ライフサイエンスコーパス: minimal

1 ing grain orientations on the PTE signal are minimal.

2 ic (catalytic) effects of the PNP-Ni(II) are minimal.

3 CFP only (2 parameters); (2) OCT biomarkers, minimal (3 parameters); (3) OCT biomarkers, extended (7

4 obesity (BMI >= 30)-and 3 WL categories-<5% (minimal), 5% to <10% (moderate), and >=10% (severe).

5 Based on these observations, we develop a minimal active-fluid model that reproduces the experimen

6 minary report focused more on the use of the minimal ADC (mADC) value on the solid component, to diff

7 n-14 for efficient retrograde transport with minimal adverse effects on endogenous transport.

8 These IGHV3-53 antibodies show minimal affinity maturation and high potency, which is p

9 imaginable), nausea and vomiting, sedation, minimal alveolar concentration of volatile anesthetic, f

10 oach to achieving higher resolution with the minimal amount of materials and data.

11 cient system and rapid detection times using minimal amounts of sample volumes, while simultaneously

12 Despite minimal anatomical overlap of lesions, both EL_INST and

13 Symptoms of neurotoxicity were minimal and transient.

14 ifferences in meibogenesis were deemed to be minimal and unlikely to have a measurable physiological

15 isual acuity change (DeltaBCVA, logarithm of minimal angle of resolution [logMAR]) from baseline (bef

16 (1.30 +/- 0.49 to 0.87 +/- 0.58 logarithm of minimal angle of resolution [logMAR]; P < .001), BSCVA (

17 as 34 +/- 14 years and the mean logarithm of minimal angle of resolution of visual acuity was 1.89 +/

18 7 +/- 0.8 and the average final logarithm of minimal angle of resolution visual acuity was 1.2 + 1.0.

19 The average presenting logarithm of minimal angle of resolution visual acuity was 1.7 +/- 0.

20 nclude mild wave or atmospheric climates and minimal anthropogenic impacts.

21 ensis) are apex predators that have received minimal attention within urban areas.

22 This allows for a classification of minimal autocatalytic motifs called cores.

23 We previously demonstrated that a minimal B-repeat construct (Brpt1.5) forms an antiparall

24 particles have been proposed as contact-free minimal-background nanobarcodes, and yet it has been dif

25 ivity and specificity were compared between 'minimal' baseline and 6 week sample CRP data and the 'co

26 For several diatomic molecules in a minimal basis set, we benchmark our approach against wid

27 oceeds through loose transition states, with minimal bond formation to the nucleophile and bond cleav

28 To address this question, we study a minimal but generic model for a nematic network in which

29 verse events and serious adverse events were minimal, but 2 deaths (7.4%) occurred that were felt unr

30 cope of high-activity CBEs while maintaining minimal Cas9-independent off-target editing.

31 Interestingly, the type I-C system employs a minimal Cascade effector complex, which encodes only thr

32 s were identified in normal cells exhibiting minimal cell stress and death phenotypes (for example, l

33 levance for efforts to develop artificial or minimal cell systems.

34 Using purified proteins, we report a minimal cell-free system that demonstrates interdomain c

35 f the major bottom-up approaches to building minimal cells.

36 ir payload (~11-13% w/w), good stability and minimal cellular toxicity, and could be further decorate

37 omerulopathy (ORG), while the frequencies of minimal change disease (MCD), focal segmental glomerulos

38 EPTUNE renal biopsies from 242 patients with minimal change disease or FSGS, with duplicate readings

39 llapsing glomerulopathy and the patient with minimal change disease revealed that all four patients h

40 lapsing glomerulopathy, 1 was diagnosed with minimal change disease, 2 were diagnosed with membranous

41 d in systems neuroscience, we show that this minimal change in initial conditions prior to training l

42 ss and plant species richness, root biomass, minimal changes in soil texture and pH.

43 oss decades for all five species, suggesting minimal changes in trophic levels.

44 y and 4-copy mice, while Rp treatment caused minimal changes than controls.

