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2 es that stabilize a reaction intermediate by mimicking a "flipped-out" conformation of the target cyt
3 form that operates using the analysed fluid, mimicking a blood sample, for early stage detection of H
5 e dataset collected from multiple hospitals, mimicking a DHDN where health data are horizontally part
6 itutions within FUS's PrLD and observed that mimicking a few phosphorylation sites strongly inhibited
9 genetic, and pharmacological perturbations, mimicking a range of physiological and pathological situ
11 alternatively spliced 25-amino acid exon 9* mimicking a splice variant of alpha(1C) upregulated in t
15 r (RAL; an integrase inhibitor) suppression, mimicking active and ART-controlled HIV infection in viv
18 xpression in response to microbial component-mimicking agents in epidermal keratinocytes that form th
20 ogeneous clinical presentations, potentially mimicking amyotrophic lateral sclerosis or distal heredi
26 ticles (Cu(5.4)O USNPs) with multiple enzyme-mimicking and broad-spectrum ROS scavenging ability for
31 s hierarchical composites and atomic lattice-mimicking architectures, have achieved optimal combinati
32 did not change Abeta-burden in a mouse model mimicking aspects of AD at baseline, and only mildly red
33 nd to squeeze through microfluidic channels, mimicking aspects of the tight perivascular conduits and
38 tural complexity at different length scales, mimicking biomolecules, can occur in active-metal cluste
39 The core of the review discusses models for mimicking blood vessels, the respiratory tract, the gast
40 etween the axonally connected networks, i.e. mimicking both local and circuitry functionality of the
41 genesis resulting in alveolar simplification mimicking BPD in neonatal mice, but the underlying mecha
43 sion of m1 and m3 under androgen deprivation mimicking castration and androgen receptor inhibition.
45 ses acquire m(6)A in their RNA as a means of mimicking cellular RNA to avoid detection by innate immu
46 and epithelial thymic stromal compartments, mimicking changes seen during early adult maturation.
48 vironmental circadian disruption (ECD) model mimicking circadian disruption occurring during shift wo
50 alyses of the crystal structure of a phospho-mimicking, condensation-proficient CPB mutant reveal tha
51 m survival of spores and cysts under climate-mimicking conditions, investigated spore and cyst ultras
52 /A) Instead, administration of oleate, while mimicking constitutively active Acc1 in WT cells, allevi
56 wn to counteract Arabidopsis defense through mimicking defense signaling molecules, jasmonates (JAs).
58 ver 18 kg m(-2), to receive either a fasting mimicking diet (FMD) or their regular diet for 3 days pr
59 a indicate that the combination of a fasting-mimicking diet and vitamin C represents a promising low
60 upport further clinical studies of a fasting-mimicking diet as an adjuvant to oestrogen therapy in ho
61 iving oestrogen therapy, cycles of a fasting-mimicking diet cause metabolic changes analogous to thos
63 ibitor), adding periodic cycles of a fasting-mimicking diet promotes long-lasting tumour regression a
65 breast cancer, periodic fasting or a fasting-mimicking diet(3-5) enhances the activity of the endocri
67 in collagen-I matrices of varying densities, mimicking different three-dimensional (3D) tissue constr
72 dividuals are transplanted within structures mimicking emergent traits that suppress waves or sedimen
73 ature virions to transform into A-particles, mimicking engagement by the functional receptor ICAM-5,
74 e two scaffolds, Optimaix (laminar structure mimicking entities of the diaphysis) and DegraPol (highl
75 ns, whereas the PDAC cells grown in the lung-mimicking environment showed the enrichment of ALDH+/CD1
76 e hydrophobic and surrounded by the membrane-mimicking environment while the edges are hydrophilic an
77 re of an Abeta oligomer formed in a membrane mimicking environment, namely an Abeta(1-42) tetramer, w
78 oxide dismutase-, and glutathione peroxidase-mimicking enzyme properties exhibit cytoprotective effec
80 n of the long isoforms of Cask and Madd, and mimicking exon skipping in these transcripts through ant
82 n to promote survival in castrate conditions-mimicking first line treatment resistance with hormonal
86 hibition, further experiments utilizing BMP2-mimicking GDF5 variants clearly indicate a more complex
87 ine-triplet was replaced with either phospho-mimicking glutamic acids (mdxS3E) or nonphosphorylatable
88 replacement of one of them with acetylation-mimicking glutamine increases the sensitivity of mutant
90 d their wild-type littermates to a fast food-mimicking, high-fat high-sucrose diet and profiled the m
92 ng small airway microfluidic culture device, mimicking how lung cells may experience smoke in vivo.
