ライフサイエンスコーパス: mitotic index

1 hymidine incorporation, PCNA expression, and mitotic index).

2 transplanted into normal mice showed reduced mitotic index.

3 e highest in proliferating tissues with high mitotic index.

4 RB and a concomitant decrease in the cardiac mitotic index.

5 zed with higher levels in tissues with a low mitotic index.

6 on positively correlated with tumor size and mitotic index.

7 blast-like cells in the hemolymph with high mitotic index.

8 mised spindle architecture and increased the mitotic index.

9 , and this prolongation leads to an elevated mitotic index.

10 oes not result in a temporal increase in the mitotic index.

11 d treatment with TPA+ATRA also decreased the mitotic index.

12 epatocyte proliferation, as monitored by the mitotic index.

13 d by fluorescence-activated cell sorting and mitotic index.

14 the percentage of cycling myocytes and their mitotic index.

15 her two mutants, other than slightly reduced mitotic indexes.

16 s rates at 24 hours, proliferation rates and mitotic index 24 hours after growth stimulation, and the

17 with at least one of the following features: mitotic index 5 per 2 mm(2), Ki67 proliferative index 5%

18 cohorts showed marked increases in the skin mitotic index after dosing.

19 ith Ad5IkappaB but not Ad5LacZ decreased the mitotic index after partial hepatectomy.

20 rican Americans after adjusting for baseline mitotic index, age, gender, and pack-years of smoking [a

21 tasis (P = 0.0331), but only marginally with mitotic index, AJCC stage, nodal metastasis, or blood va

22 ording to age, sex, tumor location and size, mitotic index, American Society of Anesthesiology score,

23 d in G2 phase arrest, which was confirmed by mitotic index analysis.

24 rrelated with increased histologic grade and mitotic index and a decreased disease-free interval (DFI

25 ograft growth, with a concurrent decrease in mitotic index and a significant increase in apoptosis.

26 cle arrest at G(2), as demonstrated by a low mitotic index and Cdc2 activity.

27 etion of Gravin correlates with an increased mitotic index and disorganization of seminiferous tubule

28 The mitotic index and doubling time for LLCPK-1alpha were no

29 n-dependent differences in blastemal length, mitotic index and expression of the Fgf target genes mkp

30 Mitotic index and grade were associated with both ploidy

31 In addition, a lower mitotic index and lower mitotic cyclin-dependent kinase

32 Genetic interaction maps based on mitotic index and nuclear size grouped candidates into k

33 eration, as assessed by a scoring method for mitotic index and proliferating nuclear cell antigen sta

34 table Neurog3 protein, has a relatively high mitotic index and prolonged epithelial residency.

35 8 hours did not increase significantly their mitotic index and protected the cells from the cytotoxic

36 r increased abundance contributes to the low mitotic index and protection of genomic integrity in cel

37 ease DNA synthesis (BrdU, S phase), mitosis (mitotic index and regenerated liver weight, M phase), an

38 or the knockdown of Cdc25A remedies the high mitotic index and rescues the premature differentiation

39 , consequently resulting in reduction of the mitotic index and significant inhibition of tumor growth

40 ated birds exhibited a decreased endothelial mitotic index and substantially diminished neuronal recr

41 Cell multiplication, mitotic index and telomerase increased but did not compe

42 roblasts from null mutants reveals a reduced mitotic index and the presence of polyploid cells.

43 ressive breast tumors, i.e., those with high mitotic index and the so-called triple-negative breast t

44 e, RB-fed pigs had significantly lower ileal mitotic index and villus width, and significantly increa

45 icular cells of these mice, they had a lower mitotic index and were not transformed.

46 ade) on the basis of proliferative activity (mitotic index and/or Ki67 proliferative index) and tumor

47 regenerative response was assessed by PCNA, mitotic index, and BrdU labeling.

48 ured retinal size, cell density, cell death, mitotic index, and cell birth index.

49 py increased mouse survival, decreased tumor mitotic index, and decreased tumor microvessel density,

50 l or missing imaginal discs, greatly reduced mitotic index, and fragmented and abnormally condensed c

51 NR increased DNA synthesis, mitotic index, and mass restoration in the regenerating

52 phase, bromodeoxy uridine [BrdU] = S phase, mitotic index, and regenerated liver weight = M phase).

53 Sex, histology, ulceration, mitotic index, and SN basin location were not predictive

54 cytes was assessed by MCM5 labeling, myocyte mitotic index, and telomerase function.

