ライフサイエンスコーパス: monoester

1 but not tryptamine adenosine phosphoramidate monoester.

2 a lower DeltaG(++) for the phosphorothioate monoester.

3 hydrolysis of the resulting phosphoramidate monoester.

4 pids to yield diacylglycerol and a phosphate monoester.

5 to occur through disproportionation of diol monoester.

6 synthesis of aromatic and aliphatic sulfate monoesters.

7 ting sulfate for the biosynthesis of sulfate monoesters.

8 high-yielding synthesis of protected sulfate monoesters.

9 talyzed hydrolysis of phosphate diesters and monoesters.

10 and wax synthase led to the synthesis of wax monoesters.

11 to values previously reported for phosphate monoesters.

12 ate for AP-catalyzed hydrolysis of phosphate monoesters.

13 s along with some acyclic chloro-substituted monoesters.

14 of the preferential hydrolysis of phosphate monoesters.

15 proximately 10(2)-fold slower than phosphate monoesters.

16 for the nonenzymatic hydrolysis of phosphate monoesters.

17 inorganic phosphate and decreased phosphate monoesters.

18 tudy accounted for less than 6% of the total monoesters.

19 , diverse branching patterns, and 11 sulfate monoesters.

20 corresponding diols and hydrolyzes phosphate monoesters.

21 lyze the hydrolysis of various organosulfate monoesters.

22 x 10(26)-fold for the hydrolysis of sulfate monoesters.

23 ovided first the originally assigned sulfate monoester 1 and then the reassigned and renamed phosphat

24 Acute oral intake of a ketone monoester, 10 g whey protein, or their co-ingestion in t

25 Selected deblocked derivatives, i.e., two monoesters (13 and 14), four phosphonic acids (15-18), a

26 s of the initially produced phosphonoformate monoesters 14, 15, 18, and 20.

27 with optional saponification produces diyne monoester 15 or monoacid 3, which can be further functio

28 nd then the reassigned and renamed phosphate monoester 2, relied on diagnostic (1)H NMR spectroscopic

29 hate (EDNPP) but reacts very slowly with the monoester 2,4-dinitrophenyl phosphate (DNPP).

30 triester 1-CO(2)()Et > diester 2-CO(2)()Et > monoester 3-CO(2)()Et) and may lead to substitution reac

31 We herein used a mixture of four phthalate monoesters (33% mono-butyl phthalate, 16% mono-benzyl ph

32 ed antiviral activity of AZT phosphoramidate monoesters 3a and 4a in PBMCs and CEM cells, the mechani

33 oil, or R-3-hydroxybutyrate-R-1,3-butanediol monoester (3HB-BD ester).

34 No conversion of monoester 4c to phosphonic acid 4a was observed in rats

35 eridine to yield O-ethyl piperidinophosphate monoester (5).

36 cruzi, and Leishmania donovani in vitro.Only monoesters 7-9 with a log P value of >2.7 were active in

37 transformation of 8:2 fluorotelomer stearate monoester (8:2 FTS) in aerobic soils was conducted by mo

38 n number), and the fraction of hydrocarbons, monoesters, acids and alcohols have been determined in 9

39 roduct of the tRNA splicing reaction, to the monoester ADP-ribose 1"-phosphate (Appr-1"p).

40 indings demonstrate that SapM is an atypical monoester alkaline phosphatase, with a serine-based mech

41 Somewhat unexpectedly, a phosphonate monoester also formed stable adducts with the Abs.

42 l antagonist, and certain 12-deoxyphorbol 13-monoesters also function as partial antagonists but with

43 xhibits resonances due to a single phosphate monoester an two pyrophosphates.

44 zymatic transition states for aryl phosphate monoester and aryl methylphosphonate hydrolysis reaction

45 ext, we addressed the preferential phosphate monoester and diester catalysis of PafA and NPP, respect

46 A series of N-S-blocked glutathione monoester and diester derivatives based on N-benzyloxyca

47 Phosphorus monoester and diester organic species were dominant and

48 he effects of thio-substitution on phosphate monoester and diester reactions.

49 l catalytic proficiency for the most similar monoester and diester substrates in the two enzymes.

