ライフサイエンスコーパス: molecule

1 change in polarity from a polar to non-polar molecule.

2 it acts as a hemolytic and pro-inflammatory molecule.

3 intermediate (MbA-R(2)) to complete the MbA molecule.

4 ide conjugates with up to 80 boron atoms per molecule.

5 be quickly degraded upon addition of a small molecule.

6 e moiety, while VIM-2 by triazole-containing molecules.

7 future pathway for optical readout of these molecules.

8 ntly to the excited-state chemistry of these molecules.

9 that contains hydrated minerals and organic molecules.

10 achieve the assembly-line like production of molecules.

11 chnology for the synthesis of drugs or small molecules.

12 insights into their interactions with ligand molecules.

13 em in machine learning for excited states of molecules.

14 ining the spatial distribution of biological molecules.

15 rotein complexes or degrade immune signaling molecules.

16 te the search for pharmacologically relevant molecules.

17 the mechanical properties of individual tRNA molecules.

18 ter solvation shell as compared with organic molecules.

19 gly appreciated for their roles as signaling molecules.

20 ockwise/counterclockwise chiral cap and core molecules.

21 deling, transcription factors, and signaling molecules.

22 ect the outcomes of the reactions of complex molecules.

23 recognized as bona fide information-carrying molecules.

24 encapsulate and separate guest and non-guest molecules.

25 molecules or small interacting complexes of molecules.

26 timized for fast elimination of the toxic NO molecules.

27 ct the likely biological activity of encoded molecules.

28 g antibodies (ADAs) against each of the DART molecules.

29 continued turnover likely to free the NAD(+) molecules.

30 for the quantitative analysis of therapeutic molecules.

31 s the design and selection of drug candidate molecules.

32 igher levels of ICAM (intercellular adhesion molecule)-1 and TF expression following TNF (tumor necro

33 cules (median) (IQR: 23, 87) of 5-LO, and 53 molecules (62, 156) of FLAP monomer.

34 ited state is the first state created when a molecule absorbs a visible photon.

35 novel NMR-based machine learning tool "Small Molecule Accurate Recognition Technology" (SMART 2.0) fo

36 o participate in tandem or cooperative small-molecule activation and catalysis.

37 ogically activating PKM2 via ML-265, a small molecule activator of PKM2, during acute outer retinal s

38 that both adiponectin and AdipoRon, a small-molecule adiponectin receptor agonist, suppress colon ca

39 Using single-molecule analyses, we examined the mechanism by which E4

40 ide effects and provides an attractive probe molecule and lead compound.

41 oiety within the structure of the epothilone molecule and providing new and useful structure-activity

42 d triplet excited state quenchers for single-molecule and super-resolution imaging.

43 rbon-carbon bond between the skeleton of the molecule and the carboxylic group and the liberation of

44 or pockets that are only accessible to small molecules and constitutes a rich subset of binding sites

45 rotocol to eliminate interference from small molecules and degraded proteins.

46 ses are focused on single tetracenothiophene molecules and demonstrate that an in situ-induced direct

47 view, we summarize various c-MYC G4 specific molecules and discuss their effects on c-MYC gene expres

48 rong positive correlation with cell adhesion molecules and IFN response pathways and a strong negativ

49 library of isotopically labeled bottlebrush molecules and measured the bottlebrush correlation peak

50 sis of relative isotope ratios of protonated molecules and measures of exact masses of formed fragmen

51 loci (53 of them novel) identifying several molecules and mechanisms involved in cell regulation.

52 a provide novel insights into the signalling molecules and mechanisms regulating trophoblastic cell f

53 The BCF depends on the size of interacting molecules and on their location when fixed in space and

54 tibility complex (MHC) class Ia and class II molecules and provide anti-microbial and anti-tumour imm

55 electronic interactions between photochromic molecules and semiconducting polymers are far from being

56 il, we discuss chemical features of chimeric molecules and their use for targeted delivery and for ta

57 nt transporters, down-regulation of adhesion molecules and tumor suppressing phosphatases, and altera

58 n (TSPO), the reported target for this small molecule, and instead were driven by a metabolic switch

59 ate that targeting FPR1 by a selective small molecule antagonist, such as ICT12035, can provide a new

60 that the waiting time distributions of each molecule are a signature of the system's state.