55 grade, cathepsin-D, Ki-67, S-phase fraction, mitotic index, and vascular invasion showed a significan

56 grade, cathepsin-D, Ki-67, S-phase fraction, mitotic index, and vascular invasion showed a significan

57 e more perfused, exhibited a two-fold higher mitotic index, and were more highly positive for insulin

58 The mitotic index, as assessed by MIB-1 staining, was consis

59 Cell cycle analysis and the mitotic index assay showed that following DNA damage ind

60 BrdU staining, which was used to a calculate mitotic index at several times postoperatively.

61 of keratinocyte differentiation markers, or mitotic index attributed to p53 loss.

62 A patients, TGF-beta1 levels correlated with mitotic index, Breslow index and melanoma growth rate, a

63 to BbF is higher in liver, which has a lower mitotic index but higher metabolic capacity than BM; how

64 thymidine incorporation into hepatic DNA and mitotic index by immunochemical detection of Ki67) and 4

65 thymidine incorporation into hepatic DNA and mitotic index by immunochemical detection of Ki67) and a

66 Mitotic index changes substantiate these interpretations

67 tion doubling time and a 2-fold reduction in mitotic index compared with controls.

68 tutively in some human cancer cell lines and mitotic index correlates with cell cannibalism in primar

69 r (prod) gene of Drosophila causes decreased mitotic index, defects of anaphase chromatid separation,

70 MIB-1, BrDu labeling, and mitotic index-derived proliferation data were highly cor

71 , including accelerated growth rates, higher mitotic index, enhanced invasiveness, increased motility

72 of Bub3, Mad2, or Mps1 resulted in a lowered mitotic index, errors in chromosome segregation (includi

73 e in programmed cell death and a decrease in mitotic index, especially in the region of the distal ti

74 AEtr cells had a reduced mitotic index following nocodazole treatment, suggesting

75 due to a defect in proliferation, since the mitotic index for transgenic and wild-type glands was si

76 results were correlated with tumor Ki-67 and mitotic index, from in vitro assays of the tumor tissue.

77 with at least one of the following features: mitotic index >= 5 per 2 mm(2), Ki67 proliferative index

78 csp mutant embryos have an increased mitotic index, have highly disorganized mitotic spindles

79 the observed phenotypes including a reduced mitotic index, high frequency of aneuploidy and persiste

80 dictors of progression-free survival or high mitotic index in a large breast cancer dataset.

81 that it correlates with an expression-based mitotic index in cancer tissue.

82 the survival curve; (ii) measurement of the mitotic index in cells collected after treatment with co

83 al patterning defects without decreasing the mitotic index in dorsal domains.

84 immunochemical detection of Ki67) and 40 h (mitotic index in HE sections) after partial hepatectomy.

85 munochemical detection of Ki67) and at 32 h (mitotic index in HE sections) in the control group of ra

86 hymidine incorporation into hepatic DNA, the mitotic index in hematoxylin-eosin (HE) sections and by

87 ]pyrene are smaller in size and have a lower mitotic index in MIF-KO mice relative to their WT counte

88 erexpressing cells showed a reduction in the mitotic index in the presence of a spindle poison and fa

89 Compared with cell culture, the peak mitotic index in tumors exposed to Ptx was lower and the

90 sed dosage of the same loci caused a reduced mitotic index in vitro.

91 T3 with small interference RNA increases the mitotic index, in particular, the number of cells in pro

92 is elevated in tissues and cells with a high mitotic index, including cancer cells.

93 is elevated in tissues and cells with a high mitotic index, including cancer cells.

94 The CSC mitotic index increased 29-fold in acute and 14-fold in

95 The mean vascular density and mitotic index increased from stage 2 to stage 3 metastas

96 g cell nuclear antigen (PCNA) expression and mitotic index increased substantially in 50% but not 30%

97 tion fatty animals showed an increase in the mitotic index indicating a delay of regeneration in stea

98 bryos also had an increased endothelial cell mitotic index, indicating that aberrant endothelial cell

99 Mitotic index is an important component of histologic gr

100 mall intestine, colon/rectum, or other), and mitotic index (<5 or > or =5 mitoses per 50 high-power f

101 that cause microtubules to disassemble, the mitotic index (MI) progressively increases as the cells

102 A mitotic index (MI) was calculated as the percentage of n

103 ized by immunocytochemical staining, and the mitotic index (MI) was determined between postnatal day

104 We used gene expression profiling, mitotic index (MI), and quantification of tumor infiltra

105 carcinomas and did not correlate simply with mitotic index, modified Dukes' stage, or tumor size.

