ライフサイエンスコーパス: molecular function

1 gesting a new avenue for active control over molecular function.

2 d into a stable conformation and exert their molecular function.

3 ess, seven in cellular component, and six in molecular function.

4 elated disease, diversity, biogeography, and molecular function.

5 NA binding and RNA binding were enriched for molecular function.

6 and GATOR2, a positive regulator of unknown molecular function.

7 alize the relationship between evolution and molecular function.

8 on TSC2/tuberin with novel insight into the molecular function.

9 include voids and channels, are critical for molecular function.

10 collection, defined by shared Gene Ontology molecular function.

11 tradeoffs between immunogenic potential and molecular function.

12 ty of highly magnetic handles on cellular or molecular function.

13 s of BLOC-2, a protein complex with no known molecular function.

14 ss species is predictive of sites with known molecular function.

15 such as the target gene or the location of a molecular function.

16 ll maintain their conserved H3K36me3-binding molecular function.

17 icate that cellular source can indeed impact molecular function.

18 e defects, we tested for changes in cell and molecular function.

19 out Arabidopsis TRAPPII complex topology and molecular function.

20 een ancient protein orthologs with conserved molecular function.

21 and GATOR2, a positive regulator of unknown molecular function.

22 s, respectively indicative of host-dependent molecular functions.

23 s well as postsynaptic proteins with diverse molecular functions.

24 ul way to link disease-associated changes to molecular functions.

25 y a role in multiple biological processes or molecular functions.

26 s and to study their splicing mechanisms and molecular functions.

27 y structures that are enriched for different molecular functions.

28 ving an excess of coding genes with specific molecular functions.

29 diverse array of new constituents with broad molecular functions.

30 ures, and reveal details on the basis of RNA molecular functions.

31 kinases provide valuable insights into their molecular functions.

32 in (CP) as an exemplary gene to dissect PAX8 molecular functions.

33 disease risk factors within a set of defined molecular functions.

34 of chemical structures that can be mined for molecular functions.

35 role in vertebrate development and possible molecular functions.

36 Do these impact molecular function?

37 targets covered 220 biological processes, 67 molecular functions, 45 cellular components, and 10 KEGG

38 ation may be an important determinant of its molecular functions, a clear understanding of GPS2 diffe

39 in several key aspects, and they have myriad molecular functions across many cellular pathways and pr

40 A3H antiviral activity encompasses multiple molecular functions, all of which depend on recognition

41 ct temporal patterns attributable to diverse molecular functions, although the majority of differenti

42 epresented gene ontology terms, pathways and molecular functions, among the DEG, were associated with

43 reproduces 48% of cellular component, 41% of molecular function and 41% of biological process GO term

44 We conclude that while predictions of the molecular function and biological process annotations ha

45 blishes a benchmark standard for mapping the molecular function and cellular connectivity of the rode

46 effects of combinations of mutations on both molecular function and epitope content.

47 The molecular function and fate of mRNAs are controlled by R

48 ipitation studies were used to determine the molecular function and impact of MCUB on the high-molecu

49 ult, the effect of most genome variations on molecular function and overall fitness remains unknown a

50 So far, the molecular function and regulation of ATP13A2 remains und

51 The molecular function and structural action of the dehydrin

52 s missense variants, for which the impact on molecular function and subsequent roles in cancer risk a

53 infection, thus providing a link between TCS molecular function and the epidemiology of deadly bacter

54 Our findings establish a direct link between molecular function and the large-scale topology of neuro

55 ce patterns of proteins maintaining the same molecular function and the possible limits of this diver

56 in proteins to both elucidate mechanisms of molecular function and to develop therapeutic strategies

57 Assessment of molecular functions and biological processes reveals tha

58 IR-predicted milk BHB concentrations yielded molecular functions and biological processes that may be

59 which were associated with several important molecular functions and biological processes, including

60 any important questions remain regarding its molecular functions and biological roles, as well as the

61 s of CaM-interacting proteins with undefined molecular functions and biological roles.

62 ed proteins were involved in a wide range of molecular functions and cellular processes, and showed d

63 from these mice were extensively analyzed on molecular functions and compared with platelets from a p

64 dress this question, here we investigate the molecular functions and genome-wide DNA binding patterns

65 ive interface for linking compounds to their molecular functions and higher level biological effects.

