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1 atically isolated from lean, healthy Ossabaw miniature swine.
2 ng and smell, at rest and during exercise in miniature swine.
3 n) using L-[1-13C]Leu as a tracer in 24 male miniature swine.
4  allografts procured from healthy MHC-inbred miniature swine.
5 poiesis and provide long-term engraftment in miniature swine.
6 cs of PBSCs were determined in 2-5-month-old miniature swine.
7 ft and support host thymopoiesis in euthymic miniature swine.
8 dies of allogeneic thymic transplantation in miniature swine.
9 ng-lasting acceptance of renal allografts in miniature swine.
10  implanted in the iliac arteries of nine NIH miniature swine.
11 tal major histocompatibility complex-defined miniature swine.
12 ajor histocompatibility complex (MHC)-inbred miniature swine.
13 lpha-1,3-galactosyltransferase gene knockout miniature swine.
14 to fully MHC-mismatched renal transplants in miniature swine.
15 combined immunodeficient (NOD/SCID) mice and miniature swine.
16 eneic stem cell or spleen transplantation in miniature swine.
17 ajor histocompatibility complex (MHC)-inbred miniature swine.
18 lity complex (MHC) mismatch in thymectomized miniature swine.
19 f antibodies to non-MHC antigens in tolerant miniature swine.
20 eactivity against either standard or GalT-KO miniature swine.
21 ormed across a class I MHC barrier in inbred miniature swine.
22 es and maintains tolerance to both organs in miniature swine.
23 larized thymic lobe (VTL) transplantation in miniature swine.
24 e tissue allografts across an MHC barrier in miniature swine.
25 an intact, vascularized thymic lobe (VTL) in miniature swine.
26 nts were present in the genomic DNA of these miniature swine.
27 to six MHC-matched, minor antigen-mismatched miniature swine.
28 x (MHC)- mismatched barriers in juvenile MGH-miniature swine.
29  vascularized thymic lobe transplantation in miniature swine.
30 n both "tolerant" and "nontolerant" chimeric miniature swine.
31 thout the need for whole body irradiation in miniature swine.
32 l of chronic lung rejection using MHC-inbred miniature swine.
33 lanted beneath the renal capsule of juvenile miniature swine.
34 isease across MHC barriers in mixed chimeric miniature swine.
35 pic lung transplants (n=3) were performed in miniature swine across a major histocompatibility comple
36 leen transplantation (SpTx) was performed in miniature swine across full major histocompatibility com
37 or reactivity against: 1) human; 2) standard miniature swine; and 3) GalT-KO peripheral blood lymphoc
38                                              Miniature swine are likely to be suitable organ donors f
39 recipient bone marrow cells (BMC), using the miniature swine as a model.
40 ere implanted in the coronary arteries of 31 miniature swine at 28 days after creation of a fibrocell
41 immunotoxin was administered i.v. to several miniature swine at doses ranging from 0.15-0.2 mg/kg eit
42 sis of Hoechst dye-stained human, rhesus and miniature swine bone marrow cells reveals a small, disti
43 toxin provides excellent T-cell depletion in miniature swine but is associated with significant dose-
44 ismatched renal allografts can be induced in miniature swine by treatment with a short course of cycl
45 nce of class I disparate renal allografts in miniature swine can be induced by a short course of cycl
46 nce to class I-disparate renal allografts in miniature swine can be induced by a short course of cycl
47 rs for cloning, resulting in the creation of miniature swine containing mono- and biallelic mutations
48 aining within the expected range for Yucatan miniature swine-derived kidneys.
49                             Partially inbred miniature swine developed in this laboratory provide a u
50                               Three herds of miniature swine, each homozygous for a different set of
51 1,3 galactosyltransferase knockout (GalT-KO) miniature swine enjoyed survival comparable to that of a
52 s II identical renal grafts is achievable in miniature swine following a short immunosuppressive trea
53 promised mice for one tumor cell line and in miniature swine for 1 of 2 tumor cell lines expanded for
54  copies of closely related proviruses in the miniature swine genome.
55    Over the last 40 y, a specialized herd of miniature swine has been intentionally bred to develop l
56 1,3-galactosyltransferase knockout (GalT-KO) miniature swine has eliminated anti-Gal antibodies as th
57                                              Miniature swine have been shown to share many relevant i
58           Studies utilizing partially inbred miniature swine have demonstrated that a short course of
59         Recent studies in young (5-7 months) miniature swine have demonstrated that the thymus is inv
60      Such animals were identified within the miniature swine herd and may further enhance the safety
61   The identification of animals in an inbred miniature swine herd that consistently fail to produce r
62  these recombinants are exogenous viruses in miniature swine; i.e., they are not present in the germ
63 lografts has been accomplished previously in miniature swine in our laboratory.
