigen indeed recognize the naturally occurring

55 As GLP-1 mimetics are administered systemically in humans, we eva

56 Suitable membrane mimetics are crucial to the performance of structural an

57 Glucagon-like peptide 1 (GLP-1) mimetics are effective drugs for treatment of type 2 dia

58 Three reported dietary restriction mimetics are mainly effective across C. elegans strains,

59 es of iminosugar-type 2-deoxy(thio)glycoside mimetics are reported.

60 Specifically, mimetics are sought that can enact control over the self

61 the potential of protein tertiary structure mimetics as an emerging class of PPI modulators.

62 profound implications for the utility of BH3-mimetics as drugs.

63 ystematically reexamines the role of hypoxia mimetics as experimental substitutes for hypoxia and pro

64 al of Affimers, a recent example of antibody mimetics, as suitable bioreceptors for the detection of

65 els with alanine- (DNA-PKcs(PQR)) or phospho-mimetic aspartate (DNA-PKcs(SD)) substitutions at the S2

66 ontrast, replacing serine with phosphoserine-mimetic aspartic acid (S386D) in ANDV N robustly inhibit

67 Also, the acetylation mimetic attenuated the mesangial cell hypertrophy and fi

68 tions, and we explore a plethora of membrane mimetics available for the structural and mechanistic un

69 f a series of designed C2-symmetric cytokine mimetics, based on the designed ankyrin repeat protein (

70 ic Bcl-2 proteins, and can be blocked by BH3 mimetic Bcl-2 inhibitors.

71 e, we report crystal structures of substrate mimetic bearing ACPs in complex with the elongating KSs

72 y seeks information about how these membrane-mimetic bilayers assemble onto the C(18)-derivatized sil

73 nd fluorescence microscopy of supported MRSA mimetic bilayers treated with oligoTEAs.

74 The NGF-mimetic bioactivity of Nsp was first confirmed on the ba

75 nes is a critical step in the design of cell-mimetic biosensors, bioreactors, and artificial cells.

76 bits growth of tumor cells and acts as a RAS mimetic by binding to Ras binding domains of RAS effecto

77 s), involving both CA II and a soluble CA IX mimetic (CA IX-mimic), revealed the structural basis of

78 dates the mechanism of helix-induced, enzyme-mimetic catalysis, emphasizes the importance of solvent

79 e fungus-hematite interactions can behave as mimetic catalysts, similar to nanozymes that imitate per

80 Aligned mimetics caused cardiac fibroblasts to elongate while ra

81 tion can be stabilized by small-molecule CD4 mimetics (CD4mc) or soluble CD4 (sCD4) in combination wi

82 ed upon binding of CD4 or small-molecule CD4 mimetics (CD4mc).

83 results demonstrate that the design of virus-mimetic cell interactive NPs is a valuable strategy to e

84 both flow cytometry and mass cytometry in a mimetic cell mixture and human peripheral blood mononucl

85 Here, we utilize enzyme-mimetic CeO(2) nanocrystals that are sensitive to H(2)O(

86 from inflammatory cell death induced by SMAC-mimetic chemotherapeutic agents (small-molecule activato

87 te and in complex with hepcidin and the iron mimetic cobalt.

88 strom crystal structure of Tpt1 in a product-mimetic complex with ADP-ribose-1"-phosphate in the NAD(

89 ADCC in the presence of a small-molecule CD4-mimetic compound (CD4mc).

90 Small-molecule CD4-mimetic compounds (CD4mc) bind gp120 and act as competit

91 In contrast to CD4 complementation by CD4-mimetic compounds, activation of CD4-independent infecti

92 ay parallel to that triggered by CD4 and CD4-mimetic compounds.

93 An unphosphorylated mimetic construct is active and highly polarized, while

94 pattern variation within species, as well as mimetic convergence between species.