45 ysis after 3.5 months SCIT updosing detected minimal changes to pathway/upstream regulator profiles d

46 turn from orange to yellow upon heating with minimal changes to the microscopic morphology following

47 Consequently, we generate a minimal chemically-defined culture medium in which IGF1

48 symptoms] to 24 points [most symptoms]; the minimal clinically important difference for change in sc

49 her scores are better; range, 0-100), with a minimal clinically important difference of 0.5 SD.

50 stress score (range, 0 [best] to 90 [worst]; minimal clinically important difference, 5.7 points).

51 Care scale (range, 0 [worst] to 184 [best]; minimal clinically important difference, 9 points) and s

52 reatment effect, and results relative to the minimal clinically important difference.

53 nity cycle and propose a broadly applicable 'minimal combination' of therapies designed to increase t

54 tained during ketone formation, establishing minimal competing racemization by deprotonation.

55 fMRI provided reliable evidence of preserved minimal consciousness.

56 Among them, SigG1 features a minimal conserved ECF sigma(2)-sigma(4) architecture and

57 They are based on minimal constitutive promoters (~120 base pairs), for wh

58 f fruit multi elemental characteristics with minimal contribution of soil elements.

59 ovides a noninvasive method of PFT requiring minimal cooperation.

60 inary logistic regression model included the minimal corneal thickness, the anterior coma to 90 degre

61 e health and longevity in an aging system at minimal cost of maintenance and intervention.

62 In this report, we further extend minimal cylinder analysis to study the biophysical prope

63 0%) of 3.0 pM at a constant amount of DT (4x minimal cytopathic dose) in the IgG format.

64 inish the invasiveness of breast cancer with minimal cytotoxic effects, thus departing from the cytot

65 within macrophage cells, and in some cases, minimal cytotoxicity.

66 period in rats, morphing electronics caused minimal damage to the rat nerve, which grows 2.4-fold in

67 h improved outcomes in pediatric sepsis, but minimal data exist to guide empiric therapy.

68 It requires minimal data pre-processing and has an easy experimental

69 Histopathological diagnoses and a minimal dataset of clinical variables were collected fro

70 learance of the Active ADC, while exhibiting minimal deconjugation of the pyrrolobenzodiazepine (PBD)

71 veering over the obstacle rapidly, making a minimal deviation to avoid a collision, and subsequently

72 sive strategy in the overall group reflected minimal differences among asymptomatic patients and larg

73 o differences in IgG1 Fc glycan profiles and minimal differences in IgG2 Fc glycans were noted, where

74 allowing neural populations to interact over minimal distances.

75 t" grafts to maximize recipient benefit with minimal donor risk.

76 atively abundant, can be harvested and cause minimal donor site morbidity.

77 The minimal duration of follow-up after end of therapy was t

78 A minimal effect of stress on porosity and permeability wa

79 contraction amplitude by only 50% and had a minimal effect on contraction frequency.

80 synergistic antitumor effects in vitro, with minimal effect on normal prostate epithelial cells.

81 found that serum HBsAg clearance has only a minimal effect on the expansion of HBV-specific naive CD

82 e value (PPV) improved substantially, with a minimal effect on the negative predictive value (NPV).

83 -kappaB activation in oligodendrocytes had a minimal effect on their viability and function under nor

84 estimated relative potency of 454 IU/mg and minimal effective dose 50% (MED50%) of 3.0 pM at a const

85 s, while border closures appear to have only minimal effects at mitigating the spread of the disease,

86 ed by latencies relative to each other (with minimal effects of sniff).

87 mics and transcriptomics data suggested only minimal effects on endonucleolytic nonsense-mediated mRN

88 NK(1) receptor agonists had minimal effects on ICC-IM, whereas neostigmine and carba

89 , showing that the presence of the metal has minimal effects on the overall protein structure.

90 uction as a quick test that saves time, with minimal effort required.

91 -molecule localization microscopy (SMLM) and minimal emission fluxes (MINFLUX) microscopy in the loca

92 uring experimental evolution in a chemically minimal environment containing glucose as the sole carbo

93 al features present: B. subtilis gyrase is a minimal enzyme, and its subunits can functionally intera

94 esults concluded that heptasaccharide is the minimal epitope and a potential candidate for the vaccin

95 roduce weight loss in controlled trials, but minimal evidence exists regarding long-term efficacy und

96 nd returned to baseline afterward, providing minimal evidence for assistance-driven changes in active

97 There was minimal evidence of abuse, and no evidence of dependence

98 We found minimal evidence that state-of-the-art machine learning

99 a relatively new field, departments may have minimal experience in evaluation of faculty contribution

100 ity predictions for protein production using minimal experimental effort regardless of the lysate qua

101 Using minimal exposure to specification cues, we derive stem c

102 s with lung cancers that are associated with minimal exposure to tobacco smoke.

