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1 al, whereas moDC-generated cells were mostly monofunctional.
2 contain a single carboxyl group, making them monofunctional.
3 er time, with CD8(+) responses becoming more monofunctional.
4 ys after both vaccinations and was primarily monofunctional.
8 catalysts are discussed, organized into: (1) monofunctional, (2) M/NH bifunctional, and (3) aromatiza
9 is N-acetylated, supporting the concept that monofunctional acetylation is an activation, rather than
12 ducts of bifunctional activation to those of monofunctional activation was 6-20-fold higher at the ac
14 ow a site-specific phenanthriplatin-DNA d(G) monofunctional adduct affects the Pol II elongation and
16 of the chloride ligands, forms highly potent monofunctional adducts on DNA having a structure and spe
17 nor groove of DNA, are the first examples of monofunctional adenine adducts of divalent platinum form
18 ally differentiated T cells, the presence of monofunctional Ag-specific T cells, and increased expres
20 sed on the type of mediated transformations: monofunctional (alkene and alkyne metathesis), bifunctio
21 apn2Delta strain enhances sensitivity to the monofunctional alkylating agent methyl methanesulfonate
24 he DNA ligase I mutant cell line 46BR.1G1 to monofunctional alkylating agents, indicating that a cyto
25 and crosslinking agents but not sensitive to monofunctional alkylating agents, UV, or ionizing radiat
27 resistance of tumor cells to treatment with monofunctional alkylators, implicating inhibition of APE
29 satility of this reaction can be extended to monofunctional amines and alcohols, yielding a variety o
30 h N,N'-p-phenylenedimaleimide (pPDM) and its monofunctional analog phenylmaleimide (PM) were measured
35 inally, subtle structural variations between monofunctional and bifunctional enzymes point to how the
37 enzoylglycine as a substrate at pH 6.0 using monofunctional and bifunctional monooxygenase activities
39 ll responses and examined the frequencies of monofunctional and dual functional Th1/T cytotoxic type
40 lts in significantly enhanced frequencies of monofunctional and dual functional Th1/Tc1 and Th17/Tc17
41 , in contrast, diminishes the frequencies of monofunctional and dual functional Th2/Tc2 and Th9/Tc9 c
42 is characterized by elevated frequencies of monofunctional and dual-functional CD4(+) Th1 cells foll
43 n the spontaneous and Ag-specific Fo of both monofunctional and dual-functional Th1 cells compared wi
44 zed by a parasite Ag-dependent regulation of monofunctional and dual-functional Th1, Th2, and Th17 ce
45 also exhibited significantly decreased Fo of monofunctional and dual-functional Th17 cells upon Ag st
46 oth the spontaneous and the Ag-induced Fo of monofunctional and dual-functional Th2 cells was signifi
47 he HD vaccine elicited significantly greater monofunctional and polyfunctional CD4+ and CD8+ T-cell r
48 f Mycobacterium tuberculosis H37Rv encodes a monofunctional and secreted chorismate mutase (*MtCM) wi
49 +) T cells from SYMP individuals were mostly monofunctional and were directed mainly against nonoverl
51 y of damaged bases and is therefore either a monofunctional AP lyase or may be a glycosylase-lyase on
52 on are available, but similar studies of the monofunctional archaeal enzyme that catalyzes only GTP-d
53 mosome 2 is coincident with genes encoding a monofunctional Asp kinase 2 and a bifunctional Asp kinas
54 t), threonine (Thr), and isoleucine involves monofunctional Asp kinases (AKs) and dual-functional Asp
55 ional isozyme, with an artificially produced monofunctional aspartokinase I, or with a fusion constru
56 l enzyme was also created between the native monofunctional aspartokinase III, an allosteric enzyme r
57 bifunctional ATP sulfurylase/APS kinase and monofunctional ATP sulfurylases shows a limited number o
62 movement of the linker group is seen at the monofunctional binding step from changes of chemical shi
65 The differences in redox behavior of the monofunctional bis(imino)acenaphthene (BIAN) and bifunct
67 ting in Negishi cross-couplings between four monofunctional branch (dendritic) modules and the tetraf
69 enzymes for this detoxification include the monofunctional catalases KatB and KatE and the bifunctio
74 her species, however, these enzymes occur as monofunctional catalytic activities on separate enzymes.