64 he family of study were not present in other miniature swine in the herd that produced humantropic PE
65  immunosuppression and used partially inbred miniature swine, in which the genetics of major histocom
66 ion between swine leukocyte Ag (SLA)-matched miniature swine, in which tolerance can be established w
67 d recombinant PERV-A/C loci in the genome of miniature swine, indicate that exogenous PERV is the pri
68 ce of class I mismatched renal allografts in miniature swine is induced by a short course of cyclospo
69 te systemic tolerance to renal allografts in miniature swine is induced in 100% of cases across a two
70 or-specific tolerance to renal allografts in miniature swine is uniformly induced across a two-haplot
71 rus transplantation in a large animal model (miniature swine) is feasible using this heterotopic mode
72                   After transplantation of a miniature swine kidney, maintenance therapy comprised co
73                                              Miniature swine lacking Gal (Gal pigs) have been produce
74 ajor histocompatibility complex (MHC) inbred miniature swine large animal model that the construction
75 hed against PAEC from partially inbred SLAdd miniature swine lysed only PAEC and phytohemagglutinin-s
76                      These MHC-characterized miniature swine (Mc-MS) have been used for the study of
77                     We also have described a miniature swine model of fully mismatched allogeneic com
78  investigation was to establish a transgenic miniature swine model of RP using the human P23H RHO gen
79 n RHO P23H transgene in the retina creates a miniature swine model with an inheritance pattern and re
80 re, we demonstrate, in a clinically relevant miniature swine model, induction of immunologic toleranc
81 inary results show that in this well-defined miniature swine model, recombinant swine cytokine combin
82 ter transplantation of a limb allograft in a miniature swine model.
83 in fractions in different organs, we infused miniature swine (n = 8 per group) with saline, insulin a
84 C) obtained by leukapheresis from MHC-inbred miniature swine (n=6) were transplanted into baboons.
85 both major histocompatibility complex-inbred miniature swine (n=7) and human decay-accelerating facto
86 1 region was found to be invariant among MGH miniature swine of different haplotypes, despite 25 year
87 (P1 and P14) obtained from homozygous inbred miniature swine of three haplotypes (aa, cc, and dd), re
88 ed with WBI- or CPP-based therapy, and after miniature swine or hDAF kidney transplantation.
89                       Kidneys harvested from miniature swine or pigs transgenic for human decay-accel
90             During our studies of autoBMT in miniature swine, performed without CsA treatment, we not
91        PCR amplification of genomic DNA from miniature swine peripheral blood lymphocytes, using prim
92 ted human cells following cocultivation with miniature swine peripheral blood mononuclear cells (PBMC
93 ogenous retrovirus taken from lymphocytes of miniature swine (PERV-MSL) has been characterized.
94                                      GalT-KO miniature swine produce anti-Gal antibodies and titers i
95                                              Miniature swine provide a genetically defined large-anim
96                                       Inbred miniature swine provide a large animal model in which th
97                              Fifteen SLA(dd) miniature swine received 1.5 Gy whole body irradiation a
98                                         Five miniature swine received autologous BMC conditioned with
99                   In addition, three SLA(dd) miniature swine received class I mismatched kidney with
100                                    Seventeen miniature swine received class-I mismatched kidneys with
101                                 Ten SLA(d/d) miniature swine received fully MHC-mismatched renal allo
102 jor histocompatibility complex (MHC)-defined miniature swine received haploidentical hematopoietic ce
103                                    Seven MGH-miniature swine received heterotopic intestinal grafts,
104                                              Miniature swine receiving a transplant of a class I-mism
105             T-cell chimerism predominates in miniature swine receiving hematopoietic-cell transplanta
106                                          Six miniature swine recipients received fully MHC-mismatched
107 by vascularized renal allografts in juvenile miniature swine recipients.
108 on of mixed chimerism across MHC barriers in miniature swine, severe graft-versus-host disease was av
109 ly retransplanted into MHC-matched, diabetic miniature swine, similar in weight to the original recip
110                                        Naive miniature swine SLA(dd) T cells were rendered hyporespon
111 NA transcript profiles in a family of inbred miniature swine (SLA(d/d) haplotype) in which individual
112 ed pigs and 6 of 17 (35%) MHC matched inbred miniature swine survived more than 100 days.
113                              Sixteen Yucatan miniature swine (Sus scrofa).
114                                       Inbred miniature swine that are treated for 12 d with a high do
115 at transmitted HTRC PERV as well as from one miniature swine that did not transmit HTRC PERV.
116  Here we report the identification of inbred miniature swine that failed to produce human-tropic repl
117  of animals within a research herd of inbred miniature swine that lack the capacity to transmit PERV
118 human cells and were also identified in some miniature swine that lacked this ability.