94 in vitro tissue and organ models capable of mimicking human physiology severely hinders the developm
96 re demonstrated by tests with a liver cancer mimicking hydrogel phantom, a solution sample, and porci
97 5%) to pathologically high (50%) variability mimicking hypertension, superimposed on 0.1 mean area st
98 secretion of endogenous EPO under conditions mimicking hypoxia, ruling out an artifact of heterologou
100 portantly, therapy inhibiting (anti-IL-6) or mimicking (IGF-1) the cardiac hMSC secretome can rescue
102 ation of myeloid cells expressing RM CD200R, mimicking interactions that are predicted to occur in vi
107 Here, we advance restoration science by mimicking key emergent traits that locally suppress phys
108 we report a series of experiments with twig-mimicking larvae of the American peppered moth Biston be
110 r materials scientists, fueling the dream of mimicking life-like motion and tasks in untethered, man-
111 ) inhibit C. jejuni growth by binding to GM1-mimicking lipooligosaccharides and increasing permeabili
112 Hepatocyte spheroids are useful models for mimicking liver phenotypes in vitro because of their thr
113 Pretreatment with E-4031 to block I(Kr) (mimicking long QT syndrome 2) or with sea anemone toxin
114 xin II to impair Na(+) channel inactivation (mimicking long QT syndrome 3) prolonged AP duration (APD
116 ctive sites, have provided opportunities for mimicking metalloprotease and for bridging the gap betwe
117 In this work, we show that environments mimicking microgravity conditions can harness the size a
118 y that targets Abeta and tau concurrently by mimicking misfolded protein clearance mechanisms of immu
129 ynamic networks (CDNs) as functional modules mimicking native circuits by demonstrating CDNs-guided p
130 The production of artificial proteins by mimicking native-like structures has shown to be a promi
135 iquid interface provide a renewable route of mimicking natural photosynthesis and yielding chemicals
138 ating the formation of lithium embryos, thus mimicking natural, pathological immunization mechanisms.
139 explore whether this effect is due to DWV-A mimicking naturally occurring changes in brain gene expr
140 been dedicated to artificial photosynthesis mimicking nature to split H(2)O into H(2) and O(2) by so
147 pressing Cre and either wildtype, or mutants mimicking or preventing phosphorylation, revealed that s
148 indicated that expression of the acetylation-mimicking p53 mutant in vivo induces activation of p53 t
149 ) mouse model, expression of the acetylation-mimicking p53-mutant protein effectively suppressed K-Ra
153 competitive immunoassays, we designed a ZEA mimicking peptide extended by a biotin-linker and confir
154 potassium channels, using specific S4-S5(L)-mimicking peptides, we previously demonstrated that S4-S
156 an experimental proof of concept on a tissue-mimicking phantom and then, apply the method to in vivo
157 cessful OPi-OP detection conducted in a skin-mimicking phantom gel demonstrates the suitability of th
161 rphology, and reduced TRIM32 protein levels, mimicking phenotypes in patients afflicted with LGMD2H.
162 errant root meristem and stomatal divisions, mimicking phenotypes of plants with reduced RETINOBLASTO
164 ovides controlled release of insulin closely mimicking physiological basal insulin requirement for an
167 n-driven self-assembly has created molecules mimicking Platonic, Archimedean and even Goldberg polyhe
168 ies of two patients who developed vasculitis mimicking polyarteritis nodosa and giant cell arteritis.
173 he correct answer of a second decision, thus mimicking real-life situations in which confidence guide
175 ically inhibiting the ISR kinases(14-17), or mimicking reduced p-eIF2alpha with the ISR inhibitor ISR
178 This paper demonstrates bifunctional enzyme mimicking roles of a metal-free nanozyme hybrid of chemi
182 ely, pretreatment with GS-967 shortened APD (mimicking short QT syndrome), and E-4031 reverted APD sh
184 rd solid solution strengthening, another one mimicking solute cloud formation, and a third one where
186 que primary sequence, binds to alpha-Cbtx by mimicking structural features of the nAChR binding pocke
187 hosphorylated LC3B Thr-50 in vitro A phospho-mimicking substitution of Thr-50 impaired binding of sev
188 microscopy, we revealed that phosphorylation-mimicking substitutions at Ser-10, or to a lesser extent
189 SO)-induced cardiac oxidative damage-a model mimicking sympathetic nervous system (SNS) overstimulati
190 thods and Results: Using IL-10 knockout mice mimicking systemic inflammation condition, we compared t
192 nstitution of LC3B-KO cells with the phospho-mimicking T50E variant inhibited autophagic p62 degradat
194 CD8 T cells with agonistic CD3 and CD28 Abs, mimicking TCR and costimulatory signals, coordinately in
196 erning required a lipid membrane composition mimicking that of early endosomes, with PI(3)P enhancing
198 ssful in creating a catalytic site precisely mimicking that suggested for natural metallonucleases re
199 emistry (DCC) library to generate a receptor mimicking the 5-sided box-like shape of Rme2 reader prot
201 on sized particles in mucus under conditions mimicking the adult human small intestinal environment.
