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1 axis are difficult to investigate because of miscoding.
2 e mechanism for translational inhibition and miscoding.
3 ly rescue translocation defects arising from miscoding.
4 -tRNA, inhibiting translocation and inducing miscoding.
5 ed to make suboptimal choices reflecting the miscoding.
6 ansient initial selection process to promote miscoding.
7 eby inhibiting translocation and stimulating miscoding.
8 tant S12 mutants display decreased levels of miscoding.
9 end maturation of 16S rRNA and translational miscoding.
10 ments that explain their observed effects on miscoding.
11   Results generated here for replicating the miscoding 8-oxo-G are compared to those published for th
12  site, which potentially may account for its miscoding activity.
13 tructural changes in the ribosome induced by miscoding agents in vitro with their in vivo phenotype.
14               Aminoglycosides are a group of miscoding agents that bind to the ribosome and reduce th
15                                              Miscoding agents viomycin and 30% ethanol also cause sim
16 duce the conformational changes triggered by miscoding agents.
17 m, and is often compromised by translational miscoding agents.
18 ation, several of the mutations that promote miscoding alter residues located at the S4-S5 interface.
19           Finally, we find that G418-induced miscoding alters gene expression with substantial effect
20 ases and have revealed the lesion to be both miscoding and genotoxic.
21 Ribosomal ambiguity (ram) mutations increase miscoding and map to disparate regions, consistent with
22 vivo, our data show that they are absolutely miscoding and may be refractory to repair after transles
23 e (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and can interfere with RN
24 -F dG and, by inference, N (7)-CH(3) dG have miscoding and mutagenic potential.
25                                          The miscoding and mutagenic properties of dG-C8-AAF and dG-C
26 ecomes capable of replicating DNA containing miscoding and noncoding lesions.
27 e modifications have increased translational miscoding and stop codon readthrough frequencies.
28                         All of these promote miscoding and undoubtedly destabilize the S4-S5 interfac
29         Registration data were corrected for miscoding, and Lorenz-curve analysis was used to estimat
30                                          The miscoding antibiotic paromomycin, which binds the decodi
31                                 Here, we use miscoding antibiotics and ribosome mutants to probe how
32 RNA decoding and translocation suggests that miscoding antibiotics may impact protein synthesis by im
33                             Furthermore, the miscoding antibiotics paromomycin and streptomycin rescu
34 sine-to-inosine (A-to-I) editing, ruling out miscoding as a possible mechanism for mitochondrial malf
35 his collection includes mutants that promote miscoding, as well as those that restrict decoding error
36      A major product of DNA oxidation is the miscoding base 8-oxoguanine (8-oxoG).
37 ecise deterministic values for the degree of miscoding between events and non-events tolerable simult
38 sidered as potentially mutagenic as a highly miscoding but rare lesion.
39 on of dA can retard polymerization and cause miscoding but that overall fidelity is not compromised b
40 ion in its D-arm achieves elevated levels of miscoding by accelerating these forward rate constants i
41  used as models to discern the mechanisms of miscoding by DNA polymerases.
42 itro studies indicate that these lesions are miscoding, can block the progression of DNA polymerases,
43  these tRNAs are toxic to cells due to their miscoding capacity in eukaryotic translation systems.
44 t/second step conformations, resembling tRNA miscoding caused by altered equilibrium between open/clo
45           O(6)-methylguanine (O(6)-MeG) is a miscoding DNA lesion arising from the alkylation of guan
46 ects underlie their biological processing as miscoding DNA lesions whose mutagenic properties may con
47 tional changes (from anti to syn) that cause miscoding during DNA replication.
48  repaired uracil derivative that is strongly miscoding during replication.
49 nd R53A, were substantially resistant to the miscoding effects of paromomycin.
50                              Ethanol induced miscoding errors during protein synthesis, from which th
51  The propensity of aminoglycosides to induce miscoding errors that suppress the termination of protei
52 on the messenger RNA, as well as by inducing miscoding errors.
53 n resuming translation elongation stalled by miscoding errors.
54 iota, and dTTP misincorporation is the major miscoding event by all four Y-family human DNA pols.
55 s, severely blocks DNA synthesis and induces miscoding events in human cells.