66 for tissue development, the link between its molecular functions and its roles in any given different

67 gest that METH abrogates immune cellular and molecular functions and may be deadly to phagocytic cell

68 Molecular functions and mechanisms implicating SCA genes

69 are abundant in metazoans, can have diverse molecular functions and might have been coopted for host

70 that regulate downstream cellular processes, molecular functions and protein-protein interactions.

71 molecules are an efficient way of regulating molecular function, and a plethora of downstream signall

72 protein target-disease, -signaling pathway, -molecular function, and protein-protein interactions enh

73 s in superkingdoms, influence the make up of molecular functions, and enhance organismal complexity b

74 e pathogenic role of KLHL14 in DLBCL and its molecular function are largely unknown.

75 ontology analysis indicated that their main molecular functions are in nucleotide binding (20.9%), h

76 plasma lipid levels, their physiological and molecular functions are not fully characterized.

77 ontrol and development, though their precise molecular functions are not fully understood.

78 y a role in oxidative stress resistance, its molecular functions are not well established.

79 ease (AD) and psychiatric disorders, but its molecular functions are not well understood.

80 fs (MbI, MbII, MbIIIa and MbIIIb) have had a molecular function assigned to them, but the precise rol

81 tissue units, and biophysical constraints to molecular function associated with these units, to prese

82 Identifying the molecular functions associated with microbiome-plant int

83 We found specific blends molecular functions associated with these two mutation p

84 otype to normal, which indicates a conserved molecular function between OsRZFP34 and AtRZFP34.

85 xtend our knowledge about the human 5-HT(3)A molecular function but also provide novel insights into

86 ase genes for humans and gene candidates for molecular functions, but they are rarely used to predict

87 ilico methods focusing on the micro level of molecular function can help to understand the macro syst

88 Noncoding genomic sequences-for which molecular functions cannot usually be inferred-harbor a

89 d by mEN are from the biological process and molecular function categories, suggesting that the GO te

90 , anatomies, pathways, biological processes, molecular functions, cellular components, pharmacologic

91 shared 3' untranslated region motifs, and a molecular function collection, defined by shared Gene On

92 Intra-cluster molecular function consistency was examined by analysis

93 to find covariance networks that can predict molecular functions, correlations between profiles of re

94 specially useful for the dissection of actin molecular function due to redundancy and neofunctionaliz

95 iation of hMSCs; however, its regulation and molecular function during this process is not fully unde

96 tly share common biological processes and/or molecular functions (empirical p = 6e-5 and 0.03 respect

97 llular localization, biological process, and molecular function, enabling functional characterization

98 ical processes, 64 cellular component and 42 molecular functions, enriched in 22 KOG groups, and clas

99 in many different biological activities and molecular functions, especially transcription factors, w

100 e-gated channels give new insight into their molecular functions focusing on regulation, subunit asse

101 Together, these data expose a molecular function for MbIV and indicate that HCF-1 is a

102 o forms of syndromic deafness and suggests a molecular function for Myosin IIa in auditory organs.

103 bundles of F-actin, providing an unexpected molecular function for septins in cytokinesis.

104 our knowledge, the first demonstration of a molecular function for Sequence Insertion 1 in the beta

105 llular localization, biological process, and molecular function for the human gene and homologs in th

106 However, the exact molecular functions for the four proteins are unknown.

107 No molecular function had been linked to this accessory pro

108 Thus far, no enzymatic activity or precise molecular function has been ascribed to NS5A that is com

109 However, its molecular function has remained enigmatic.

110 ale studies of their expression dynamics and molecular function have provided conflicting interpretat

111 demonstrated in recent years, the underlying molecular functions have only recently begun to be eluci

112 Their molecular functions, however, were previously unknown, i

113 sion and histone profiling have revealed UTX molecular function in establishing appropriate chromatin

114 However, their molecular function in mammals remains largely unknown.

115 lusters bring together proteins of identical molecular function in more than 97% of the clusters, imp

116 ationship between nanoscale organization and molecular function in real time.

117 nally involved in key cellular processes and molecular functions in bacteria.

118 Rs in important cellular level processes and molecular functions in bacterial systems.

119 ral crest cells (NCCs) to study cellular and molecular functions in craniofacial development with res

120 tages of mouse limb development and distinct molecular functions in different tissue compartments.

121 (IDPs/IDRs) contribute to a diverse array of molecular functions in eukaryotic systems.

122 schizophrenia candidate genes with specific molecular functions in neurons, which could be used to e

123 s known about how the parasite performs most molecular functions in such different environments.

