ライフサイエンスコーパス: monomer

1 d gold nanoparticles (AuNPs), and functional monomer.

2 XPA binds and bends DNA by ~60 degrees as a monomer.

3 an additional density consistent with an SLN monomer.

4 isplays a much higher chiral purity than the monomer.

5 lymerization of a bicyclic beta-lactam sugar monomer.

6 molecule and 1-vinylimidazole as functional monomer.

7 he cytotoxicity of high levels of arrestin-1 monomer.

8 of 5-LO, and 53 molecules (62, 156) of FLAP monomer.

9 obenzeneboronic (p-ABA) acid as a functional monomer.

10 ver three domains of one capsid protein (CP) monomer.

11 -B without any increase in abundance of UVR8 monomer.

12 ated with the Lewis basicity of the polar co-monomers.

13 highly functionalized aromatic and aliphatic monomers.

14 d penultimate subunit accessible for binding monomers.

15 radiating single crystals of suitably packed monomers.

16 without prior knowledge of the number (n) of monomers.

17 th mussel-inspired lysine- and aromatic-rich monomers.

18 wer-level neutralizing antibodies induced by monomers.

19 activation and dissociation of ACE2-bound S1 monomers.

20 ilitates the circular reutilisation of these monomers.

21 of monomers and hydrophobic hydration in the monomers.

22 a lateral chain aggregation initiated by PEG monomers.

23 ibits (almost) barrierless TICT rotations in monomers.

24 e amyloid fibril formation by recruitment of monomers.

25 itutions to levels that are not tolerated in monomers.

26 same monomer but adjacent in two neighboring monomers.

27 ug monomers with hepatocyte-targeting GalNAc monomers.

28 ergistic effect upon coassembly of the three monomers.

29 nyl)diquinoxalino[2,3-a:2',3'-c]phenazine as monomers.

30 as dimers, but to a control RNA primarily as monomers.

31 lymerization from biomolecule functionalized monomers.

32 mers accelerates the aggregation reaction of monomers.

33 r dimers can diffuse more rapidly than water monomers.

34 ely populated high free energy states of the monomers?

35 The reversible recognition of monomer 4 and P for Al(3+) was also proved in presence o

36 -electron microscopy, structures for the p53 monomer (~50 kDa) and tetramer (~200 kDa) were resolved

37 The self-assembling monomer, a bridge-expanded homolog of [2.2]paracyclophan

38 ymerizing an anthracene-functionalized epoxy monomer, a diepoxy comonomer, and a dicarboxylic acid cu

39 oupled conformational fluctuation of protein monomers, a dewettinglike transition with the change of

40 ibrils encoded in the conformations that the monomers access at equilibrium?

41 for the conversion of amorphous PET film to monomers across all nonzero MHETase concentrations teste

42 e effector binding surfaces on each subunit; monomers adopted a typical small G protein fold.

43 compared (that is, incorporated as separate monomers) against a monomer architecture in which the ca

44 O(2) preferentially distributing the pyrrole monomers along with the silk internal fibrillar structur

45 The accurate translation of reads into the monomer alphabet turns the notoriously difficult problem

46 ctive complex combining one WT and one D274A monomer also stalled after one electron was transferred

47 is incorporated into a dimer, compared to a monomer analogue.

48 P4H-TM was found both as a monomer and a dimer in the solution, but the monomer-dim

49 diads) reported to date, which occurred when monomer and catalyst stereochemistry were fully matched

50 t modern haemoglobin evolved from an ancient monomer and characterize the historical 'missing link' t

51 s of magnetic field-dependent phthalocyanine monomer and dimer absorption spectra.

52 ted-state dimer, as well as exchange of both monomer and dimer species with high-molecular-weight oli

53 also present the solution structure of OAS1 monomer and dimer, comparing their hydrodynamic properti

54 AR-V7 can enter the nucleus as a monomer and drive a transcriptional program and DNA-dama

55 Herein, we showed that OSGEPL1 is a monomer and is unique in utilising C34 as an anti-determ

56 The interaction mode between the functional monomer and the monoanions was elucidated by (1)H NMR ti

57 rices, are reconstituted by co-incubation of monomers and amyloid fibers.

58 ent by amyloid fibrils both by competing for monomers and blocking secondary nucleation sites.

