ライフサイエンスコーパス: modern human

1 Neanderthal but belonged to an anatomically modern human.

2 analyze Neanderthal sequences segregating in modern humans.

3 east Asia in association with a dispersal of modern humans.

4 its links to a Late Pleistocene dispersal of modern humans.

5 ter group of Denisovans after diverging from modern humans.

6 otion that East Africa was the birthplace of modern humans.

7 ese inhibitors predispose to two scourges of modern humans.

8 elationship between Pleistocene hominins and modern humans.

9 e evidence for the symbolic culture of early modern humans.

10 d materials required to sustain hyper-dense, modern humans.

11 piRNA loci are rapidly diverging even among modern humans.

12 still limited in their endurance compared to modern humans.

13 r functional or structural traits typical of modern humans.

14 t four major lineages deep in the history of modern humans.

15 haping genotypic and phenotypic variation in modern humans.

16 e to painful stimuli in Neanderthals than in modern humans.

17 iting our knowledge of these predecessors of modern humans.

18 al selection against Neanderthal variants in modern humans.

19 australopiths and early Homo was faster than modern humans.

20 ity (bone strength relative to body size) in modern humans.

21 thers indicating only subtle differences vs. modern humans.

22 portant for the study of dispersal routes of modern humans.

23 idered as less technologically advanced than modern humans.

24 es of tooth formation differed from those in modern humans.

25 sed genetic load in Neanderthals relative to modern humans.

26 tions (M932L, V991L, and D1908G) relative to modern humans.

27 l DNA was subjected to negative selection in modern humans.

28 le emergence of the mutation in anatomically modern humans ~150 000 years ago and indicate that balan

29 bute to comparative research suggesting that modern human abilities are supported by evolutionarily o

30 dispersal, i.e., a single major diffusion of modern humans across Eurasia and Australasia [3-5]; and

31 The spread of modern humans across the globe has led to genetic adapta

32 icrobial communities that interact most with modern human activities.

33 Neandertal and modern human adults differ in skeletal features of the c

34 he last refuge of Neanderthal populations as modern humans advanced across Eurasia.

35 ly methylated regions that likely emerged in modern humans after the split from Neanderthals and Deni

36 pression differences between Neanderthal and modern human alleles, indicating pervasive cis-regulator

37 , fossil evidence suggests that anatomically modern humans (AMH) and various archaic forms coexisted

38 Genetic evidence for anatomically modern humans (AMH) out of Africa before 75 thousand yea

39 e phyla between chimpanzees and anatomically modern humans (AMH), with chimpanzees possessing a great

40 mains generally associated with anatomically modern humans (AMHs) and evidence of a probable Neandert

41 nd largely extinct expansion of anatomically modern humans (AMHs) out of Africa.

42 comparison of Neanderthals and anatomically modern humans (AMHs), and revealed that they interbred.

43 tinctly different from those of anatomically modern humans (AMHs), despite the close relationship bet

44 replacement of Neanderthals by anatomically modern humans (AMHs).

45 f Neandertals and the spread of anatomically modern humans (AMHs).

46 the population divergence of Neandertals and modern human ancestors, and it refutes alternative scena

47 y dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the

48 thousand years ago and presents a mixture of modern human and primitive features.

49 rican continent is regarded as the cradle of modern humans and African genomes contain more genetic v

50 (Neanderthals and Denisovans) interbred with modern humans and contributed to the contemporary human

51 covery of interbreeding between anatomically modern humans and extinct hominins; the development of a

52 not remained stable even since the origin of modern humans and might have changed numerous times duri

53 d material with early or recent anatomically modern humans and more primitive neurocranial and endocr

54 roove complex", all of which are uncommon in modern humans and more typically found in Middle Pleisto

55 Interbreeding between modern humans and Neandertals has resulted in introgress

56 Thus, the history of admixture between modern humans and Neandertals is most likely more comple

57 Middle to Upper Palaeolithic interface, both modern humans and Neanderthals contemporaneously inhabit

58 spanning chimpanzees, ancient hominids, and modern humans and reveals new aspects of MEI biology in

59 ty from structural MRI scans of thousands of modern humans and study the effects of introgressed frag

60 in Eastern Morocco revealed 15,000-year-old modern humans and suggested that North African individua

61 rphology that is shared with Neandertals and modern humans, and considered adaptive for intensified m

62 genetically diverged from other anatomically modern humans, and they likely experienced strong select

63 n the slow overall growth and development of modern humans appeared.