124 To shed light on Tob1 molecular functions in the immune system, we have conduc

125 n while Eukarya acquired a number of diverse molecular functions including those involved in extracel

126 l and appeared to affect a broad spectrum of molecular function, including hotspots at paralogous res

127 were associated across several categories of molecular function, including mitochondria integrity mai

128 -CFC proteins have been described, but their molecular functions, including how the mammalian homolog

129 in a wide range of biological processes and molecular functions, including three pathogenesis-relate

130 er, these proteins appear to harbor opposing molecular functions, indicating that they may act indepe

131 Remarkably, we find that the emergence of molecular functions induces hierarchical modularity and

132 ultifunctionality is defined with respect to molecular functions instead of biological processes.

133 In addition, we demonstrate that Pax3 molecular function involves chromatin remodeling of its

134 been implicated in assembly but ascribing a molecular function is confounded by the observation that

135 nization in nonadipose tissues; however, its molecular function is incompletely understood.

136 the oxidative stress response and that this molecular function is likely conserved in other DUF328 f

137 esponse to and repair of DNA damage, but its molecular function is not clear.

138 actor EWS-FLI1 drives Ewing sarcoma, but its molecular function is not completely understood.

139 de regulation of replication timing, but its molecular function is poorly understood.

140 e associated with centrioles, although their molecular function is unclear.

141 hanism by which O3-derived oxysterols affect molecular function is unknown.

142 n recognize m(6)A marks and are mediators of molecular functions like RNA splicing, mRNA decay, and t

143 on of Kcnq1 and Scn10a and suggest that this molecular function may underlie pathophysiology associat

144 ese results indicate that genes with similar molecular functions may have distinct genetic roles in d

145 We investigated the molecular function of a chloroplastic NFU-type iron-sulf

146 Here, we investigated the cell and molecular function of a specific form of HS sulfation, 2

147 To gain a better understanding of the molecular function of A6, we established a HeLa cell lin

148 Thus, the work presented here links the molecular function of Bicc1 in mRNA target-specific tran

149 We investigated the molecular function of C2 calcium-dependent domain contai

150 Strikingly, the molecular function of Cerberus remains poorly understood

151 However, the orientation and therefore the molecular function of chloroplast Toc75 POTRA domains re

152 Here we report the 2.1 A X-ray structure and molecular function of ClbS, a gene product that confers

153 To elucidate the molecular function of CLYBL, we used comparative operon

154 The molecular function of coilin, which is intrinsically dis

155 with observations in neurons [8, 9] and the molecular function of DCX is not well understood, we rev

156 Thus, our study characterizes the molecular function of Dph7 for the first time and provid

157 The molecular function of enzymes is defined as their abilit

158 However, the molecular function of Epe1 is not well understood.

159 The molecular function of Erv14 thus remains unclear, with p

160 The molecular function of Fam65b and whether misregulation o

161 thus solve the long-standing mystery of the molecular function of FIT2 and highlight the maintenance

162 Deep characterization of molecular function of genetic variants in the human geno

163 Our work reveals the molecular function of Hh signaling in extrinsic sheath t

164 ovides basic information on the genetics and molecular function of HLA molecules, as well as general

165 analyses, we characterize the evolution and molecular function of human lncRNA JPX.

166 eview discusses our current knowledge of the molecular function of IFN-inducible GTPases in providing

167 The molecular function of ISCA1 and ISCA2 proteins, i.e., ho

168 ionary context for ongoing debates about the molecular function of LARP1.

169 The molecular function of LIN-46, and how the lin-28-lin-46

170 rein, we report the genome-wide location and molecular function of LRH-1 in breast cancer cells and r

171 pendent nucleosome remodeling is the primary molecular function of Lsh, which may promote de novo met

172 The molecular function of Mask, or its mammalian homologs Ma

173 The identification of this clear molecular function of Matrin3 should help to clarify the

174 Nevertheless, the molecular function of MOZART1/Mzt1 is largely unknown.

175 etastasis in a tumor type, and second, which molecular function of MSG controls metastasis.

176 ting mitotic MT generation in flies, but the molecular function of Mst remains unknown.

177 Since the exact molecular function of New1 is unknown, it is unclear if

178 some profiling (Ribo-Seq) to interrogate the molecular function of New1.

