ライフサイエンスコーパス: minipig

1 implants in a large animal model (Goettingen minipigs).

2 anti-B5 immune response in both mice and the minipig.

3 cy was successfully induced in 12 Goettingen minipigs.

4 e of tibial bowing in a subpopulation of NF1 minipigs.

5 tabolomics of the temporal region in Ossabaw minipigs.

6 ment of dehiscence-type recession defects in minipigs.

7 acrophage-rich and -poor arterial tissues in minipigs.

8 h period when dosed intramuscular to dogs or minipigs.

9 ncreas gland and pancreatic duct ligation in minipigs.

10 ent doses once daily for ten days to healthy minipigs.

11 extracted mandibular premolar teeth in three minipigs.

12 ther young domestic pigs or adult Goettingen minipigs.

13 erated in a 28-day safety study in Gottingen minipigs.

14 8 implants were placed into sockets in three minipigs.

15 erior descending coronary artery (LAD) of 41 minipigs.

16 in all plasma samples isolated from four NIH minipigs.

17 created fossa ovalis ASD was attempted in 15 minipigs.

18 ar antigen (PCNA) in livers from ethanol-fed minipigs.

19 s (ADSCs) were harvested from knee joints of minipigs.

20 malizes the blood glucose levels of diabetic minipigs.

21 ated in infected diabetic wounds in mice and minipigs.

22 xenotransplantation from gene edited Yucatan minipigs.

23 ogy of the porcine larynx in eight Minnesota Minipigs (12-37 weeks).

24 Hanford minipigs (20 to 25 kg), anesthetized with pentobarbital

25 ue-Dawley rats (280 +/- 30 g) and Vietnamese minipigs (31 +/- 7 kg).

26 In dose escalations studies in diabetic minipigs, a higher therapeutic index for MK-2640 (threef

27 enicity of human anti-PLA 2 R1 antibodies in minipigs, a model for MN that intrinsically expresses PL

28 erse effects, a plasma half-life of 113 h in minipigs after intravenous injection, and acceptable che

29 Studies in minipig and dog demonstrated that IRPAs had sufficient e

30 Fifty-six rats, 27 minipigs and 11 conscious dogs underwent LV and arterial

31 surgical site was observed in LukAB-treated minipigs and dissemination of bacteria was dramatically

32 , is well tolerated in both mouse models and minipigs and reduces E. coli load in the mouse gut bette

33 nsufficiency via pancreatic duct ligation in minipigs and the long term follow up of the animal's hea

34 )17 cells to promote liver fibrosis in mice, minipigs, and human patients with cirrhosis.

35 Further analysis of humans, minipigs, and mice suggested that cross-talk between his

36 rteries and ascending pharyngeal arteries of minipigs, and subsequently assessing the health status a

37 th at various post-surgical time points in a minipig animal model.

38 from patients with PLA 2 R1-associated MN to minipigs, antibodies were detected in the minipig glomer

39 Due to similarities with humans, minipigs are an attractive option to study novel vaccine

40 rneal graft rejection in the semi-inbred NIH minipig as a model of human rejection.

41 2) derivatives were evaluated in dogs and in minipigs, at a dose of 5mg-eq. nalmefene/kg and plasma n

42 ress this, we studied eight adult Goettingen minipigs before and after an approximately 60% reduction

43 ts show multidimensional characterization of minipig behavior, and how it develops and changes with a

44 on fraction (HFrEF) was induced in Gottingen minipigs by means of tachypacing over 6 weeks.

45 olemic conditions in PCSK9(D374Y) transgenic minipigs, cephalad hypertension accelerated coronary ath

46 In PEI minipigs, CFA values increased from 60.1% +/- 9.3% befor

47 icantly smaller long bones in NF1(+/ex42del) minipigs compared to controls, indicative of shorter sta

48 ge neocartilage derived from highly passaged minipig costal chondrocytes, a species relevant to the p

49 om bovine articular chondrocytes to expanded minipig costal chondrocytes, yielding a 46% improvement

50 We developed a minipig deep surgical wound infection model offering 3 i

51 The minipigs developed histomorphological characteristics of

52 se, was necessary to prevent inflammation in minipigs (effective dexamethasone dose was 100mug delive

53 Thirteen TIPS were created in 13 minipigs: eight with PETP-covered Wallstents, five with

54 RV free wall-paced minipigs exhibited significantly more LV dyssynchrony th

55 Here, we show in a human-sized minipig eye that suprachoroidal injection of 50 mul of N

56 Two minipigs failed to develop exocrine insufficiency most l

57 The carotid artery of minipigs fed an atherogenic diet was injured by repetiti

58 btilisin kexin type 9 (PCSK9)(D374Y) Yucatan minipigs for >1 year.

59 ucose in insulin-deficient diabetic mice and minipigs (for minipigs >25 kg, glucose regulation lasted

60 in diabetic mice, and by 11 days in diabetic minipigs (from 2 to 13 days, under standard CSII-wearing

61 to minipigs, antibodies were detected in the minipig glomeruli, but not in response to plasma from he

62 Yucatan miniature swine (YMS), and Gottingen minipigs (GM) using our culture medium.

63 in-deficient diabetic mice and minipigs (for minipigs >25 kg, glucose regulation lasted >20 h with pa

64 Pancreatic duct ligation in minipigs is an excellent method of inducing exocrine pan

65 from patients with PLA 2 R1-associated MN to minipigs led to histological characteristics of human ea

66 Minipigs, like humans, express PLA 2 R1 on podocytes.

67 ngosine into ex-vivo perfused and ventilated minipig lungs results in increased levels of sphingosine

68 A 4-h EVLP run using minipig lungs was performed.

69 e effects in ex-vivo perfused and ventilated minipig lungs.