64 he large brain and small postcanine teeth of modern humans are among our most distinctive features, a

65 Modern humans are instead niche modifiers, continually c

66 skeletal differences between Neandertals and modern humans are largely established by the time of bir

67 haracteristics and cognitive capabilities of modern humans are well-documented, less is known about h

68 Anatomically modern humans arose in Africa ~300,000 years ago, but th

69 Modern humans arrived in Europe ~45,000 years ago, but l

70 dence (and hence lumbar lordosis) similar to modern humans, articulation of lumbar and cervical verte

71 n addition to using MELT to discover MEIs in modern humans as part of the 1000 Genomes Project, we al

72 Denisovans-which interbred with anatomically modern humans as they dispersed out of Africa.

73 sites and demonstrates that the presence of modern humans associated with Upper Paleolithic toolkits

74 ast continents to be explored and settled by modern humans at the end of the Pleistocene.

75 t elements fell within the expected range of modern humans at this age.

76 The latter assume that modern humans benefited from some selective advantage ov

77 eference genome is part of the foundation of modern human biology and a monumental scientific achieve

78 ousand years old, therefore the emergence of modern human biology is commonly placed at around 200 th

79 ing to a recent evolutionary origin of fully modern human body shape.

80 Neanderthals and modern humans both occupied the Levant for tens of thous

81 Nevertheless, natural selection persists in modern humans, both as differential mortality and as dif

82 Comparisons of modern human brains with those of chimpanzees provide an

83 ltiple interactions between Neanderthals and modern humans, but there is currently little genetic evi

84 have discovered that HK2 viruses produced in modern humans can package HK2 sequences and transmit the

85 ruda fossil is significant for the spread of modern humans carrying the IUP into Europe and suggests

86 Southern Italy, have demonstrated that early modern humans collected and processed various plants.

87 As modern humans continue to live under extended periods of

88 t into the complexity and diversification of modern human culture during a key period in the global d

89 ly a statistic that avoids assumptions about modern human demography by taking advantage of two high-

90 the mechanisms underlying sex differences in modern human diseases.

91 The data indicate a rapid modern human dispersal across southern Europe, reaching

92 ts support the notion of a mosaic process of modern human dispersal and replacement of indigenous Nea

93 Modern human dispersal into Europe is thought to have oc

94 As modern humans dispersed from Africa throughout the world

95 How modern humans dispersed into Eurasia and Australasia, in

96 n important for understanding the origins of modern human diversity.

97 Neanderthal-derived variants that survive in modern human DNA; however, the neural implications of th

98 During bipedal walking, modern humans dorsiflex their forefoot at the metatarsop

99 Many Neanderthal sequences survive in modern humans due to ancient hybridization, providing an

100 n, the time of replacement of Neandertals by modern humans during the Late Pleistocene in Europe.

101 on on the role of carnivores in Anatomically Modern Humans' economic and cultural systems is limited.

102 ter understand the biological foundations of modern human endocranial shape, we turn to our closest e

103 mechanisms that may contribute to the unique modern human endocranial shape.

104 aracterized by a series of founder events as modern humans expanded into multiple continents.

105 g in favourable environmental conditions for modern human expansion.

106 tantially to later people or represent early modern human expansions into Eurasia that left no surviv

107 activate it, are distinct in many ways from modern human experiences with pandemics.

108 , show extensive bone deposition, whereas in modern humans extensive osteoclastic bone resorption is

109 Here genomic analyses of anatomically modern humans, extinct Denisovan hominins and mice revea

110 might have played a key role in shaping the modern human face and vocal tract.

111 we evaluate the evolutionary history of the modern human face in the context of its development, mor

112 t not with modern humans suggesting that the modern human face is developmentally derived.

113 cies grows, the question of how and when the modern human face originated remains unclear.

114 Huesos (SH) and different from the retracted modern human face.

115 buted to the derived anatomy observed in the modern human fifth ray.

116 It is relevant to debates about when modern humans first dispersed out of Africa and when the

117 ens of thousands of years after anatomically modern humans first left Africa and thousands of years a

118 This study provides evidence that the modern human foot was derived from an ancestral form ada

119 humans were involved in their production, as modern-human fossil and genetic evidence of such antiqui

120 eolithic toolkits in the Levant predates all modern human fossils from Europe.

121 0 ka) Neanderthals and one Upper Paleolithic modern human from northeastern Italy via spatially resol

122 we analyse DNA from a 37,000-42,000-year-old modern human from Pestera cu Oase, Romania.

123 was determined by the repeated migration of modern humans from Africa into Eurasia.