56                                          The miscoding events include both base substitution and fram
57 ping breast, ovary, and endometrial cancers, miscoding events occurring at model estrogen-derived DNA
58 C codon mistranslation arises primarily from miscoding events such as the selection of noncognate his
59 nts exploring the role of the E-site tRNA in miscoding failed to recapitulate the observations of ear
60                                          The miscoding frequencies induced by pol eta and kappaDeltaC
61                                          The miscoding frequency and specificity of 4-OHEN-dA varied
62                                          The miscoding frequency and specificity of 4-OHEN-dC were st
63                                              Miscoding frequency and specificity of 8-NO(2)-dG varied
64                                          The miscoding frequency varied depending on DNA polymerase u
65 ne decreased both the TLS efficiency and the miscoding frequency.
66         In wild-type MEFs, TLS was extremely miscoding (>90%) with G --> T transversions being predom
67 nd problems associated with missing data and miscoding in medico-administrative databases.
68               Each of these mutations causes miscoding in vivo and stimulates elongation factor therm
69 on of these studies showed that HOPdG is not miscoding in vivo at the level of sensitivity of these s
70 encing patterns of modified bases, including miscoding, insertions and deletions (indels), and trunca
71                  Thus, 4-OHEN-dC is a highly miscoding lesion capable of generating C --> T transitio
72                                      dX is a miscoding lesion capable of preferentially generating G-
73                         Thus, 4-OHEN-dA is a miscoding lesion generating A --> T transversions and A
74 nd that the 4-OHEN-dC DNA adduct is a highly miscoding lesion generating C --> T transitions and C --
75                       dA-N(6)-3MeE is a more miscoding lesion than dG-N(2)-3MeE.
76          These data suggest that 8-oxoG is a miscoding lesion that presents a minimal, if any, block
77 -HOPdG has been shown previously not to be a miscoding lesion when replicated in Escherichia coli.
78 aldehyde-derived adduct, 8-HM-epsilonC, is a miscoding lesion.
79 e desolvation during the replication of this miscoding lesion.
80 on, we found that N3-CMdT and O(4)-CMdT were miscoding lesions and predominantly directed the misinse
81 ly may contain abasic sites, cross-links, or miscoding lesions are acquired by the environmental bact
82  characteristic DNA damage pattern caused by miscoding lesions that differs from present day DNA sequ
83 his is useful for situations where potential miscoding might transpire, it does not account for situa
84 lkylated substrates have been performed, the miscoding nature of these and related individually alkyl
85                                          The miscoding occurred only when replicative DNA polymerases
86 arious data sources and made corrections for miscoding of important diseases (eg, ischaemic heart dis
87 ting that the effect of RimJ on rescuing the miscoding of S5(G28D) is indirect.
88 d Results Program registries to determine if miscoding of staging variables related to cutaneous mela
89                                  Significant miscoding of thickness that is concentrated in ultrathin
90 into ensemble information encoding, such as "miscoding" of the response position and lack of distinct
91               We explored the possibility of miscoding ontogenetically variable characters by running
92 he correct repair of the abundant and highly miscoding oxidative DNA lesion 7,8-dihydro-8-oxo-2'-deox
93 utations in the rRNAs that result in various miscoding phenotypes and resistance to known ribosome-ta
94                                          The miscoding potency of 4-OHEN-dC may be associated with th
95  was proposed that S(6)mG, owing to its high miscoding potential (pairing preferentially with thymine
96 olymerases may differ significantly in their miscoding potential and that in vitro analysis can be us
97 the susceptibility of X to depurination, its miscoding potential during replication by polymerases, a
98  and much information is available about its miscoding potential in vitro and in vivo.
99 ing to deglycosylation and ring-opening, its miscoding potential is not well-understood.
