1 Collectively, the current results suggest a
model wherein 14-3-3varepsilon binds to Ser12-phosphoryl
2 We propose a
model wherein 25OH activation of OSBP promotes the bindi
3 to maintain genomic stability and point to a
model wherein 53BP1 and H2AX cooperate to repress resect
4 ogether, our findings support a "continuous"
model wherein a common neural progenitor population excl
5 on full-length LYS7, suggest an alternative
model wherein a dimer of LYS7 interacts with a dimer of
6 , Chaudhuri et al. (2015) present a cortical
model wherein a hierarchy of timescales arises from loca
7 Overall, we propose a
model wherein a modest effect on RNA splicing is suffici
8 These data support a
model wherein a network of MIT and MIT-like domain inter
9 n period of 8.7 years were consistent with a
model wherein a normal plateau phase of variable length
10 tence and concomitant immunity, suggesting a
model wherein a parasite reservoir repopulates itself in
11 In conclusion, our data support a
model wherein a pre-TfH wave of IL-4 secreted by interfo
12 We propose a
model wherein a Ran-mediated vesicular fusion step is re
13 uction in DNA-binding affinity and support a
model wherein a single cell cycle-dependent Ser/Thr kina
14 Overall, our data are consistent with a
model wherein a single molecule of bezlotoxumab neutrali
15 present evidence in support of the 'sliding
model' wherein a RecA filament diffuses along a dsDNA tr
16 We propose a working
model, wherein a cycle of H2B ubiquitination/deubiquitin
17 y analyzed using equilibrium receptor gating
models, wherein a postulated class of equivalent etomida
18 nowledge of drug availability, and support a
model wherein aberrant circuitry linking dorsolateral pr
19 d precursor protein processing and support a
model wherein Abeta production is amplified by plaque-in
20 Altogether, our results support a
model wherein Ac1PIM2, a major form of PIMs produced by
21 These data suggest a
model wherein activated Fus3p is recruited back to the c
22 Together, these data are consistent with a
model wherein activation of ASIC1A, particularly in neur
23 Our results are consistent with a
model wherein active Ded1 promotes translation but inact
24 We propose a working
model wherein after lysosomal hydrolysis of LDL-choleste
25 ; here we construct, to our knowledge, a new
model wherein airway narrowing and closure dynamics are
26 ar localization of these proteins suggests a
model wherein alginate is modified at the polymer level
27 This led to a
model wherein Alt 2 and the phylogenetically conserved A
28 nditioned taste aversion learning in the rat
model, wherein animals associate a novel taste with visc
29 and chronic rejection, we developed a murine
model wherein anti-MHC class I Abs or control (C1.18.4/a
30 en-CD3 above basal levels, consistent with a
model wherein antigenic engagement induces maximum PRS e
31 These data suggest a
model wherein APC controls enterocyte differentiation by
32 Our findings imply a
model wherein APC controls intestinal cell fating throug
33 These findings support a
model wherein Apc serves a dual role in regulating Wnt a
34 ves a P35-insensitive caspase and supports a
model wherein apical and effector caspases function thro
35 The data are consistent with a
model wherein apoA-V(1-146) alpha-helices circumscribe t
36 We propose a
model wherein APOL1 channel activity is the upstream eve
37 Together, these results support a
model wherein aptamers suppress viral replication by cum
38 Our studies are consistent with a
model wherein ARC3 directly inhibits Z-ring assembly in
39 In summary, our data support a
model wherein As(2)O(3) increases rAAV transduction both
40 results of this study are consistent with a
model wherein ATP binding regulates the anti-inflammator
41 This is consistent with a
model wherein ATP may first bind to Mlh1, resulting in e
42 asive front of human CRCs supports a revised
model wherein Axin2 acts as a potent tumor promoter in v
43 These data are consistent with a
model wherein basal transient sumoylation of the NH2-ter
44 rrently relevant stimulus, consistent with a
model wherein behavioral relevance modulates the impact
45 ell described by a simplified shrinking core
model wherein binding equilibration is much more rapid t
46 These data support a
model wherein binding of a catalytic ion to a precatalyt
47 We propose a
model wherein binding of Rev dimers to MTs at their ends
48 In a biotic biofilm
model, wherein biofilms form on cultured airway cells, t
49 tions are consistent with the predictions of
models wherein blinking is controlled by diffusion of th
50 stream of E2F1; this was confirmed in murine
models, wherein Brm loss induced E2F1 deregulation in a
51 These findings support the
model wherein c-Myc promotes cell growth and transformat
52 These data support a
model wherein C75 of the genomic HDV ribozyme acts as a
53 From these results, we propose a
model wherein caffeine abrogates the G(2)/M checkpoint b
54 Together these data support a
model wherein calcium-induced MMP-9 expression is differ
55 These findings suggest a
model wherein carcinogenesis in BRCA2 mutation carriers
56 ophages is only routinely observed in animal
models wherein CD4 T cells are almost entirely depleted.
