ライフサイエンスコーパス: modest

1 es are in development, response rates appear modest.

2 ts benefits in estrogen-sufficient rats were modest.

3 population, but their predictive ability is modest.

4 overall functioning in daily life are often modest.

5 However, the magnitude of associations was modest.

6 y in 'immunologically cold' tumours has been modest.

7 val gains in high-income countries were very modest.

8 ated with DNMs has thus far been shown to be modest.

9 exone to treat alcohol use disorder (AUD) is modest.

10 SCZ probands, exome-wide DNM burden remained modest.

11 d structural and functional recovery remains modest.

12 in patients with multiple sclerosis remains modest.

13 ension reactions, but the difference is more modest.

14 ictive performance of the current methods is modest.

15 However, this effect was relatively modest.

16 act of decreases in SS on OCT reliability is modest (-0.67 to -1.25 DeltaRNFL per 1-point decrease in

17 K20me3 and an increase in H4K20me1, but only modest (1.4-7.8%) perturbation in genome-wide expression

18 Neuronal responses in AC showed modest (~10%) differences in response gain across vigila

19 icked in nociceptors from naive animals by a modest 5 min depolarization of RMP (15 mm K(+); -45 mV),

20 of 3'-5' exonuclease function resulted in a modest 5-8-fold error rate increase.

21 However, a more modest 57% reduction in parking is achievable with only

22 the majority of disease risk elevations are modest (a few percent), a considerable number of disease

23 Despite the modest ability to inhibit rat brain acetylcholinesterase

24 AGB density reasonably well, they only have modest ability to reproduce the regional spatial gradien

25 ostasis are responsible for the surprisingly modest action potential duration shortening.

26 ty for glutamine over ammonia and displays a modest activation of the glutaminase domain compared to

27 ctively referred to as XTC) appear to retain modest activity against human immunodeficiency virus-1 w

28 ion delivering IMP-105 (43), a compound with modest activity against Leishmania donovani intracellula

29 Both compounds had modest activity in 7H9 broth, but only NAM inhibited rep

30 reduction between 2016 and 2030), with only modest additional incidence reductions in adults aged 35

31 heritability for impulsivity (A(2) = 0.33), modest additive genetic or common environmental effects

32 nced differences were accompanied by an only modest albeit significant advantage in ordinary, non-bod

33 ty of self-reported prior antibiotic use was modest among individuals presenting with fever to tertia

34 rage of midwife-delivered interventions by a modest amount (10% every 5 years), a substantial amount

35 A modest amount of noise can also enhance the fitness effe

36 ept monotherapy, is well tolerated and shows modest anatomic benefit with potential to reduce treatme

37 A modest and balanced cell-mediated immune response specif

38 However, the risk is modest and FHT is likely safe with regard to noninfectio

39 wall width and spontaneous polarization, are modest and governed by the change in epitaxy-induced com

40 urvival outcomes after LT in our cohort were modest and may reflect the need for more aggressive ther

41 erved metabolic and hemodynamic changes were modest and most likely contribute only partially to the

42 Because cross-informant agreement is modest and no single informant provides comprehensive as

43 hinge-bending regions, the method provides a modest and statistically significant improvement over a

44 peanut epicutaneous immunotherapy, observing modest and statistically significant induction of desens

45 3)-inducible gene expression signatures were modest and variable if statistically significant.Conclus

46 ective in channel protein turnover exhibited modest and varied effects on ATP levels, which suggested

47 oportion of convalescent plasma samples have modest antibody levels and that commercially available t

48 esponse, mild SARS-CoV-2 infections induce a modest antibody response.

49 rred, requiring dose deescalation, with only modest antitumor activity.

50 Effects of these agents on pain were modest (around 1 cm on a 10-cm visual analogue scale, ap

51 previous work, the mass resolving power was modest, around 30-40.

52 We found a modest association between self-reported progestogen use

53 for individual BCAA metabolites suggested a modest association for leucine with obesity-related canc

54 pendent signal tagged by rs4008366 presented modest association with eosinophilic asthma.