95 Importantly, acetylation mimetic cortactin restored the impaired synaptic transmi

96 r strategy for building hyper-stable de novo mimetics could be applied generally to signalling protei

97 uses axon degeneration and suggest that Bclw-mimetics could provide effective therapy to prevent CIPN

98 genic mouse models were generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each

99 A competing cell-penetrating peptide mimetic derived from the Na(V)1.8 WW binding motif decre

100 f that process, we hypothesized that peptide mimetics derived from the phospholipid binding domain of

101 This ligand mimetic design and optimization approach can be expanded

102 1-42) peptides form coclusters with membrane mimetic detergent micelles.

103 By contrast, randomly oriented mimetics did not change focal adhesion tension sensation

104 in sensitizers (thiazolidinediones), insulin mimetics, dis-inhibitors (the mTORC1 inhibitor rapamycin

105 pment of soluble envelope glycoprotein (Env) mimetics displaying ordered trimeric symmetry has ushere

106 owever, HIFalpha stabilization using hypoxia mimetics, does not recapitulate the effect of hypoxia on

107 n complexes resistant to displacement by BH3-mimetic drugs currently in use or being evaluated for ca

108 ensive hitchhiking of linked variants on the mimetic dsx haplotype that occurred at the origin of mim

109 ering of anti-PSMA peptide-decorated exosome mimetics (EMs) targeting advanced prostate cancer (PC).

110 rminus adopt helical structure in a membrane-mimetic environment.

111 However, the PTM mimetics exist as a mixture of tetramer and dimer, indic

112 Another NCAM peptide mimetic, FGL(L), had acute anxiogenic effects and chroni

113 A related NCAM peptide mimetic, FGL(S), had antidepressant effects without modu

114 To address this we developed bio-mimetic fish-like robots which allow us to measure direc

115 UMI-77 is an established BH3-mimetic for MCL-1 and was developed to induce apoptosis

116 and selective monoacid-based phosphotyrosine mimetic for mPTPB inhibition.

117 lipid concentrations and considered a better mimetic for natural membranes.

118 y isolated and cultured on ECM topographical mimetics for 72 hours.

119 ave the potential for the development of BOK-mimetics for sensitizing 5-FU-resistant cancers.

120 icited by combining copper chelators and BH3 mimetics for treatment of BRAF(V600E) mutation-positive

121 he peptidisc, a 'one-size fits all' membrane mimetic, for the capture of the Escherichia coli cell en

122 tive and highly polarized, while the phospho-mimetic form is not.

123 eins mutated either to the potential phospho-mimetic glutamic acid (Y102E) or to the nonphosphorylate

124 the two succinylated lysines in UCP1 to acyl-mimetic glutamine and glutamic acid significantly decrea

125 blockade of E-selectin using small molecule mimetic GMI-1271/Uproleselan effectively inhibits this n

126 for CA125 as capture reagent and peroxidase mimetic gold nanoparticles as label for detection of CA1

127 n analyte by using an aptamer and peroxidase mimetic gold nanoparticles that ensures circumventing th

128 Here we design a nacre-mimetic graphite-based nanofluidic structure in which th

129 d a selective small molecule alphavbeta6 RGD-mimetic, GSK3008348, and profiled it in a range of disea

130 tantly however, combination of PI3Ki and BH3 mimetics had a profound, BIM-dependent cytotoxic effect

131 ly fibroblasts on flat and randomly oriented mimetics had increased percentages of fibroblasts with a

132 losteric plasmin inhibitors based on heparin mimetics have been developed.

133 ther mammary cancer cells embedded in tissue-mimetic hydrogels are nearly 4-fold stiffer than the sur

134 glycosylation for a recombinant trimer Spike mimetic immunogen and for a soluble version of human ACE

135 AICAR acts as an exercise mimetic in settings of fatty liver disease, an important

136 tical label for the detection of the peptide mimetic in the competitive ULISA.

137 Here we describe a microenvironment mimetic in vitro cell culturing system that incorporates

138 tility of antimicrobial catechol siderophore mimetics in managing bacterial infections.