124 Levantine corridor hypothesis suggests that modern humans from Africa spread into Europe via the Lev

125 The timing of a migration reversal of modern humans from Eurasia into North Africa is suggeste

126 patterns of social behavior that distinguish modern humans from other living primates likely played s

127 One of the features that distinguishes modern humans from our extinct relatives and ancestors i

128 Neandertal and Denisovan DNA persist in the modern human gene pool, but have been systematically pur

129 nderthal ancestry, has been deleterious on a modern human genetic background, as reflected by its dep

130 s the persistence of its risk alleles in the modern human genome.

131 with the evolution of RV-C and helped shape modern human genomes against the virus-susceptible, albe

132 ed archaic hominin sequence that survives in modern human genomes and what these genomic excavations

133 Many modern human genomes retain DNA inherited from interbree

134 d (3) the introgression of ancient MEIs into modern human genomes.

135 make a direct comparison between archaic and modern human genomes.

136 and Bacteroides, the dominant genera in the modern human gut microbiome.

137 st 45,000 years before present, anatomically modern humans had spread across Eurasia [1-3], but it is

138 The early onset of weaning in modern humans has been linked to the high nutritional de

139 the possible relationship with anatomically modern humans has captured our imagination and stimulate

140 Life, from the earliest cells to modern humans, has evolved in intimate association with

141 Modern humans have a short, retracted face beneath a lar

142 tal sequences that persist in the genomes of modern humans have been identified in Eurasians, compara

143 Today, modern humans have evolved with an oversized brain commi

144 Here, we test the hypotheses that (i) recent modern humans have low trabecular density throughout the

145 Modern humans have more fragile skeletons than other hom

146 ng in archaic hominins and introgressed into modern humans have played an important role in local pop

147 ebate about the Neanderthals' replacement by modern humans highlight the role of environmental pressu

148 ce, combined with dental development akin to modern humans, highlights their similar metabolic constr

149 r effective population sizes throughout most modern-human history.

150 e tall and narrow body shape of anatomically modern humans (Homo sapiens) evolved via changes in the

151 nvestigated genetic differentiation of early modern humans, human admixture and migration events, and

152 as related to the colonization of Eurasia by modern human hunter-gatherers, who competed with wolves

153 n spite of this, however, there have been no modern human imaging studies of its acute effects on the

154 ulate the number of teeth and facial size of modern humans in a coordinated manner.

155 Documenting the first appearance of modern humans in a given region is key to understanding

156 a population that diverged early from other modern humans in Africa contributed genetically to the a

157 probably predate the arrival of anatomically modern humans in Eastern Europe.

158 Whereas there is no evidence of the earliest modern humans in Europe contributing to the genetic comp

159 c decline in Neandertal ancestry observed in modern humans in Europe over the past 45,000 years.

160 -level carnivores, even after the arrival of modern humans in Europe.

161 However, the H. naledi foot differs from modern humans in having more curved proximal pedal phala

162 n resonance dating of mammalian teeth, place modern humans in Sumatra between 73 and 63 ka.

163 different from most other early anatomically modern humans in the Levant.

164 Most modern humans, in contrast, concentrate in large cities

165 ples from 51 deciduous teeth of 12 different modern human individuals of known dietary histories, as

166 he present, containing multiple anatomically modern human individuals.

167 2-3 month-old modern human infants produce "protophones", including at

168 Modern humans inhabit a variety of environments and are

169 stantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is c

170 om body parts of endemic animals, suggesting modern humans integrated exotic faunas and other novel r

171 ient hominin lineage most closely related to modern humans, interbred with ancestors of present-day h

172 iderable complexity in archaic contact, with modern humans interbreeding with multiple Denisovan grou

173 Based on genetic evidence the dispersal of modern humans into Eurasia started less than 55 ka ago.

174 ole of plant foods in the dispersal of early modern humans into new habitats globally.

175 of thousands of years prior to the spread of modern humans into the rest of Eurasia and their replace

176 at Neanderthals were cognitively inferior to modern humans is becoming increasingly untenable.

177 Africa, the ancestral home of all modern humans, is the most informative continent for und

178 e possible cause-effect relationship of this modern human-like (MHL) hand anatomy, its associated gri

179 ted to Australopithecus africanus exhibits a modern human-like bipedal locomotor pattern, while that

180 While there is debate about when modern human-like bipedalism first appeared in hominins,

181 dually along a single morphocline, achieving modern human-like configuration and function within the

182 rints provide the oldest direct evidence for modern human-like weight transfer and confirm the presen

183 early divergent and currently extinct ghost modern human lineage.

184 that the San genetic lineage is basal to all modern human lineages.

