ライフサイエンスコーパス: molecular evolution

1 ctions have long been theorized to influence molecular evolution.

2 able signature in the genomes, shaping their molecular evolution.

3 r deep understanding into snakes' history of molecular evolution.

4 s the fundamentals of fitness landscapes and molecular evolution.

5 sed to investigate fundamental principles of molecular evolution.

6 fidelity but also provides new insights into molecular evolution.

7 olution continue to be a central question in molecular evolution.

8 trand in genetic information transfer during molecular evolution.

9 tion and genetic information transfer during molecular evolution.

10 te energetics and structural specificity for molecular evolution.

11 erogeneous viruses and rapid GII.4 norovirus molecular evolution.

12 bit highly variable and often rapid rates of molecular evolution.

13 l populations has occupied a central role in molecular evolution.

14 , genotype 4 (GII.4) norovirus immune-driven molecular evolution.

15 f sequence evolution is a central subject of molecular evolution.

16 cots, illustrating a striking parallelism in molecular evolution.

17 can exert a strong influence on pathways of molecular evolution.

18 interference alters the expected patterns of molecular evolution.

19 rther analyses indicate specific patterns of molecular evolution.

20 action of cavitational phenomena determines molecular evolution.

21 them an interesting model for understanding molecular evolution.

22 ombination's causal influence on the rate of molecular evolution.

23 re roughly equivalent from the standpoint of molecular evolution.

24 bee genome and also experience high rates of molecular evolution.

25 nts of mutations is a long-standing issue in molecular evolution.

26 up of these pathogens and insight into their molecular evolution.

27 or many analyses in comparative genomics and molecular evolution.

28 ly consistent with a nearly neutral model of molecular evolution.

29 d the importance of genetic drift in shaping molecular evolution.

30 axed before abandoning the neutral theory of molecular evolution.

31 tive selection using site-specific models of molecular evolution.

32 he early Earth could have fostered prebiotic molecular evolution.

33 n problems and address novel questions about molecular evolution.

34 cyclase receptors, implying a combinatorial molecular evolution.

35 uch selection imposes a global constraint on molecular evolution.

36 dynamic and unstable regions prone to rapid molecular evolution.

37 h as cancer and are also the raw material of molecular evolution.

38 w being made between symbiotic lifestyle and molecular evolution.

39 diction, comparative genomics and studies of molecular evolution.

40 neous mutation are fundamental parameters of molecular evolution.

41 nisms forms the core of current knowledge of molecular evolution.

42 r genetic variability; the neutral theory of molecular evolution.

43 bstitution rate matrix is a key parameter of molecular evolution.

44 ubbles could have hosted the first cycles of molecular evolution.

45 l genomic data with a probabilistic model of molecular evolution.

46 supporting a current hypothesis for adaptive molecular evolution.

47 ason to pursue SMTP discovery with synthetic molecular evolution.

48 ding the role of minor states in biology and molecular evolution.

49 t a unique opportunity for detailed study of molecular evolution.

50 hod that has revealed many key mechanisms of molecular evolution.

51 actions have been shown to increase rates of molecular evolution, a trend generally attributed to the

52 ergence, we investigated the history ofclpP1 molecular evolution across green plants by extracting se

53 st reproduction strongly influences rates of molecular evolution across mitochondrial and nuclear sit

54 e provide evidence of constrained convergent molecular evolution across the metazoan tree of life.

55 we have limited knowledge of how it impacts molecular evolution across the underlying social genes.

56 We examined patterns of molecular evolution across three independent origins of

57 Phylogenetic models are an important tool in molecular evolution allowing us to study the pattern and

58 Hence, we argue for a molecular evolution alongside a clinical and phenotypic

59 Molecular evolution analyses did not detect significant

60 Molecular evolution analyses indicate that the H2 haplot

61 econstruction and with codeml and baseml for molecular evolution analyses.

62 Molecular evolution analysis is a general approach that

63 We thus propose the use of molecular evolution analysis to aid in the determination

64 Many approaches for inferring adaptive molecular evolution analyze the unfolded site frequency

65 protein domains is an important mechanism in molecular evolution and a valuable strategy for protein

66 Parallel molecular evolution and adaptation are important phenome

67 nce motif discovery and pattern recognition, molecular evolution and adaption, among others.

