ライフサイエンスコーパス: monkeypox virus

1 an transmission of the west African clade of monkeypox virus.

2 feared but now eradicated virus, as well as monkeypox virus.

3 d sensitive assays used for the detection of monkeypox virus.

4 375 individuals that tested positive for the monkeypox virus.

5 une regime (69 U/ml) prior to challenge with monkeypox virus.

6 olog was maintained in many OPXVs, including monkeypox virus.

7 an outbreak of the west African clade of the monkeypox virus.

8 ion from a lethal intravenous challenge with monkeypox virus.

9 a, vaccinia, camelpox, mousepox, cowpox, and monkeypox virus.

10 d new and emerging infectious agents such as monkeypox virus.

11 ase after an otherwise lethal challenge with monkeypox virus.

12 d 94.1% sensitivity and 100% specificity for monkeypox virus.

13 mpox, a disease caused by infection with the monkeypox virus.

14 ly conserved in most, including smallpox and monkeypox viruses.

15 omolgus macaques were exposed to aerosolized monkeypox virus (10(5) PFU).

16 lid swelling and developed skin lesions from monkeypox virus 2 days later.

17 We developed 3 assays to detect monkeypox virus, 2 (MPXV+ and MPXV) for m2000 RealTime a

18 revented spread of vaccinia virus as well as monkeypox virus, a human pathogen.

19 re essential for protection of macaques from monkeypox virus, a variola virus ortholog.

20 lymerase chain reaction on a rectal swab for Monkeypox virus after a recent trip to Brazil, where he

21 oing unprecedented community transmission of monkeypox virus among gay, bisexual, and other men who h

22 onkeypox is a zoonotic illness caused by the monkeypox virus, an Orthopoxvirus in the same genus as t

23 us Ankara (MVA) is used as a vaccine against monkeypox virus and as a viral vaccine vector.

24 by vaccinia virus vaccines are conserved in monkeypox virus and can elicit memory T cell responses,

25 r.IMPORTANCE Several OPXV species, including monkeypox virus and cowpox virus, cause zoonotic infecti

26 The 2022 outbreak of the clade IIb monkeypox virus and subsequent global spread lead to an

27 uspected mpox, 31 of which were positive for monkeypox virus and were included in our analysis (four

28 es of three outbreaks as yellow fever virus, monkeypox virus, and a noninfectious cause, the latter u

29 thogenic orthopoxviruses like variola virus, monkeypox virus, and cowpox virus (CPXV), but not vaccin

30 (HSV-2), human immunodeficiency virus (HIV), monkeypox virus, and hepatitis B virus.

31 accinia virus, the emerging infectious agent monkeypox virus, and the potential biothreat variola vir

32 r both, and the experiences with SARS-CoV-2, monkeypox virus, and Zika virus highlight the feasibilit

33 reexpansion in association with sterile anti-monkeypox virus (anti-MPV) immunity after MPV challenge.

34 causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposef

35 The prairie dog, using monkeypox virus as a challenge virus, has provided a val

36 macaques were challenged intravenously with monkeypox virus at 4, 6, 10, and 30 days after immunizat

37 enetic constrains are sufficient to diminish monkeypox virus' capacity for enhanced specificity as a

38 e macaques were not protected against lethal monkeypox virus challenge if their CD4(+) cell count was

39 th MVA provided protection for >2 years in a monkeypox virus challenge model.

40 us compound ST-246 in prairie dogs against a monkeypox virus challenge of 65 times the 50% lethal dos

41 Recent monkeypox virus challenge studies have established the b

42 could be boosted as a recall response after monkeypox virus challenge.

43 Monkeypox virus clade I is endemic in several central Af

44 re analysed using quantitative PCR to assess monkeypox virus contamination levels.

45 ception, exhibiting extreme vulnerability to monkeypox virus, cowpox virus, and vaccinia virus and th

46 eactivity with orthopox viruses and specific monkeypox virus detection with MPXV.

47 the rapid development of clinical assays for monkeypox virus detection.

48 novel, non-discriminatory classification of monkeypox virus diversity.

49 Monkeypox virus DNA was detected by PCR from vaginal swa

50 Monkeypox virus DNA was detected in 29 of the 32 persons

51 ection of 100 genome copies per reaction for monkeypox virus, effectively distinguishing it from othe

52 Clade Ib, a new strain of clade I monkeypox virus, emerged in eastern DR Congo, sparking a

53 odeoxyglucose ([(18)F]-FDG) in monkeys after monkeypox virus exposure to monitor the immune response

54 ocuments the isolation and identification of monkeypox virus from humans in the Western Hemisphere.