59 mposed of custom-designed anion and receptor monomers and demonstrates the utility of emerging functi

60 showed that MSA-2 exists as interconverting monomers and dimers in solution, but only dimers bind an

61 tude difference in (-)ESI efficiency between monomers and dimers is expected to be broadly applicable

62 included residual intensities for protonated monomers and fragment ions with characteristic drift tim

63 he exchange dynamics of non-covalently bound monomers and hence requires fine microstructure control.

64 We use mass photometry to observe tubulin monomers and heterodimers in solution simultaneously, th

65 nalysis revealed that the set of known human monomers and HORs remains incomplete.

66 it ppt(v) limits of detection for protonated monomers and hundred ppt(v) limits of detection for prot

67 tance R(MM) from ~4 to ~2 nm, orientation of monomers and hydrophobic hydration in the monomers.

68 "block," were built from positively charged monomers and neutral oligo-ethyleneoxy monomers, where c

69 versions tested previously were presented as monomers and not in their natural dimer configuration.

70 kinetics with a critical nucleus of size ~7 monomers and that the efficiency of nucleation were foun

71 estimate such models simultaneously both for monomers and their dimers have been missing.

72 hat MsrB2 selectively reduces oxidized actin monomers and thereby counteracts MICAL1, an enzyme known

73 dditionally, we demonstrate an example where monomers (and oligomers) obtained from the hydrogenation

74 tranded DNA with cytosine-rich stick ends (C-monomer) and are internalized into cells through lysosom

75 ic (cryo-EM) maps, limit binding to incoming monomers, and flatten the terminal subunit, which likely

76 e tetramer apart into inactive beta-tryptase monomers, and may provide an alternative strategy for an

77 (EDI)- and EDII-targeted response, while the monomer antigens stimulated an EDIII epitope response an

78 ructural properties of water between the two monomers approach bulklike characteristics at a separati

79 incorporated as separate monomers) against a monomer architecture in which the catechol and amine wer

80 onal and stereoisomeric dimers from a single monomer are lacking.

81 globulin-like ZPN and ZPC subdomains of each monomer are separated by a long linker that interacts wi

82 stals, growth dominates over nucleation when monomers are added slowly, so as to limit their concentr

83 e to monomer concentration, which changes as monomers are depleted during growth.

84 Bio-derived monomers are efficiently polymerized to make block polye

85 mbled particles composed of esterified cutin monomers, are involved in the synthesis of the procuticl

86 rolled and iterative fashion, releasing each monomer as a 2-oxazolidinone.

87 emic solid serine generates a neutral serine monomer as the principal species in the vapor phase, wit

88 o the free energy of interaction between the monomers as well as into monomer exchange mechanisms and

89 How BAX monomers assemble into a higher-order conformation, and

90 on of these non-canonical, backbone-extended monomers at the N- and C- terminus of peptides using wil

91 Profilin's differential affinities for actin monomers, barbed ends and polyproline are thus tuned to

92 rming an atomically structured channel, four-monomer-based random heteropolymers (RHPs)(14) can mimic

93 ationic RAFT polymerization of a vinyl ether monomer bearing a secondary dormant RAFT agent, which su

94 chanical response of an HA chain as aggrecan monomers bind and form a bottlebrush.

95 Because TALE monomers bind the idealized symmetrical lac operator seq

96 A new study reports that the actin-monomer-binding protein profilin 1 dictates protrusion c

97 n of a known product, confirmed to be the Vi monomer both de-O- and de-N-acetylated by mono- and bidi

98 Individual monomers bound each other in a short-pitch helix complex

99 ) are located >40 angstrom apart in the same monomer but adjacent in two neighboring monomers.

100 predicted from the interactions between two monomers but is an emergent result of multibody interact

101 we not only monitor configuration of protein monomers, but also the properties of water.

102 ynthesized by copolymerizing traditional PSA monomers, butyl acrylate and acrylic acid, with mussel-i

103 One such protein, NS1, encoded as a monomer by the viral genome, plays a major role via symm

104 omplex formation, and (iii) fast exchange of monomers by competitive substitution, which together ena

105 The 28-36 identified monomers (C(7-10)H(10-18)O(3-6)) constitute 15.6-20.5% o

106 eation of Alzheimer-associated Abeta peptide monomers can be catalyzed by preexisting Abeta fibrils.

107 defined polymers derived from nonpolar vinyl monomers can be efficiently prepared using early transit

108 (e.g. BSA, HSA, GOx, beta-galactosidase) and monomer classes including acrylates, methacrylates, styr

109 hers under ambient conditions with excellent monomer compatibility.