61 vels and stability of intermediate signaling molecules are a crucial hijacking point for a successful

62 Inactivated beta(2)-AR (Nb60) molecules are also largely immobile but relatively less

63 of mass transfer showed that most pheromone molecules are deflected around the microstructure at low

64 nd discuss direct effects that gut bacterial molecules are likely exerting on specific brain cells.

65 d in a few regions, and more-complex organic molecules are not observed.

66 e effectively creates a microgap, where DmFc molecules are oxidized to DmFc(+).

67 These molecules are rapidly inactivated by the action of dipep

68 Here we show that, in PDAC, MHC-I molecules are selectively targeted for lysosomal degrada

69 emporal transcription factors, as a group of molecules, are potent determinants of synaptic partner c

70 om the secondary nucleation of the precursor molecules around the toroids.

71 es, which can accommodate a variety of guest molecules as proton carriers and to systemically regulat

72 Proteases, inflammatory signaling molecules, as well as proteins involved with cell adhesi

73 insulin, which are presented by HLA class II molecules associated with T1D risk.

74 vity (that is, reacting diversely with small molecules at one extreme or selectively with protein tar

75 oupled with uniquely easy migration of water molecules between the layers allows for ion exchange wit

76 This structure reveals that two Rab33B molecules bind to the diverging alpha-helices of the dim

77 3)C distance data indicate three cholesterol molecules bound near F673 in each trimer.

78 We identified the molecules bufalin and lycorine as drug candidates for th

79 herical assemblies in other related discotic molecules by the introduction of similar bulky functiona

80 The conductance through a single molecule can be measured by contacting the molecule with

81 second phase of polymer growth, opened hGBP1 molecules can be incorporated in the growing polymer whe

82 al process through which double-stranded RNA molecules can silence the gene carrying the same code as

83 e scalable syntheses of a variety of complex molecules carrying sulfate diesters at various positions

84 this can be achieved in the context of small-molecule catalysts has had sizable impact on the field o

85 as well as the CD2 ligand and cell adhesion molecule CD58, all of which may be involved in monocyte-

86 gned a series of novel monophosphonate small-molecule CD73 inhibitors.

87 an be used to create highly nonlinear single-molecule circuits.

88 "geometric packing parameter" dictate small molecule compatibility with 3HM's alkyl tail core.

89 Development of small molecule compounds that target several cancer drivers ha

90 sor was tested for the detection of thrombin molecule concentrations ranging from 0.625 mug/ml to 20

91 Single-molecule conductivity of the longest oxa[19]helicene dit

92 PROTACs are heterobifunctional molecules consisting of one ligand for binding to a prot

93 irus attachment protein sigma1 is a trimeric molecule containing tail, body, and head domains.

94 properties of catenated nitrogen molecules, molecules containing internal chains of bonded nitrogen

95 A chromene-based small molecule, CXL146, selectively eliminates cancer cells wi

96 providing the central framework for organic molecules, development of biocatalytic methods for their

97 Importantly, we also identify a small molecule dicarboxylate that acts as an essential cofacto

98 ent, paving the way to cost-effective single-molecule DNA sequencing, capable of handling widely vary

99 Further addition of water molecules does not significantly alter the observed hydr

100 s-reaction of the sensor with four reference molecules (dopamine, bovine serum albumin, glucose and e

101 harvesting and chemical adsorption of CO(2) molecules dramatically, achieving 103.21 mmol g(cat) (-1

102 itiating the downstream release of the small molecule drug by a retro DA reaction.

103 ed and quantified the flow and flux of small molecule drugs through the layers and structures of ex v

104 pain management, effective targets for small-molecule drugs.