57 These studies support a
model wherein cell-matrix engagement regulates the funct
58 A
model wherein cell-type-specific methylation landscapes,
59 on and structure that is not replicated by a
model wherein cells receive random feedforward inputs.
60 We propose a
model wherein chronic stress results in glucocorticoid r
61 These findings support a
model wherein CIITA inhibits MMP-9 expression by binding
62 The results are consistent with a conceptual
model wherein cis-DCE reduction requires active Fe(0) si
63 Mutational analyses of SNAP190 support a
model wherein CK2 phosphorylation triggers an allosteric
64 reveals that (1) gating is best described by
models wherein closed and open states communicate via a
65 Overall, our study puts forth a
model wherein combined actions of Set1 and Jhd2 via modu
66 to chemoradiation, we developed a GBM tumor
model wherein conditional genetic ablation of prolyl 4-h
67 Our data support a
model wherein conformational changes in SF3b1 promote U2
68 These findings support the
model wherein cooperative interactions among intrinsic s
69 led a binding mode similar to that initially
modeled wherein covalent attachment of the nucleophilic
70 Our results suggest a
model wherein CP-31398-mediated stabilization of p53 may
71 chanisms for increasing torque and supported
models wherein critical interactions occur atop the C ri
72 These results suggest a
model wherein CSL-dependent Notch signaling confers prot
73 Collectively, our data support a
model wherein cyclin D1 has a mitogenic (CDK4-dependent)
74 toplasm of cells, which is consistent with a
model wherein cytosolic APOBEC3G packages into assemblin
75 ogether, these results are consistent with a
model wherein DDX1 acts as an RNA chaperone, remodeling
76 the stem II structural transition leads to a
model wherein DDX1 can act as an RNA chaperone, folding
77 Our results are consistent with a
model wherein Ded1 stalls translation and specifically r
78 The data presented are consistent with a
model wherein defective MntABC results in decreased cell
79 Our data support a
model wherein deregulation of cyclin D1 nuclear export m
80 These findings support a
model wherein diabetes-induced O-GlcNAcylation of 4E-BP1
81 an extension of the conformational selection
model, wherein different substrates select different sta
82 that regulates pDC development, supporting a
model wherein differentiation into pDCs represents a pri
83 was recently challenged with an alternative
model wherein disrupting RubisCO activity prevents photo
84 This effect is consistent with a
model wherein distal polyanionic surfaces of the nanocag
85 We describe a working
model wherein distinct classes of transcription factors
86 onal and apoptotic; thus, our data support a
model wherein division-linked generation of T(DIM) contr
87 The results support a
model wherein dNTP elevation is needed to facilitate non
88 Based on our results, we propose a
model wherein E4-ORF1 binding to Dlg1 triggers the resul
89 These findings support a
model wherein E93 expression functions as an instructive
90 These findings led us to propose a
model wherein each LXXLL motif has an additive effect, a
91 Our data are consistent with a
model wherein early resistance to B. malayi is mediated
92 Our results support a
model wherein efficient electron propagation can explain
93 Taken together, our data support a
model wherein EGF promotes Tcf/Lef transcriptional activ
94 Furthermore, we describe a new
model wherein EMT induced by TGFbeta requires translatio
95 Our data support a
model wherein epicardial-derived pericytes populate the
96 The combined data suggest a
model wherein epigenetic and genetic elements cooperativ
97 Together, these studies support a
model wherein episodic Blimp-1-mediated plasma cell diff
98 on or function of the U6 snRNA, supporting a
model wherein excess Lsm1 reduces the availability of th
99 The data also suggest a
model wherein factors implicated in aging (for example,
100 These results advance a new
model wherein Fn polymerization serves as a structural s
101 We present a
model wherein FoxO degradation is a component of a stabi
102 We propose a
model wherein fras1 prompts late-p1 formation and thereb
103 ses of these mutant forms of Tor1p support a
model wherein functional interactions between the FRB an
104 provide strong support for a GAL gene switch
model wherein Gal80 rapidly dissociates from Gal4 throug
105 these findings serve as the foundation for a
model wherein GDNF and CGRP interact in a paracrine mann