119 enomic DNA libraries were generated from one miniature swine that transmitted HTRC PERV as well as fr
120     These viruses were invariably present in miniature swine that transmitted PERV to human cells and
121                                              Miniature swine that were tolerant of heart and/or kidne
122                  Analyses of fetal and adult miniature swine tissues revealed a broad mRNA expression
123 ated whether tolerance could be generated in miniature swine to composite tissue allografts across a
124                We have used partially inbred miniature swine to determine the role of class I MHC ant
125 otransplantation were carried out in Yucatan miniature swine to explore the effects of IDN6556 on isl
126 eloped a surgical technique for spleen Tx in miniature swine to investigate its immunologic impact in
127 neys were transplanted from Gal-positive MGH miniature swine to MGH GalT-KO swine with systemic immun
128           Previous studies demonstrated that miniature swine treated with 12 days of cyclosporine (Cs
129 jor histocompatibility complex (MHC)-matched miniature swine treated with 12 days of cyclosporine.
130 ce of class I-mismatched renal allografts in miniature swine treated with 12 days of high dose Cyclsp
131 into major histocompatibility complex-inbred miniature swine treated with a 12-day course of cyclospo
132 involved in tolerance to renal allografts in miniature swine treated with a short course of calcineur
133 C class I disparate hearts transplanted into miniature swine treated with a short course of cyclospor
134 This study found a high incidence of PTLD in miniature swine undergoing allogeneic hematopoietic stem
135                                              Miniature swine underwent bilateral nephrectomy and clas
136                                   Twenty-two miniature swine underwent class I major histocompatibili
137                    (1) Islet-cell isolation: miniature swine underwent either partial pancreatectomy
138               Massachusetts General Hospital miniature swine underwent occlusion of the midleft anter
139                                       Twelve miniature swine underwent vascularized musculoskeletal a
140  previously demonstrated T-cell depletion in miniature swine using a CRM9-based CD3-immunotoxin, pCD3
141 full MHC-mismatch barrier was established in miniature swine using a high-dose allogeneic peripheral
142 chieved in euthymic and not in thymectomized miniature swine using this treatment regimen.
143 nor-specific tolerance can be established in miniature swine, using a relatively mild, non-myeloablat
144 ning stable mixed hematopoietic chimerism in miniature swine, using MHC-matched donors and recipients
145 ogenicity of MHC alloantigens in MHC-defined miniature swine via primary and secondary MLR culture as
146               Bone marrow harvested from SLA miniature swine was T-cell depleted and injected intrava
147 m Massachusetts General Hospital MHC-defined miniature swine, we assessed immunogenicity across a ful
148 llograft induces tolerance to both organs in miniature swine, we examined the renal elements responsi
149                            By using UTC from miniature swine, we previously demonstrated that despite
150 d islet-kidney (IK) transplantation model in miniature swine, we studied whether an islet-toxic tripl
151 screening negative for MHC allele SLA of MGH miniature swine were bred.
152  peripheral blood stem cell transplantation, miniature swine were conditioned with thymic irradiation
153                                              Miniature swine were immunized with cardiac myosin (CM)
154                                 Adult female miniature swine were subjected to chronic, progressive a
155                                          Two miniature swine were thymectomized before thymic tissue
156                                              Miniature swine were treated with varying doses of pCD3-
157 reported that Massachusetts General Hospital miniature swine, which had accepted class I-mismatched k
158  safety of clinical xenotransplantation from miniature swine will be most enhanced by the utilization
159                                        Using miniature swine with a defined major histocompatibility
160              Previously, we generated inbred miniature swine with a null allele of the alpha-1,3-gala
161 pe class I disparity is uniformly induced in miniature swine with a short course of cyclosporine (CsA
162 cular response to the Multi-Link stent in 19 miniature swine with experimentally induced coronary ath
163 mestic farm pigs and between pairs of inbred miniature swine with genetically defined major histocomp
164                     PBPC were mobilized from miniature swine with porcine interleukin 3 (pIL-3), porc
165 ograft vasculopathy, we immunized MHC inbred miniature swine with synthetic polymorphic peptides span
166 Tissue-engineered arteries were implanted in miniature swine, with patency documented up to 24 days b
167                      A cohort of 5 Wisconsin Miniature Swine (WMS) were studied.
168  derived iPSCs from fibroblasts of Wisconsin miniature swine (WMS), Yucatan miniature swine (YMS), an
169 lerosis using a large swine model (Wisconsin Miniature Swine, WMS).
170 t two different haplotypes of inbred Yucatan miniature swine (y/y and z/z).
171  of Wisconsin miniature swine (WMS), Yucatan miniature swine (YMS), and Gottingen minipigs (GM) using

 
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