50 ect ((15)k) in the nitro group, and (for the monoester and diester) the secondary oxygen-18 isotope e

51 negatively charged N3'-->P5' phosphoramidate monoester and positively charged phosphoramidate diester

52 owing EH showed significant decreases in the monoester and pyrophosphate regions, with a correspondin

53 he second ester bond from the 8-5-benzofuran monoester and therefore, ferulic acid esterase A does no

54 ater intracellular levels of phosphoramidate monoester and/or phosphorylated AZT.

55 te contain high amounts of organic P such as monoesters and diesters, compared to the other two sites

56 lcohols is required for the synthesis of wax monoesters and ether lipids.

57 gh levels in tissues known to synthesize wax monoesters and ether lipids.

58 lates into the corresponding carboxylic acid monoesters and mixed esters (including tert-butyl esters

59 R/PMH hydrolyses phosphonate monoesters and phosphate diesters with similar efficienc

60 s contribute to hydrolysis of both phosphate monoesters and phosphate diesters.

61 hates into functional biomass (i.e., phospho-monoesters and phospho-diesters).

62 bait substrates, new hydrolases for sulfate monoesters and phosphotriesters were identified, mostly

63 l reassignment as a phosphate versus sulfate monoester, and the assignment of its relative and absolu

64 , two cis-astaxanthin isomers, 5 astaxanthin monoesters, and 10 astaxanthin diesters (7+/-1mg astaxan

65 selenium adducts were prepared as diesters, monoesters, and dianionic dicarboxylates.

66 lass of enzyme-labile Po, followed by labile monoester- and diester-P.

67 Pyromellitate monoester anhydrides form efficiently in dichloromethane

68 nd their corresponding alcohols and glycerol monoesters are attractive candidates for the components

69 he hydrolytic rates of phosphate and sulfate monoesters are compared directly, and the misleading imp

70 lar metabolism of nucleoside phosphoramidate monoesters are distinct from that of phosphoramidate die

71 , or triester-like, because phosphorothioate monoesters are hydrolyzed by AP approximately 10(2)-fold

72 Alkyl sulfate monoesters are involved in cell signaling and structure.

73 dging bond orders to phosphorus in phosphate monoesters are not significantly altered by differences

74 ibiting submicromolar activities; among them monoesters are particularly active.

75 Wax monoesters are synthesized by the esterification of fatt

76 oth enzymes, despite the fact that phosphate monoesters are the cognate substrates for AP but promisc

77 introduce the dynamic exchange of phthalate monoesters as a novel chemistry platform for covalent ad

78 ferulic acid esterase A was able to release monoesters as products of reactions with all three forms

79 catalytic activity of phage Abs selected by monoester binding was evident.

80 PTPases catalyze the hydrolysis of phosphate monoesters by a two-step mechanism that proceeds through

81 eous hydrolysis of unactivated alkyl sulfate monoesters by S-O bond cleavage.

82 lyisoprenols also were incorporated into wax monoesters by the enzyme.

83 In the monoester case, a more positive DeltaS(++) arising from

84 of 1b that is similar to that of a phosphate monoester complex with the same leaving group, rather th

85 s were better inhibitors of T.b. brucei than monoester compounds, and some displayed high activity ag

86 activity of a series of AZT phosphoramidate monoesters containing amino acid methyl ester (3a-11a) a

87 use of H-phosphonate and H-phosphonothioate monoesters containing the base labile 9-fluorenemethyl p

88 for the reaction of p-nitrophenyl phosphate monoester coordinated to a dinuclear Co(III) complex.

89 fourfold increase in binding of phosphomanan monoester core complex (PPME), a natural mimic of an L-s

90 y different biological properties from their monoester counterparts, and they may be relevant to the

91 ailable B-hydroxybutyrate-(R)-1,3-butanediol monoester (DeltaG; KE-2) diet.

92 able beta-hydroxybutyrate-(R)-1,3-butanediol monoester (DeltaG; KE-2) diet.

93 s a potent herbicide whereas its phosphonate monoester derivative, glyceryl glyphosate, is approximat

94 e than that of the uncatalyzed hydrolysis of monoester dianions (-1.23).

95 The nature of the hydrolysis of phosphate monoester dianions in solutions and in proteins is a pro

96 C, while the rate of hydrolysis of phosphate monoester dianions increases 10,300,000-fold.

97 e energy relationships (LFERs) for phosphate monoester dianions with different leaving groups showed

98 elerate the rates of hydrolysis of phosphate monoester dianions.