139 olonged neuronal survival when exposed to PD mimetics in the presence of astrocytes in a co-culture m

140 filing reliably predicted sensitivity to BH3 mimetics in vitro and in vivo.

141 CL and assessed the in vitro efficacy of BH3 mimetics, including the BCL2 inhibitor venetoclax, the B

142 r understanding of the molecular basis of PD mimetic-induced Parkinsonism and the discovery of neurop

143 Furthermore, we observed that PIC, a viral mimetic, induces Lnc13 translocation from the nucleus to

144 A synthetic substrate mimetic inhibited diverse fungal Cdc14 homologs with sim

145 In a reporter mouse, the mimetic inhibited Th2 polarization.

146 conformations of these potent transmembrane-mimetic inhibitors are similar to those of bound natural

147 on along with the impact of a Panx1-specific mimetic inhibitory peptide, 10Panx, on macrophage hemich

148 Reltecimod, a CD 28 T-lymphocyte receptor mimetic, inhibits T-cell stimulation by an array of bact

149 imate change is increasing the proportion of mimetic interactions in which models occur first and red

150 The use of DPP4 inhibitors and/or GLP-1 mimetics is associated with a lower rate of Parkinson's

151 uch as antimicrobial peptides (AMPs) and AMP mimetics is necessary to improve our understanding of th

152 chemical structure analysis and to produce a mimetic Kdo-lipid A domain AlmG substrate to that synthe

153 Selectivity remains a challenge for ATP-mimetic kinase inhibitors, an issue that may be overcome

154 spired ceramic-polymer composites with nacre-mimetic lamellar and brick-and-mortar architectures are

155 We demonstrate that mimetic lines evolved from the non-mimetic population as

156 inhibitors of CYP4Z1 designed as fatty acid mimetics linked to the bioactivatable pharmacophore, 1-a

157 asured peptide-cholesterol contacts in virus-mimetic lipid bilayers using solid-state NMR spectroscop

158 onstituted this "short NC" gp41 into a virus-mimetic lipid membrane and conducted solid-state NMR exp

159 as combined with the glucagon-like peptide 1 mimetic liraglutide, the two peptides synergized to redu

160 g term cycling of full cells using the nacre-mimetic lithium-metal anodes is also demonstrated.

161 provides a case study of how to engineer ECM-mimetic materials for therapeutic immune stimulation in

162 that cells adjacent to the basement membrane mimetic Matrigel survived MEK inhibition, while the cell

163 m the poor in vivo stability of the membrane-mimetic media often used for solubilizing the membrane p

164 In the event that a broad spectrum exercise mimetic might ever be developed, we discuss some generic

165 regimen containing Env cross-linked to a CD4-mimetic miniprotein (gp140-M64U1) in rhesus macaques.

166 reases acetylated Miro1 in axons, and acetyl-mimetic Miro1 K105Q prevents CSPG-dependent decreases in

167 ntly, a low-DNA-binding-affinity acetylation-mimetic MITF mutation supports melanocyte development an

168 lations employing the highly mobile membrane mimetic model to describe spontaneous partitioning of th

169 tissue-specific manner, tissue-targeted RSPO mimetic molecules are desired.

170 sical principles of the assembly of collagen-mimetic molecules.

171 hosphorylation, though a hyperphosphorylated mimetic mutant failed to bind TNPO3 and mislocalized to

172 ty, whereas overexpression of a 499E phospho-mimetic mutant increased filopodia length.

173 A C-terminal acetylation-mimetic mutant of S6 kinase suppressed high glucose-stim

174 The deacetylation mimetic mutant, but not the WT and the acetylation mimet

175 c mutant, but not the WT and the acetylation mimetic mutant, of MLH1 confers resistance to 6-thioguan

176 Analyses with phospho-defective and phospho-mimetic mutants of FoxM1b identified a critical role of

177 lls, phosphorylation of Y155, or its phospho-mimetic mutation (Glu), prevents the interaction of RLC

178 Also, a phospho-mimetic mutation of A303 in NEMO, corresponding to S473

179 rol-bound beta(1)AR coupled to the G-protein-mimetic nanobody(6) Nb80.