55 nvestigated environmental contamination with monkeypox virus from infected patients admitted to isola

56 museum specimens, as reported previously for monkeypox virus genomes from historical orangutan specim

57 All new and already published monkeypox virus genomes from the Central African Republi

58 med a retrospective cross-sectional study of monkeypox virus genomic sequences among PCR-confirmed mp

59 ies outside of Africa, despite the fact that monkeypox virus has been causing disease in parts of Afr

60 usly limited to endemic areas with clade 1a, monkeypox virus has recently spread to non-endemic regio

61 Cowpox and monkeypox viruses have taken an alternate approach by en

62 022, the world was alerted to circulation of monkeypox virus in many high-income countries outside of

63 Our results suggest endemicity of monkeypox virus in Nigeria, with some evidence of human-

64 ain reaction and culture revealed infectious monkeypox virus in skin lesions of all 3 patients; 2 pat

65 5% CrI: 55.78, 86.85) of infections with the monkeypox virus in the UK were captured over the outbrea

66 ed a valuable nonhuman animal model in which monkeypox virus infection closely resembles human system

67 nd November, 2022, global outbreaks of human monkeypox virus infection have been reported in more tha

68 demiological and clinical characteristics of monkeypox virus infection in cisgender (cis) and transge

69 Before April 2022, monkeypox virus infection in humans was seldom reported

70 Monkeypox virus infection of nonhuman primates (NHPs) pr

71 Monkeypox virus infection results in a systemic, febrile

72 locations with high numbers of diagnoses of monkeypox virus infection were approached and invited to

73 ted data for a total of 136 individuals with monkeypox virus infection who presented between May 11 a

74 One year after monkeypox virus infection, 6 of 7 individuals had IFN- g

75 ted with VV, 7 individuals with a history of monkeypox virus infection, and 8 individuals with a hist

76 en and non-binary individuals with confirmed monkeypox virus infection.

77 s in people with HIV, including COVID-19 and monkeypox virus infection.

78 The T cell memory response to MPXV (monkeypox virus) infection has not been fully investigat

79 An outbreak of monkeypox virus infections in non-endemic countries was

80 comes of polymerase-chain-reaction-confirmed monkeypox virus infections.

81 Understanding the mechanisms of monkeypox virus innate immune evasion will help us to un

82 n facilities and potential for suspension of monkeypox virus into the air during specific activities.

83 Subsequent monkeypox virus intranasal infection of vaccinated prair

84 Monkeypox virus is a less efficient human pathogen than

85 Monkeypox virus is an emerging, zoonotic orthopoxvirus w

86 Monkeypox virus is an Orthopoxvirus (genus includes vari

87 Monkeypox virus is believed to be predominantly transmit

88 Clade I monkeypox virus is endemic in DR Congo.

89 uses smallpox) is the most pathogenic, while monkeypox virus is intermediate in pathogenicity between

90 Mpox, caused by the monkeypox virus, is a serious public health threat in Af

91 Monkeypox virus (MPV) is a virulent human pathogen that

92 Monkeypox virus (MPV) is an orthopox virus in the Poxvir

93 monstrate that the Poxviridae family members monkeypox virus (MPX) and variola virus (VarV) use conse

94 We identified two lineages of monkeypox virus (MPXV) among two 2021 and seven 2022 US

95 In this review, 50 questions regarding monkeypox virus (MPXV) and the current MPX outbreak were

96 a virus (VACV) antigens B5, A27, and A33 and monkeypox virus (MPXV) antigens E8, B6, B2, M1, A27, A35

97 cted on surface carriers inoculated with the monkeypox virus (MPXV) by applying six disinfectant solu

98 The basic biology of monkeypox virus (MPXV) can be inferred from other poxvir

99 Infection with monkeypox virus (MPXV) causes disease manifestations in

100 which modified M1, A35 and B6 proteins from monkeypox virus (MPXV) clade Ia are conjugated individua

101 ria in 2019-2020 reveal multiple lineages of monkeypox virus (MPXV) co-circulated in humans for sever

102 Here we determined the apo structure of monkeypox virus (MPXV) Core(Pro) and the structure of Co

103 Monkeypox virus (MPXV) disease has been declared a publi

104 timing and zoonotic and geographic origin of monkeypox virus (MPXV) emergence in humans.