99 th the data reported for analogous phosphate monoester, diester, and triester reactions.

100 PMDA in CH2Cl2/Et3N led to the formation of monoesters (e.g., 18) or diesters (11, 12), as needed, r

101 ment of binders that interact with phosphate monoesters; electro-osmosis is used to drive the tagged

102 Addition of alpha,gamma-diesters and alpha-monoesters enhanced chemical stability and provided exce

103 and for the first time palmitate and oleate monoesters esterified with 1-octadecanol and 1-eicosanol

104 tric Lewis acid catalyst (BF(3)), these diol monoesters form dioxonium cation intermediates that are

105 Glycerol monolaurate (GML), a fatty acid monoester found naturally in humans, has been reported t

106 A decrease in the lutein monoesters fraction was observed, coinciding with an inc

107 ne derivatives which include combinations of monoesters, free acids, and amines, some of which are in

108 n cultured cells led to the formation of wax monoesters from straight chain saturated, unsaturated, a

109 ters and six of their metabolites (phthalate monoesters) from highly consumed seafood species.

110 Monoesters, homodiesters and heterodiesters of (all-E)-v

111 A bacterial phosphonate monoester hydrolase was evaluated in plants as a conditi

112 ew member of this superfamily, a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leg

113 between arylsulfatases (ASs) and phosphonate monoester hydrolases (PMHs).

114 of this superfamily, namely the phosphonate monoester hydrolases from Burkholderia caryophylli and R

115 transition state for AP-catalyzed phosphate monoester hydrolysis and support previous models suggest

116 In particular, the phosphate monoester hydrolysis reaction catalyzed by Escherichia c

117 er catalytic proficiency by AP for phosphate monoester hydrolysis relative to sulfate monoester hydro

118 studies suggest that AP catalyzes phosphate monoester hydrolysis through a loose transition state, s

119 the PTPases appear to bring about phosphate monoester hydrolysis through a similar mechanism, there

120 inear free energy relationship for phosphate monoester hydrolysis to explore the effect of modulating

121 - and solvent-assisted pathways of phosphate monoester hydrolysis, and show that the solvent-assisted

122 AP is evolutionarily optimized for phosphate monoester hydrolysis, it is possible that the active sit

123 imental and theoretical studies on phosphate monoester hydrolysis, significant questions remain conce

124 ancement observed for AP-catalyzed phosphate monoester hydrolysis.

125 ate monoester hydrolysis relative to sulfate monoester hydrolysis.

126 rate enhancement for AP-catalyzed phosphate monoester hydrolysis.

127 tically distinct possibilities for phosphate monoester hydrolysis.

128 In solution phosphate monoesters hydrolyze via a highly dissociative mechanism

129 f a ketone d-beta-hydroxybutyrate (D-betaHB) monoester in fasting healthy participants with ultrahigh

130 beta-lactamases are inhibited by phosphonate monoesters in a reaction that involves phosphonylation o

131 o the behavior and manipulation of phosphate monoesters in molecular biology.

132 rgy surfaces for the hydrolysis of phosphate monoesters in solution, establishing quantitatively that

133 For instance, 72-84% of the detected monoesters in the organic soils of this study were actua

134 ietary R-3-hydroxybutyrate- R-1,3-butanediol monoester increases resting energy expenditure (REE) and

135 tudy aimed to evaluate the effects of ketone monoester intake and elevated blood beta-hydroxybutyrate

136 ion of pyrophosphate to form a metaphosphate monoester intermediate or formation of a circular phosph

137 The chloro-substituted monoester is formed by initial Pd(II)-Cl insertion acros

138 Only a resonance due to phosphate monoester is observed after removal of the noncovalent c

139 Subsequent deblocking to reveal sulfate monoesters is accomplished in near-quantitative yield.

140 The hydrolysis of simple phosphate monoesters is among the most difficult reactions that ar

141 hopanoid, bacteriohopanetetrol phenylacetate monoester, is vesicle-specific.