110 ational experiments to define a spherical 24-monomer complex composed of 12 HSP27 dimers with a phosp

111 5HD) assembles as tetrameric forms with each monomer composed of 12 alpha-helices and 9 beta-sheets.

112 , and microfluidics to independently control monomer composition and polymer height of each pixel.

113 olecular design in conjunction with rational monomer composition can direct architecture, self-assemb

114 of these patterned surfaces are dependent on monomer composition, polymer height, and brush distribut

115 rmation of Ag nanocubes as a function of PVP monomer concentration (C(m)) and molecular weight (M(w))

116 second-order and first-order dependences on monomer concentration, respectively.

117 thesizing or activating monomers to regulate monomer concentration, stabilizing growth conditions eve

118 ntrol because it is exquisitely sensitive to monomer concentration, which changes as monomers are dep

119 tic analyses of aggregation data at multiple monomer concentrations reveal that all seven mutants ret

120 Each monomer contains nine transmembrane helices (TMs), six o

121 an acyl transferase enzyme that links cutin monomers, contributes to massive cuticle deposition duri

122 of this Ru-(OH)(n) complex not only reduces monomer conversion and catalyst lifetime but also influe

123 salt additives, and catalyst loading on ROMP monomer conversion and catalyst lifetime.

124 evaluated the use of a new collagen-reactive monomer (CRM), isocyanate-terminated urethane methacryla

125 Co-localization of monomers, crosslinkers, and chain-transfer agents (CTA)

126 ates dimer and monomer photoreception, dimer/monomer cycling, abundance of native COP1 and RUP protei

127 For that, functional monomers derivatized with substituents forming stable co

128 onent supramolecular polymer by the rational monomer design and paves the way toward the use of multi

129 ochemical applications, which concerns novel monomer design, chemical methodology/strategy establishm

130 tly, and crystal structures of the M204-scFv monomer, dimer, and trimer revealed conformational diffe

131 at at endogenous levels most of TRKA is in a monomer-dimer equilibrium and that the binding of NGF in

132 monomer and a dimer in the solution, but the monomer-dimer equilibrium was not regulated by Ca(2+).

133 mbly either as a tail-to-tail dimer, showing monomer-dimer sigmoidal transitions, or as a head-to-tai

134 ation (CID) of avidin tetramers into compact monomers, dimers, and trimers with cross sections consis

135 Whereas many of these proteins bind actin monomers directly, formins use the actin-binding protein

136 especially considering the easily accessible monomer diversity and peptoid helical folding propensity

137 the pre-organization of H-bonding containing monomer during network curing.

138 ation reduces the cytotoxicity of arrestin-1 monomer, ensuring long-term photoreceptor survival.SIGNI

139 n bonding in the [3.3]paracyclophane and (b) monomer entropy associated with the scissoring motion of

140 ned by their intermolecular interactions and monomer exchange dynamics and hence structural predictio

141 raction between the monomers as well as into monomer exchange mechanisms and dynamics, which have a c

142 rovided useful mechanistic insights into the monomer exchange rates and free energy of interactions b

143 specimens were UV-sterilized (8 J/cm(2)) and monomer extracted in growth medium (1, 3 or 7 days).

144 bination of all three factors produces actin monomers faster than any two factors alone.

145 ting packaging (considering plasticisers and monomers) followed by HDPE bottles, in the case of phtha

146 reasing due to its successful application as monomer for the manufacture of bioplastics.

147 The DEC-205 monomer forms a compact structure comprising two interca

148 se methods can at least reliably distinguish monomers from dimers and trimers.

149 hod for synthesizing acyclic diketene acetal monomers from diols and vinyl ether, and their polymeriz

150 , this technique was then applied to hairpin monomers functionalized with a mutant green fluorescent

151 of tannin acyl-hydrolase hydrolyzing HTs, CT monomer gallates and depsides - has been reported in mic

152 ysis in neutral pH water, whereas the Co-TPP monomer gives a 50 % mixture of H(2) O(2) and H(2) O.

153 es with (essentially) random combinations of monomer glycoforms; (4) native top-down sequence analysi

154 omes in a DNA binding site-dependent manner: Monomer Gsx2 binding represses transcription, whereas ho

155 ture of core-substituted naphthalene diimide monomers has been further utilized to characterize the t

156 ind that both nucleotide states of the actin monomer have significantly less twist than their crystal

157 tic cleft and recruit FEN1 to one unoccupied monomer in a toolbelt fashion.