106 at the restrictive temperature, we propose a
model wherein Gfd1 serves as a bridging factor between G
107 Our results are consistent with a
model wherein GINS trades places with Sld3 at a replicat
108 We used such a
model wherein GVL is exclusively mediated by T cells tha
109 Here, we describe a somatic mouse
model wherein H3.3(K27M) and Trp53 loss alone are suffic
110 ProHA x TRAMP mice), as well as an analogous
model wherein HA is expressed in normal tissues as a mod
111 CD81 and claudin-1 endocytosis, supporting a
model wherein HCV stimulates receptor trafficking to pro
112 Our results are consistent with a
model wherein heme release from HasAp to the N-terminal
113 The data support a
model wherein HIV-1 entry occurs in three stages: recept
114 These results support a
model wherein Hsp90 interacts predominantly with the cyt
115 Our results suggest a
model wherein hSWI/SNF-directed nucleosome movement away
116 The results are interpreted in terms of a
model wherein HypA controls the flow of nickel traffic i
117 The findings support a
model wherein hyperglycemia-induced REDD1 blunts the Nrf
118 These data support a
model wherein IE1 oligomerizes prior to DNA binding to f
119 These findings support a
model wherein IE1 oligomerizes within the cytosol as a p
120 Our data support a
model wherein IFNs local to the maternal-fetal interface
121 Our results support a
model wherein IL-7 transduces a replicative signal to no
122 Collectively, these data support a
model wherein IL12Rbeta1DeltaTM is a secreted product of
123 iving biofilm formation in vivo We propose a
model wherein impaired cellular respiration stimulates S
124 We propose a
model wherein imprinting defects at chromosome 11p13 may
125 in vivo and in vitro, were consistent with a
model wherein improved C-helix "leucine zipper" interact
126 These findings invoke a
model wherein incomplete DNA synthesis during S phase le
127 -syn in the presence of Ca(2+), we propose a
model wherein initial lipid interaction occurs via the N
128 These data are compatible with a
model wherein interaction of MDA-9/syntenin with c-Src p
129 Our results suggest a
model wherein interactions among TFAP2A, CITED2, and p30
130 These findings support a
model wherein interactions between transcription factors
131 These findings support a
model wherein interoceptive processing in the mid-insula
132 in support of this hypothesis, and propose a
model wherein IRE1 surveys the integrity of the ER, acti
133 veral lines of evidence combine to support a
model wherein it acts to maintain barrel structure while
134 We propose a Kv4.3 gating
model wherein KChIP2 isoforms accelerate recovery, slow
135 Our data support a
model wherein KLCs promote activation of kinesin-1 for c
136 Together, these data support a
model wherein KLK5-mediated PAR-2 activation regulates t
137 We describe a murine
model wherein leukocytes interacting with inflamed micro
138 suppressed murine colitis in an experimental
model wherein lipopolysaccharide is known to play an imp
139 In a xenograft
model wherein,
live renal cancer cells were implanted un
140 These results support a
model wherein LT from RORgammat(+) cells orchestrates th
141 isms and three-dimensional (3D) cell culture
models wherein mammalian epithelial cells undergo morpho
142 Together these data support a
model wherein matrix-induced clustering ofalpha3beta1 in
143 We proposed a
model wherein mechanical loading, i.e. stretch, stimulat
144 isoforms and provide further evidence for a
model wherein membrane potential promotes charged CQ tra
145 The data suggest a
model wherein Metnase promotes integration of exogenous
146 e established an immune-mediated TRALI mouse
model, wherein mice with cognate antigen were challenged
147 Wine grapes present a unique biogeography
model, wherein microbial biodiversity patterns across vi
148 We posit a
model wherein microRNAs are critical for downregulation
149 Together, these data were consistent with a
model wherein MKL1 transduces signals from the cytoskele
150 Our combined data support a
model wherein modest alterations in B cell-intrinsic, BC
151 These findings support a novel
model wherein modulation of the Treg response as a resul
152 s result can be explained by a reinforcement
model wherein movement errors influence decision-making,
153 Our data support a
model wherein MSL2 and MSL3 control plastid size, shape,
154 were interpreted using a cooperative binding
model wherein multiple non-covalent interactions create