70 e-level implant after 2 months of healing in minipig mandibles.

71 Gottingen minipigs mirror the physiological radiation response obs

72 Here, we studied a NF1 minipig model (NF1(+/ex42del)) for the first 12 months o

73 defects, is applied in a clinically relevant minipig model in vivo.

74 Pancreatic duct ligation in a minipig model leads to exocrine pancreatic insufficiency

75 s, similar to that of 1.2 g pancreatin, in a minipig model of PEI.

76 The NF1(+/ex42del) minipig model progressively demonstrates signature attri

77 on is a scalable approach, as we show with a minipig model, and may facilitate the clinical translati

78 gels as a scaffold on pulp regeneration in a minipig model.

79 wall or LV apical pacing, we used a chronic minipig model.

80 pared to positive and negative controls in a minipig model.

81 differences in wound healing in this Yucatan minipig model.

82 the bilateral distal femur of six Gottingen minipigs (n = 12 defects in 6 knee joints of 3 immature

83 January 2016 and December 2017, 10 Gottingen minipigs (n = 5 male; n = 5 female; mean age, 6 months +

84 elaxometry and ACL tensile testing data from minipigs (n = 65).

85 D374Y-PCSK9 hypercholesterolemic minipigs (n=5) were instrumented with an intracoronary s

86 t- and carbon tetrachloride (CCl(4))-induced minipig NASH model, and genetically modified mice to unr

87 of HDAC2 and DNMT1 alleviated fibrosis in a minipig NASH model.

88 repair of infarcted heart muscle in rats and minipigs, of injectable and conductive scaffolds consist

89 The NIH minipig offers a robust model of human rejection suitabl

90 Human anti-PLA 2 R1 antibodies bound to minipig PLA 2 R1 in vitro and in vivo .

91 was successfully cultured from all four NIH minipig plasmas on the swine cell line ST-IOWA.

92 Twelve Yucatan minipigs provided four sites per animal.

93 Finally, in a randomized efficacy study, 14 minipigs received allogeneic cardiospheres (1.3 x 10(6))

94 NIH minipigs received corneal allografts with MHC and minor

95 Five minipigs received focal stereotactic radiosurgery with s

96 Yucatan minipigs received intravenous eNAMPT mAb 2 h after initi

97 In passive transfer experiments, minipigs received plasma or purified IgG from patients w

98 Six Gottingen Minipigs received thoracolumbar (T14-L1) lateral white m

99 ed absorption compared with oral Taxotere in minipigs, resulting in relative bioavailability and Cmax

100 ere observed in scaled-up device implants in minipigs retrieved after 2 months.

101 LV apex at 120 bpm for 1 year (7 age-matched minipigs served as controls with spontaneous heart rates

102 emonstrate that xenografts transplanted from minipigs show only modest growth and do not substantiall

103 A translational approach from humans to minipigs showed that human anti-PLA 2 R1 antibodies are

104 In separate transgenic minipigs, the intra-arterial localization of FDG was det

105 In type 1 diabetic mice and minipigs, this system can maintain normoglycaemia for lo

106 or and physiological function of the Yucatan minipig throughout maturation.

107 normocholesterolemic conditions in wild-type minipigs to examine the underlying mechanisms.

108 We used 17 minipigs to study implants under a controlled load, with

109 (TID) of their amino acids was determined in minipigs, to calculate the digestible indispensable amin

110 D) of their amino acids (AA) was measured in minipigs, to calculate the digestible indispensable amin

111 In arteries of domestic pigs and minipigs treated with paclitaxel-coated balloons with pr

112 monary artery and left atrium) in 18 healthy minipigs under acute haemodynamic interventions.

113 Yucatan minipigs underwent induction of MI and 2-3 weeks later w

114 14 Goettingen minipigs underwent pancreatic duct ligation via midline

115 fter ingestion of four dairy matrices by six minipigs: unheated or heated skim milk and corresponding

116 Data of the long-term health status of minipigs upon EPI induction are still not available.

117 ncentrations can be achieved in both dog and minipig using nalmefene prodrugs and that the pharmacoki

118 tion pulmonary artery catheter was placed in minipigs via the internal jugular vein.

119 acute lung injury was studied using Hanford minipigs weighing 18 to 25 kg.

120 Minipigs were fed a complete meal with either cubed F&V

121 Wild-type and D374Y-PCSK9 transgenic Yucatan minipigs were fed a high-fat, high-cholesterol diet to i

122 After the minipigs were killed, lung tissue was sampled to measure

123 The minipigs were monitored for up to 45 days or time to eut

124 Sinclair minipigs were randomly divided into three groups: burn (

125 was observed from day 7 post-implantation in minipigs, whereas in rats this did not occur until day 1

126 , PTCA was performed in hypercholesterolemic minipigs whose left anterior descending (LAD) coronary a

127 Whereas oral administration in mice or the minipig with collard-derived insoluble pB5 did not gener

128 transplantation was performed in 10 Yucatan minipigs with coronary arteries from farm pigs as donors

129 ternal elastic lamina in a carotid artery of minipigs with hypercholesterolemia induced by feeding th

130 observed measures of functional recovery in minipigs with infarcted hearts after the delivery of cel

131 mia and negligible hypoglycaemia in mice and minipigs with type 1 diabetes.

132 al pharmacokinetic profiles in rat, dog, and minipig, with low to moderate clearance (26%, 7%, and 18

133 Eight healthy, male, young BR-1 minipigs, with no periodontal disease were treated.