106 Risk factors for relapse are tumour size, mitotic index, non-gastric site and tumour rupture.

107 ssion caused by LPS and increased hepatocyte mitotic index, nuclear cyclin D1 translocation, and phos

108 TP53 mutations (44% vs 15%, P<.001), higher mitotic index (odds ratio [OR], 11.0; 95% confidence int

109 n after injury and an elevated cardiomyocyte mitotic index of 10-20% for the MRL compared with 1-3% f

110 n vitro growth characteristics and increased mitotic index of 94-A/K embryos, and molecular structura

111 crease in thymidine incorporation and in the mitotic index of aphidicolin synchronized cells.

112 ventral region of the hippocampus while the mitotic index of NSCs in the dorsal portion of the hippo

113 , mainly due to the low in vivo and in vitro mitotic index of plasma cells.

114 Yet, the mitotic index of precancerous cells and the observable l

115 The proliferation rate and mitotic index of the grafted cells were higher on BL tha

116 Conversely, the mitotic index of the p.Q434del epidermis was significant

117 ino-mediated depletion of Wee2 increases the mitotic index of the paraxial mesoderm and this results

118 Thus, the low mitotic index of the paraxial mesoderm plays an essentia

119 f the amides caused a marked increase in the mitotic index of treated cells, indicating that tubulin

120 of myocytes into the cell cycle resulted in mitotic indexes of 0.08 percent and 0.03 percent, respec

121 at more closely associated with outcome than mitotic index or in vitro BrDu data.

122 t predictors of DFS were proliferation rate (mitotic index or MIB-1) and tumor grade.

123 with features such as large tumor size, high mitotic index, or tumor rupture may also be at higher ri

124 itive association with tumor size (P =.002), mitotic index (P <.0001), histologic grade (P <.0001), a

125 ion, 3.6%), which was highly correlated with mitotic index (P = .0001).

126 Within the first 5 years of follow-up, mitotic index (P =.004), grade (P =.004), ploidy (P =.00

127 eries of open operative resection, the tumor mitotic index predicts local recurrence.

128 ne where neural progenitor cells with a high mitotic index proliferate and in the cortical plate wher

129 significantly reduced regenerative capacity (mitotic index, proliferating cell nuclear antigen, and r

130 compared with lean Zucker rats (PCNA, BrdU, mitotic index, regenerated liver weight) at days 1 and 2

131 3(TA.LO) progenitors, with a doubling of its mitotic index relative to normal Neurog3 expression, sug

132 The mitotic index remained unaltered in vivo, whereas the ap

133 we found that these tumors exhibited a high mitotic index, resembling poorly differentiated (PD)-Pan

134 crease in mitotic cells, but within 24 h the mitotic index returned to baseline.

135 ion of cells with 4 n DNA content, increased mitotic index, separated centrosomes, elevated histone H

136 Measurements of DNA synthesis and mitotic index showed modest effects of Myc to increase l

137 Precystic collecting ducts had an increased mitotic index, suggesting that cell proliferation may dr

138 formation was available: primary site, size, mitotic index, surgical margins, and 2 or more years of

139 cause it generates endothelium with a higher mitotic index than endothelium derived from local source

140 in diameter, more invasive, and had a higher mitotic index than tumors in p53+/+ and p53+/- mice.

141 ological examination indicated a decrease in mitotic index that paralleled the changes in T1rho.

142 e undergoing mitosis was determined, and the mitotic index (the ratio of the number of nuclei undergo

143 es, as deduced from the number of cells, the mitotic index, the amount of apoptosis and the expressio

144 RKIP depletion causes decreases in the mitotic index, the number of metaphase cells, and traver

145 mitotic RPCs during development, causing the mitotic index to increase markedly over time compared wi

146 Patient age, tumor size, mitotic index, tumor ulceration, and necrosis were stati

147 lleviates the reduction in CDC2 activity and mitotic index upon exposure to DNA damage.

148 After 2 weeks in Gln- medium, the mitotic index was 0.3% and the [3H]TdR-labeling index (1

149 Furthermore, the mitotic index was elevated in neural folds and hindgut o

150 The effect of mitotic index was largely a result of the difference bet

151 ial cells by day 8, and the endothelial cell mitotic index was significantly elevated before day 8.

152 12 days after cholestasis induction and the mitotic index was very high upon cholestasis in p38alpha

153 Du labeling index, MIB-1 immunolabeling, and mitotic index were also associated with shortened diseas

154 , growth pattern, mean vascular density, and mitotic index were determined with the aid of immunohist

155 red, their growth rate, apoptosis level, and mitotic index were not affected by the loss of p21, sugg

156 es (Nottingham Combined Histologic Grade and mitotic index) were performed on paraffin-embedded tissu

157 MEK inhibition reverses the reduction in the mitotic index, whereas hyperactivation of Raf mimics the

158 st, tcf3 gene knockdown results in a reduced mitotic index without affecting dorsal patterning.