179 ABSTRACT: The molecular function of non-muscle (NM) isoforms of myosin

180 However, the molecular function of other Dkks remains largely unknown

181 The molecular function of Pex11, however, is not known.

182 However, the molecular function of PLAC8 remained unclear, and accumu

183 The molecular function of PNUTS in these processes is comple

184 Our work elucidates the molecular function of PRDM10 in maintaining global trans

185 ype PPR proteins can help in elucidating the molecular function of proteins encoded in the organellar

186 Here, we characterize the cellular and molecular function of REP34, a REP protein with a mass o

187 To unravel the molecular function of RPGRIP1L, we analyzed Rpgrip1l(-/-

188 The molecular function of Sam37 has been unknown.

189 yo2 smy1 conditional mutants, we uncover the molecular function of Smy1 as a factor that enhances the

190 Thus, both the molecular function of STEAP1 and its role in cancer prog

191 er, our data provide support for a conserved molecular function of TCF7L1 as a transcriptional repres

192 ined the structure, tissue distribution, and molecular function of the cartilage-specific lectin CLEC

193 ferentially with polyubiquitylated PCNA, the molecular function of the chain and the relevance of its

194 nnel signaling, advance our knowledge of the molecular function of the CRAC channel, and suggest new

195 We identify the molecular function of the evolutionarily conserved ER pr

196 al transmission and maturation, although the molecular function of the gene and the cause of the appa

197 Characterization of the molecular function of the human genome and its variation

198 Partitioning was consistent with the known molecular function of the individual cloned genes.

199 lly overlapping contexts wherein the elusive molecular function of the Memo domain could be finally r

200 This study uncovers the molecular function of the natural variant, TZP (Tandem Z

201 We characterized the molecular function of the Pseudomonas syringae pv. tomat

202 for ciliary motility across eukaryotes, the molecular function of the RSs is unknown.

203 The novel molecular function of the systems developed here led to

204 for class switch recombination (CSR), but no molecular function of the transcripts has been described

205 synchronous regulation of Hox genes and the molecular function of their colinearity remain unknown.

206 organization of the plasma membrane, but the molecular function of their major protein subunits, the

207 iated via GABAB receptors (GABABRs), but the molecular function of these receptors in cognition is il

208 ns, relatively little is known regarding the molecular function of these receptors.

209 analysis provides the first insight into the molecular function of this cell type in C3 species, and

210 patic differentiation was identified and the molecular function of this factor was examined in embryo

211 b(-)(/-)) mice were generated to dissect the molecular function of this protein in the heart.

212 act to shape these structures; however, the molecular function of this protein is not yet resolved.

213 However, the molecular function of this virulence determinant was unc

214 the biogenesis of the respiratory chain, the molecular function of twin Cx9C proteins is largely unkn

215 rs, mechanistic insights into the underlying molecular functions of a number of these oncogenic fusio

216 The molecular functions of brain gangliosides include regula

217 itical macronutrient for the biochemical and molecular functions of cells.

218 ene expression patterns in leukemic cells to molecular functions of defined transcription factors in

219 neurotransmitter receptors through distinct molecular functions of differentially localized proteoly

220 tribute to tendon repair, but the origin and molecular functions of extrinsic tissues in tendon repai

221 can be used to successfully investigate the molecular functions of genes inE.

222 To study the molecular functions of hnRNPLL at a genome-wide level, w

223 ligand-binding sites is invaluable to infer molecular functions of hypothetical proteins, trace evol

224 the innate immune system and to explore the molecular functions of individual ISGs.

225 The molecular functions of Integrator subunits beyond the RN

226 Despite their abundance, the molecular functions of long non-coding RNAs in mammalian

227 To elucidate the molecular functions of maize glossy mutants that reduce

228 s over the past two decades to elucidate the molecular functions of MeCP2, the mechanisms underlying

229 The molecular functions of most of the factors that have bee

230 ment and physiology have been described, but molecular functions of mTERF proteins in plants are unkn

231 Here we compare the molecular functions of Myf5 and MyoD, two highly related

232 Insights into the molecular functions of MYOCD have been obtained from cel

233 update on recent progress in elucidating the molecular functions of nematode effectors.

234 Here, we dissected the molecular functions of NKX2-1 by defining its chromosoma

235 gether, this study provides insight into the molecular functions of non-canonical AUX/IAA proteins in

236 Together these findings identify the molecular functions of PAXX in KU accumulation at DNA en

237 ovide powerful strategies for modulating the molecular functions of proteins in mammalian cells.

238 The known molecular functions of pseudouridine, which include stab

239 on with HuR and provide new insight into the molecular functions of RBPs in the regulation of intesti

240 impact of this accelerated evolution on the molecular functions of retained paralogs.