68 We adapted methods from molecular evolution and applied them to 7,664 tumors acr

69 omenal array of bioscience fields, including molecular evolution and bioinformatics; genome-, proteom

70 r and proteomic techniques to understand the molecular evolution and diversity of Type III antifreeze

71 there is only a limited understanding of the molecular evolution and epidemiology of EV-D68 during th

72 Here, we focus on the molecular evolution and expression of the AGL6-like gene

73 lloids are remarkable for their slow rate of molecular evolution and for being the only extant plant

74 ocus sequence type (ST) 8 to reconstruct the molecular evolution and global dissemination of ST8, inc

75 ic fibrosis and finds evidence of convergent molecular evolution and historical contingencies.

76 e-based advances in understanding Plasmodium molecular evolution and its relationship to disease mech

77 Taken together, these findings elucidate the molecular evolution and long-sought mechanism of GPR4, G

78 The answer has profound implications for molecular evolution and our ability to engineer biologic

79 collection of peer-reviewed publications in molecular evolution and phylogenetics that have reported

80 DENV-3 clinical isolates to characterize the molecular evolution and phylogeography throughout 10 yea

81 ific RNAi, but also to elucidate patterns of molecular evolution and physiology.

82 Deeper evaluation of the molecular evolution and population genetics of AMP genes

83 s importance in both basic research (such as molecular evolution and protein attribute prediction) an

84 In molecular evolution and quantitative genetics, the natur

85 We present a genome-wide analysis of molecular evolution and regulatory neofunctionalization

86 f Gluc variants was generated using directed molecular evolution and screened for relative light outp

87 Here, we combine molecular evolution and structural and functional analys

88 may play a major role in shaping patterns of molecular evolution and variation.

89 gical device for understanding the basics of molecular evolution and, more specifically, the adaptive

90 e ideal resources for comparative studies of molecular evolution, and advances in sequencing and comp

91 ic result is central to our understanding of molecular evolution, and it continues to influence phylo

92 these results in the context of the origin, molecular evolution, and possible fate of this remarkabl

93 mizygosity in females can impact patterns of molecular evolution, and we show that rates of evolution

94 ations to identify fundamental principles of molecular evolution; and atom-level, highly realistic co

95 We applied a neoteric molecular evolution approach to gain insight into the fu

96 Powerful molecular evolution approaches have been developed to te

97 angiosperm clades demonstrate that rates of molecular evolution are consistently low in trees and sh

98 species are difficult because their rates of molecular evolution are exceptionally high.

99 We find that rates of molecular evolution are higher in the mutualists genome

100 The identification of parallel molecular evolution as a pathogen spreads among multiple

101 as successful in communicating the basics of molecular evolution as John Maynard Smith's protein spac

102 r lineage-specific heterogeneity in rates of molecular evolution (associated, for example, with evolu

103 ests rejected a neutral equilibrium model of molecular evolution at 10 of 50 loci.

104 Rigorous molecular evolution-based methods to infer evidence for

105 We uncovered rapid and extensive molecular evolution between reptiles (including birds) a

106 e, we present a case of extensive convergent molecular evolution between snake and agamid lizard mito

107 We focused on comparing patterns of molecular evolution between the Abpa genes expressed in

108 xample by altering the character and pace of molecular evolution, but investigations of such effects

109 the study of protein stability, folding, and molecular evolution, but it remains unclear how these as

110 atic interactions play a fundamental role in molecular evolution, but little is known about the spati

111 onary relationships with events during early molecular evolution, but may promote understanding of th

112 Successful directed molecular evolution campaigns repeatedly test diverse se

113 Molecular evolution can be conceptualized as a walk over

114 Here we show how synthetic molecular evolution can be used to evolve potentially ad

115 These results indicate that molecular evolution could be used to modulate Gluc biolu

116 hales) in order to determine how patterns of molecular evolution differ between cytochrome b and the

117 This mode of molecular evolution disregards any conservation of the a

118 dy improves the current understanding of the molecular evolution, divergence, and gene expression of

119 is to join up with mainstream efforts in the molecular evolution domain, the continuum field descript

120 Documented cases of convergent molecular evolution due to selection are fairly unusual,

121 timating conditionally independent models of molecular evolution for different genes and different po

122 find that estimates of the rate of adaptive molecular evolution from closely related species may be

123 fossil record-can push the reconstruction of molecular evolution further back into the Early Pleistoc

124 Germline mutation determines rates of molecular evolution, genetic diversity, and fitness load

125 One of the most influential observations in molecular evolution has been a strong association betwee

126 Variation in rates of molecular evolution has been attributed to numerous, int

127 Molecular evolution has focused on the divergence of mol

128 Variable rates of molecular evolution have been documented across the tree

129 Numerous models of molecular evolution have been formulated to describe the

130 Theories of adaptive molecular evolution have recently experienced significan

131 scheme are potentially informative of early molecular evolution: (i) the absence of any codons for D

132 The history and mechanism of molecular evolution in DNA have been greatly elucidated

133 The results suggest that molecular evolution in enzyme-free replication systems w

134 n of organisms and can be a driving force of molecular evolution in humans and the great apes.