155 erns were more consistent with a crypt niche
model wherein multiple stem cells were present and repla
156 Taken together, these data support a
model wherein Munc18c transiently switches from associat
157 These findings support a
model wherein mutant DISC1 leads to SR degradation via d
158 Our studies suggest a molecular
model wherein mutually antagonistic intermolecular compe
159 This mechanism differs from the standard
model wherein nascent C3b generated in the fluid phase a
160 Herein, we used an animal
model, wherein NC1-peptide cloned into the pCI-neo mamma
161 Collectively, our results support a
model wherein non-stem cancer cells have the potential t
162 These results support a
model wherein Notch signaling in bone marrow normally ac
163 ogether, these studies suggest a heterotypic
model wherein Notch signaling in vSMCs provides early in
164 These data are consistent with a
model wherein Notch signaling represses SMC differentiat
165 Based on these results we propose a
model wherein nuclear accumulation of the cyclin E/Cdk2/
166 We propose a
model wherein Nup159 and Gle1-IP(6) regulate Dbp5 cycles
167 e examined by using generalized linear mixed
modeling wherein observations were nested for each radio
168 with the self-organized criticality (SOC), a
model wherein occasionally occurring "catastrophic event
169 Further analysis supported a
model wherein one monomer of TRN-SR2 is bound to one mon
170 Our findings suggest a new
model wherein Op-IAP3 interacts directly with SfIAP to m
171 Further, we postulate a Goldilocks
model, wherein optimal glycan interactions can influence
172 The present results are discussed within a
model wherein oscillators influence one another in a pha
173 Together, these findings suggest a
model wherein Pak1 regulation of cyclin D1 expression mi
174 Our findings suggest a
model wherein pericyte recruitment to endothelial cells
175 Our data are consistent with a
model wherein PfCRT catalyzes electrochemically downhill
176 These results reinforce a
model wherein phosphorylation of specific residues of BR
177 Our data support a
model wherein PilW, PilX, and PilY1, in addition to thei
178 Altogether, our data suggest a
model wherein PL is a prodrug whose intracellular hydrol
179 spects of the H3K27M inhibitor and support a
model wherein PRC2 becomes trapped at H3K27M-H3K27me3 bo
180 ed a similarity-based reinforcement learning
model wherein prediction errors generalize across simila
181 Here we describe a maternal SLE mouse
model wherein pregnant dams harbored DNA-specific, NMDAR
182 The T. brucei data fit a
model wherein processing factors assemble at the 5'ETS s
183 Our results point to a
model wherein protein kinase A and its vesicle-associate
184 Our data suggest a coordination
model wherein PrP(C) vesicles maintain a stable populati
185 cell migration [15, 16], our data support a
model wherein PTB-domain-containing adaptor proteins reg
186 These results support a
model wherein Pumilio utilizes CNOT deadenylase and deca
187 d of rgd2-R;pve1-M2 double mutants suggest a
model wherein PVE1 functions downstream of RGD2 in a pat
188 We present a
model wherein Rad51 helps recruit Sgs1-Top3 to sites of
189 We present a unified
model wherein Rad54 acts as an hDNA pump that drives D l
190 Our results are consistent with a
model wherein rbf represses synthesis of icaR, which in
191 Allosteric
models wherein receptor binding shifts the equilibrium t
192 State-performance correlations support a
model wherein reconsolidation of hippocampus-dependent f
193 We propose a distinctive
model wherein RecQ melts dsDNA internally to initiate un
194 Our data support a spatiotemporal
model wherein recruitment of AMPK in association with co
195 These findings suggest a
model wherein recruitment of CD4 to the IS allows its ph
196 The results presented support a
model wherein regulation of the binding of UBF to Rb and
197 We discuss a
model wherein repair of a double-strand gap requires mul
198 , this has led us to propose a "looped belt"
model, wherein residues 133-146 comprise a flexible loop
199 dependent, an observation consistent with a
model wherein Rev self-association acts to transiently m
200 Combined, these results suggest a
model wherein Rev-associated nuclear export signals coop
201 ial epidermal identity occurs and suggests a
model wherein RGD2 is required to coordinate dorsiventra
202 A
model wherein S170 phosphorylation functions as part of
203 ction of human skin and provide 3D epidermal
models wherein SCC prevention can now be explored.