55 etylase activity of SIRT6 but this effect is modest at best.

56 Risks were retained, with modest attenuations, for the offspring of heterotypic pa

57 ity was low based on alcohol electronics and modest based on alcohol sterics.

58 t incorporate sensory retraining can provide modest benefits, but the majority of patients are left w

59 ns in SFA, but we are unable to exclude more modest benefits.

60 between WISC-V tasks (0.663), and relatively modest between NIH Toolbox Pattern Comparison and other

61 clic analogues of biphalin with excellent to modest binding affinity for mu-, delta-, and kappa-recep

62 ding site in the channel saturates with only modest block.

63 nabling dinitrogen to be functionalized with modest but catalytic yields of six equivalents of second

64 We found a modest but non-significant improvement in prediction wit

65 The osvoz1 and osvoz2 single mutants display modest but opposite M. oryzae resistance in the non-Piz-

66 Celiac disease may be associated with a modest but persistent increased long-term mortality risk

67 s is derived from animal studies that show a modest but reproducible improvement in cardiac function

68 tients in the high depressive stratum showed modest but significant effects on core depressive sympto

69 llular markers of immune exhaustion and in a modest but significant improvement in self-reported QoL.

70 There was a modest but significant loss of fungiform taste buds in P

71 hat activation of K(Ca)3.1 channels caused a modest but significant sensitization of cancer cells to

72 Models integrating these features provided modest, but statistically significant, ability to predic

73 eory predicts that warming should cause only modest carbon loss from tropical soils relative to those

74 C4KO mice developed modest cardiac dysfunction and dilation in response to e

75 While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic a

76 Responses in auditory cortex only showed modest changes during sleep, whereas sleep robustly atte

77 ignificant changes in motor pausing and only modest changes in slipping.

78 els of Antarctic fish chaperomes showed very modest changes overall, contrary to the common view of c

79 It remains unknown, however, whether modest changes to [Na(+)](o) that promote electrophysiol

80 n emerging pathogen, the climate drives only modest changes to pandemic size.

81 of BRD2, BRD3, BRD4 and BRDt have displayed modest clinical activity in monotherapy cancer trials.

82 rs with activating RET gene alterations with modest clinical efficacy.

83 Climate impacts from WT are modest compared to regional changes induced by historica

84 terspike interval in SCI-nociceptors, with a modest contribution (~10-15%) from tetrodotoxin (TTX)-se

85 Despite the relatively modest contribution of the glycans to the total molecula

86 ions in the optimum, despite their currently modest contribution to variation in selection.

87 latability of sucrose is strongly reduced by modest cooling.

88 In more advanced disease, we observed modest corneal flattening compared to baseline (Kmax 63.

89 ile lab visits to fixed-site monitors reveal modest correlation (spatial R(2) = 0.51) with medians of

90 There was only a modest correlation among traits, indicating a lack of a

91 ids as checked by a family member provided a modest correlation of visual acuity compared to the char

92 erquartile range, 0.007-0.71) and a weak and modest correlation with Framingham risk score (FRS) (r =

93 ighly heterogeneous syndrome that bears only modest correlations with its biological substrates, moti

94 In contrast, a modest daily dose of BO elevated serum concentrations of

95 on of robust functional anatomical maps with modest data.

96 There was a modest decrease in CD8+ T-cell activation (-17.53% chang

97 performance, while the Aptima assay showed a modest decrease in overall PPA.

98 olution-based TrEnDi, iTrEnDi demonstrated a modest decrease in sensitivity, likely due to analyte lo

99 In contrast, RMT achieves only a modest degree of block in the M2 S31N channel at 1 mM, w

100 e mismatches generally reduce knockdown to a modest degree, but spacer nucleotides 15-21 are largely

101 Being acquired was associated with a modest differential decline in performance on the patien

102 r biologically meaningful interpretation and modest dimensionality compared with voxelwise approaches

103 There was modest discrimination (AUC = 0.73) between sepsis with o

104 and control (AUC = 0.83), with slightly more modest discrimination between bacterial and viral (AUC =

105 these prediction models demonstrate poor-to-modest discrimination.