142 determine whether the ingestion of a ketone monoester (KE) drink before a 2-h oral-glucose-tolerance

143 ch D-beta-hydroxybutyrate-(R)-1,3 butanediol monoester [ketone ester (KE)] replaced equicaloric amoun

144 Ingestion of higher doses of a ketone monoester (KME) supplement have been shown to lower bloo

145 Exogenous ketone monoester (KME) supplements rapidly increase plasma beta

146 (CALF-25), which contains a new phosphonate monoester ligand, was synthesized through a hydrothermal

147 ions, CYP4B1 covalently binds heme through a monoester link furnished, in part, by a conserved I-heli

148 We introduce a strategy to capture phospho-monoester lipids and improve the detection of long-chain

149 nambiguous structural identification of four monoesters (lutein 3'-O-linoleate, lutein 3-O-linoleate,

150 general, this work suggests that phosphonate monoesters may provide a novel molecular tool for determ

151 condensation of an amine with H-phosphonate monoesters, mediated by a coupling agent, followed by ox

152 the presence of large amounts of circulating monoester metabolites, which pose significant developmen

153 iastereomerically pure phenylphosphonic acid monoester monoamide led to the formation of P-stereogeni

154 inhibitory than similar monoacid-monoester, monoester-monoamide, or diester derivatives.

155 Monoesters, monoamides, and diamides tested generally ex

156 0-fold more inhibitory than similar monoacid-monoester, monoester-monoamide, or diester derivatives.

157 ed a stereoselective dianion alkylation of a monoester of 1,2-cyclohexanedicarboxylic acid and an ann

158 le in six steps from 2-bromovanillin and the monoester of methyl 6-hydroxycyclohexene-1-carboxylate.

159 nephosphonic acids replace the two phosphate monoesters of 1, 3-BPG and lead to several stable, tight

160 ulting ketoaldehyde afforded the important 1-monoesters of 2-ketoalkanedioic acids.

161 A series of phosphoramidate monoesters of 3'-azido-3'-deoxythymidine (AZT) bearing a

162 ic solvents, regardless of the DES used; the monoesters of astaxanthin with C18-fatty acids were the

163 cle glycogen contained covalent phosphate as monoesters of C2, C3, and C6 carbons of glucose residues

164 f intramolecular condensation of a series of monoesters of dicarboxylic acids have been shown to be h

165 ters prepared from enantiomerically enriched monoesters of disubstituted malonic acid.

166 often pictured as polyoxyethylated sorbitan monoesters of saturated and/or unsaturated fatty acids.

167 alkaline hydrolysis of neutral arylsulfonate monoesters or charged phosphate diesters and fluorophosp

168 lectivity for hydrolysis of either phosphate monoesters or diesters, we have measured a promiscuous s

169 sterified with myristic and palmitic acid as monoesters or diesters, were found.

170 tial specificity for hydrolysis of phosphate monoesters or phosphate diesters.

171 s were also measured for the reaction of the monoester p-nitrophenyl phosphate by Ce(IV) bis-Tris pro

172 ropyl phosphodiester spacer (S), a phosphate monoester (p), or a hydroxyl group (h).

173 tivation for the hydrolysis reactions of the monoesters, p-nitrophenyl phosphate and p-nitrophenyl ph

174 atidylinositol 4-phosphate, which contains a monoester phosphate attached to its myo-inositol headgro

175 VII and protein C bind preferentially to the monoester phosphate of PA because of its accessibility a

176 tor VII and protein C bind preferentially to monoester phosphates, which may have implications for th

177 cleavage have previously been reported to be monoester phospholipids, which would result from substra

178 ce oral bioavailability of the corresponding monoester phosphoramidate.

179 first step for the hydrolysis of a phosphate monoester (pNPP(2-)) in enzymes of the alkaline phosphat

180 in the transition state of reactions of the monoester pNPPT is more advanced than for its phosphate

181 in flow, enabling multigram synthesis of the monoester products.

182 effect of the chain length of the fatty acid monoester promoieties was examined.

183 ved for mezerein, for the 12-deoxyphorbol 13-monoesters prostratin or 12-deoxyphorbol 13-phenylacetat

184 ability of GpdQ to hydrolyze the phosphonate monoesters provides an alternative selection strategy in

185 ingested one of the following: 1) the ketone monoester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (KET)

186 As methylene phosphonate monoesters react modestly faster than phosphate diesters

187 is reaction and similar to the PP1-catalyzed monoester reaction.

188 tion in sebaceous gland lipids (wax diesters/monoesters, sterol esters).

189 t/Km)S conditions, the methylene phosphonate monoester substrate dCCCUCUT(mp)TA4 (where mp indicates

190 of DiFMU approximately 4.7) in the phosphate monoester substrate makes the assay highly sensitive.