180 t stimulation and coupling to a G(s)-protein-mimetic nanobody.

181 g, we exploited nanoscale discoidal membrane mimetics (nanolipoprotein particles) to capture and pres

182 ility of engineered high-density lipoprotein-mimetic nanoparticles (eHNPs) to cross the BBB and deliv

183 ibacterial implant surfaces with insect-wing mimetic nanopillars made of synthetic materials.

184 Nanozymes or enzyme mimetic nanostructures possessing intrinsic catalytic ac

185 is was pharmacologically mimicked by the BH3 mimetic navitoclax, identified as top compound in a scre

186 Our virus-mimetic NPs showed outstanding target-cell affinity with

187 ibrary of 60 nonsaccharide glycosaminoglycan mimetics (NSGMs) led to the discovery of 23 hits against

188 les, called non-saccharide glycosaminoglycan mimetics (NSGMs), as direct allosteric plasmin inhibitor

189 A cell permeant phosphopeptide mimetic of Niban (NiPp) was generated.

190 A LIG-bound sulfate anion is a plausible mimetic of the essential RNA terminal 2'-PO4.

191 ocedure, the synthesis of a thioether ring B mimetic of the natural lantibiotic haloduracin beta was

192 Eltrombopag, a synthetic small molecule mimetic of TPO that interacts with c-MPL at a position d

193 Thus, these data suggest that mimetics of AA starvation could provide an alternative s

194 identify improved small molecule functional mimetics of H2-RLX with selective, full agonist or posit

195 ised the growth, survival and response to PD mimetics of human SH-SY5Y neuroblastoma and U-87MG gliob

196 utes to the creation of enzymatically stable mimetics of IDR-1018 and identify a promising new cyclic

197 ired chemists for decades to seek artificial mimetics of proteins with improved or novel properties.

198 ion, and small-molecule, [2Fe-2S]-containing mimetics of the active site (H-cluster) of these metallo

199 c thiodisaccharides, which can be considered mimetics of the repeating units of hyaluronan and kerata

200 host colonization suggests that CIP peptide mimetics offer strategies to inhibit surface sensing, pr

201 We propose that addition of BH3 mimetics offers a therapeutic strategy to markedly impro

202 mice by reconstitution of apoptosis with BH3 mimetics or clodronate-encapsulated liposomes.

203 BH3 mimetics or PI3Ki were unable to restore hormone sensiti

204 Here, we report a BMP9 peptide mimetic, P3, designed from the type I receptor binding s

205 0 intraspecific variants, including three co-mimetic pairs.

206 ether peripherally administered NCAM peptide mimetics penetrate the brain and alter the behavior of s

207 Results indicate that NCAM peptide mimetics penetrate the brain and support the suggestion

208 latively short polyanions (synthetic heparin-mimetic pentasaccharide), with the majority of the prote

209 f antibodies of patients using a recombinant mimetic peptide (PGL1M3R) as recognition element and exp

210 dy aimed to investigate a synthetic TGFbeta1 mimetic peptide (TGFbeta1-mim) for its ability to modula

211 rmore, blocking LYCAT activity using a LYCAT mimetic peptide attenuated cell migration, suggesting a

212 was encapsulated into apolipoprotein (ApoE) mimetic peptide decorated nanoparticles (ApoE-NPs), with

213 ailure; furthermore, support the use of Cx43 mimetic peptide Gap27 as an effective therapeutic tool t

214 propose to determine salutary effect of Cx43 mimetic peptide Gap27 in the progression of heart failur

215 Four weeks after AV-Shunt surgery, the Cx43 mimetic peptide Gap27 or scrambled peptide, were adminis

216 We investigated whether this coreceptor-mimetic peptide improves the potency of broadly neutrali

217 Here we investigated whether the coreceptor-mimetic peptide mim6 improved the potency of bNAbs with

218 on of a RB-derived S249/T252 phosphorylation-mimetic peptide suppresses radiotherapy-induced upregula

219 wer doses (10, 50, and 100 mg/kg), the Panx1 mimetic peptide, 10Panx, reproducibly exacerbated the se

220 than CD4-Ig due to its C-terminal coreceptor-mimetic peptide.

