ライフサイエンスコーパス: molecular entity

1 the brain hemispheres and a newly identified molecular entity.

2 thereby enabling de novo sequencing of this molecular entity.

3 nucleophilic region in another, or the same, molecular entity.

4 (n = 9 [18.8%]); only 1 (2.1%) was for a new molecular entity.

5 s are based on the performance of the single molecular entity.

6 f 170 genes identified UC and CD as distinct molecular entities.

7 re recently revealed to exist as independent molecular entities.

8 e fast and efficient covalent conjugation of molecular entities.

9 s-a-vis structural characterization of these molecular entities.

10 that can broaden the utilization of DEP for molecular entities.

11 point radially to the outside, shielding the molecular entities.

12 synthetically manipulated into various small molecular entities.

13 rgeting the LANA-DNA interaction using small molecular entities.

14 and more costly than pivotal trials for new molecular entities.

15 ses on the role of lipid classes rather than molecular entities.

16 ary containing approximately 2 million small molecular entities.

17 nd that SOCE and ECCE represent two distinct molecular entities.

18 hat exist in lipid bilayers are not isolated molecular entities.

19 on the basis of prior information) and other molecular entities.

20 The underlying challenge is to design new molecular entities able to act as allosteric chemical sw

21 ated nanoparticles (NPs) targeted with small molecular entities, able to bind to prostate specific me

22 mine whether, as recently proposed, the same molecular entity accounts for excitation by both types o

23 : (i) metal-based dopants, (ii) molecule and molecular entities and (iii) organic conducting polymers

24 irectional instructions made up of different molecular entities and address it to specific recipient

25 th were reviewed to obtain the number of new molecular entities and biologic license applications app

26 Small-molecular entities and biologics acting on various stemn

27 fundamental properties relating to these two molecular entities and discuss the potential impact on e

28 esearchers with measurements of thousands of molecular entities and enable the investigation of the i

29 od and Drug Administration approvals for new molecular entities and medical devices for indications w

30 step process characterized by a multitude of molecular entities and their interactions.

31 c region associated with a halogen atom in a molecular entity and a nucleophilic region in another, o

32 r all four parathyroid glands, is a distinct molecular entity and does not represent the molecular pa

33 broadly comparable with that for established molecular entity and event extraction tasks.

34 ar entities, ChEBI contains groups (parts of molecular entities) and classes of entities.

35 l-hazards models of review times for all new molecular entities approved between 1950 and 2005.

36 ivatives represent over one-third of all new molecular entities approved by FDA.

37 as estimated by both life expectancy and New Molecular Entities approved by the Food and Drug Adminis

38 The three molecular entities are prepared from the same monomeric

39 on with the chemical synthesis of additional molecular entities are required.

40 ike subtype were found to represent a unique molecular entity as any other cancer type, including the

41 to precisely move an individual and specific molecular entity between two separate probes, opening av

42 together organic chemistry and neuroscience, molecular entities can be generated that match the endog

43 of these disorders, illustrating how a novel molecular entity can contribute to our understanding of

44 ch on Alzheimer disease is the nature of the molecular entity causing dementia.

45 the relative concentration of 394 out of 423 molecular entities changed significantly during maturati

46 In addition to molecular entities, ChEBI contains groups (parts of mole

47 Discovering new molecular entities combined with dereplication of known

48 There are several molecular entities common to the immune and nervous syst

49 ing (131)I) involves radioiodinating a small molecular entity, conjugating it to the mAb, and purific

50 These new molecular entities, designated "CNS neuroblastoma with F

51 ul MS/MS information for at least 80% of all molecular entities detected in the MS scan replicates.

52 What molecular entity determines the extracellular function o

53 nner, suggesting the recognition of distinct molecular entities displayed by the damaged organelles.

54 , Europe, Japan and other countries; and two molecular entities (e.g. mefuparib) of interest for COVI

55 etween regions of excess electron density in molecular entities (e.g., lone pairs or pai bond orbital

56 of the nature of fluorescence, with discrete molecular entities emitting a stream of single photons.

57 novel signature for further analysis of the molecular entities emitting these fluorescent signatures

58 PCMD8 push-pull configured molecular entity exhibited highest first hyper-polarizab

59 Volcano tests enabled to detect significant molecular entities explaining the variability associated

60 e dynamic interplay and interactions between molecular entities, facilitating deeper insights into ce

61 (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds

62 r results establish Cav2-enzyme complexes as molecular entities for fast electrochemical coupling tha

63 Food and Drug Administration approved 40 new molecular entities for indications within the neuroscien

64 mic reticulum (ER) via structurally distinct molecular entities for membrane formation and expansion.

65 ug discovery has successfully identified new molecular entities for neglected protozoan disease resea

66 PET have led to the approval of several new molecular entities for PET imaging by the U.S. Food and

67 eta-d-glucopyranosylgenistein as a promising molecular entity for intervention in amyloid events of b

68 suggest that the KChIP proteins represent a molecular entity for the observed difference between ara

69 mors that mechanistically distinguishes this molecular entity from other TRAIL-based therapeutics.

70 h, that deals with new uses for a well known molecular entity has been used extensively in cancer dru

71 iming to enable rapid access to complex bRo5 molecular entities have become increasingly valuable for

72 knitted threads of two exclusively different molecular entities have created some really interesting

73 Peptides are important biological molecular entities in biomedical research.

74 ll molecules are able to serve as functional molecular entities in cellular environments.

75 ical models are required for the response of molecular entities in DEP fields.

76 uture exploration of this promising class of molecular entities in drug discovery.

77 n a simulation using historical data for new molecular entities in oncology from 1990 to 2011, we fin

78 The molecular entities in question are either natural produc

79 lication in molecular sorting of two or more molecular entities in solid devices, or become useful as

80 nisms, especially when one looks at discrete molecular entities in solution.