103 al memory and effector memory phenotype with minimal expression of coinhibitory molecules, and they w

104 In wheat, selection of awns with minimal extension, termed awnletted, has occurred during

105 We established that the minimal Fe-Fe distance in the octahedral chains is a key

106 Our study thus uncovers the minimal feed-forward machinery of the endosomal Rab casc

107 ith advanced fibrosis compared to those with minimal fibrosis and healthy controls (p = 0.003).

108 electrically generated strain that consumes minimal footprint and is extremely frugal in its use of

109 r longitudinal studies investigating whether minimal footwear is more beneficial for fall prevention

110 As in the cat, connections were minimal for motoneurons innervating the most distal intr

111 ing accuracy and observe that this impact is minimal for similar reductions in compressed size, altho

112 endocrine therapy versus tamoxifen alone is minimal for those at low recurrence risk.

113 The proteins MCU and EMRE form the minimal functional unit of the mitochondrial calcium uni

114 ctural and genome-wide analyses of roles for minimal G4s in transcriptional regulation have been repo

115 prise, we also find single-stranded loops of minimal G4s within individual LG4 loci are frequently hi

116 mulations, we show that the application of a minimal gate voltage bias can induce stress in the chann

117 at least two Mycoplasma genitalium in silico minimal genomes.

118 ichia coli population during adaptation to a minimal glucose medium containing citrate (DM25).

119 Minimal histological analysis of the membranes was condu

120 r spaces to be explored efficiently and with minimal human intervention, thereby liberating the scien

121 TraX can handle large-scale experiments with minimal human involvement, allowing researchers to simul

122 experiments are qualitatively described by a minimal hydrodynamic model.

123 atment groups, and both techniques induced a minimal hyperopic shift.

124 Addition of vancomycin had minimal impact on CDI rates (data not shown).

125 BoCz-Lip showed minimal impact on cell viability as well as internal LDs

126 s quo, by 2030, vaccination alone would have minimal impact on cervical cancer mortality, leading to

127 e of CHIKV infection in the spleen but had a minimal impact on CHIKV infection in the joint.

128 We found that risk-based targeting had minimal impact on population averages or disparities and

129 uld have been necessary rather than 31, with minimal impact on the recommended courses of action.

130 Our results indicate minimal impacts to Hg concentrations in water and fish f

131 BPE was minimal in 61 patients, mild in 56, moderate in 19, and

132 ial translocation and subsequent sepsis were minimal in 7 Gy GIARS mice treated with GL.

133 In contrast, suppression was minimal in T2DM.

134 hopathology linked to objective measures was minimal in the absence of subjective reports.

135 play of nascent RNA molecules from RNAP in a minimal in vitro transcription reaction.

136 clusion of a protein factor extrinsic to the minimal in vitro transcription reaction.

137 Furthermore, the printed construct elicits minimal inflammatory responses, and is shown to be effic

138 describe all the paths in a network and the minimal information to describe the paths of its skeleto

139 s, whereas an ambient selective process with minimal infrastructure support remains to be demonstrate

140 When compared to minimal-inhibitory concentrations (MICs) in laboratory m

141 of natural Ig, which is germline-like due to minimal insertion of N region additions.

142 ent samples down to 5 viral copies, requires minimal instrumentation, and is highly scalable and inex

143 quantitative analyses of capping levels with minimal instrumentation.

144 ut have limited weight-lowering efficacy and minimal insulin sensitizing action.

145 tic term [Formula: see text], to explore non-minimal interactions between geometry, scalar and matter

146 ioactive compound from its surroundings with minimal interactions with the local environment.

