ライフサイエンスコーパス: minus-end-directed motor

1 Cytoplasmic dynein is the major microtubule minus end-directed motor.

2 lasmic Dynein 1, or Dynein, is a microtubule minus end-directed motor.

3 but not KIF13B undergoes a tug-of-war with a minus-end directed motor.

4 a gal suggests that the head of Nod may be a minus-end-directed motor.

5 on antagonistic activities of plus end- and minus end-directed motors.

6 ongression depends on the cooperation of two minus end-directed motors.

7 T, the human homologue of the KAR3 family of minus end-directed motors.

8 ng, suggesting that they were transported by minus end-directed motors.

9 by the opposing activities of plus end- and minus end-directed motors.

10 bidirectionally, employing both plus-end and minus-end directed motors.

11 ytoskeleton has pointed instead to roles for minus-end-directed motors.

12 be created by complexes combining plus- and minus-end-directed motors.

13 rucial role in the coordination of plus- and minus-end-directed motors.

14 formation of aggresomes, suggesting that the minus-end-directed motor activities of cytoplasmic dynei

15 ndrites indicate that models suggesting that minus end-directed motor activity is sufficient for dend

16 es, where it then organizes microtubules via minus-end-directed motor activity.

17 tor, the clustering of their minus ends by a minus-end-directed motor, and the loss of MTs by dynamic

18 plored how the balance between plus end- and minus end-directed motors, as well as the influence of m

19 mic dynein complex is an active, microtubule minus-end-directed motor, as expected.

20 However, in the SAC model, minus-end-directed motors bind the minus ends of MTs as

21 eraction of microtubules with both plus- and minus-end directed motors bound to a fluid membrane.

22 ve studied the shape of myosin VI, the actin minus-end directed motor, by negative stain and metal sh

23 Cytoplasmic dynein is a large minus end-directed motor complex with multiple functions

24 along microtubules by using the microtubule minus-end-directed motor complex of dynein/dynactin.

25 dynein/dynactin, a multi-subunit microtubule minus-end-directed motor complex, and NuMA, a microtubul

26 Our data reveal the novel finding that a minus-end-directed motor contributes to the organization

27 es (MTs) are substrates upon which plus- and minus-end directed motors control the directional moveme

28 d simulations, we propose a model on how two minus end-directed motors cooperate to ensure spindle po

29 -end binding proteins, suggesting that these minus-end-directed motors could interact with growing mi

30 r to translocation of the MTOC, in which the minus end-directed motor cytoplasmic dynein, localized a

31 e mitotic functions of the major microtubule minus-end directed motor cytoplasmic dynein 1.

32 Instead, we found that mutations in the minus-end-directed motor cytoplasmic dynein, completely

33 plus end-directed motor, kinesin-II, and the minus end-directed motor, cytoplasmic dynein in highly p

34 at links cargos of aggregated protein to the minus end-directed motor, cytoplasmic dynein.

35 Crosstalk between the minus-end directed motor dynein and kinetochore-microtub

36 We find that while the minus-end directed motor Dynein cooperates with Dynactin

37 While it is clear that the minus-end-directed motor dynein is required for this pro

38 Inhibitory antibodies indicated that the minus-end-directed motor dynein is required to prevent p

39 the transport of a subset of cargoes by the minus-end-directed motor dynein, although the full exten

40 in that mediates linkage of cargoes with the minus-end-directed motor dynein.

41 Here, we have characterized the roles of two minus end-directed motors, dynein and Ncd, in such proce

42 Cytoplasmic dynein is the microtubule minus-end-directed motor for the retrograde axonal trans

43 ac-man model, in which 1) kinetochore-based, minus end-directed motors generate poleward forces for a

44 cortex required Bud6p, Bim1p, and dynein, a minus-end-directed motor helping tether the receding plu

45 involved in organelle transport) and ncd (a minus-end-directed motor involved in chromosome segregat

46 Linking of CAMSAP2 to a minus-end-directed motor leads to the formation of an MT

47 Cell biologists have long speculated that a minus end-directed motor localized at kinetochores contr

48 Likewise, minus end-directed motors may move cargoes toward anteri

49 motors containing the stalk and neck of the minus-end-directed motor, Ncd, fused to the motor domain

50 se mitotic spindles with inactive kinesin-14 minus-end-directed motors often have shorter spindle len

51 ng of nuclear congression and identified two minus end-directed motors operating in parallel in this

52 Cytoplasmic dynein 1 (dynein) is the primary minus end-directed motor protein in most eukaryotic cell

53 ge, is transported to the nucleus via the MT minus-end-directed motor protein dynein.

54 a wide range of cellular functions for this minus-end-directed motor protein.

55 Kar3 is the minus-end-directed motor protein; Cik1 binds to Kar3 and

56 mobilized on microtubules by the activity of minus end-directed motor proteins that interact either d

57 ted with centrosomal microtubules (C-MTs) by minus end-directed motor proteins.

58 g microtubules, driven by teams of plus- and minus-end-directed motor proteins.

59 They implicate cortical domains where minus end-directed motors, such as dynein, are activated

60 nein-1 (dynein) is a microtubule-associated, minus end-directed motor that traffics hundreds of diffe

61 Drosophila Ncd, the other well characterized minus-end directed motor that is a homodimer, Kar3 is a

62 Kinesin-14 family proteins are minus-end directed motors that cross-link microtubules a

63 Cytoplasmic dynein is a microtubule minus-end-directed motor that is thought to power the tr

64 -directed motors are balanced by forces from minus-end-directed motors that pull spindle poles togeth

65 act at microtubule tips synergistically with minus-end directed motors to produce a system that can g

66 ative actions of the bipolar kinesin-5 and a minus-end-directed motor, which then pulls the sliding M