81 during the past decade in organizing dynamic molecular entities in such solid frameworks.

82 With the growing number of new molecular entities in the pipeline, a fast and direct ch

83 e colocalization relationships between three molecular entities in three-color microscopy images.

84 nce is expected to form one dominant, stable molecular entity in solution with well-resolved NMR peak

85 ion in a murine model to determine how these molecular entities influence the development of immunity

86 Furthermore, interactions between molecular entities inside an omics profile are not patie

87 When a new molecular entity is predicted to exhibit high clearance

88 agonism with the use of 2 discrete, specific molecular entities led to substantial exacerbation of ar

89 In the future new molecular entities may be screened directly in human ES

90 to a failure to generate new propagons, the molecular entities necessary for [PSI(+) ] propagation i

91 Cost estimates for developing new molecular entities (NME) are reaching non-sustainable le

92 The terms new chemical entity (NCE), new molecular entity (NME), new active substance (NAS), and

93 ials of AAs and regular FDA approvals of new molecular entities (NMEs) for oncology indications since

94 ted to the FDA between 2000 and 2012 for new molecular entities (NMEs), which are active ingredients

95 y is accomplished by the self-assembly of 21 molecular entities of four different kinds, one central,

96 l be of particular utility for profiling the molecular entities of heparin materials, as well as for

97 Our knowledge of how the different molecular entities of the cell interact with one another

98 However, the molecular entity of the tension sensing mechanism remain

99 ification, whereby the relationships between molecular entities or classes of entities and their pare

100 re reviewed for therapies categorized as new molecular entities or new active ingredients.

101 Overall, 87 approvals (49%) were for new molecular entities or original biologics and 89 (51%) we

102 as well as for constructing multifunctional molecular entities or stimuli-responsive materials.

103 two Ca(2+) entry pathways represent distinct molecular entities or two different activation mechanism

104 five percent of the latter were either a new molecular entity or a new biological entity, and 55% wer

105 ) and above and below the planar portions of molecular entities (pai-holes).

106 ug delivery systems enable treatment for new molecular entities per se, for instance by overcoming bi

107 The molecular entities present on a cell or organ transplant

108 ric butyrophilin (BTN) 2A1 and BTN3A1 as the molecular entity providing "signal 1" to the Vgamma9Vdel

109 Several types of molecules or molecular entities ranging from neutral TCNQ, I(2), and

110 Elucidating the molecular entities required for the catalytic activation

111 tion of the myokine irisin, which may be the molecular entity responsible for muscle-bone connectivit

112 ted that endogenous ClC-3 represents a major molecular entity responsible for native VSOACs in cardia

113 n the identification and optimization of new molecular entities selectively targeting ion channels of

114 terprise has always been the creation of new molecular entities, such as pharmaceuticals or polymeric

115 Numerous different molecular entities, such as various crystals, pore-formi

116 We aimed to identify final molecular entities targeted by the autoimmune assault on

117 toxic small molecule drugs, ADCs are complex molecular entities that are intrinsically heterogeneous.

118 The conjugation of small molecular entities that capture RCA with high affinity i

119 Macrocycles are molecular entities that display a combination of molecul

120 e been described in different cells, but the molecular entities that mediate polyamine influx and eff

121 rmone Jasmonic Acid (JA) has been shown, the molecular entities that mediate this interaction have ye

122 rade signaling has been elusive, because the molecular entities that propagate Trk receptor tyrosine

123 ters into biomolecules has also led to smart molecular entities that were previously inaccessible in

124 t group for subsequent derivatization with a molecular entity that comprises the electrolyte.

125 of integrating these hormones into a single molecular entity that offers unique potential for treatm

126 regates proteins, RNA, and DNA into a single molecular entity that selectively destroys invading nucl

127 ed, Egl-10, Pleckstrin (DEP) domain, but the molecular entity that serves as the plasma membrane anch

128 The system consists of three molecular entities: the right-handed and left-handed con

129 We thoroughly characterized all new molecular entities, therapeutic biologics, and gene and

130 The transition from independent molecular entities to cellular structures with integrate

131 binding affinity of multiple ligands on one molecular entity to receptors.

132 It is all about bringing two different molecular entities together to achieve the required mole

133 polymers (it is unclear if the monomer is a molecular entity tout court) but demonstrate a physical

134 recently, and it is now clear that distinct molecular entities underlie the various electrophysiolog

135 cal level to mechanophores, force-responsive molecular entities, using Click-chemistry.

136 This new molecular entity was characterized by circular dichroism

137 ents of thiophene and fluorene into a single molecular entity was synthesized and characterized.

138 These molecular entities were created by covalently linking tw

139 ficantly enriched or differentially abundant molecular entities were found to be associated with the

140 These molecular entities were synthesized by first covalently

141 f late-stage functionalization to access new molecular entities which can be employed in medicinal ch

142 We conclude that distinct molecular entities, which are both likely to be derived

143 ion of the multitude of interactions between molecular entities, which in turn is a prerequisite for

144 Sixty-two new molecular entities with a primary oncology indication.

145 nt of synthetic oligomers as discrete single molecular entities with accurate control over the number

146 that the G-quadruplex grooves can recognize molecular entities with better drug-like and selectivity

147 for the assembly or diversification of novel molecular entities with improved physicochemical or biol

148 gmuir's concept of isovalency, in which 'two molecular entities with the same number of valence elect

149 mation expands carboxylic acids into diverse molecular entities with wide applications, underscoring

150 ITI-007 is a new molecular entity with a pharmacologic profile that combi

151 channel Kv1.2, were described to cause a new molecular entity within the epileptic encephalopathies.