204 malignant counterparts in an ex vivo system mimicking the bone marrow microenvironment, would define
206 ched 3D structure within 21 days of culture, mimicking the cellular composition of the bronchioalveol
207 LADA and for comparison in a first rat model mimicking the characteristics of patients with LADA.
208 ergent-induced lipid scrambling of liposomes mimicking the charge asymmetry of bacterial membranes wi
209 ha) and interleukin-1 (IL-1beta) and thereby mimicking the chronic neuroinflammatory environment obse
210 tablishment of resistance from single cells, mimicking the clonal expansion of a resistant lineage fo
211 dy responses, underscoring the importance of mimicking the complex protein structures that are found
212 arriers and provided low-burden information, mimicking the concept of the U.K. Ministry of Transport'
213 ant PCBs were tested singly and as a mixture mimicking the congener profile in maternal serum for act
214 diments were then cooled by 10-40 degrees C, mimicking the cooling in subsurface oil reservoirs subje
215 that Stx2a binds to an 11-mer peptide (P11) mimicking the CTD of P stalk proteins with low micromola
217 urbed in mutant mice and in explant culture, mimicking the defects associated with canal atresia.
218 rank transmission bias in a field experiment mimicking the diffusion of a behavioral innovation.
222 ely inhibits LRRK2-phosphorylation of Rab10, mimicking the effects of LRRK2 kinase inhibition in prom
223 nhibits the shedding of the SDC4 ectodomain, mimicking the effects of matrix metalloproteinase inhibi
225 h depression may reduce excitability in A25, mimicking the effects of the neurotypical serial pathway
227 a mouse model expressing wild-type human FUS mimicking the endogenous expression pattern and level wi
228 generation RNA sequencing, viral cDNA clones mimicking the enterovirus RNA sequences found in patient
229 ition, we developed a computer model closely mimicking the experimental conditions and used this mode
232 ever, the implementation of cameras directly mimicking the eyes of common arthropods is complicated b
234 BX5+NKX2-5-, TBX5-NKX2-5+, and TBX5-NKX2-5-, mimicking the first heart field, epicardial, second hear
238 These results highlight the importance of mimicking the highly structured flavivirus surface when
240 raving after prolonged voluntary abstinence, mimicking the human condition of relapse after successfu
244 human heart after myocardial infarction (by mimicking the infarcted, border and remote zones), and r
245 in coculture experiments with live bacteria mimicking the infected stomach lining, we found that H.
246 ues inhibited slc13 transport function, thus mimicking the inhibitory effect of the slc13 inhibitor,
248 OH-NQs drives their biological activities by mimicking the interactions with the natural substrate.
249 Thus, vitamin K antagonists act through mimicking the key interactions and conformational change
252 (His) variant of Arabidopsis OR, genetically mimicking the melon OR(His) allele, and found that it al
253 interaction has been studied in vitro, where mimicking the membrane curvature of the binding environm
254 n remeasured strain phenotypes in chemostats mimicking the metabolite-limited community environments,
255 hypothesized that a recurrent neural network mimicking the modular structure of the anatomical circui
258 ls with controlled surface functionalization mimicking the nanoplastics formed during natural degrada
259 A sulfur vacancy on the MoS(2-x) basal plane mimicking the natural Mo-nitrogenase active site is modi
260 eir native habitats, raised under conditions mimicking the natural thermal regime-that is, warmer and
261 get Merkel cells in organoid hair follicles, mimicking the neural circuitry associated with human tou
262 o investigate retinopathy in a model closely mimicking the normal progression and metabolic features
263 iPSCs, namely iPSC-liver buds (iPSC-LBs), by mimicking the organogenic interactions among hepatocytes
264 Designed as transition-state analogues by mimicking the oxacarbenium ion, novel pyrimidine-2,4-dio
265 ct microenvironments in radial layers, thus, mimicking the pathophysiological environment of a tumor.
269 ted R-loops for initiation of DNA synthesis, mimicking the process of replication restart in vivo The
270 Here, using an in-house microfluidic device mimicking the pulmonary capillary bed, we show that the
274 , while optogenetic inhibition of SNr cells (mimicking the SNr deactivation observed during an active
277 efine electronic properties of the materials mimicking the structure of the benchmark 2,2',7,7'-tetra
278 and isomerized at high conversions (>97 %), mimicking the traditionally produced refined products.
279 talysts or via two-step excitation processes mimicking the Z-scheme of natural photosynthesis are cur
281 intain the majority of bacterial strains, as mimicking their native environmental niches adequately c
287 change of anionic phosphatidylglycerol (PG), mimicking this key asymmetry of bacterial membranes.
291 Laboratory experiments under conditions mimicking those during midsummer in the natural environm
293 cenarios: (A) Homogeneous gamma-irradiation, mimicking total-body exposures, vs. mixtures of irradiat
294 and (iv) automatic dynamic permeation tests mimicking transdermal measurements in Franz-cell configu
295 farct risk after 12- to 20-minute occlusions mimicking transient ischemic attacks (14/19 vs 6/18 with
298 on cells could be achieved under conditions mimicking unlimited depth using the CR-embarked light so
299 TIE2-L914F mutant cells form enlarged lumens mimicking vascular lesions present in VM patients, indep
300 , we designed 4 different ventricular models mimicking wave propagation in cardiac tissues under norm