76 contrast, symptomatic individuals have more monofunctional CD44(high)CD62L(high)CD8(+) central memor
80 gene expression but generated low-frequency, monofunctional CD8(+) T lymphocytes with restricted anat
82 tions (p < 0.001), and a lower proportion of monofunctional cells (p < 0.001) compared with terminall
84 ted in ASYMP individuals compared to more of monofunctional central memory CD62L(high) CD44(high) CD8
85 there were frequent less-differentiated and monofunctional central memory CD8(+) T cells (TCM cells)
86 ontrol was achieved through the inclusion of monofunctional chain transfer agents during the polymeri
88 , providing genetic evidence for the role of monofunctional chromium-DNA adducts in the toxic effects
89 agreement with the calculated values for the monofunctional cinnamic acid, as well as the multifuncti
90 lycosyltransferases and transpeptidases, and monofunctional class B PBPs with only transpeptidase act
91 cently, however, it was established that the monofunctional class B PBPs work together with transmemb
92 e revealed a large TPS family, including the monofunctional class I diTPS PxaTPS8, which converts ger
94 ts of orthologous PbdiTPSs and PcdiTPSs were monofunctional class I enzymes that lacked functional cl
96 s an additional function to the portfolio of monofunctional class II diTPSs, which catalytically most
97 s-I/II diterpene synthases (diTPSs), whereas monofunctional class-II and class-I enzymes operate in a
98 in gymnosperms were characterized, including monofunctional class-II enzymes forming labda-13-en-8-ol
101 ncRNA targeting in A549 and IMR90 cells, the monofunctional complex may not cause toxicity in normal
103 nd decrease in stoichiometry relative to the monofunctional compound, supporting the overall design s
105 ing cisplatin as well as other, less active, monofunctional compounds such as [Pt(NH3)3Cl](+) and cis
106 ffluent from the first flow reactor contains monofunctional compounds, such as alcohols, ketones, car
108 both synthesize and hydrolyze alarmones) and monofunctional (consisting of only synthetase or hydrola
109 (II) complexes with trans geometry or with a monofunctional coordination mode, polynuclear platinum(I
110 This inhibitor, however, is unique in being monofunctional, cyclic and far shorter (14 amino acid re
112 cle with TArgeting Binders), a plug-and-play monofunctional degradation platform that can drag extrac
115 plastoquinone-9 has driven the evolution of monofunctional demethylnaphthoquinol methyltransferases
117 their covalent structure in the presence of monofunctional diols that competed for bonding with the
118 The domain organization resembles that of monofunctional diterpene synthases and is consistent wit
121 dentified a previously unrecognized group of monofunctional diTPSs in T. cryptomerioides, which sugge
122 correlated with increased resistance to the monofunctional DNA alkylating agent methyl methanesulfon
126 ble for processing spontaneous, chemical, or monofunctional DNA glycosylase-initiated AP sites via it
128 n DNA polymerase beta, are hypersensitive to monofunctional DNA methylating agents such as methyl met
130 though they exhibit increased sensitivity to monofunctional DNA-alkylating agents, but not to other D
131 ships that may apply to the entire family of monofunctional DNA-damaging agents and pave the way for
134 limiting step in the kinetic pathway for the monofunctional E. coli enzyme is the release of product,
135 yl-CoA isomerases revealed the presence of a monofunctional enoyl-CoA isomerase (ECI) in addition to
136 belongs to the aroQ class of CMs, encodes a monofunctional enzyme (AroQf) able to complement the CM
137 identical assays were performed with a known monofunctional enzyme (uracil DNA glycosylase) and a kno
138 ed synthetic acceptors implicated PamC1 as a monofunctional enzyme capable of generating a beta-(1 ->
139 odynamic signatures of ligand binding to the monofunctional enzyme differ significantly from those me
140 omains 40% to 60% identity with the exported monofunctional enzyme of Pseudomonas aeruginosa (PheC).