105 Down syndrome cell adhesion molecules (dscam and dscaml1) are essential regulators o

106 omplete pattern of physiological antioxidant molecules, due to the use of reaction schemes and probes

107 The cell adhesion molecule E-cadherin is a major component of adherens jun

108 ydrogel resins simultaneously adsorbs septic molecules, e.g. lipopolysaccharides (LPS), cytokines and

109 functions in synergy with a related adhesion molecule, ELFN1, and their concerted interplay during de

110 HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged clini

111 target in cancer and inflammation, and small-molecule ERK5 kinase inhibitors have been developed.

112 olecular tuning allowed for the synthesis of molecules exhibiting strong visible-range absorption.

113 In vitro single-molecule experiments confirmed that yeast condensins ext

114 een immune cells and phosphatidylserine (PS) molecules exposed on the surface of apoptotic-tumor bodi

115 w experimentally that approximately 80 water molecules flood rhodopsin upon light absorption to form

116 Earlier single-molecule fluorescence imaging of the archaeal model glut

117 ee helical periods (100-130 bp) using single-molecule fluorescence resonance energy transfer (FRET).

118 rganic and inorganic substrates using single-molecule force spectroscopy (SMFS).

119 In this work, we employ single-molecule force spectroscopy and molecular dynamics simul

120 out of 647 residues) when examined by single molecule force spectroscopy in vitro displays the proper

121 Using single-molecule force spectroscopy, we also define the response

122 Using biochemical and single-molecule Forster resonance energy transfer (smFRET) expe

123 P1 on fibrin without crosslinks using single-molecule Forster Resonance Energy Transfer (smFRET).

124 Here, we used single-molecule FRET assays with a nanodisc membrane reconstitu

125 Here, we combine single-molecule FRET experiments and molecular dynamics studies

126 to measure levels of spontaneous release of molecules from mast cells in colonic mucosa from patient

127 tion by restricting the interaction of water molecules from the edges of Ti(3)C(2)T(x).

128 Carbon monoxide (CO) is a cell-signaling molecule (gasotransmitter) produced endogenously by oxid

129 automated computational design algorithm is molecule generation, where the machine is required to de

130 One molecule generator, based on match molecular pairs, perf

131 The qubit addressed in the molecule has a frequency of either 13.4 kilohertz(1) or

132 Small molecules have been classically developed to inhibit enz

133 Noncoding RNA molecules have been implicated in critical roles coverin

134 esentation via the nonclassical MHC class Ib molecule HLA-E, with nearly complete identity between th

135 E-selectin and intercellular adhesion molecule (ICAM)-1 are biomarkers of endothelial activati

136 (2020) use an innovative single-molecule imaging approach in yeast cells to measure chro

137 Here, we use live-cell single-molecule imaging in human cells to determine rate consta

138 Single molecule imaging of p44/p62 complexes without XPD reveal

139 Using single-molecule imaging, we demonstrate that both condensin I a

140 cture is stabilized, similar to a surfactant molecule in a micelle, pointing the farnesyl moieties in

141 istent with NAE 18:3 being a lipid signaling molecule in plants with a requirement for G-proteins to

142 that AI-2 serves as a widely used signaling molecule in the coordination of cell behavior among prok

143 em mass spectrometry can detect thousands of molecules in a biological sample.

144 rmore, photophysical studies of the isolated molecules in a frozen glass, in combination with DFT/MRC

145 Realizing decision-making with a few molecules in artificial cells has remained a challenge.

146 rence between the knob-into-hole and WT IgG4 molecules in E. coli.

147 eased expression of CD54, MHC Class I and II molecules in endothelial but not epithelial cells, which

148 ance and positioning of cellular RNA and DNA molecules in fixed samples.

149 ss involves assembly and disassembly of many molecules in multiple cellular compartments and their tr

150 Efforts to sequence single protein molecules in nanopores(1-5) have been hampered by the la

151 ass I major histocompatibility complex (MHC) molecules in the endoplasmic reticulum (ER) and reroutes

152 he targeted synthesis of clinically-relevant molecules in the presence of specific IgG biomarker anti

153 en (64)Cu-ATSM signal and levels of reducing molecules in vivo, as well as to evaluate the change in

154 ent in S/N are achieved for various kinds of molecules including DNA, peptides, proteins, and oligosa

155 g neurons that express multiple itch-related molecules including MrgprA3, MrgprC11, histamine recepto

156 the antibodies bound a heterogeneous set of molecules, including myelin, axonal cytoskeleton, and io

157 he effects of oral administration of a small molecule inhibitor for CCR2, CCR2i, which blocks CCR2-me

158 This was further confirmed using a small-molecule inhibitor of ferroptosis that prevents CZ-induc

159 3, or IL18 and in mice given MCC950, a small molecule inhibitor of the NLRP3-inflammasome.