106 ontinuous-flow LVADs exclusively and exhibit modest discrimination.

107 oups for the genotype (cvAUC, >=0.94), and a modest discriminative ability existed for the phenotype

108 coupled to NMDAR currents and to relatively modest disynaptic inhibition.

109 Thus, despite only having a modest effect in in vitro assays, opsonizing Ab had a dr

110 pol III repression by MAF1 and demonstrate a modest effect of MAF1 on global translation via reduced

111 We discovered that ASFV infection had only a modest effect on host miRNAs, with only 6 miRNAs differe

112 Neurobehavioral testing demonstrated a modest effect on spatial learning and memory in SAM-expo

113 gesting that anti-VEGF injections may have a modest effect on the RNFL thickness after several years

114 with trametinib, a MEK inhibitor, had only a modest effect on these cultures.

115 Cottonseed extracts exhibited modest effect on TTP family gene expression in macrophag

116 with depression either are rare or have very modest effect sizes.

117 cretagogue effect, while proteins only had a modest effect.

118 wth of HR(+) cancer cells but exhibited only modest effects against tumor cells residing in the ECM n

119 knockdown in nonphlebotomized mice had only modest effects on hepatic ferritin subunit levels and no

120 RS2-dependent decay, ARS2 knockdown has only modest effects on viral gene expression 24 h after lytic

121 While ICI alone had modest effects, DAC followed by either of ICI therapies

122 nts with advanced cancer, but they have only modest efficacy and limited tolerability(1,2).

123 sed into clinical trials, but most show only modest efficacy owing to an inability to effectively era

124 ly circulating strain is likely to have only modest efficacy.

125 based solar cells were limited to relatively modest efficiencies (<4%) owing to limitations such as p

126 rom benign sodium nitrite in the presence of modest electric fields.

127 over 90% selectivity on a carbon basis at a modest electrode potential of -0.536 V vs. the reversibl

128 but led to improved muscle reinnervation and modest electrophysiological recovery during later stages

129 conclusion, in Apoe(-/-) and Ldlr(-/-) mice, modest elevation in plasma and platelet cholesterol incr

130 ft ventricular ejection fraction <=40% and a modest elevation of NT-proBNP (N-terminal pro-B-type nat

131 y of data showed that ADHD medications cause modest elevations in resting heart rate and blood pressu

132 The modest emissions reflect the low emissions intensity of

133 for its unfolded form, coexisting with more modest enhancements for their folded counterparts.

134 Nevertheless, TAC overages are generally modest especially in recent years-key reasons appear to

135 tions about missing data, the trial provides modest evidence that conservative management of primary

136 part because of the paucity of HSCs and the modest ex vivo expansion of HSCs in media that contain p

137 nstrates good atom economy, requiring only a modest excess of the phosphinoboronate.

138 We report that while there is modest expansion of TH(+) glomus cells in the carotid bo

139 lone, or in combination with M3, resulted in modest extension of lifespan relative to control SOD1-G9

140 thout GFP targeted glioma but yielded only a modest extension of survival.

141 nantly on cancer research, with a relatively modest footprint in CVD.

142 ailable mechanoacids, however, is limited by modest force-free stability or a scissile response that

143 Only a modest fraction of the genes identified as 'markers' of

144 Including modest fractions of the halogen emissions reported from

145 Modest functional group interactions can play important

146 arious West and Central African peoples with modest gene flow from specific European and Amerindian p

147 prostate, but less so for others because of modest heritability and lower incidence.

148 s now enable genetic analysis of traits with modest heritability, such as diet.

149 TLR2-stimulated monocytes produced modest IFNbeta levels that caused productive downstream

150 Bodyweight loss was modest (IM = 7.8%, SP-17 = 6.5%; p > 0.05) as was fat lo

151 Additionally, unlike the very modest impact of a loss of m(4)C methylation in bacteria

152 inical benefit from early administration and modest impact on parameters of inflammation.