147 tracing and IgH repertoire analyses revealed minimal interconversion between T-bet(-) and T-bet(+) MB

148 can be combined with GFP-based sensors with minimal interference and shows high photostability, perm

149 biosensor is highly specific for SDS and has minimal interference from other detergents, metals, and

150 d to actuate and control distinct modes with minimal interference, and significant power can be trans

151 tion with functional optical indicators with minimal interference.

152 ng to their heterobimetallic construction on minimal interprotein-bonding footprints.

153 workflows to run complex analyses requiring minimal intervention by users.

154 Samples can be obtained minimal-invasively, tested for treatment-determining gen

155 Along with minimal invasiveness, the synergy of both enzymes was ve

156 N-siCas-3 on islets in culture, resulting in minimal islet loss.

157 opy in all patients with typical symptoms is minimal; its use should be restricted to people aged 55

158 This study establishes a new minimal length of protective immunity.

159 e, we establish a new experimentally defined minimal length of protective ZIKV immunity.

160 udy establishes a new experimentally defined minimal length of protective ZIKV immunity.IMPORTANCE ZI

161 We defined the minimal length of the RNA template for in vitro de novo

162 mental results for single cells, we derive a minimal length scale for the patterns in the substrate t

163 Whereas a minimal level of attention seems to be required for lear

164 the most challenging to classify because the minimal level of full-length (FL) transcripts required f

165 Nonionic and anionic formulations show minimal levels of these responses, which contributes to

166 is already in the membrane and involves only minimal ligand-protein interactions.

167 speed up Hopper by orders of magnitude with minimal loss in performance.

168 model requires an expander that spreads with minimal loss throughout a morphogen field.

169 hogens, relative to fresh contamination, but minimal marker levels.

170 In combination with minimal material consumption (reactions performed in 300

171 acterize the heterogeneity of a sample using minimal material with high resolution within a matter of

172 We developed a minimal mathematical model demonstrating growth factor s

173 n led to excellent extraction efficiency and minimal matrix effect.

174 ollowed by interrogation for the presence of minimal/measurable residual disease (MRD) by molecular g

175 imized for a maximal number of compounds and minimal measurement time are required.

176 Minimal mechanical disruption during digestion, warm enz

177 c exchanges that sustain the heterotrophs in minimal media devoid of any organic carbon source, point

178 ressing heterologous VcChiP could grow on M9 minimal medium supplemented with small chitooligosacchar

179 during drawing tasks, including a task with minimal memory load-when participants copy an image duri

180 rigidly within vacancy clusters and exhibits minimal mobility unlike free gaseous O(2), making it mor

181 Our theory is based on a minimal model and describes the experimental findings in

182 icrobial Consumer Resource Model (MiCRM) - a minimal model for microbial communities with resource co

183 ltivariate Cox regression modeling defined a minimal model including white cell count at diagnosis, p

184 In this study, we develop a minimal model of Abeta fibrillization to investigate the

185 Both the full subcellular model and the minimal model present the same scenarios depending on th

186 After benchmarking our method against a minimal model, we illustrate its broader applicability w

187 opy, insulin sensitivity index calculated by minimal modeling from a frequently sampled intravenous g

188 These findings highlight the promise of minimal models for microbial ecology.

189 tion comparable to Prf1-/- mice, albeit with minimal mortality.

190 report the development of miCas9 by fusing a minimal motif consisting of thirty-six amino acids to sp

191 We present a minimal multilocus distance (MMD) method which rapidly d

192 ited by low sensitivity, nonspecificity, and minimal multiplexing capacity.

193 ith patients with no retinopathy, those with minimal nonproliferative diabetic retinopathy (NPDR) had

194 With minimal notice, experiments were terminated, cell lines

195 a programmable assembly process involving a minimal number of chemical transformations.

196 We show that the minimal number of coupled chromophores needed to undergo

197 It also allows the minimal number of distinct subunits when designing artif

198 as demanded for rapid sepsis diagnosis where minimal numbers of bacteria need to be found in a 1-10 m

199 te large datasets from multiple species with minimal observer interference.

200 cNAc tetrasaccharides in 72-86% yields, with minimal occurrence of aglycon transfer.

201 nhancer activity and gene transcription with minimal off-targets.

202 L/6NTac, less so for C57BL/6NTac(Cdh23+) and minimal or absent in C3H/HeJ mice.

203 Specifically, horizontal cupping with minimal or no nasal displacement of vessels, and superio

204 xenotransplantation because many humans have minimal or no natural antibody to TKO pig cells.