160 with increased sensitivity to the OGT small molecule inhibitor OSMI-1.

161 g to destabilize MYCN protein, such as small-molecule inhibitors of Aurora A and mTOR, are currently

162 This study aimed to discover small-molecule inhibitors targeting RANKL trimer formation.

163 nositol ribophostin is the most potent small-molecule Ins(1,4,5)P(3) receptor agonist without a nucle

164 synthesis to predict and then produce small molecules inspired by biosynthetic gene clusters.

165 A recently discovered light-molecule interacting phenomenon, supracence only measure

166 Here single-molecule intermolecular FRET measurements of wild-type E

167 supplementation attenuated expression of key molecules involved in adipose tissue browning and amelio

168 on of the ID complex, in which one ubiquitin molecule is conjugated to each of FANCI and FANCD2.

169 is a manifestation of how profoundly a water molecule is distorted when embedded in its extended hydr

170 Reversing the polarity in molecules is a versatile tool for expanding the boundari

171 cellular defense against these electrophilic molecules is conjugation to glutathione, then metaboliza

172 eads for chemical biological probes and drug molecules is demonstrated through site-selective protein

173 The peptide-free state of these molecules is not well understood.

174 ynamically distinct network of 9 +/- 1 water molecules is present within the nanocavity of the host.

175 ide characterization of structurally complex molecules, it works as a reader of molecular information

176 Small-molecule kinase inhibitors have the potential for broad

177 electronic relaxation of an excited atom or molecule leads to ionization of a neighboring one via Co

178 methods were further employed to add single molecule level details on the potential interactions bet

179 DNA-encoded small molecule libraries (DELs) have enabled discovery of nove

180 r histocompatibility complex class I (MHC I) molecules loaded with peptides.

181 ned to render large three-dimensional single-molecule localization microscopy datasets.

182 Single-molecule localization microscopy is a powerful tool for

183 uality and conditions for regular and single-molecule localization microscopy on live-cell samples.

184 e, we demonstrate the applications in single-molecule manipulation studies of the temperature depende

185 The gut microbiota synthesize hundreds of molecules, many of which influence host physiology.

186 e findings demonstrate that P. aeruginosa QS molecules may confer protection to neighboring yeasts ag

187 We also identify how other MND-associated molecules may impact these cascades, in particular throu

188 Our real time single molecule measurements of full length p53 tetramers bindi

189 activate covalent bonds in mechanosensitive molecules (mechanophores).

190 tified higher order assemblies containing 40 molecules (median) (IQR: 23, 87) of 5-LO, and 53 molecul

191 sGC or PDE activity and the effect of small molecules modulating their function can be studied with

192 The properties of catenated nitrogen molecules, molecules containing internal chains of bonde

193 anode, the solvation behavior of the solvent molecules must be understood because the electrochemical

194 tribution and intracellular drug delivery of molecules, nanoparticles, and other therapeutic agents.

195 tein, and lipid-dye interactions with single-molecule, nanoscale resolution.

196 We identified Neural Cell Adhesion Molecule (NCAM1) as a potential ZIKV receptor and furthe

197 Triply bound dinitrogen molecules occupy channels of these frameworks.

198 d activator of transcription 5, a downstream molecule of PL signaling, was observed in islets from Ad

199 leverage differentially upregulated surface molecules on cancer cells.

200 were utilized to address the effect of water molecules on prominent reaction steps and their associat

201 ve POM cores with virtually any (bio)organic molecule or metal cation, generating a wide range of mat

202 operties of materials at the level of single molecules or small interacting complexes of molecules.