158 an interspace of ~41 angstrom of microtubule monomer in cells.

159 Oncogenic BRAF(V600E) signals as an active monomer in the absence of active RAS, however, in many t

160 nd that membrane-bound Dvl2 is predominantly monomer in the absence of Wnt (observed mean size 1.1).

161 rm higher-order oligomers that arrange MRAP2 monomers in a parallel orientation.

162 ng cysteine mutations that cross-link sigma1 monomers in nonreducing conditions.

163 rmula: see text]) states, which resemble the monomers in the fibril structure.

164 ze tough viscoelastic matrices from acrylate monomers in the presence of woven fabrics, which generat

165 ates via entropy-driven randomization of the monomers in the rosette.

166 e system and application to diverse acrylate monomers, including the synthesis of well-defined di- an

167 longation by directly regulating the rate of monomer incorporation at the barbed end.

168 orescence, and how profilin binding to actin monomers increases the fluorescence.

169 g amyloid than antibodies that recognize the monomer, indicating that the ability of random sequences

170 revealed unmodeled densities between protein monomers, indicative of lipids that likely mediate conta

171 s, the electrostatic interaction between two monomers induces an integrative self-sorting of rosettes

172 blood at low concentrations, these exist as monomers, initiating cellular signals.

173 zation, which disrupts the ideal ordering of monomers inside fibrin protofibrils and fibers.

174 y that in the absence of phosphatase, CaMKII monomers integrate over Ca2+ signals of certain frequenc

175 1-KWL1-b heterotetramer in which each KWL1-b monomer interacts with a monomer of the Cmu1 homodimer.

176 In the E isomer form, the chiral m-BTA monomers intercalate into stacks of a-BTA and dictate th

177 tic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mit

178 involves the insertion of a single acrylate monomer into the Pd(II)-polyolefin intermediates, which

179 myloid-beta (Abeta) peptide aggregation from monomers into amyloid fibrils, a hallmark of Alzheimer's

180 triggering a rapid isomerization of 1-alkene monomers into internal olefins by adding a Lewis acid.

181 mediated polymerization of backbone-extended monomers into polypeptides is challenging due to their p

182 an their crystal structures and that the ATP monomer is flatter than the ADP form.

183 Surface charge distribution within each monomer is remarkably asymmetric, revealing probable pro

184 Web show that the monomer is stabilized at low pH and that its backbone ch

185 f natural building blocks into polymerizable monomers is inefficient, requiring multistep synthesis a

186 In contrast, the activity of INP monomers is less affected by pH changes.

187 l (G) lignin, the other major type of lignin monomer, is derived from polymerization of coniferyl alc

188 When the ACD dimer dissociates into monomers, it partially unfolds and exhibits enhanced act

189 hanced upon addition of a second achiral BTA monomer, leading to a perfect control of the helicity ei

190 as well as a seven-coordinate uranium-methyl monomer, {Li(OEt(2) )Li(OEt(2) )(2) UMe(7) Li}(n) were b

191 is the export of the lipid-linked cell wall monomer, Lipid II, by its transporter MurJ.

192 aments, which we estimate to be less than 20 monomers long, to the membrane.

193 es, we propose a dynamic equilibrium between monomer <-> dimer <-> tetramer <-> hexamer, which become

194 formed from mNBH could be reduced to mainly monomers (<100 kDa) after enzymatic digestion of nucleic

195 In the design, a tetratopic monomer (M) was prepared with two terminal alkynes in th

196 mentary measurements and calculations on the monomer Mn(acac)(3), we conclude that the wavepacket mot

197 te lignin polymerization by oxidizing lignin monomers (monolignols).

198 ulations suggest that AimB binds MreB at its monomer-monomer protofilament interaction cleft and that

199 n which each KWL1-b monomer interacts with a monomer of the Cmu1 homodimer.

200 Each component monomer of the Top2 homodimer nicks one of the DNA stran

201 The X-ray structure of a truncated monomer of Type III Dio (Dio3), which deiodinates TH inn

202 s are present as apparently freely diffusing monomers on the surface of a simple cell model.

203 res before being ultimately degraded back to monomers once the fuel is consumed.

