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1  indirect genetic effects can contribute to "missing heritability".
2 the complex traits remains unaccounted for ('missing heritability').
3 opment of CD has led to the acceptance of a 'missing heritability'.
4 and there is a debate on the source of this 'missing heritability'.
5 ndings suggest a multifarious nature of the 'missing heritability'.
6 l as rare alleles might in part explain the 'missing heritability'.
7  by microRNAs, might also contribute to the 'missing heritability'.
8  effects, may make a key contribution to the missing heritability.
9 f complex diseases but not to the problem of missing heritability.
10 is has so far largely failed to recover this missing heritability.
11    Rare variants have been implicated in the missing heritability.
12 ved in BP regulation and explain part of the missing heritability.
13 haracterized and may account for part of the missing heritability.
14                      This may partly explain missing heritability.
15  as DNA methylation might contribute to this missing heritability.
16 plain the heritability estimates, suggesting missing heritability.
17 ht have strong effects and contribute to the missing heritability.
18 e to explain a significant percentage of the missing heritability.
19 ants and covariates, may help to uncover the missing heritability.
20 ible avenue of attack for finding additional missing heritability.
21 y also partially ascertain the source of the missing heritability.
22 ded to capture weak loci contributing to the missing heritability.
23 ts with larger effects might account for the missing heritability.
24 explain possible reasons for this remaining "missing heritability."
25 ent dilemma in common diseases: Where is the missing heritability?
26 man genetic variation, resolving some of the missing heritability and leading to the discovery of nov
27 h plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europe
28  bias can account for incomplete penetrance, missing heritability and non-Mendelian diseases.
29 ng variants will contribute only modestly to missing heritability and population risk stratification.
30         Here we examine potential sources of missing heritability and propose research strategies, in
31  Our framework identifies a key component of missing heritability and provides a novel paradigm to un
32  responsible for the small additive effects, missing heritability and the lack of replication that ar
33 genetic and molecular avenues to explain the missing heritability and to better elucidate the mechani
34 ucation resources, and more research to find missing heritability and to resolve uncertain results.
35 enotypic variance, leading to the issues of 'missing' heritability and its explanation.
36 PINK1, providing insights into the issue of "missing heritability" and fostering further exploration
37 nvironment (GxE) interactions contribute to "missing heritability" and these may act through epigenet
38 asize the focus on delineating the basis of 'missing heritability' and shift the focus to elucidation
39 pproaches have been taken to determine this 'missing heritability' and to further characterize the kn
40 e-specific functions, suggests paradigms for missing heritability, and enables the dissection of comm
41 rare variants that further contribute to the missing heritability, as recently reported for SIM1.
42 eting heritability and hence the meaning of "missing heritability" becomes problematic.
43 ay account for a substantial portion of this missing heritability, but their discoveries have been im
44 netic variation has been invoked to explain "missing heritability," but its discovery is often neglec
45 leading many to question how the remaining, 'missing' heritability can be explained.
46   Here we provide evidence that part of the 'missing heritability' can be explained by an overestimat
47     One alternative approach to overcome the missing heritability caused by genetic heterogeneity is
48 , we show here that a substantial portion of missing heritability could arise from overestimation of
49 dological implications and contribute to the missing heritability debate.
50       Epilepsy is a disease with substantial missing heritability; despite its high genetic component
51 (40 to 50% of risk); hence the importance of missing heritability due in part to rare variants.
52 studies are characterized by the problem of "missing heritability." Epistasis, or genetic interaction
53 e in multiple myeloma (MM), yet considerable missing heritability exists.
54 example, we examined two possible sources of missing heritability: first, variants with smaller effec
55 rare variants might explain a portion of the missing heritability for ADHD.
56                   Our data indicate that the missing heritability for common autoimmune diseases may
57                                    Informing missing heritability for complex disease will likely req
58 s an additional hypothesis for the source of missing heritability for complex traits.
59 re mutations in GRHL3 that might explain the missing heritability for CPO, we sequenced GRHL3 in case
60            For example, 80% of the currently missing heritability for Crohn's disease could be due to
61 igate the genetic architecture and degree of missing heritability for gene expression in peripheral b
62 se results demonstrate that a portion of the missing heritability for lipid traits and CAD can be exp
63 tentially represent an important portion of "missing heritability" for human diseases.
64 ciation studies (GWAS), there still remains "missing heritability" for many traits.
65  could explain a significant portion of the "missing heritability" for other complex genetic traits.
66 n studies and could account for some of the 'missing heritability' for these diseases.
67 ndicating there is essentially no remaining 'missing heritability' for vitiligo.
68                 It is not a likely source of missing heritability, for example, or major influence on
69  mechanisms of significant loci and excavate missing heritability from some insignificant loci.
70 e-mapping of the HLA region could narrow the missing heritability gap.
71 that are relevant to attempts to narrow the 'missing heritability' gap.
72                                 Much of the "missing heritability" has been revealed to be hidden in
73                      Several sources for the missing heritability have been proposed, including the c
74              Multiple explanations for this 'missing heritability' have been proposed.
75              Recent efforts to unravel this 'missing heritability' have focused on garnering new insi
76                  It has been argued that the missing heritability in common diseases may be in part d
77 ith large effect sizes may contribute to the missing heritability in complex traits.
78 ncluding epigenetic changes, to identify the missing heritability in genetic disorders.
79                                              Missing heritability in genome-wide association studies
80 ic variants explain an important part of the missing heritability in Gitelman syndrome.
81 rogeneity, potentially uncovering sources of missing heritability in multimorbidities.