203 r has entered clinical trial; however, small-molecule orally available antiviral drugs have yet to be

204 In this paper, we utilize SMOLM, single-molecule orientation localization microscopy, to directl

205 This is demonstrated for small molecules, peptides, and proteins up to 66 kDa on three

206 ce has been determined as 1500 (+/-8%) water molecules per Ar(1800)(+) ion, consistent with our resul

207 limit of detection of 6.0 x 10(2) copies of molecules per reaction.

208 e presence of the capsid destabilising small molecule PF-74 also induced a cGAS-dependent IFN respons

209 -derived BBB model that displays an adhesion molecule phenotype that is suitable for the study of imm

210 ing rapid exchange of metabolites and signal molecules, plant cells use the extracellular matrix as a

211 ced spin selectivity (CISS), whereby helical molecules polarize the spin of electrical current, is an

212 triple bond and the nonpolarity of the N(2) molecule pose thermodynamic and kinetic challenges for p

213 access to enantioenriched 1,3-difluorinated molecules possessing interesting and well-defined confor

214 The prepared molecules present a persistent nonplanar framework and a

215 t the fluorescent signal emitted from single-molecule probes, which rapidly degrades resolution with

216 o-chitooligosaccharides (LCOs) are signaling molecules produced by rhizobial bacteria that trigger th

217 broad range of single analytes such as small molecules, proteins, nanoparticles, exosomes, and amyloi

218 al gamma work distribution applied to single molecule pulling experiments.

219 We also report anticancer molecule RA190, which binds covalently to hRpn13 and UCH

220 he final state nondestructively, leaving the molecule ready for further manipulation.

221 e enrichment sequencing (RenSeq) with single-molecule real-time sequencing of PacBio for 18 accession

222 cine demonstrated that H(2)S is the effector molecule regulating Mtb survival in macrophages.

223 Molecules regulating interneuron function under redox co

224 previously published state-of-the-art small-molecule relative binding affinity calculations, which h

225 y development, but little is known about the molecule(s) regulating FGF signaling during nephron deve

226 tion inhibitors from a high-throughput small-molecule screen for fragile X tremor ataxia syndrome.

227 au burden in human neurons and, from a small-molecule screen, identify the mTOR inhibitors OSI-027, A

228 DART molecule serum concentrations were well above those cons

229 structure-agnostic features to characterize molecules, should serve to mitigate these issues.

230 ich can jointly regulate host-derived danger molecule signaling and integrate specific global respons

231 eotide resolution transcriptome-wide, single molecule SM-PAT-seq method.

232 e subdiffraction localization of fluorescent molecules, software suites for spectroscopic analysis of

233 was slowly reversible, with DNA-bound RNApII molecules sometimes binding and releasing Spt4/5 multipl

234 investigated using a newly identified small molecule, soticlestat (TAK-935/OV935).

235 n be useful electrode substrates for (single molecule) spectroelectrochemistry research.

236 Single-molecule spectroscopy allows us to quantify the effects

237 New approaches in single molecule spectroscopy and microscopy are able to resolve

238 tical step towards the untethering of single molecule spectroscopy.

239 nctionalization of natural products and drug molecules, stereospecific synthesis of useful alpha-chir

240 n achieve such compaction, but recent single-molecule studies (Golfier et al., 2020) observed diverse

241 Some single-molecule studies have, however, suggested that the SOSIP

242 -fold increase in signal intensity for polar molecules such as amino acids, which has important impli

243 l tail composition naturally adapts to added molecules such as cholesterol or proteins.

244 he synthesis of densely functionalized small molecules suitable for fragment-based drug discovery and

245 Single-molecule super-resolution microscopy has developed from

246 we identify here by three-dimensional single-molecule superresolution imaging.

247 Here, we used quantitative, single-molecule superresolution microscopy to study TNFR1 assem

248 posed of a tetratopic hydrogen-bond-acceptor molecule synthesized in the solid state.