135 o) perspectives for a more synthetic view of molecular evolution in insect societies.

136 ding of the selective pressures and rates of molecular evolution in marine eusocial animals.

137 results indicate that nonneutral convergent molecular evolution in mitochondria can occur at a scale

138 ive poliovirus vaccine in humans, we studied molecular evolution in Sabin-like poliovirus isolates fr

139 g receives from its parent would drive rapid molecular evolution in seed tissues of the flowering pla

140 viral parasite, phage Phi2, that the rate of molecular evolution in the phage was far higher when bot

141 We also show evidence for rapid molecular evolution in the songbird lineage of genes tha

142 f selection and drift in shaping patterns of molecular evolution in the zebra finch genome.

143 study of allosteric signal transmission and molecular evolution in this important enzyme family.

144 Here we analyse the dynamics of molecular evolution in twelve experimental populations o

145 have important implications for patterns of molecular evolution in variable environments, and they s

146 for inferring geographic spread and rates of molecular evolution in viruses) in a different context:

147 model for recapitulating very early steps in molecular evolution in which fitness may have been enhan

148 vergence in this case is not due to parallel molecular evolution, indicating that there may be more t

149 more prone to hybrid dysfunction due to how molecular evolution interacts with the ontogenetic timin

150 the rate of fitness gain declines over time, molecular evolution is characterized by signatures of ra

151 The importance of positive selection in molecular evolution is debated.

152 However, an unresolved question in molecular evolution is how often and how significantly f

153 A fundamental question in molecular evolution is how proteins can adapt to new fun

154 examples of genetic convergence suggest that molecular evolution is in some cases strongly constraine

155 The extent of convergent molecular evolution is largely unknown, yet is critical

156 V host lineages to have independent rates of molecular evolution is necessary for reliable phylogenet

157 Our results suggest that, whereas convergent molecular evolution is relatively common, adaptive molec

158 An open question in bacterial molecular evolution is that of the formation and breakup

159 One of the foundational results in molecular evolution is that the rate at which neutral su

160 One central goal in molecular evolution is to pinpoint the mechanisms and ev

161 which proteins change is a key parameter in molecular evolution, its determinants are poorly underst

162 iversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial a

163 The estimation of parameters in molecular evolution may be biased when some processes ar

164 ote that computationally based insights into molecular evolution may heavily depend on the software u

165 ons, our results suggest that rapid rates of molecular evolution may not arise primarily as a consequ

166 g in a simplified way, in combination with a molecular evolution model.

167 In a manner conceptually similar to molecular evolution models in which the evolutionary rat

168 Molecular evolution models that partitioned rates of cha

169 rtant new interdisciplinary linkages between molecular evolution, molecular biology, and enzymology.

170 establishes the classical neutral theory of molecular evolution (NTME) as the basis for evaluating d

171 which the estimates of the rate of adaptive molecular evolution obtained by extending the McDonald-K

172 We describe the molecular evolution of a MinD-like ATPase into a flagell

173 ymmetric cell divisions, suggesting that the molecular evolution of AGS protein is key in the transit

174 cations have played an important role in the molecular evolution of ant communication.

175 Here we examine the molecular evolution of baculoviruses and nudiviruses, a

176 hypotheses for the processes underlying the molecular evolution of behavior.

177 RNA sequence space but are relevant for the molecular evolution of biological RNA.

178 ription factor and provide insights into the molecular evolution of c-di-GMP binding to proteins.

179 To understand the molecular evolution of CAS and OASS in the BSAS enzyme f

180 s provide a rich arena for understanding the molecular evolution of complex metabolic traits.

181 s study provides additional insight into the molecular evolution of d-Ala:d-X ligases and could contr

182 of understanding of the ecological roles and molecular evolution of delta-HXTXs.

183 describe a generic protocol for the directed molecular evolution of designer receptors exclusively ac

184 rules of speciation as well as rules in the molecular evolution of development.