204 Taken together, our results support a
model wherein Ser(138) phosphorylation sensitizes IRP1/c
205 are consistent with a 'differential fusion'
model wherein sexual selection reduces rates of fusion a
206 We suggest a
model wherein sheathing bases and parallel veins are bot
207 Our data support a
model wherein silent information regulator 4 tethers the
208 occur as individual complexes, supporting a
model wherein sister cohesion is mediated locally by a s
209 We propose a
model wherein Sld2 blocks the interaction between GINS a
210 The results support a
model wherein slow-moving replication forks caused by th
211 In summary, these results suggest a novel
model wherein SNP-modulated RNA splicing modulates CD33
212 the strength of interference and suggested a
model wherein some crossovers experience interference wh
213 We propose a
model wherein specific DNMT-histone methyltransferase ne
214 involved in this response, and we proposed a
model wherein SREBP-1c and carbohydrate response factor
215 Data presented support a
model wherein SrrAB-dependent biofilm formation occurs i
216 clinical strategy in a stringent preclinical
model, wherein standard-of-care chemotherapy is followed
217 Based on our findings, we propose a
model wherein STIM1-mediated store-operated calcium entr
218 ole cells as well as cell-free systems fit a
model wherein stimulus-induced acetyltransferase activat
219 We conclude by proposing a
model wherein stochasticity in the nuclear location of t
220 Thus, our findings support a
model wherein substrate discrimination via the Tyr pocke
221 l data, the structure supports a mechanistic
model wherein subunit H inhibits ATPase activity by stab
222 We propose a
model wherein SufT, and by extension the DUF59, is essen
223 These new data support a
model wherein Tcf3-mediated control of Nanog levels allo
224 vidence, we propose the Piggyback-the-Winner
model wherein temperate dynamics become increasingly imp
225 Our data are consistent with a
model wherein TH1/TH17 differentiation is attenuated in
226 We propose a
model wherein the 4E-T/4EHP interaction engenders a clos
227 These data suggest a
model wherein the active site of LCAT is shielded from s
228 Taken together, these data support a
model wherein the alpha-helices in the receptor-binding
229 Our findings lead to a
model wherein the amidase complex regulates the density
230 Taken together, these data suggest a new
model wherein the antiapoptotic function of IAP requires
231 We propose an evolutionary
model wherein the appearance of the most active enzyme i
232 The combined results support a
model wherein the beta-hairpin PG-1 peptide acts as an a
233 etic and biochemical evidence corroborates a
model wherein the biosynthesis and translocation of DAT
234 Such observations led to the long-standing
model wherein the Calvin cycle is necessary during photo
235 We discuss a
model wherein the cancer-associated substitution limits
236 Altogether, our experimental data suggest a
model wherein the catalytic site is essentially preforme
237 fore and after RYGB are in accordance with a
model wherein the cerebral extracellular 5-HT level modu
238 CM proteins onto chromatin, which supports a
model wherein the composite action of multiple G1 CDK co
239 our previous experimental data, we propose a
model wherein the conformational transitions are importa
240 , Renno-Costa et al. introduce a theoretical
model wherein the convergence of the medial and lateral
241 These results are consistent with a
model wherein the cytokinin/WUS pathway and retrograde s
242 Our findings support a
model wherein the degron is exposed when SMN is monomeri
243 To this end, we developed a transgenic mouse
model wherein the firefly luciferase gene expression was
244 Altogether, our experimental data support a
model wherein the flexibility and conformational transit
245 These findings support a
model wherein the immunomodulatory capacity of F. tulare
246 Collectively, our data support a
model wherein the in vivo role of VitD3 during TB is not
247 Results are accommodated by a
model wherein the Mg(2+)-free pKa observed for WT arises
248 These data support a new
model wherein the N-terminal domain is required to media
249 ntify such a region in SOCS36E and propose a
model wherein the N-terminal of SOCS36E blocks access to
250 This suggests a
model wherein the neocentromere represents a primordial
251 The results were most consistent with a
model wherein the non-ion-paired C1(2+*) excited state t
252 r transport velocities are consistent with a