249 Small-molecule targeted RNA degradation will thus provide a ge

250 -mixing strategy, we kinetically organized a molecule that can elongate into toroids with a radius of

251 Leupeptin is a bacterial small molecule that is used worldwide as a protease inhibitor.

252 Thus, Fgl2 is a TFR cell effector molecule that regulates humoral immunity and limits syst

253 Extracellular ATP (eATP) is a signaling molecule that variably affects all cells of the immune s

254 Artificial water channels are synthetic molecules that aim to mimic the structural and functiona

255 icited by butyrophilin and butyrophilin-like molecules that are structurally similar to the immunosup

256 machine-learning approach to identify small molecules that broadly correct gene networks dysregulate

257 the ficolins are soluble pattern recognition molecules that contribute to complement activation via t

258 gene expression analysis, we identified two molecules that could have a role in the altered genome-w

259 Molecules that covalently bind macromolecular targets ha

260 f enantiomorphic solids is carried out using molecules that differ only in the isotopic composition o

261 zyme activity; however, new classes of small molecules that endow new functions to enzymes via proxim

262 s) are a class of postsynaptic cell adhesion molecules that interact with presynaptic neurexins (NRXN

263 Small molecules that selectively kill senescent cells (SCs), t

264 inement with the molecular size of the probe molecule, the free volume element size probability distr

265 alculations of the excited- and ground-state molecules, the results provide insights into both the el

266 l antibodies (mAb) with the potency of small molecule therapeutics, are one of the fastest growing ph

267 are normally difficult to target with small molecule therapies.

268 hich bacteria secrete and sense a diffusible molecule, thereby enabling bacterial groups to coordinat

269 (+) cation is located between the surfactant molecules; this has an important influence on the reacti

270 identify Fgl2 as a soluble TFR cell effector molecule through single-cell gene expression profiling.

271 still exist in regard to the ability of this molecule to induce signaling via rhesus macaque CD200R,

272 nd through a well-designed linker, the first molecule to successfully inhibit PTP activity through de

273 nging because of the inability of most small molecules to accumulate inside GN bacteria.

274 gant tool to efficiently deliver hydrophobic molecules to animal models.

275 y permit the cell-specific delivery of small molecules to improve the post-MI healing process.

276 degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of p

277 systems evolved to transport the hydrophilic molecules to their sites of action.

278 Using single molecule total internal reflection fluorescence microsco

279 Here, we combine single-molecule tracking and super-resolution microscopy, light

280 investigate the combustion pathways of these molecules, tunable vacuum ultraviolet (VUV) light (in th

281 In addition, three novel molecules (UBXN4, MFSD12, and ACTR6) from RNA-seq served

282 alculate the NMR chemical shifts of a set of molecules using any available combination of DFT theory,

283 that express cellular prion protein (PrP(C)) molecules varying in amino acid composition.

284 e factor attachment protein receptor (SNARE) molecule vesicle-associated membrane protein 4 (VAMP4) a

285 Inhibition of TRPCs by small molecules was shown to be promising in treating renal di

286 he current view, we designed and synthesized molecules where two isomeric, yet, different, 8pai antia

287 study the structural characteristics of this molecule, which will provide important insights into its

288 olymorphism causes mismatches in recombining molecules, which can be detected by MutS homolog (MSH) m

289 change in polarity from a polar to non-polar molecule, while for the VP4, amino acid differences at p

290 e molecule can be measured by contacting the molecule with atomic precision and forming a molecular b

291 s are an important class of plant signalling molecule with both external rhizospheric and internal ho

292 2-pyridone, containing the CB2 agonist-type molecule with excellent yield.

293 litated that first moment in which early RNA molecules with catalytic capability began their evolutio

294 Ynamides are fascinating small molecules with complementary reactivities under radical,

295 a variable platform that provides access to molecules with diverse shapes, sizes and functions.

296 ors targeting radiopharmaceuticals are small molecules with fast blood clearance and urinary excretio

297 as a readily interacting moiety of drug-like molecules with high potential for interactions to protei

298 apeutic areas, providing differentiated drug molecules with increased specificity and extended half-l

299 ine modulation of the activation dynamics of molecules within mechanotransduction on the cellular res

300 s required to design high-quality, drug-like molecules within the appropriate chemical space.