191 h the nonbridging oxygen(s) of the phosphate monoester substrate provides a substantial amount of the

192 Ser102, and the negatively charged phosphate monoester substrate.

193 e phosphodianion-binding energy of phosphate monoester substrates is used to drive conversion of thei

194 The enzymatic hydrolysis of a series of aryl monoester substrates yields a Bronsted beta(lg) of -0.32

195 69) and similar to the beta(lg) measured for monoester substrates, indicative of similar transition s

196 hydrolysis reactions with several phosphate monoester substrates.

197 o discriminate between phosphate diester and monoester substrates.

198 The C5-C6 rotameric populations of 6-O-monoesters, symmetrical 6,6'-diesters, and 2,6,6'-triest

199 ferase 1 and 2 enzymes, exhibited modest wax monoester synthesis activities.

200 The data suggest that wax monoester synthesis in mammals involves a two step biosy

201 Among the phosphonate monoesters tested, the hydrolysis product of rVX, isobut

202 ation of the alkylphosphonic acids and their monoesters, the influence of pH on these separation syst

203 enzyme catalyzes the hydrolysis of phosphate monoesters through a loose, dissociative transition stat

204 mixture of myristoleic acid and its glycerol monoester to construct vesicles that were Mg(2+)-toleran

205 rees C for hydrolysis of a series of sulfate monoesters to a pK(a)(LG) value of 16.1, typical of an a

206 oups may undergo transfer from alkyl sulfate monoesters to biological target molecules.

207 oducts and a higher proportion of carotenoid monoesters to diesters compared to ripe fruits were obse

208 Building from phosphate monoesters to diesters may have enabled the synthesis of

209 A) over tryptamine adenosine phosphoramidate monoester (TpAd).

210 lar-weight (MW) model study shows that these monoesters undergo fast transesterification via a dissoc

211 Evidence indicates that phosphate monoesters undergo hydrolysis by a loose transition stat

212 A wide range of benzylic phosphonic monoesters underwent clean ortho-arylation in high yield

213 lyzed ortho-arylation of benzylic phosphonic monoesters using potassium aryltrifluoroborates.

214 etween these two, the less complex palmitate monoester was chosen to demonstrate that dog plasma nalm

215 metal complex of the p-nitrophenyl phosphate monoester was found to hydrolyze by a single-step concer

216 e and a series of substituted aryl phosphate monoesters, we demonstrate that the preferred mechanism

217 ffects of desolvation of dianionic phosphate monoesters were carried out, and the possible effect of

218 ofin, palmitate, oleate and hydroxypalmitate monoesters were detected, and for the first time palmita

219 cholesterol, C31 diene/triene, and three wax monoesters were detected, representing some of the large

220 s of up to 982 ng g(-1) (d.w.) and phthalate monoesters were found at concentrations of up to 178 ng

221 Monoesters were identified as the predominant products (

222 The monoesters were reacted with different fatty acids to gi

223 rms of diesters, only the 5-5- and the 8-O-4-monoesters were substrates for the enzyme, forming the c

224 s method, and several phthalate diesters and monoesters were successfully quantified.

225 P itself, preferentially hydrolyze phosphate monoesters, whereas others, such as nucleotide pyrophosp

226 Fostriecin is a unique phosphate monoester which exhibits weak topoisomerase II inhibitio

227 or the hydrolysis of a series of phosphonate monoesters which are the hydrolysis products of the high

228 is was mimicked by incubating cells with GSH monoester, which increased intracellular GSH similarly t

229 f the spontaneous hydrolyses of aryl sulfate monoesters, which proceed by S-O cleavage.

230 ide derivatives 7 of their (R)-mandelic acid monoesters, which provided access to the individual dias

231 ze a variety of chemically diverse phosphate monoesters while making contacts solely to the transferr

232 ur substitution accelerates the rates of the monoesters while slowing the rates of diesters and of tr

233 ondensation reaction of H-phosphonoselenoate monoesters with amines promoted by iodine as an oxidizin

234 es of the reactions of a series of phosphate monoesters with different leaving groups.

235 s the synthesis of a series of oligofructose monoesters with fatty acids of different chain length (C

236 ert aryl olefins to the corresponding glycol monoesters with high chemo- and diastereoselectivity.