205 th COVID-19 were classified as having either minimal or severe disease.

206 These attributes coupled with minimal ototoxocity in animal models combine to make apr

207 ted HFpEF from HFrEF and donor controls with minimal overlap, and this persisted after adjusting for

208 This GRP, as well as its minimal peptide epitope Crip21, serve as a pathogen-asso

209 tumor cells had the strongest effect on the minimal perfusion and receptor density for standard and

210 asure strain at high spatial resolution with minimal perturbation in living sytems.

211 With minimal perturbation to cells, ECORE allows long-term op

212 d previously to image interfacial water with minimal perturbation)(12), enables real-space imaging of

213 c architecture between depression defined by minimal phenotyping and strictly defined major depressiv

214 r results show that reliance on results from minimal phenotyping may bias views of the genetic archit

215 This is in marked contrast to the minimal phototoxicity required in live-cell experiments.

216 on conducting electrolyte in the presence of minimal plasticizer, with a wide electrochemical stabili

217 Our minimal polymer model reproduces the formation of lamin-

218 olymer scaffolds for soft tissue repair with minimal postsurgical complications is a compelling clini

219 en and in limited-resource settings has been minimal, primarily because of their expense, the large r

220 (Triticum aestivum), was just upstream of a minimal promoter and that none of these four known enhan

221 Dose-dependently, MYC increased output at minimal promoters with or without an E-box.

222 old to mimic the spatial conformation of the minimal pseudo-dipeptide binding motif of pepstatin A, a

223 gnal-to-noise ratio and contrast, as well as minimal radiation damage) and subtomogram averaging (thr

224 arameters among groups, and all subjects had minimal radiographic evidence of emphysema.

225 ge in copy number gains, and presence in the minimal region common to overlapping copy number variant

226 Bacterial regrowth tests confirmed minimal regrowth potential after the disinfection.

227 functional antagonist, siponimod, conferred minimal renal protection and desensitized S1P(1) These f

228 In an effort to improve upon RTS,S, a minimal repeat-only, epitope-focused, protective, malari

229 efficiency, raising the possibility that the minimal requirement for DNA double-strand break (DSB) fo

230 , responsible team members proposed a set of minimal requirements, optimal clinical recommendations,

231 ry data show that patients with undetectable minimal residual disease (MRD) before HCT and those with

232 d vs RVd (62.6% vs 45.4%; P = .0177), as did minimal residual disease (MRD) negativity (10-5 threshol

233 The rate of minimal residual disease (MRD) negativity using modified

234 s currently the standard technique to define minimal residual disease (MRD) status outside the bone m

235 The primary endpoint was detection of minimal residual disease (MRD) within 1 yr after ASCT at

236 complete remission (CR) rates often include minimal residual disease (MRD), leading to relapse and r

237 ere detected in 6 patients who had increased minimal residual disease during induction therapy, and a

238 ikely find considerable utility in assessing minimal residual disease following treatment and for ear

239 psed or refractory patients had undetectable minimal residual disease in both the blood and marrow.

240 Five out of 6 patients in CR were also minimal residual disease negative (MRD-).

241 treatment cytogenetics, and end-of-induction minimal residual disease.

242 founding by propensity score adjustment, and minimal residual systematic bias through negative contro

243 2.4%) had residual DCIS only, 20 (54.1%) had minimal residual tumor (<5 mm), and 19 of 25 (76.0%) exh

244 nificant resistance against fast motions but minimal resistance against slow motions, allowing for th

245 the time required to perform prediction with minimal resource requirements allowing for comprehensive

246 broad detection of synthetic cathinones with minimal response toward interferents and generally demon

247 stable for up to 10 years after surgery with minimal risk of immunologic rejection, herpetic recurren

248 for hyperthyroidism are hypothyroidism and a minimal risk of radiation-induced malignancies.

249 ques handle increasingly large datasets with minimal sacrifices in quality for tasks such as sequence

250 Tg at the maximal investigated pressure and minimal salt concentration were -31.6 and -34.4 cm(3)/mo

251 ntal investigations because of its low cost, minimal sample preparation, non-destructive nature and s

252 ly structurally characterized proteins using minimal sample volume and a high-throughput approach.

