ライフサイエンスコーパス: mispairing

1 formed in vivo (indicating initial disulfide mispairing).

2 o the risk of heavy and light variable chain mispairing.

3 ting that the barrel contributes to subunits mispairing.

4 uman airways was regulated by slipped-strand mispairing.

5 reduced recombination-induced sgRNA-barcode mispairing.

6 bs without heavy/heavy and light/heavy chain mispairing.

7 paired activity possibly caused by disulfide mispairing.

8 on the helix destabilization associated with mispairing.

9 face collagen-like protein by slipped-strand mispairing.

10 primer/templates that are misaligned due to mispairing.

11 Fc eliminates the possibility of light chain mispairing.

12 ions resulting in frequent T.dGTP and A.dGTP mispairing.

13 s playing a major role in the slipped-strand mispairing.

14 ment of product-related variants such as TCB mispairings.

15 ated including frequent A:A (template: dNMP) mispairings.

16 on to acquire critical MS data and detecting mispairings.

17 FAA is hypermutable, and that slipped-strand mispairing, a mutational mechanism recognized as importa

18 lyprotein can be modulated by slipped-strand mispairing across a pentanucleotide repeat, ACAGC, withi

19 E. coli AlaRS has an intrinsic capacity for mispairing alanine onto nonalanyl-tRNAs including tRNA(C

20 new setup has not only proved successful in mispairing analysis but has also revealed its potential

21 The results of undetectable mispairing and high biological activity have indicated t

22 rigin of the tandem repeat by slipped-strand mispairing and its subsequent turnover.

23 (TRBC) knockout, thus avoiding TCRalphabeta mispairing and maximizing TCR expression and function.

24 t protein mass spectrometry for profiling of mispairing and other product-related impurities, includi

25 tify nucleoside analogs that mimic this base-mispairing and preferentially inhibit apicoplast DNA rep

26 TRBC), were deleted in T cells to reduce TCR mispairing and to enhance the expression of a synthetic,

27 tility is associated with meiotic chromosome mispairing, and is a likely consequence of recombining b

28 mportantly, we uncovered strand slippage and mispairing as the predominant mechanism for generation o

29 get recognition, as evidenced by lack of TCR mispairing, as well as preserved specificity.

30 ertion biases arise primarily from mRNA:tRNA mispairing at codon positions 1 and 3 and reflect, in pa

31 nto the DNA strand of an RNA.DNA hybrid, and mispairing at high frequency.

32 aspartic acid), probably arising by slipped mispairing between 2 copies of a direct repeat (GCGAGCAC

33 cture of the receptor and to competition and mispairing between endogenous and transgenic receptors.

34 is delayed by misfolding of P3-P9, including mispairing between residues in P9 and the tRNA.

35 Mixed dimers, formed by mispairing between the endogenous and transgenic TCRs, m

36 However, in all mispairing cases, phosphodiester bond formation was inef

37 that (a) TRS instability is mediated by DNA mispairing caused by the accumulation of supercoiling wi

38 tion threshold are associated with increased mispairing caused by the optimal partitioning of writhe

39 This mispairing causes alterations in gene expression, and ce

40 in the presence of oxidants and their potent mispairing characteristics suggest that oxazolone may pl

41 O(6)-POB-dG is a strongly mispairing DNA lesion capable of inducing both G-->A and

42 ously chosen as a spiked control to minimize mispairings due to sample preparation.

43 ously chosen as a spiked control to minimize mispairings due to sample preparation.

44 d its reversion take place by slipped-strand mispairing during DNA replication and that swarming moti

45 e generated by a mechanism of slipped-strand mispairing during DNA replication.

46 those of others, we propose a model of slip mispairing during error-prone repair synthesis to explai

47 Slipped-strand mispairing during replication is likely to have generate

48 involve intramolecular or intermolecular DNA mispairing, even pairing across a replication fork.

49 es at a high frequency due to slipped-strand mispairing events that occur during DNA replication.

50 mechanisms potentially involving noncognate mispairing events.

51 ck base pair with template dG and not during mispairing events.

52 hrough does not promote novel or alternative mispairing events; rather, readthrough effectors cause q

53 pendent pathway involves replication slipped mispairing, evoked from stalling at hairpin structures f

54 ent with a mutagenic mechanism involving T-G mispairing followed by a next-nucleotide effect involvin

55 e past, the methoxy groups do not facilitate mispairing, implying that they are not recognized by any

56 n, which was concomitant with slipped-strand mispairing in a poly(C) tract of the fucosyltransferase

57 56dupA and c.676dupC) in FERMT1, and slipped mispairing in direct nucleotide repeats was identified a

58 ess the effect of local DNA sequence on base mispairing in order to determine the mechanism of sequen

59 ow that chain termination is caused by tG:dG mispairing in the enzyme active site.