105 llected weekly to estimate the time to clear monkeypox virus (MPXV) from skin lesions.

106 from GISAID and GenBank were used to analyse monkeypox virus (MPXV) genetic diversity.

107 While the monkeypox virus (MPXV) genome encodes a homologue of the

108 e prevalence of large deletions in clade IIb monkeypox virus (MPXV) genomes during the global 2022 ou

109 On May 6, 2022, a powerful outbreak of monkeypox virus (MPXV) had been reported outside of Afri

110 Monkeypox virus (MPXV) has been linked to vertical trans

111 spring 2022, the global epidemiology of the monkeypox virus (MPXV) has changed.

112 The resurgence of monkeypox virus (MPXV) has increased demand for validate

113 Monkeypox virus (MPXV) has recently caused a global dise

114 Recurrent mpox outbreaks caused by the monkeypox virus (MPXV) have prompted the World Health Or

115 The 2022 global outbreak of Monkeypox virus (MPXV) highlighted challenges with polym

116 resulted from zoonotic spillover of clade I monkeypox virus (MPXV) in Central Africa and clade II MP

117 RNAscope detected abundant replication of monkeypox virus (MPXV) in epithelial cells and dendritic

118 ivity has been associated with the spread of monkeypox virus (MPXV) in the ongoing, global 2022 epide

119 In early 2022, a cluster of monkeypox virus (MPXV) infection (mpox) cases were ident

120 nd unvaccinated patients, and hypotheses for monkeypox virus (MPXV) infection after vaccination.

121 Monkeypox virus (MPXV) infection has recently expanded i

122 Mpox, caused by monkeypox virus (MPXV) infection, has emerged as a signi

123 Monkeypox virus (MPXV) infections in humans cause neurol

124 The spread of nonzoonotic monkeypox virus (MPXV) infections necessitates the reeva

125 A global outbreak of clade IIb Monkeypox virus (MPXV) infections spread rapidly across

126 Monkeypox virus (MPXV) is a human pathogen that is a mem

127 Monkeypox virus (MPXV) is a poxvirus endemic to Central

128 Monkeypox virus (MPXV) is a reemerging virus of global c

129 Monkeypox virus (MPXV) is an orthopoxvirus closely relat

130 Monkeypox virus (MPXV) is an orthopoxvirus closely relat

131 Infection of nonhuman primates (NHPs) with monkeypox virus (MPXV) is currently being developed as a

132 Monkeypox virus (MPXV) is endemic in Africa, where it ca

133 Monkeypox virus (MPXV) is endemic in western and Central

134 Monkeypox virus (MPXV) is endemic within Africa where it

135 Monkeypox virus (MPXV) is genetically structured in 2 ma

136 Monkeypox virus (MPXV) is the causative agent of mpox, a

137 nd clinical data associated with 18 cases of monkeypox virus (MPXV) isolated from 19 clinical samples

138 was caused by a subclade IIb descendant of a monkeypox virus (MPXV) lineage traced back to Nigeria in

139 The 2003 monkeypox virus (MPXV) outbreak and subsequent laborator

140 The monkeypox virus (MPXV) outbreak confirmed in May 2022 in

141 The ongoing monkeypox virus (MPXV) outbreak is the largest ever reco

142 Monkeypox virus (MPXV) poses a global health emergency,

143 Since 2022, two human-adapted monkeypox virus (MPXV) strains have caused large outbrea

144 Pathology and Monkeypox virus (MPXV) tissue tropism in severe and fata

145 mpox driven by unprecedented human-to-human monkeypox virus (MPXV) transmission, we designed BNT166,

146 ntly, a sustained human-to-human outbreak of monkeypox virus (MPXV), a member of the Orthopoxvirus ge

147 The mpox outbreak, caused by monkeypox virus (MPXV), accelerated the development of m

148 To better understand the occurrence of monkeypox virus (MPXV), an emerging Orthopoxvirus in hum

149 facing a second wave of infections from the monkeypox virus (MPXV), characterized by an exponential

150 the evidence for respiratory transmission of monkeypox virus (MPXV), examining key works from animal

151 Monkeypox virus (MPXV), originally characterized in the

152 (Mpox), a zoonotic illness triggered by the monkeypox virus (MPXV), poses a significant threat since

153 Mpox disease, caused by the monkeypox virus (MPXV), remains a global health concern

154 sing PD-IRIS, we quantitatively detected the Monkeypox virus (MPXV), the etiological agent for Monkey

155 Monkeypox virus (MPXV), which causes disease in humans,

156 x outbreak highlighted the serious threat of monkeypox virus (MPXV), yet effective treatments are lac

157 ssay reliably detected antibody responses in monkeypox virus (MPXV)- and vaccinia virus (VACV)-expose

158 ox, that protected nonhuman primates against monkeypox virus (MPXV)-induced severe disease.