141 evolved from bifunctional diTPS rather than monofunctional enzymes (TPS-c and TPS-e) of gibberellin
145 e functionally divided into two classes: the monofunctional enzymes that catalyze only biotin additio
146 hown for bifunctional PutAs, but whether the monofunctional enzymes utilize an analogous channeling m
147 ional type I polyketide synthases (PKSs) and monofunctional enzymes via two complementary tools: Retr
148 dissociated FASII system, which consists of monofunctional enzymes, and acyl carrier protein (ACP) a
149 dation, which can be catalyzed by individual monofunctional enzymes, multifunctional enzymes comprisi
158 d detailed biochemical characterization of a monofunctional feedback-insensitive HSD from any plant.
159 the C-H bond cleavage were measured for the monofunctional form of the enzyme using a double-label t
160 ing differences between the bifunctional and monofunctional forms of the dihydrofolate reductase enzy
161 of these enzymes and their relationships to monofunctional FUKs and GFPPs are poorly understood.
165 ths after ART, IRIS patients were strikingly monofunctional (generally interferon gamma alone), even
168 ufficient, in the case of MutY, to convert a monofunctional glycosylase to a bifunctional glycosylase
169 , we observed tissue-specific alterations in monofunctional glycosylase-initiated BER activity, e.g.
172 o the DNA glycosylase MutY: both enzymes are monofunctional glycosylases, which are trappable to thei
174 ed by mutagenesis study and the structure of monofunctional glycosyltransferase in complex with moeno
175 ccus aureus membrane-bound transglycosylase, monofunctional glycosyltransferase, in complex with a li
176 ass B penicillin-binding proteins (PBPs) and monofunctional glycosyltransferases and by bifunctional
177 inireview, we highlight the discovery of the monofunctional glycosyltransferases RodA and FtsW and de
178 n contrast, fungi and Chlorella virus encode monofunctional guanylyltransferase polypeptides that lac
179 h type of reference sensor (bifunctional and monofunctional) has a distinctive structural feature, wh
182 and the protonated amines are the strongest monofunctional hydrogen bond acids that we have studied.
183 The carboxylate anions are the strongest monofunctional hydrogen bond bases, and the protonated a
184 GDP leaving group in the ground state and a monofunctional hydrogen bond donor in the transition sta
185 -65 mutants, suggesting this residue to be a monofunctional hydrogen bond donor to the GDP leaving gr
186 c T-lymphocytes were predominantly TNF-alpha monofunctional in pregnant and postpartum women living w
187 potential enzyme forms (bifunctional versus monofunctional) in the plant biotin pathway are unknown.
189 Michael acceptors and phenolic antioxidants (monofunctional inducers), and reactive oxygen species (R
191 operties of the hybrids, which form the same monofunctional-intercalative DNA adducts as the parent c
193 ple bonds, there is no evidence for a stable monofunctional intermediate-only starting material and t
195 ith aspartokinase III, a naturally occurring monofunctional isozyme, with an artificially produced mo
197 donor sites of HIV-1 integrase, whereas the monofunctional L-708,906 derivative binds selectively to
198 single base change: the D297G mutant of the monofunctional l-Ala-d/l-Glu epimerase (AEE) from Escher
200 ross-linking of SH1 and SH2 groups and their monofunctional labeling with NPM are ascribed to the inh
202 rther stabilization is realized by replacing monofunctional ligands with difunctional versions that c
204 ority of TD HIV-specific CD8(+) T cells were monofunctional (median 69% [interquartile range: 57-83])
206 nion binding constant that exceeds that of a monofunctional model compound by almost 4 orders of magn
208 SH1-SH2 cross-linking and those due to their monofunctional modification, we used S1 with the SH1 and
209 ed homing endonuclease, was grafted into the monofunctional Mycobacterium xenopi GyrA intein at the p
210 he yeast Saccharomyces cerevisiae contains a monofunctional NAD(+)-dependent 5,10-methylenetetrahydro
213 on of N,N'-dimethylacrylamide (DMAC) using a monofunctional or bifunctional trithiocarbonate-capped p
214 hydrolase 1 (Aph1), the founding member of a monofunctional (p)ppApp hydrolase family of enzymes.