221 The self-assembly of collagen-mimetic peptides (CMPs) that form sticky-ended triple he

222 Here, we designed collagen-mimetic peptides (CMPs) with previously reported Gly ->

223 Collagen triple helices, comprising collagen-mimetic peptides (CMPs), are employed as molecularly pro

224 -complementary heteromeric pairs of collagen-mimetic peptides (CMPs).

225 logy and a translational potential for APOA1 mimetic peptides for the treatment of IBD.

226 ing isothermal titration calorimetry and CBD-mimetic peptides, as well as CaM-agarose affinity pulldo

227 ificantly exceeding that of analogous mussel-mimetic peptides.

228 We further demonstrated that APOA1 mimetic peptides: i) inhibited LPS and oxidized 1-palmit

229 c surface molecules, the use of synthetic EV mimetics permits the study of specific EV receptor-ligan

230 Females conceivably benefit from the mimetic pheromone during mate search but must discrimina

231 The NCAM peptide mimetic, plannexin, acutely increased and chronically de

232 of type I IFNs with the double-stranded RNA mimetic poly(I:C) likewise produces pain hypersensitivit

233 C57BL6/N mice by administration of the viral mimetic, poly(I:C), on gestation day 12.

234 10] or late gestation (GD19) MIA, via viral mimetic polyI:C, produces deficits in inhibitory neuron

235 rate that mimetic lines evolved from the non-mimetic population as recently as 1,000 yr ago and were

236 To this end, we compared mimetic and non-mimetic populations of Echinochloa crus-galli from the Y

237 Here, we exploit the enzyme-mimetic properties of platinum nanoparticles combined wi

238 not only suggest that a tissue-specific RSPO mimetic protein can stimulate regeneration in a cell-spe

239 ntial use of a metabolically stable spermine mimetic, (R,R)-1,12-dimethylspermine (Me(2)SPM), to redu

240 We define the mimetic relationships between 2,352 pairs of stinging Hy

241 eatment with Tempol, an superoxide dismutase mimetic, rescued kidney injury in knockout mice without

242 d S473 in OPTN and its corresponding phospho-mimetic residue in ABIN-1 (E484) are essential for high

243 BH3 mimetic resistance is characterized by decreased mitocho

244 es drugs that are persistently active in BH3 mimetic-resistant myeloblasts, including FLT-3 inhibitor

245 upon treatment with the thrombopoietin (TPO) mimetic romiplostim (TPO(high)).

246 Furthermore, overexpression of a phospho-mimetic S175E AMOT mutant, which has been established to

247 Overexpression of a phosphorylation mimetic (S226D) in young 3xTg mice strongly promotes APP

248 Recently, we developed APC-mimetic scaffolds (APC-ms), which present signals to T c

249 contrast, the apoptotic modulator drugs SMAC mimetics sensitized B-cell acute lymphoblastic leukemia

250 tes spike encoded signals generated from bio-mimetic sensors with in-memory computing based learning

251 The generated mimetics showed enhanced proteolytic stability and reduc

252 females glean reliable information from both mimetic signals and their model cues remains unknown.

253 Moreover, Phosphor-NIP30 mimetics significantly increase the growth inhibitory ef

254 e previously synthesized reported N8 peptide-mimetic small molecule (blocking p22phox-Rubicon interac

255 chondria-derived activator of caspase (SMAC) mimetics (SMs) are selective antagonists of the inhibito

256 that tyrosine sulfation serves as a receptor mimetic strategy for recognizing and suppressing the pro

257 phospho-deficient [Su(H)(S269A)] and phospho-mimetic [Su(H)(S269D)] variants: the latter displayed re

258 markedly increased by appending a coreceptor-mimetic sulfopeptide to its C terminus.