159 e United States following the importation of monkeypox virus (MPXV)-infected animals in a consignment

160 Prior to this outbreak, the durability of monkeypox virus (MPXV)-specific immunity induced by MVA-

161 on of A29 which is the target protein of the monkeypox virus (MPXV).

162 irus (NVO) or confirmed positive for NVO and Monkeypox virus (MPXV).

163 erging zoonotic infectious disease caused by Monkeypox virus (MPXV).

164 Here, we report that cross-reactive monkeypox virus neutralizing antibodies were detectable

165 cted individuals are key factors driving the monkeypox virus (now termed mpox virus or MPXV) outbreak

166 Given the evolving nature of the monkeypox virus, ongoing research and strong public heal

167 The spread of monkeypox virus (Orthopoxvirus monkeypox) clade Ib from

168 t of testing in the United States during the monkeypox virus outbreak and support restricting the num

169 The ongoing monkeypox virus outbreak highlights the need for rapid a

170 An ongoing global monkeypox virus outbreak in 2022 includes the US and oth

171 mergencies, like the SARS-CoV-2 pandemic and monkeypox virus outbreak, continue to have a major effec

172 ata sets of SARS-CoV-2, influenza virus, and monkeypox viruses, outlining the public health utility o

173 ys: RealStar Orthopoxyvirus PCR and FlexStar Monkeypox virus PCR (Altona Diagnostics), Novaplex MPXV

174 The monkeypox virus phylogenetic diversity was geographicall

175 r limit of detection was 200 copies/mL using monkeypox virus plasmids in pooled UTM matrix.

176 oratories successfully implemented the human monkeypox virus primer scheme in various amplicon sequen

177 agnostics), Novaplex MPXV (Seegene), VIASURE Monkeypox virus Real Time PCR Reagents (CerTest Biotec),

178 The poorly understood nature of monkeypox virus reservoirs in both countries is a region

179 protein (OMCP) is conserved among cowpox and monkeypox viruses, secreted by infected cells, and bound

180 equences from this study clustering with two monkeypox virus sequences from the current DR Congo outb

181 Monkeypox virus sequences were obtained and analysed usi

182 d from the coronavirus, the emergence of the monkeypox virus signaled a potential new pandemic, highl

183 Our findings suggest that multiple monkeypox virus strains are co-circulating in the human

184 transmission dynamics and suggests that any monkeypox virus subclade has the potential to cause sust

185 elting temperature [T(m)], 56.40 degrees C), monkeypox virus (T(m), 56.24 degrees C), and vaccinia vi

186 (m)s, 61.7 to 62.7 degrees C), 15 strains of monkeypox virus (T(m)s, 61.9 to 62.2 degrees C), 40 stra

187 lScheme to develop a primer scheme for human monkeypox virus that can be used with many sequencing an

188 nt of smallpox (variola virus), the zoonotic monkeypox virus, the vaccine and zoonotic species vaccin

189 After challenge with monkeypox virus, unimmunized animals developed more than

190 rowth rates of cases by reporting date, when monkeypox virus was confirmed and reported to UKHSA, wer

191 Monkeypox virus was recovered in cell cultures of seven

192 People infected with monkeypox virus were aged between 2 days and 50 years (m

193 In May 2022, individuals infected with the monkeypox virus were detected in the UK without clear tr

194 Individuals who tested positive for monkeypox virus were from Cuvette-Centrale (19 [61%] of

195 s E virus and SARS-CoV-2, and one DNA virus, monkeypox virus, which either primarily or secondarily a

196 uring human infections with the smallpox and monkeypox viruses, which are highly homologous to ectrom

197 % identity in all orthopoxviruses except for monkeypox viruses, whose O3 homologs have 2 to 3 amino a

198 that tested presumptively positive for human monkeypox virus with amplicon-based and metagenomic sequ