82 hlights a promising strategy for identifying missing heritability in obesity and other complex traits
83                                  To identify missing heritability in PAH we integrated deep phenotypi
84 wever, there is increasing evidence that the missing heritability in psoriasis could be explained by
85 STR variation as an important contributor to missing heritability in regulating complex traits.
86  in a 'tri-allelic genotype' can account for missing heritability in some hypomorphic OCA1 albinism p
87 tion across the genome can contribute to the missing heritability in T2D and related metabolic traits
88 tag SNP, thereby accounting for some of the "missing heritability" in GWAS.
89 r approach addresses, in part, the issue of "missing heritability" in the sense that much of the heri
90  have been proposed as a possible source of 'missing heritability' in complex human diseases.
91                         Likely causes of the missing heritability include broad phenotype definitions
92 variants, one hypothesis is that much of the missing heritability is due to rare genetic variants.
93             To determine whether some of the missing heritability is due to rare variants conferring
94    Our results also suggest that most of the missing heritability is due to the inability to detect v
95                               Therefore, the missing heritability is small for both traits.
96                    A potential source of the missing heritability is the contribution of rare variant
97                     One explanation for the "missing heritability" is that there are many additional
98     A major barrier to finding more of this 'missing heritability' is assessment--the use of diverse
99 indings can provide insights for solving the missing heritability issue.
100 iling view has been that the explanation for missing heritability lies in the numerator--that is, in
101                                              Missing heritability may be partly due to ignored gene-g
102                                        Some 'missing' heritability may be mediated by epigenetic chan
103                                        Such 'missing heritability' may be partly due to gene x enviro
104                   Some contribution to this 'missing heritability' may come from copy-number variants
105 ension and suggest that some portion of the "missing" heritability might be recovered through integra
106                                 Some of the 'missing heritability' might be explained by copy number
107 reasingly large-scale populations to uncover missing heritability more efficiently.
108                                    In short, missing heritability need not directly correspond to mis
109  inconsistencies and account for some of the missing heritability of blood pressure and are generally
110 entify biological signatures, understand the missing heritability of complex diseases and ultimately
111 ide a partial explanation for the problem of missing heritability of complex diseases.
112 genome (coding and noncoding) to fill in the missing heritability of complex disorders.
113 equilibrium, are a major source of the still missing heritability of complex traits and disease.
114 tial of our approach to identify some of the missing heritability of complex traits.
115 ery of rare variants which may contribute to missing heritability of coronary artery disease (CAD).
116            It is postulated that much of the missing heritability of CRC is enshrined in high-impact
117          There are also issues regarding the missing heritability of disease that cannot be entirely
118 ffects could substantially contribute to the missing heritability of height.
119 r findings may explain some of the so-called missing heritability of HSCR and suggest a mechanism for
120 ariants, which potentially contribute to the missing heritability of human disease.
121  it does not appear to be hiding much of the missing heritability of intelligence.
122             We hypothesized that some of the missing heritability of IQ might lie hidden in the human
123 t similar maternal effects might explain the missing heritability of late-onset human diseases, such
124  should be considered when investigating the missing heritability of neurodegenerative diseases.
125  the independent alleles contributing to the missing heritability of RA.
126 genetics has been haunted by the mystery of "missing heritability" of common traits.
127 atic mutations in cancer and explaining the "missing heritability" of quantitative traits.
128 s potentially explain some of the so-called "missing heritability" of SNV-based GWASs.
129 he contribution of multi-allelic TRs to the "missing heritability" of the human genome.
130 thods may provide valuable insight into the "missing heritability" of traits and provide biological i
131  to explain a significant proportion of the 'missing heritability' of asthma.
132 can be a useful tool to explain some of the 'missing heritability' of complex trait variation.
133  solve genetically unresolved cases and the 'missing heritability' of polygenic traits.
134  variation do not substantially explain the 'missing heritability' of this complex trait.
135 uld explain additional phenotypic variance ('missing heritability') of common traits, and help identi
136  explaining additional phenotypic variance ('missing heritability') of complex diseases like SLE.
137 he identification of novel causal genes, the missing heritability paradox in complex diseases remains
138               OCA is notable for significant missing heritability, particularly among individuals wit
139 of European ancestry in order to examine the missing heritability present in Parkinson's disease (PD)
140 bstantially advance our understanding of the missing heritability problem and have important implicat
141                        One solution to this 'missing heritability problem' may be rare missense varia
142 ase heritability, an observation termed the 'missing heritability problem'.
143 detection is less relevant for resolving the missing heritability problem.
144                               To solve this "missing heritability" problem, we implemented a strategy
145                  This is referred to as the "missing heritability" problem.
146 nt-common disease hypothesis may explain the missing heritability remaining after accounting for iden
147 ions with various complex diseases, yet the "missing heritability" remains alarmingly elusive.
148 e network effect may account for some of the missing heritability seen when comparing sibling-based t
149  to be identified, and a large proportion of missing heritability still needs to be accounted for.
150 d that rare variants account for some of the missing heritability that cannot be explained by common
151               It has emerged to explain the 'missing heritability' that a marginal genetic effect doe
152                                  The phrase 'missing heritability' was coined to refer to the gap bet
153                          To investigate this missing heritability, we recruited 21 families with at l
154   However, there is a high level of reported missing heritability, where only a single heterozygous m
155  PURPOSE OF REVIEW: To discuss the basis of 'missing heritability', which has emerged as an enigma in
156 on and is considered to explain part of the 'missing heritability,' which involves marginal genetic e

 
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