253 a limited set of conformational states with minimal separation of the nucleotide-binding domains in

254 The transmembrane subunit, MlaE, has minimal sequence similarity to other transporters, and t

255 nnexins, innexins, and LRRC8, pannexins have minimal sequence similarity to these protein families.

256 Here, we aim to find the minimal set of conditions under which continual evolutio

257 The complete and minimal set of host factors involved in cccDNA formation

258 nt k isotopologue peaks of a compound or the minimal set of isotopologue peaks which have a combined

259 Across all subjects, early induction of a minimal set of nasal cytokines that discriminated high r

260 perform polygenic localization, constructing minimal sets of common SNPs causally explaining 50% of c

261 pper and library for IgBLAST, which offers a minimal setup CLI and API, FASTQ support, file chunking

262 e more stable during standing and walking in minimal shoes than in conventional shoes, independent of

263 .91) Co(0.06) Mn(0.03) )O(2) (NCM9163), with minimal side effects.

264 g of MHC molecules by migrating T-cells is a minimal signal capable of inducing endothelial contracti

265 nt to extract the unwrapped information with minimal signal resolution degradation.

266 hod combines encoded LBTs, which are tags of minimal size (ca. 15-20 amino acids) affording high-affi

267 Costs ranged from about $0.4 million for minimal social distancing to about $0.9 million to $2.1

268 In this study, we sought to identify a minimal soluble fragment of HuCR1, which retains the com

269 ent GECIs in terms of reduced phototoxicity, minimal spectral cross talk with visible light excitable

270 Despite the minimal structural differences between receptor types, s

271 hetically useful yields from substrates with minimal structural prefunctionalization.

272 all of the self-intersections of a Henneberg minimal surface immersed in 3-dimensional space.

273 that of the gyroid and other triply periodic minimal surface structures, but also exceeds the theoret

274 The "COVID-minimal surgical pathway" consisted of: (A) evolving bes

275 then identified permissive architectures for minimal synthetic plant promoters enabling the computati

276 ibrary of 173 unique functional molecules in minimal synthetic steps.

277 However, a minimal system capable of recapitulating different steps

278 4 nm) and IRAK-4 (IC(50) = 20 nm), with only minimal TAK1-inhibiting activity (IC(50) = 0.5 mum).

279 archaeological remains of sheep and pig with minimal taphonomic modifications were analysed from four

280 Among children screened for minimal TB in Uganda, Ultra has higher sensitivity than

281 rmination of Bell inequality parameters with minimal technical overhead, and for new characterization

282 0.83 for cone-function anxiety) and exhibits minimal test-retest variability (rho = 0.81 [0.64-0.91]

283 is routinely used to select vessels meeting minimal threshold diameters for surgical arteriovenous f

284 In experimental atelectasis with minimal tidal recruitment/derecruitment, mechanical insp

285 cross distant regions in the deep brain with minimal tissue damage, which can bring new insights for

286 Histological evaluation found minimal tissue effects.

287 pathology, allowing chemical profiling with minimal tissue pretreatment in frozen samples.

288 IT (131)I-omburtamab was well tolerated with minimal toxicities.

289 The capsules also present minimal toxicity and maintain anti-VEGF potency, suggest

290 elay in a neuroblastoma xenograft model with minimal toxicity.

291 eatment options, RPT has shown efficacy with minimal toxicity.

292 ts, we developed a framework to identify the minimal training set required to build a predictive mode

293 Yet, capsids assemble rapidly with minimal trapped intermediates, a realization of the Levi

294 emonstrated activity-dependent efficacy with minimal treatment-related organ radiotoxicity.

295 The aim of this work was to determine a minimal tumor perfusion and receptor density for (177)Lu

296 he processive nuclease Cas3, together with a minimal Type I-C Cascade-based system for targeted genom

297 Autoradiography demonstrated minimal uptake of flortaucipir, although flortaucipir co

298 ea is needed along with reuse of most water, minimal use of pesticides and herbicides, and no nutrien

299 Minimal validation and limited access to transparent sof

300 aracterize the phase diagram determining the minimal volume of transactions that would make the Light