204 g protein profilin to dynamically load actin monomers onto their flexible Formin Homology 1 (FH1) dom

205 Zn(2+) via the essential histidines than the monomer or a dimer with the histidines in the periphery.

206 Isolated M(pro)C can exist as a monomer or a domain-swapped dimer.

207 G-quadruplex (antiparallel, hybrid, parallel monomers or a 48 nt sequence with two contiguous quadrup

208 However, Galpha proteins can exist either as monomers or in a complex with Gbetagamma, and the detail

209 ith the chemical or physical crosslinking of monomers or macromers.

210 ng serving as solvents, porogens, functional monomers, organic surface modifiers, dummy templates, an

211 m copolymers in which the D and A1 units are monomers originating from PM6 or PM7, while the A2 unit

212 re IL-12 (p40:p35), IL-23 (p40:p19), the p40 monomer (p40), and the p40 homodimer (p40(2)).

213 phase space across a range of compositions, monomer pairs, and molecular weights (up to 50000 amu),

214 ce via electropolymerization of some organic monomers, particularly p-aminobenzenesulfonic acid (p-AB

215 iodic conditions that incorporates dimer and monomer photoreception, dimer/monomer cycling, abundance

216 ls, involving key synthetic elements such as monomer/polymer building blocks, cross-linkers, and func

217 P1 and RUP proteins, and interactions of the monomer population with COP1, RUP2 and potentially other

218 such as sugars, furanics, and lignin-derived monomers pose significant disadvantages in process econo

219 -(aminomethyl)cyclopentane-1-carboxylic acid monomer precursor, which has a cis-configuration between

220 itors, and bicyclic carbohydrate-beta-lactam monomers prepared by the alkene-isocyanate method.

221 DA), one of the most used natural functional monomers, provided the inspiration for this work.

222 th optically or electronically complementary monomers provides an attractive bottom-up approach for t

223 are neutral in multimers but deleterious in monomers; purifying selection would then prevent reversi

224 ein we show that electron-deficient Grignard monomers readily polymerize under visible-light irradiat

225 actin nucleation function by blocking actin monomer recruitment.

226 ficacy in a colitis mouse model, whereas the monomer reduces disease symptoms.

227 tereoselective polymerization of polar vinyl monomers remain underdeveloped.

228 Lacritin monomer restores homeostasis via autophagy and mitochond

229 atios of isocyanurate and triethylene glycol monomers, reveals highly tunable mechanical response far

230 oupled the computer-designed VLP not only to monomers (SARS-CoV-2) but also to cyclic dimers (Newcast

231 Expansion of the monomer scope to include enantioenriched vinyl ethers en

232 growing understanding of factors that drive monomer self-assembly to form supramolecular polymers, t

233 the sensors, including different functional monomers, sensing platforms and materials employed to ac

234 Three oligomers were synthesized with monomer sequence precisely dictated by the placement of

235 ur results show that oligomers with specific monomer sequences exhibit unexpected and distinct charge

236 evaluate the foldability of the 148 designed monomer sequences, where all of them were predicted to f

237 upled together in a fixed orientation in the monomer side chain.

238 and varying amounts of a water-soluble ionic monomer, sodium styrenesulfonate.

239 The enabling key principle is to design monomer species having kinetically selected molecular re

240 re complex architectures from polyfunctional monomers, species formed out of equilibrium have, to thi

241 ic biopolymers utilize defined sequences and monomer-specific molecular recognition to store and tran

242 We examined UVR8 dimer/monomer status, gene expression responses, amounts of ke

243 rotein ion channels assembled with incorrect monomer stoichiometries.

244 Here, we show that cis-inducing NtBu achiral monomers strategically positioned within chiral sequence

245 rimazole-bound AcCYP51 adopted a typical CYP monomer structure, isavuconazole-bound AcCYP51 failed to

246 ied mostly on imparting functionality to the monomer structures through covalent modification, or thr

247 A systematic analysis using monomer substitution patterns established that sequence-

248 with bioactive hydrogels using bi-functional monomers such as poly(pyrrole-co-3-pyrrolylbutyrate-conj

249 roduction of adipic acid from lignin-derived monomers, such as catechol, is a greener alternative to

250 The experimental parameters, such as monomer/template ratio, electropolymerization cycle and

251 inter-atomic hotspot interactions between VP monomers that are important for the assembly of 3 types

252 ons-long filamentous structures from protein monomers that are nanometers in size.