153 15.4%, respectively); genetic variants had a modest impact on predictions (9.5% for glucose, 0.8% for

154 Taken together, the modest improvement in aaRS efficiency provides a large p

155 the PRS in the PREDICT-PD algorithm led to a modest improvement in model performance.

156 of fat-saturated T2-weighted images provided modest improvement in sensitivity.Keywords: Efficacy Stu

157 There was only modest improvement of the former activity, but dramatic

158 A more modest improvement was observed in the fish oil arm [5.9

159 ated overall diet quality of US youth showed modest improvement, but more than half of youth still ha

160 ently of dosing schedule, is associated with modest improvements in cardiorespiratory fitness in pati

161 has been shown to provide consistent albeit modest improvements in cognitive function as measured by

162 Veterans in STEP-KOA reported modest improvements in knee osteoarthritis symptoms comp

163 ith the summary secretion score yielded only modest improvements in the prediction of the kidney clea

164 patients, their diagnostic accuracy was only modest in AD patients.

165 mmed death receptor 1 (anti-PD-1) therapy is modest in patients with metastatic or recurrent head and

166 les effect) of the enantiopure comonomer are modest in this initial system.

167 d, but their efficacy relative to placebo is modest, in part because the clinical diagnosis of major

168 MHC II expression on blood leucocytes, and a modest increase in bone marrow resident CD4 T cells.

169 A modest increase in Cas9-dependent and -independent DNA o

170 nesis was associated with enhanced FAO and a modest increase in glycolysis.

171 onditioned media from these cells elicited a modest increase in HLA surface levels in naive epithelia

172 ainly due to increased capture success and a modest increase in hunt rate.

173 Although there was also modest increase in JQ1 delivery to the liver, there was

174 ntified numerous novel ETn insertions with a modest increase in mutants.

175 We show that a modest increase in peptide length, from KY to (KY)(3), i

176 Over 3 years' follow-up, there was a modest increase in positive predictive value with the hi

177 Obesity was associated with a modest increase in risk of incident severe liver disease

178 on in cell culture, 17dmiR-H1/H6 exhibited a modest increase in viral yields.

179 ne paradoxically led to p53 accumulation and modest increase of transcriptional output owing to disru

180 Corresponding change in CRT was a modest increase to 364 mum (P > 0.05 compared with last

181 distal shift of the AIS normally produces a (modest) increase in excitability, but we explain how thi

182 d models, PM2.5 exposure was associated with modest increased risks of CVD [hazard ratio (HR) for fif

183 yielded dramatic increases in NK numbers and modest increases in CD8 T cells.

184 ations during pregnancy were associated with modest increases in central adiposity and risk of overwe

185 ines in stunting over the last 20 y, despite modest increases in gross domestic product per capita.

186 For all specialties, modest increases in productivity due to scribes may allo

187 Upon modest induction of FadR, cell size increases, but at th

188 nfirmed previous reports that IL-13 elicited modest induction of Ralpha2 in normal adult human lung f

189 wearers by more than 50% in a community with modest infection rates, some degree of social distancing

190 ry and contractile function, with a parallel modest infiltration of inflammatory macrophages.

191 triped wall in a square arena, rats showed a modest influence of the featural cue as a local marker t

192 trophysiologists are active on Twitter, with modest influence often representative of scholarly and c

193 s applied to HA-rich agricultural soils with modest ionic strength.

194 een measured and reported antibiotic use was modest (kappa = 0.72).

195 n targets are unaffected, correlating with a modest kinetic acceleration in accumulation of pS65-Ub a

196 redictors of PBRs were published, they offer modest levels of predictive performance and most of them

197 ms: by raising cytoplasmic viscosity at even modest levels of water loss to promote cell integrity du

198 that just conserves sufficient energy for a modest lifestyle involves chemically challenging reactio

199 This modest limiting Bayes factor rises to 8.7 if we accept t

200 s in Xpert HPV improve specificity with only modest losses in sensitivity, making this assay an optim

201 oints that are predicted to give rise, under modest magnetic fields or strain, to topological semimet

202 it cell, respectively, and are stabilized by modest magnetic fields.