100                         Here, we address the miscoding potential of 1-methyldeoxyadenosine (m1A), 3-m
101                               To explore the miscoding potential of 8-NO(2)-dG adduct, an oligodeoxyn
102                         We conclude that the miscoding potential of a natural abasic site in vitro cl
103 -2'-deoxyarabinoguanosine to investigate the miscoding potential of N(2),3-epsilonG by Y-family human
104                      In order to examine the miscoding potential of this adduct, oligonucleotides sub
105               Existing studies exploring the miscoding potential of this lesion are quite indirect be
106 t dG-N2-TAM in the K-ras sequence has higher miscoding potential than that in the nonspecific sequenc
107 esion (N(7) -CH(3) 2'-F dG) and examined its miscoding potential with four Y-family translesion synth
108 that both of these adducts have considerable miscoding potential with some of these polymerases, that
109 ults indicate that estrogen-DNA adducts have miscoding potential.
110 of the appropriate cytosine (C) thus showing miscoding potential.
111 us estrogen quinone-derived DNA adducts have miscoding potential: G --> A and A --> G transitions and
112                                          The miscoding potentials were also compared to those of an a
113 clude that dG-N2-tamoxifen adducts have high miscoding potentials.
114  extensively investigated lesion, due to its miscoding properties and its potential role in mutagenes
115  of 2 may be an important determinant of its miscoding properties and its reactivity to nucleophiles
116 as N3-EtdT and O(2)-EtdT display promiscuous miscoding properties during transcription.
117                                              Miscoding properties induced by estrogen quinone-derived
118                               To explore the miscoding properties of alpha-(N2-deoxyguanosinyl)tamoxi
119                                          The miscoding properties of epsilon dC determined in vitro a
120                                          The miscoding properties of pol kappa observed in this study
121                                          The miscoding properties of tamoxifen-derived DNA adducts, a
122                     We have investigated the miscoding properties of the exocyclic DNA adduct, 3,N4-e
123                                          The miscoding properties of the model estrogen-derived DNA a
124 ersion to forms that react with DNA, and the miscoding properties of the resulting DNA adducts that c
125                                          The miscoding properties of these arylamine adducts were est
126 eltaC) and full-length pol IV to explore the miscoding properties of these enzymes.
127                                          The miscoding properties varied depending on the diastereois
128 ctive in blocking translesion synthesis, its miscoding properties were similar to other dG-N(2)-BPDE
129                               To explore the miscoding property of 4-OHEN-dC adduct, site-specificall
130                                 To study the miscoding property of 4-OHEN-dC and the involvement of Y
131 aneous deamination to thymine glycol and the miscoding property of the latter may account, in part, f
132                               To explore the miscoding property of the N(2)-Et-dG DNA adduct, phospho
133 om increased decoding by near-cognate tRNAs (miscoding) rather than from decreased efficiency of term
134  ribosomal ambiguity (ram) mutations promote miscoding remains unclear.
135  codon positions was strongly and moderately miscoding, respectively, and it was decoded as an adenos
136 the combined effects of poor repair and high miscoding resulted in 10(2)- to 10(3)-fold increase in t
137                                          The miscoding specificities and frequencies of dG-N2-tamoxif
138                                          The miscoding specificities and frequencies varied depending
139 ended products were analyzed to quantify the miscoding specificity and frequency of dX using two-phas
140    Pol eta and kappaDeltaC showed more broad miscoding spectra; direct incorporations of dCMP and dAM
141   In contrast, antibiotics that do not cause miscoding, such as tetracycline, chloramphenicol, erythr
142 e BPDE-dG, but the subsequent extension from miscoding termini depends on REV1-polzeta in a RAD18-dep
143 tic values for the degree of manipulation or miscoding that can be tolerated simultaneously in both c
144 oint out the limitations of such datasets in miscoding thickness, a key prognostic variable.
145 hydrolytic deamination of cytosine to give a miscoding uracil residue.
146 cates that the dynamics for misreplicating a miscoding versus a non-instructional DNA lesion are diff
147  physical nature of the DNA lesion, that is, miscoding versus non-instructional.
148                           Using pol beta, no miscoding was detected.
149 vations of earlier studies; the frequency of miscoding was unaffected by the presence of E-site-bound
150  the context dependence of the low levels of miscoding we observe on Psi and m(1)Psi containing codon
151 hat these 8-oxoG-derived lesions are equally miscoding when replicated in E. coli lacking MutY; no si
152 adduct of PhIP at the C8 position of guanine miscoding with adenine.
153                                dX was highly miscoding with both polymerases, and incorporation of se

 
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