185 Modern humans live in an "exploded" network with unusual

186 erectus, consistent with the shift toward a modern human locomotor anatomy, or more recently in conc

187 0 and 42,900 cal B.P. and the IUP-associated modern human maxilla known as "Ethelruda" before approxi

188 , for example the appearance of behaviorally modern humans, may be unwarranted.

189 of H. antecessor-that is, similar to that of modern humans-may have a considerably deep ancestry in t

190 nderthals from the Altai Mountains and early modern humans met and interbred, possibly in the Near Ea

191 The causes of Neanderthal-modern human (MH) turnover are ambiguous.

192 Both modern humans (MHs) and Neanderthals successfully settle

193 obiota and converge along an axis toward the modern human microbiome.

194 context along one potential pathway of early modern human migration.

195 erlap with evidence for some of the earliest modern human migrations out of Africa.

196 in human ancient DNA suggested that an early modern human mitochondrial lineage emerged in Asia and t

197 the temporal and spatial complexity of early modern human morphological variability.

198 Neanderthals and Modern Humans moved eastward into Central Asia, a region

199 Modern humans moving into Asia met Neandertals, Denisova

200 It falls within a group of modern human mtDNAs (haplogroup N) that is widespread in

201 gical variation in a sample of late Holocene modern humans (n = 161) from archaeological populations

202 years after documented interbreeding between modern humans, Neandertals and Denisovans, that we see m

203 oral microbiome when compared to ancient and modern humans, Neanderthals and a wild chimpanzee.

204 dle and Late Pleistocene hominins, including modern humans, Neanderthals and Denisovans.

205 ed a rich history of admixture between early modern humans, Neanderthals, and Denisovans, and has all

206 Our results reveal that the modern human nursing strategy, with onset of weaning at

207 event in human evolution is the expansion of modern humans of African origin across Eurasia between 6

208 verlap between Neanderthals and anatomically modern humans of more than 5,000 years.

209 d after 50 kyr ago--potentially encountering modern humans on Flores or other hominins dispersing thr

210 and may have contributed such adaptations to modern humans on the Tibetan Plateau.

211 ecreate the evolutionary pathway between two modern human oncogenes, Src and Abl, by reconstructing t

212 Here we studied three ORF1 proteins: a modern human one (111p), its resuscitated primate ancest

213 d nonsynonymous mutations faster than either modern humans or Neanderthals.

214 Previously, only large-brained modern humans or their close relatives had been demonstr

215 Modern humans originated in Africa, but where exactly?

216 neage emerged in Asia and that the theory of modern human origins could no longer be considered solel

217 The serial founder model of modern human origins predicts that the phylogeny of ance

218 t hominids has reshaped our understanding of modern human origins.

219 iled description of the complex dispersal of modern humans out of Africa and their population expansi

220 indings support multiple dispersals of early modern humans out of Africa, and highlight the complex d

221 val of humans in Australia, the dispersal of modern humans out of Africa, and the subsequent interact

222 nd environmental context of the dispersal of modern humans out of Africa.

223 that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago.

224 g the D0 lineage, and published evidence for modern humans outside Africa, the most favored model inv

225 Neanderthals and anatomically modern humans overlapped geographically for a period of

226 Modern humans overlapped in time and space with other ho

227 d different bipedal push-off kinematics than modern humans, perhaps resulting in a less efficient for

228 e expression that contribute to variation in modern human phenotypes.

229 ants of Neanderthal genomes survive in every modern human population studied to date.

230 hat this individual was a female member of a modern human population that, following the split betwee

231 nescence-derives principally from studies of modern human populations and laboratory animals.

232 ary breadth underpinned the success of early modern human populations in this region, with the expend

233 stant parental relatedness that is common in modern human populations is less well understood.

234 fication of targets of positive selection in modern human populations is their complex demographic hi

235 The predominantly African origin of all modern human populations is well established, but the ro

236 The dispersal of anatomically modern human populations out of Africa and across much o

237 from Neanderthals/Denisovans to non-African modern human populations through gene flow.

238 n of biological affinities between worldwide modern human populations, derived independently from den

239 artifact likely caused by gene flow between modern human populations, which is not taken into accoun

240 ave driven a loss in microbiome diversity in modern human populations.

241 nd evolved over thousands of years alongside modern human populations.

242 l genomic variation in a worldwide sample of modern human populations.

243 ribe and explore the evolutionary history of modern human populations.

244 haracterized Pleistocene human evolution and modern human presence in southeast Europe.