241 Scrib module and begin to define the elusive molecular functions of Scrib and Dlg.

242 as diverged and expanded, differences in the molecular functions of signaling components have largely

243 The diverse molecular functions of SR45 uncovered in this study are

244 To elucidate the molecular functions of the ATG8 proteins, we engineered

245 Nevertheless, the molecular functions of the greatest number of miRNA gene

246 The molecular functions of the majority of RNA-binding prote

247 Here, we elucidated the molecular functions of the noncoding RNA, ARID5B-inducin

248 The molecular functions of these regulators are generally we

249 To dissect the molecular functions of this domain, we generated a serie

250 two genetic models generated to dissect the molecular functions of this locus and its RNA product.

251 the essential substrates of enzymes, and the molecular functions of uncharacterized proteins.

252 Methods optimized to capture effects upon molecular function often correctly predict human (OMIM)

253 otations for both the Biological Process and Molecular Function Ontology.

254 uclear protein but little is known about its molecular function or the cell types responsible for SMS

255 y comparison, very little is known about the molecular functions or physiological roles of PTBP3, alt

256 s related to diseases, biological processes, molecular functions or publications.

257 owever limited in scope to either individual molecular functions or were concerned with functional ef

258 among the most thoroughly studied regarding molecular functions, phenotypic effects, and adaptive si

259 We discuss their molecular functions, physiological roles, and influence

260 ER is a state-of-the-art sequence-based gene molecular function prediction algorithm that uses a stat

261 Most current methods perform well on molecular function prediction, but struggle to provide u

262 eriousness (CADD) (10 or 15 thresholds), and molecular function (protein loss-of-function [LoF] only,

263 arious types of experimental data, including molecular function, protein structure, and associated ph

264 conserved developmental regulators, but the molecular function provided by the regions flanking the

265 tivity of a gene cannot be defined simply as molecular function; rather, it is a consequence of spati

266 esponse signatures for 87 endpoints covering molecular functions relevant to toxic and therapeutic pa

267 nce, apoptosis, and viral replication, their molecular functions remain unclear.

268 endocytosis and cell differentiation but its molecular functions remained unknown.

269 entional T-cell development, but its precise molecular function remains elusive.

270 iology, notably diabetes and cancer, but its molecular function remains poorly characterized.

271 teins are conserved in eukaryotes, but their molecular function remains unknown.

272 id dendritic cell (pDC) development, but its molecular function(s) in early B cell fate specification

273 nd to record conserved sites associated with molecular function, so that they can be mapped onto user

274 rk neighborhoods, and exhibit enrichment for molecular functions such as xylan metabolism and cell wa

275 Molecular function, such as binding and catalysis, howev

276 d content is linked to proteins with certain molecular functions, such as the binding of RNA, DNA, me

277 y MFSD12, a transmembrane protein of unknown molecular function that, when suppressed, causes darker

278 mporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive

279 ting the key viral target proteins and their molecular functions that can be used in drug design, as

280 These results highlight an immense array of molecular functions that microbes use against viruses.

281 However, depending on the family and molecular function, they can also display substrate prom

282 a result of mutations in genes with multiple molecular functions, they appear to converge on common b

283 implement a diverse range of tissue-specific molecular functions throughout development and into adul

284 earlier work that suggested some links from molecular function to disease.

285 genesis, this work provides evidence pairing molecular function to physical structure for processes f

286 However, the leap from the micro level of molecular function to the macro level of the whole organ

287 data provide a principled means of assigning molecular functions to autoimmune and cardiovascular dis

288 provide a starting point for deciphering the molecular functions underlying the antagonistic activity

289 ators of male germ cell differentiation with molecular functions unrelated to A-to-I RNA editing.

290 Molecular function was primarily related to binding and

291 To investigate its primary molecular function we identified the Arabidopsis FLOWERI

292 To explore its molecular function, we determined a 2.2 A-resolution cry

293 ith cancer susceptibility and studying their molecular functions, we hope to help the interpretation

294 To understand its molecular functions, we transformed the embryo-lethal tp

295 re genes with similar expressions or similar molecular functions were grouped together.

296 ent clusters, 24 biological processes and 27 molecular functions were regulated by TGF-beta1.

297 nent clusters, 40 biological processes and 7 molecular functions were regulated by TGF-beta1.

298 des an effective strategy for modulating its molecular function within the nuclear compartment.

299 tive impact of a substitution on a protein's molecular function would be a great aid in understanding

300 r evolution has focused on the divergence of molecular functions, yet we know little about how struct