253 rize complex molecules into smaller, soluble monomers that can be respired by microbes.

254 and free energy of interactions between the monomers that dictate the self-assembly pathway and sequ

255 rt because the antigens utilized were mainly monomers that did not display quaternary-structure epito

256 epot is a polymeric prodrug synthesized from monomers that incorporate an ARV drug tenofovir alafenam

257 k has shed light on the structure of the LPL monomer, the inactive oligomer remained opaque.

258 process by cleaving polyubiquitin chains to monomers, their function has not been studied in detail

259 l delta is anchored to one of the three PCNA monomers through the C-terminal domain of the catalytic

260 -mediated RAFT polymerization of a different monomer, thus completing the synthesis of bottlebrush po

261 incorporate adjacent functionalities within monomers to act as directing groups and impart molecular

262 ltiple structural dynamic steady states from monomers to dimers, oligomers of dimers, and randomized

263 s the microscopic metal-ion binding to Abeta monomers to its macroscopic impact on the peptide self-a

264 Drug release converts those monomers to more hydrophilic pendant groups via linker c

265 reviously proposed local conversion of actin monomers to polymers, we demonstrate a surprising role f

266 fset depletion by synthesizing or activating monomers to regulate monomer concentration, stabilizing

267 ver, mechanisms to acylate (or charge) these monomers to transfer RNAs (tRNAs) to make aminoacyl-tRNA

268 larity provided by the chemical diversity of monomers, to achieve uniform behaviour in heterogeneous

269 rom R (relaxed), which is highly favored for monomers, to T (tense), which is favored for subunits in

270 e ligand-binding CRD2 subdomain retained the monomer-to-dimer ratio of the unliganded wild-type TNFR1

271 Their results demonstrate a pH-dependent monomer-to-dimer transition, clear evidence of membrane

272 This micellar to monomer transition may involve complex thermodynamic int

273 oustic signal generation efficiency than the monomer transition.

274 A monomer trap assay also shows that the combination of al

275 P), 640 triplex dimer (Tri2) and 320 triplex monomer (Tri1) subunits.

276 mmetry was obtained from achiral diacetylene monomers triggered with unpolarized UV light.

277 talyst concentration, initiator species, and monomer type were investigated.

278 f a dynamic polymer constructed from achiral monomer units can be disproportionately biased.

279 By enchaining a small fraction of chiral monomer units, the helical sense of a dynamic polymer co

280 orders of magnitude larger than those of the monomer units.

281 lled co-polymerisation of EDOT and EDOT-COOH monomers, using tetrabutylammonium perchlorate as a soft

282 ulting poly(dihydrofuran) can be recycled to monomer via depolymerization with Grubbs catalyst or deg

283 To further analyze novel monomers, we applied SD to the set of recently generated

284 r valuable chemicals or to their constituent monomers, what facilitates the circular reutilisation of

285 The serine monomer, when the flux is sufficient, assembles into the

286 arged monomers and neutral oligo-ethyleneoxy monomers, where certain designs were found to greatly en

287 a conserved interface between capsid protein monomers, where it interferes with capsid-protein-mediat

288 are more fibrillar and deprotonated than the monomers, whereas they are less ordered than the final f

289 synthesized new functional and cross-linking monomers, which are oxidized at sufficiently low potenti

290 et of prebiotically plausible xenobiological monomers, which can hydrolytically interconvert between

291 HhaI, in contrast, acts as a monomer with only one catalytic site, and cleaves the DN

292 To accomplish this, we have designed monomers with a nonplanar structure that arises from ste

293 dexamethasone (Dex, a potent GC)-containing monomers with distinctively different linker chemistries

294 was exploited to copolymerize these prodrug monomers with hepatocyte-targeting GalNAc monomers.

295 sy structure as primarily isolated phosphate monomers with N incorporated in both apical and as bridg

296 An accurate accelerated design of bis-MPA monomers with orthogonally complementary moieties and a

297 uine were first synthesized as prodrug vinyl monomers with self-immolative hydrolytic linkers or cath

298 g changes in the conformational behaviour of monomers, with a possible link to aggregation pathways a

299 pparent trimer (220 kDa) composed of ~70 kDa monomers, with an optimum pH of 7.8.

300 distinct from G-actin, meaning that incoming monomers would need to undergo isomerization that would