185 This work advances the understanding of the molecular evolution of diatom plastomes and provides a f

186 ic explanations have emerged to describe the molecular evolution of eusociality from solitary behavio

187 of PL2 progenitor enzymes and illuminate the molecular evolution of exolysis.

188 fungal TERs, and provides insights into the molecular evolution of fungal TER structure and function

189 ce of the plasma membrane environment on the molecular evolution of G protein-coupled receptors (GPCR

190 the influence of chromatin structure on the molecular evolution of genomic DNA.

191 define the phylogeographical association and molecular evolution of hantaviruses.

192 umber alterations support a model of ordered molecular evolution of IDH1(R132MUT) GBM in which the ap

193 We review available data on molecular evolution of insect sociality and highlight ke

194 To provide utility in understanding the molecular evolution of ion-selective biomembrane channel

195 o study the design principles underlying the molecular evolution of K(+) channels.

196 Here, we investigated the molecular evolution of MHC class I and II genes in five

197 and modeling mutational paths describing the molecular evolution of MS2 from low- to high-affinity ha

198 oup are needed for a better knowledge of the molecular evolution of NOS enzymes in molluscs.

199 wo powerful and compatible approaches to the molecular evolution of novel AAV vectors for human gene

200 oited to enable the design, optimization, or molecular evolution of novel broad-spectrum antiviral th

201 Here I analyze the molecular evolution of orthologous conotoxin loci of the

202 However, the molecular evolution of P450s in terms of their dynamics

203 These data infer differences in the molecular evolution of pancreatic cancer subtypes and id

204 Recent genetic mapping of the molecular evolution of pancreatic cancer suggests that a

205 estive of a mechanism in which a progressive molecular evolution of pathogen-specific B cells to MALT

206 gth PLV genomes in order to characterize the molecular evolution of PLV in bobcats and mountain lions

207 e evolution, but the mechanisms by which the molecular evolution of polyploid genomes establishes gen

208 tes with gains in TRX sensitivity during the molecular evolution of PRKs in eukaryotes.

209 One of the strongest signals of adaptive molecular evolution of proteins is the occurrence of con

210 We discuss a scenario for the molecular evolution of RapZ through re-purpose of enzyme

211 To comprehensively characterize the molecular evolution of relapsed childhood B-precursor AL

212 ssion is the correct null model for tests of molecular evolution of reproductive genes and argue that

213 These data indicate an imperative for the molecular evolution of RI and suggest a means of enhanci

214 ria parasites into diverse hosts and for the molecular evolution of RNA polymerase II.

215 A molecules and improve our understanding of molecular evolution of RNA.

216 ality control mechanism can be harnessed for molecular evolution of scFvs that are soluble in the red

217 Here we review the molecular evolution of several human metalloproteins cha

218 earch is to uncover common principles in the molecular evolution of sociality.

219 er insight into the functional landscape and molecular evolution of specialized diterpenoid metabolis

220 rmations available to calmodulin support the molecular evolution of structurally and functionally dis

221 t, provide a unique opportunity to study the molecular evolution of substrate specificity within the

222 ovides novel insight into the forces shaping molecular evolution of that virus during 5 years of pers

223 The molecular evolution of the adaptive response at the host

224 unction paradigm for peroxidases and for the molecular evolution of the dual-function enzyme DHP.

225 Molecular evolution of the gene has been extensively inv

226 Here we studied the molecular evolution of the HIV-1 epidemic from the time

227 nt role of positive selection in shaping the molecular evolution of the immune system.

228 First, we analyzed the molecular evolution of the KANK genes in metazoan, and f

229 hGH LCR activity, and provide insight on the molecular evolution of the LCR.

230 ble attention has recently been given to the molecular evolution of the opsins and other photorecepto

231 Following directed molecular evolution of the parental clone the resultant

232 e selection is not sufficient to explain the molecular evolution of the region as a whole.

233 We develop this concept by investigating the molecular evolution of the shelterin complex, which prot

234 Furthermore, molecular evolution of the supergene is dominated not by

235 Given these differences, the molecular evolution of the XTH gene products in GH16 has

236 It follows that the molecular evolution of this genomic region of HIV-1 is h

237 To understand the molecular evolution of this system, we studied the nurse

238 quences means that little is known about the molecular evolution of this virus within a single geogra

239 Here, we analyze the molecular evolution of VacA.

240 cone pigments can provide insights into the molecular evolution of vertebrate vision since they are

241 e pigment and rhodopsin provide insight into molecular evolution of vertebrate visual pigments in ach

242 This study sheds light on the molecular evolution of viruses by clearly demonstrating

243 rstanding of the complexities underlying the molecular evolution of viruses in natural populations is

244 While much is known about the ancestry and molecular evolution of Western, East Asian, and Amerindi

245 In sum, the molecular evolution of WNV in North America depicts a la

246 le indicating an inherent irreversibility in molecular evolution, oil escape also serves as a rare an

247 nvironments than previously assumed and that molecular evolution on the early Earth could have benefi

248 Molecular evolution or metabolic engineering protocols c

249 se of the difficulty of determining rates of molecular evolution over short time frames.