245 dated 41.1 to 38.1 ka cal BP, documenting a modern human presence on the western margin of Iberia ~5

246 The forceful precision grips used by modern humans probably evolved in the context of tool ma

247 archaic admixture influences disease risk in modern humans, provide hypotheses about the effects of h

248 f Neandertal gene variants on brain shape in modern humans, providing insights into the genomic basis

249 at H. floresiensis survived until long after modern humans reached Australia by ~50 kyr ago.

250 (EUP) Upper Paleolithic sequence containing modern human remains, has played an important part in th

251 behavioral distinctions between archaic and modern humans remains much debated.

252 Anatomically modern humans replaced Neanderthals in Europe around 40,

253 The Pleistocene global dispersal of modern humans required the transit of arid and semiarid

254 a subfamily acts as an endogenous mutagen in modern humans, reshaping both somatic and germline genom

255 opean populations using archaic, ancient and modern human samples.

256 rived from Neanderthals, more than any other modern human sequenced to date.

257 s divergence from orthologous chimpanzee and modern human sequences and find strong support for a mod

258 The evolutionary origins of how modern humans share and use space are often modelled on

259 us, the low trabecular density of the recent modern human skeleton evolved late in our evolutionary h

260 distant strangers that are characteristic of modern human societies.

261 has implications for delayed reproduction in modern human societies.

262 Moreover, at present, Manot 1 is the only modern human specimen to provide evidence that during th

263 different conclusions regarding how and when modern humans spread out of Africa and into the rest of

264 thals) should not be confused with ancestral modern human stages.

265 Australopithecus and early Homo but not with modern humans suggesting that the modern human face is d

266 tal Y we describe has never been observed in modern humans suggests that the lineage is most likely e

267 les (RAs) are more likely to be tolerated by modern humans than are introgressed Neanderthal-derived

268 the Neanderthal mitochondrial DNA (mtDNA) to modern humans than Denisovans has recently been suggeste

269 Fixed in modern humans, the deletion is also in archaic human gen

270 e inter-species dynamics of Neanderthals and modern humans, the eventual replacement of the Neanderth

271 In modern humans, the occurrence of missing permanent teeth

272 However, in species of Homo, including modern humans, there is a tight link between tooth propo

273 riginating in Denisovans and introgressed in modern humans throughout Oceania, and A20 I325N, from an

274 functional capabilities and evolution of the modern human thumb.

275 ' could have generated feedback that allowed modern humans to overcome disease burden earlier than Ne

276 ent the late survival of one of the earliest modern humans to settle in an isolated region of souther

277 ed that in at least a few anatomical regions modern humans today appear to have relatively low trabec

278 mane contains ancient mitochondrial DNA of a modern human type.

279 ecological aspects of both Upper Pleistocene modern humans (UPMHs) and Neandertals provides a useful

280 Phenotypes associated with modern human variation in these genes' regulation in ~23

281 mixture between Neandertals and anatomically modern humans, we analyzed patterns of introgressed sequ

282 Using the opponens muscles from a sample of modern humans, we tested the hypothesis that aspects of

283 Notably, although fully modern humans were already present in southern China at

284 y possible to determine whether anatomically modern humans were involved in their production, as mode

285 r and subsequent mixture of Neanderthals and modern humans - which, on genetic evidence, is considere

286 orphologies of a last common ancestor of all modern humans, which we compare to LMP African fossils (

287 people could be closely related to the first modern humans who later successfully colonized Europe.

288 The genetic diversity of the first modern humans who spread into Europe during the Late Ple

289 the Neanderthals' demise to competition with modern humans, who occupied the same ecological niche.

290 seen in all of primate evolution, rendering modern humans with a HC that is a clear outlier amongst

291 f Africa, and the subsequent interactions of modern humans with Neanderthals and Denisovans.

292 sub-Saharan African origin for anatomically modern humans with subsequent migrations out of Africa.

293 s of Neanderthals relative to those of early modern humans, with a particular focus on subtle differe

294 ions outside Africa to be colonized by fully modern humans, with archaeological evidence for human pr

295 Africa is the origin of modern humans within the past 300 thousand years.

296 he phylogenetic relationships of archaic and modern human Y chromosomes differ from the population re

297 nt common ancestor (TMRCA) of Neandertal and modern human Y chromosomes is approximately 588 thousand

298 in-coding differences between Neandertal and modern human Y chromosomes, including potentially damagi

299 go from a lineage shared by Neanderthals and modern human Y chromosomes, which diverged from each oth

300 ces the Neandertal lineage as an outgroup to modern human Y chromosomes-including A00, the highly div

301 onger than the TMRCA of A00 and other extant modern human Y-chromosome lineages.