203 y strong bipolar transport and only exhibits modest maximum ZTs ~ 0.85 at 900 K.

204 The modest mean differences favoring the invasive strategy i

205 Our model suggests that FAV provides a modest, medium-term survival benefit over expectant feta

206 0.1%, and 48.2% among individuals with no or modest, moderate, and increased alcohol consumption, res

207 nt to drive tumorigenesis, while addition of modest MYC overexpression drives robust tumor formation,

208 f societal relevance, we establish that even modest night-to-night reductions in sleep across the pop

209 electric and magnetic components of light at modest (non-relativistic) intensities.

210 gher oxidation states toward substrates with modest O-H bond dissociation energies (e.g., 4-substitue

211 ed sugar), each compared with a base case of modest ongoing voluntary industry reformulation.

212 ns with available hardware has resulted in a modest operational figure of merit performance (Range [F

213 s are significantly resistant, 6 motifs have modest or no associations (P values >0.05), and 1 motif

214 ades, only a single double prodrug with very modest oral bioavailability has reached human therapy as

215 The opposing trends lead to only a modest overall impact on LLPS.

216 vidual genes associated with CD demonstrated modest overlap across European-Americans and African-Ame

217 st, paclitaxel-induced DEGs displayed only a modest overlap between daytime and nighttime (Zeitgeber

218 ave transformed a muscle-powered system with modest performance and high thermal sensitivity into a s

219 ng Danish registers led to consistent albeit modest performance improvements over reference models, s

220 We observed only a modest perturbation of gut microbial community structure

221 specific deletion of Reverbalpha drives only modest physiological and transcriptional dysregulation,

222 on of in vivo calcium dynamics revealed that modest, physiological increases in ROS decrease calcium

223 Overall, we observed a pattern of modest positive associations of gestational PFOA and PFH

224 Thus, our data indicate that GPAT3 plays a modest positive role in adipogenesis and argue against t

225 -substrate nature of USP7, combined with the modest potency and selectivity of early generation USP7

226 ver at least three orders of magnitude using modest potential (<1 V) enables new approaches for produ

227 o formate by nearly 3 orders of magnitude at modest potential bias.

228 eraging stool metatranscriptomes resulted in modest power to predict interval development of preneopl

229 changes in conductivity upon illumination at modest powers.

230 nd initiate a caldera collapse, despite only modest precursors.

231 future course of ADHD symptoms and may have modest predictive power.

232 nd (4) levels of Deltatau314 proteins show a modest predictive value for dementia.

233 et of 16 healthy participants (7 males) with modest previous cannabis exposure.

234 We found that modest proliferation of hepatocytes distributed througho

235 Although they represent only a modest proportion of lake-wide loads, expanding nutrient

236 We found modest protection against PCR-confirmed pertussis among

237 HLA-B*08:01 was associated with modest protection for depression at the candidate thresh

238 ecombinant ALVAC/gp120 alum vaccine provided modest protection from human immunodeficiency virus type

239 nduced by loss of lymphocyte S1P(1) provides modest protection only in the context of reperfusion.

240 These complexes are yellow emitters with modest quantum yields.

241 Across the modest range of changes, calculated stabilities correlat

242 me, flow rate, immobilized target) such that modest, readily achievable changes in flow rates favor f

243 Maternal T1D was also associated with a modest reduction in CpG methylation of the INS gene in c

244 30) epitope-specific CD8 T cells, although a modest reduction in immune cell entry into the CNS was o

245 Barrier disruption led to a modest reduction in Mi-2beta expression and a further se

246 cies of effector memory CD4(+) T cells and a modest reduction in the frequency of interferon-gamma-pr

247 Although using FAIMS led to a modest reduction in the precision of quantitative measur

248 bellar pathophysiology and suggest that only modest reductions in Cic are needed to have profound the

249 terminal lysine residue; its deletion led to modest reductions in complement resistance.