259 of one class of bNAbs, show that coreceptor-mimetic sulfopeptides enhance neutralization through dis

260 rotein-protein complex formation in membrane mimetic systems.

261 matic affinity differences in these membrane-mimetic systems.

262 ng peroxiredoxin-6 overexpression or the SOD mimetic tempol, prevented chromatin SUMO3 depletion, HDR

263 Here, we develop synthetic antibody mimetics, termed monobodies, to interfere with STAT3 sig

264 APOA1 mimetic Tg6F therapy was also effective in reducing inte

265 has been recognized as a caloric restriction mimetic that confers health benefits, presumably by indu

266 onophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of S

267 PMA and AJH-836 (a DAG-mimetic that preferentially activates PKCepsilon) promot

268 in complex with E1, and a Cdc34~Ub thioester mimetic that represents the product of Uba1-Cdc34 Ub tra

269 Our analyses focused on BH3 mimetics that are broad acting (ABT263 and obatoclax) or

270 Nanodiscs are membrane mimetics that consist of a protein belt surrounding a li

271 ins (DARPins) are one such class of antibody mimetics that have proven useful in the clinic, in diagn

272 The development of extracellular matrix mimetics that imitate niche stem cell microenvironments

273 (MCL1) inhibitor S63845, a proapoptotic BH3-mimetic therapy, significantly decreased DKO and Mdr2(-/

274 ise, so-called 'exercise pills' or 'exercise mimetics.' These compounds have, to date, typically targ

275 y used approaches to IMS quantification, the mimetic tissue model and dilution series, were used to q

276 d precision comparable to the non-normalized mimetic tissue model data.

277 spectrometry (MS) of stable isotope labeled mimetic tissue models for the spatially resolved quantif

278 e physiological and morphological effects of mimetic titanium nanopillars on bacteria.

279 g surface, possibly acting as a nucleic acid mimetic to competitively block DNA binding.

280 activity by administering a hepcidin peptide mimetic to pregnant mice.

281 Using membrane mimetics to generate conformationally open AP2, we find

282 ation of atypical acetyl-lysine (KAc) methyl mimetics to take advantage of the differential stability

283 , can be further optimized for developing T1-mimetics to treat atherosclerosis.

284 In the first, with a Ub-adenylate mimetic (Ub-AMSN) bound, the E1 is in an open conformati

285 ical studies of WT PKM2 (wtPKM2) and the two mimetic variants demonstrated that the activity decrease

286 irst proof-of-concept that fat-specific cold mimetics via activating non-canonical thermogenesis prot

287 chondria-derived activator of caspase (SMAC) mimetics was not affected by inhibition of HSF1.

288 Profiling by BH3 mimetics was performed in CLL cells fully resistant to v

289 In contrast, a phospho-mimetic WASH variant induces endosomal actin accumulatio

290 ughput screen designed to identify bile acid mimetics we uncovered nonsteroidal small molecule scaffo

291 Utilizing lipid nanodiscs as a membrane mimetic, we show that the MA trimer binds to membranes 3

292 ious low-molecular-weight beta-(1->3)-glucan mimetics, we designed a series of minimal 2,4-dideoxy-th

293 Several dual or triple combinations of BH3 mimetics were highly synergistic in restoring killing of

294 ctions with monoclonal antibodies or peptide mimetics, which cause hypoalbuminemia, biliary loss of a

295 shold of ABT-199/Venetoclax, a promising BH3-mimetic whose cytotoxic activity is counteracted by high

296 he signaling ligand WntA plays in generating mimetic wing patterns in Heliconius butterflies, a group

297 Designing BMP mimetics with specific activity will contribute to the t

298 identify NURR1 agonists as possible exercise mimetics with the potential to ameliorate obesity and ot

299 and safety of GC4419, a superoxide dismutase mimetic, with placebo to reduce the duration, incidence,

300 tterionic micelle platform featuring a virus-mimetic zwitterionic surface, a betaine side chain and a