250 nia and death, provides insight into a novel molecular evolution pathway involving "ping-pong" zoonos

251 ntributed-from studies of the mating system, molecular evolution, plant-herbivore and plant-parasite

252 nt implications for several fields including molecular evolution, population genetics and protein des

253 The neutral theory of molecular evolution predicts that the amount of neutral

254 To resolve how rapidly molecular evolution proceeds in the tobomaviruses, we es

255 eptide sequences selected from combinatorial molecular evolution processes will be demonstrated.

256 g that age-related disease genes have faster molecular evolution rates and predicting new aging-relat

257 lationship between phenotypic plasticity and molecular evolution remains poorly understood.

258 ircular genomes to linear chromosomes during molecular evolution required the invention of telomeres.

259 Much molecular-evolution research is concerned with sequence

260 ectrochemically reversible--a consequence of molecular evolution responding to stringent biological d

261 oteins are intriguing examples of convergent molecular evolution resulting in similar enzyme properti

262 Furthermore, analyses of molecular evolution revealed an increased mutational loa

263 Patterns of molecular evolution seen here--primarily a paucity of hi

264 Differences in their rates and patterns of molecular evolution should be highly relevant to their e

265 Application of established models of molecular evolution shows that SPN is evolving under pos

266 e invoked and the corresponding scenarios of molecular evolution specified.

267 cofactor complex were targeted in a directed molecular evolution strategy that implements streamlined

268 will further develop better understanding of molecular evolution, structure, and function of SWEET tr

269 Recent genomic and molecular evolution studies have transformed our underst

270 amic evolution have largely been left out of molecular evolution studies.

271 Our molecular evolution study shows that paralogs have diver

272 While standard molecular evolution tests could not reject neutrality, o

273 sults demonstrate how changes in the rate of molecular evolution that are linked to life history trai

274 We propose a mode of molecular evolution that describes the process by which

275 The mechanistic model of molecular evolution that emerges yields testable biochem

276 have been widely used to calibrate rates of molecular evolution, the completion of the Central Ameri

277 Within molecular evolution, the so called hypercycle defines th

278 If there is little adaptive molecular evolution, then slightly deleterious mutations

279 s (such as hosts and parasites) should drive molecular evolution through continual natural selection

280 They enable molecular evolution to be monitored in real time on a ge

281 rate 33 fossil calibrations, permit rates of molecular evolution to be uncorrelated across the tree,

282 sis and synthetic chemistry, enzymology, and molecular evolution to discover or create enzymes with n

283 Here we used molecular evolution to modify the NNGRRT PAM of Staphylo

284 transition metal centre and the potential of molecular evolution to modulate the reactivity and subst

285 Here, we exploit parallel molecular evolution to understand virulence evolution in

286 To understand why molecular evolution turned out as it did, we must charac

287 over new mechanisms of organelle biogenesis, molecular evolution underlying eukaryotic diversity, and

288 ution rates, selective constraints and other molecular evolution variables of interest an increasingl

289 atalytic properties, structural features and molecular evolution, vis-a-vis fungal laccases where pos

290 Graminoid molecular evolution was investigated by chloroplast geno

291 By applying rational design and molecular evolution we have engineered R. palustris bact

292 By introducing biophysical insights in molecular evolution, we are able to identify the adaptiv

293 ulation factor VIII and predictive models of molecular evolution, we engineer protein variants with i

294 Using synthetic molecular evolution, we previously discovered a family o

295 f these properties is an unsolved problem in molecular evolution with broad implications for protein

296 In practice, this work explicitly bridges molecular evolution with population genetics with applic

297 hows evolutionary CBM in eukaryotes predicts molecular evolution with precision.

298 This lineage also shows moderate rates of molecular evolution, with instances of punctuated evolut

299 whether such genes show distinct patterns of molecular evolution within species, we examined sequence

300 ar structure and function into computational molecular-evolution work.