250 rnal and postweaning WSD and corresponded to modest reductions in insulin-stimulated Akt phosphorylat

251 Both APM types have been associated with modest reductions in Medicare spending without apparent

252 Surprisingly, we uncovered only modest region-specific alterations in Htr2c RNA editing

253 While the proximal GBSs drove modest reporter induction by glucocorticoids, this regio

254 Assuming modest restaurant item reformulation, both health and ec

255 This leads to a modest restriction of bacterial proliferation in hMDMs.

256 Only a modest reversal of retinal degeneration was observed whe

257 Although we acknowledge modest sample size, estimated particle burden increased

258 have produced mixed findings and mostly had modest sample sizes and measured the exposure during the

259 t accommodate general environment variables, modest sample sizes, heterogeneous noise, and binary tra

260 uential physicians appear to have relatively modest scholarly and clinical activity.

261 We also uncovered modest selection against noncoding SVs in cis-regulatory

262 y, low activity against human nNOS, and only modest selectivity for nNOS over related enzymes.

263 ons, repetitive steps, and ligands with only modest selectivity.

264 h imaging and endoscopic methods having only modest sensitivity for the diagnosis of cholangiocarcino

265 Despite modest sensitivity, low-cost, repeat screening of the en

266 In addition, modest serial mediation was found, mapping a pathway fro

267 A modest shift in the equilibrium can switch the system fr

268 We conclude that modest slab-to-wedge sulfur transport occurs, but that s

269 Participation in BPCI was associated with modest spillovers in episode savings.

270 ge, and balanced by resource partitioning, a modest stabilizing mechanism that promotes coexistence.

271 e optic nerve sheath diameter demonstrated a modest, statistically significant correlation with intra

272 Recent studies have elevated 53BP1 from its modest status of (yet another) DNA damage factor to mast

273 Modest structural changes to the C-3, C-4, and C-5 posit

274 n several maternal characteristics predicted modest stunting reductions, including parity, interpregn

275 Our data support only modest subcortical filtering, with robust, step-like att

276 nical trials, however, have shown relatively modest success in RA as compared with other indications.

277 care, this treatment strategy provides only modest survival benefits.

278 ct while the CyRPA/RIPR combination showed a modest synergistic effect with Hewlett's [Formula: see t

279 K18 ACE2 transgenic mice produced a modest TH1/2/17 cytokine storm in the lung and spleen th

280 risk increase was opposite to, although more modest than, the degree of protection from coronary arte

281 olecules to the CNS thus contributing to the modest therapeutic successes.

282 uggests that backbone hydrogen bonds provide modest thermodynamic stability to membrane protein struc

283 While modest, these differences are critical for our precise u

284 yields and diastereoselectivity ranging from modest to excellent depending on the substrate).

285 at the 19-stranded barrel surprisingly holds modest to low stability in a lipid-dependent manner.

286 ribution of lower crustal intrusions implies modest total CAMP volumes of 85,000 to 169,000 km(3) ben

287 We investigate these modest toughness enhancements using computational fractu

288 contrast, rapid SAGA depletion produced only modest transcription defects at 13% of protein-coding ge

289 ed readily to novel datasets, requiring only modest Transfer Learning.

290 in the increased expression of one gene and modest truncation in the primary protein structure of an

291 We further noted a modest U-shaped relation between maternal weight gain du

292 tractable way, and we demonstrate that even modest variability implies trillions of dollars of previ

293 The relatively modest vector competence for DENV and YFV, combined with

294 investigated whether PICD could develop with modest-volume paracentesis (MVP) and the role of albumin

295 geoengineering scenario with initially only modest warming, subtropical stratocumulus clouds gradual

296 Elevated risk was apparent even at modest weight gain.

297 lucose concentrations and often resulting in modest weight loss.

298 ts in adolescents, although still relatively modest, were comparable with or slightly smaller than in

299 Despite a modest worsening in CRT after cataract surgery, BCVA was

300 inimal-length binder (hexamer) is relatively modest yet persistent, consistent with the notion of six