215 ional (p)ppGpp synthetase/hydrolase, and two monofunctional (p)ppGpp synthetases, YwaC and YjbM.
216 domain protein RmdB from S. venezuelae is a monofunctional PDE that hydrolyzes c-di-GMP to 5'pGpG.
218 her demonstrate that, unlike the traditional monofunctional peroxidases, the oxyferrous state in DHP
219 and mouse PECI, a novel gene that encodes a monofunctional peroxisomal Delta(3),Delta(2)-enoyl-CoA i
220 rocesses the most abundant DNA lesion of the monofunctional phenanthriplatin anticancer drug candidat
221 PAM-1; although release of newly synthesized monofunctional PHM/H3A was increased, release of soluble
223 DeltaG++ = approximately 23 kcal/mol for the monofunctional platination of guanine, our model gives D
225 r DNA adducts, further supporting a role for monofunctional platinum anticancer agents in human cance
229 henanthridinechloroplatinum(II), is a potent monofunctional platinum complex that displays a spectrum
230 ))(6)NH(2)[cis-PtCl(2)(NH(3))]](+) contain a monofunctional platinum coordination sphere linked to a
232 hloroplatinum(II), cDPCP or pyriplatin, is a monofunctional platinum(II) analogue of the widely used
233 ical and biological properties of a cationic monofunctional platinum(II) complex, cis-diammine(pyridi
236 of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds like {Pt(dien)}(2+
240 erococcus faecalis gene coaB encodes a novel monofunctional PPCS which has been cloned into pET23a an
244 se enolase superfamily, we discovered that a monofunctional progenitor could acquire the ability to c
246 ike spinach is apparently a consequence of a monofunctional protein methyltransferase incapable of me
247 , whereas, in most other organisms, FARs are monofunctional proteins of similar size and domain struc
248 nic transcript potentially encoding separate monofunctional proteins that can be produced following a
252 PyrD (encoded by At4g20960) is known to be a monofunctional pyrimidine deaminase, but no pyrimidine r
254 (pol II) complex stalled at a site-specific monofunctional pyriplatin-DNA adduct in the active site.
257 Modification of Cys707 with the fluorescent monofunctional reagents 7-diethylamino-3-(4'-maleimidylp
259 presentative bis-glutathione conjugate and a monofunctional reference compound indicates that the biv
263 st CCR5, plus a marker epitope (AU1), or its monofunctional RNAi-carrying homologue, SV(RNAiR5).
264 that a bifunctional sensor is better than a monofunctional sensor both at amplifying changes in the
267 ies of the reagents toward SH2, the rates of monofunctional SH2 modification on SH1-labeled S1 were a
268 s metallopolymer can be controlled by adding monofunctional subcomponents to end-cap the conjugated l
269 in can be further dissected into overlapping monofunctional subdomains, since purified peptides displ
272 odular PKSs along with physically separated, monofunctional TEs (TE IIs) has been reported for a numb
276 homolog may preferentially cooperate with a monofunctional transglycosylase as the alternative sourc
277 s engineered onto the homologous domain of a monofunctional transmembrane variant of the rPACAPR (rPA
278 molecular explanations for the existence of monofunctional transpeptidases and glycosidases (glycosi
279 hesized and evaluated alongside an analogous monofunctional triphenylphosphine acrylamide (TPPAm).
280 TS reactivity in human and Escherichia coli monofunctional TS and in T. gondii and Leishmania major
281 tural and mechanical regulation of entangled monofunctional UPy-PEG fibrils by cross-linking bifuncti
285 ase DNA glycosylase, single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1), and local
287 e that contains both ketones and alcohols to monofunctional variants with bulk properties superior to
288 Animals given either the bifunctional or the monofunctional vector were largely protected from KA-ind
289 ussion is organized according to the number (monofunctional versus bifunctional materials) and type o
291 wever, most of the approaches are static and monofunctional, which can only reduce building energy co
292 ter suppressed if the transmitting sensor is monofunctional, which is the more appropriate design whe
294 on, is very much polyfunctional (rather than monofunctional), yet polyfunctional for reasons we had n
295 bifunctionality in the largest genomes, to a monofunctional, yet not necessarily specialized, ineffic