60 ach Hb receptor independently by slip-strand mispairing in the poly(G) tracts found in hpuA and hmbR.

61 ication/repair-related genes; slipped-strand mispairing is likely the mechanism responsible for the e

62 dence that this is subject to slipped-strand mispairing, leading to frameshifts that eliminate gene f

63 tudies indicate that oxazolone is a strongly mispairing lesion, inducing approximately 10-fold more m

64 us of the target genes by the strand-slipped mispairing mechanism, are often found in the genes encod

65 eats and likely originated through a slipped mispairing mechanism.

66 phase variation mediated by a slipped-strand mispairing mechanism; in each case the gene sequence con

67 f this mutation, consistent with the slipped mispairing model for the generation of short deletions d

68 t least 5-bp and may be explained by slipped-mispairing model of mutagenesis.

69 ethylG by human pol iota, in contrast to the mispairing modes observed previously for O(6)-methylG in

70 s that were consistent with a slipped-strand mispairing mutation model, as well as a smaller number o

71 evolved over several minutes, likely due to mispairing of a central helix junction.

72 Disulfide mispairing of a fraction of B9D, B10D, and B12E mutants

73 This may reflect mispairing of adenine with 8-oxoguanine in DNA attacked

74 Errors in protein synthesis due to mispairing of amino acids with tRNAs jeopardize cell via

75 Mispairing of dGTP and dTTP was similar and occurred wit

76 romosome translocations that result from the mispairing of DNA ends.

77 WS arises due to the mispairing of low-copy DNA repetitive elements at meiosi

78 Mispairing of polymeric guanine (polyG) tracts within ea

79 The helical assembly was stabilized by local mispairing of portal subunits caused by the slippage of

80 ase switching appears to involve slip-strand mispairing of repeated dinucleotides in the pilus promot

81 Mispairing of the crossbone single-strand region and alt

82 , a major limitation to this approach is the mispairing of the introduced chains with the endogenous

83 This rearrangement could be explained by mispairing of the large inverted repeats, followed by do

84 However, mispairing of the therapeutic alphabeta chains with endo

85 ngement revealed a more common result of the mispairing of these large inverted repeats--recombinatio

86 on a "looped out" template strand instead of mispairing opposite a next available template base.

87 to repeat array expansion by slipped-strand mispairing or a similar mechanism.

88 ene family appears to reflect slipped-strand mispairing or domain duplication, allowing for redundanc

89 e form variation showed that slip strand DNA mispairing or unequal recombination resulted in gain or

90 likely tautomeric forms." Indeed, among many mispairing possibilities, either tautomerization or ioni

91 sAb) constructs revealed that although chain mispairing primarily depends on the antibody sequence an

92 tion product analysis suggested that slipped mispairing, producing monomeric replicon products, may b

93 me length, we conclude that the twist in the mispairing region is similiar to that of completely pair

94 of a single receptor chain results in chain mispairing, simultaneous editing of alpha- and beta-chai

95 These include slipped strand mispairing, site-specific recombination and epigenetic r

96 ations through the process of slipped strand mispairing (SSM) by DNA polymerase during replication.

97 Slipped-strand mispairing (SSM) has not been identified as a mechanism

98 We report a general strategy to prevent TCR mispairing: swapping constant domains between the alpha

99 Base mispairing, temperature and the presence of an interstra

100 Vsa tandem repeats occurs by slipped-strand mispairing, the ability of the mycoplasmas to form a bio

101 Possibly owing to the absence of TCR mispairing, the generated T cells showed substantially b

102 be guided by information on potential chain mispairing to enable timely decision making and risk mit

103 Light chain mispairing was circumvented by using an identical light

104 In addition, chromosome mispairing was seen in male meiosis.

105 These findings strongly suggest that slipped mispairing was the cause of this second-site mutation an

106 spiroiminodihydantoin (Sp) because of their mispairing with A or G.

107 G418 increases functional near-cognate tRNA mispairing with a PSC, resulting from binding to its tig

108 e damage is 8-oxo-2'-deoxyguanosine (8-oxoG) mispairing with adenine (Ade), which can occur in two wa

109 By mispairing with adenine during replication, oxoG gives r

110 DNA polymerases, is highly mutagenic due to mispairing with adenine.

111 to perfectly match wildtype sequences while mispairing with mutants, long blockers enable 14-44 nt e

112 onably stable and strongly selective against mispairing with native bases.

113 mplating base, thereby competing against the mispairing with the templating base.

114 xample, CD3 AC-MS allowed us to separate TCB mispairings with increased CD3 binding (i.e., knob-knob

115 obably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic va

116 bers, we developed a high-throughput-capable mispairing workflow based on intact mass spectrometry wi