model wherein the normal stepping behavior of the myosin
253 I build on previous research to synthesize a
model wherein the OT, which may be more appropriately te
254 n these observations, we develop a summative
model wherein the P-body assembly phenotype of a given m
255 These data are consistent with a new
model wherein the P35 reactive site loop participates in
256 The results support a
model wherein the PFC is critical for top-down intrahemi
257 Based on prior studies, we proposed a
model wherein the poliovirus RNA-dependent RNA polymeras
258 previously known role of ppGpp and support a
model wherein the ppGpp-dependent redistribution of RNA
259 Together our data support a
model wherein the production of type I interferons drive
260 We propose a
model wherein the recruitment of ZFP-1/DOT-1.1 and depos
261 Our data lead to a
model wherein the replication complex can be assembled w
262 These data provide a
model wherein the respiratory epithelium responds to hyp
263 Taken together our results suggest a
model wherein the retraction of the spectrin-actin cytos
264 We propose a
model wherein the right-handed ((+) solenoidal) wrapping
265 We discuss a
model wherein the SA signaling pathway and plasmodesmata
266 Based on these findings, we propose a
model wherein the unique physiology of ROS-low LSCs prov
267 r data support a two-site gp120-CCR5 binding
model wherein the V3 crown and stem interact with distin
268 phorylated CTD peptides is consistent with a
model wherein the WW domain positions Ess1 to catalyze i
269 Our findings are consistent with a
model, wherein the 5-HT4R density adjusts to changes in
270 A kinetic
model, wherein the secondary structure of the nascent RN
271 ntegrative structure and a bipartite binding
model, wherein the TAR central loop engages the CycT1 TR
272 are presented together with chemical kinetic
modeling wherein the rate constants employed have been c
273 Typically, accounts invoke
models wherein the hemispheres differ in time-frequency
274 by the ENA image does not conform to current
models, wherein the heliosphere resembles a cometlike fi
275 Ps in miRNA-mediated silencing and support a
model wherein they enable miRNA-binding sites by looping
276 ilJ and the PilJ demethylase ChpB, support a
model wherein this chemotaxis cluster participates in th
277 ll lymphomas, we developed a murine lymphoma
model wherein three potential rejection antigens, human
278 in the context of a translational checkpoint
model wherein TIA and eIF2 are functional antagonists of
279 ato do not regulate each other, we propose a
model wherein tll expression restricts the ability of ce
280 These data support a
model wherein TLR responses in FM B cells are tightly re
281 The results are consistent with a
model wherein TM can directly and reversibly down-regula
282 Together, these data support a
model wherein TNK2, WASL, and NCK1 comprise a pathway im
283 acid dependent branch of ETI, with a current
model wherein TOPs sustain interconnected organellar and
284 Our results fortify a
model wherein toxicity of mutant spastin proteins, espec
285 embrane protein gp210, our results support a
model wherein transport of integral proteins to the INM
286 les in the release-ready state and support a
model wherein tryptophan-mediated protein-lipid interact
287 epigenetic function for eHsp90 and support a
model wherein tumor eHsp90 functions as a rheostat for E
288 Thus, the data support a
model wherein tumor Treg cells sustain and amplify their
289 Here we propose and test a "proximity
model" wherein two females that vary in their relative a
290 We discuss a
model wherein type III IFNs serve as a front-line defens
291 These observations suggest a
model wherein TYROBP-KO-(knock-out)-associated reduction
292 A
model wherein TyrR, IHF, and CRP collaborate to regulate
293 These findings are best explained by a
model wherein UAG codons may have ambiguous meaning and
294 Our findings support a conceptual
model wherein variable climatic conditions dominate rece
295 mer tubulation was exaggerated, supporting a
model wherein WASH links retromer-mediated cargo contain
296 We present a molecular
model wherein Xrcc2 is important to preserve or restore
297 gand binding domain, we propose an alternate
model wherein Y537F mutation favors an "open" pocket con
298 Our results suggest a
model wherein Yoda1 acts as a molecular wedge, facilitat
299 We propose a
model wherein Yps and Orb bind competitively to oskar mR
300 Our data suggest a
model wherein ZC3H3 interfaces between the polyadenylati