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1 ture of species with either Lys-40 or Lys-55 monomethylated.
2 tes 1j-l showed similar mode selectivity, as monomethylated 1j exhibited exclusively [4 + 2] reactivi
3     The three most potent analogues were the monomethylated (3R)-7-hydroxy-N-[(1S,2S)-1-{[(3R,4R)-4-(
4     The first synthesis of all five possible monomethylated [4]dendralenes has been achieved via two
5 A levels at the same site despite its unique monomethylating activity and the lack of any evidence fo
6                    In contrast, signals from monomethylated adenines decay monoexponentially.
7    The pattern of lifetimes measured for the monomethylated adenines suggests a special role for the
8                The DNA base adenine and four monomethylated adenines were studied in solution at room
9 amines undergo methylation reaction to yield monomethylated amines or ketones in moderate to good iso
10           A series of N,N-dimethylated and N-monomethylated analogues of N,N-dimethyl-2-(2'-amino-4'-
11 hemagglutinin-PRMT5 complex was also able to monomethylate and symmetrically dimethylate bovine histo
12 e-existing "old" histones continue to be K79-monomethylated and -dimethylated at a rate equal to the
13 re methylated and show that cellular Fmrp is monomethylated and asymmetrically dimethylated.
14 tivity, catalyzing the formation of omega-NG-monomethylated and asymmetrically omega-NG,NG-dimethylat
15 e demethylase that specifically demethylates monomethylated and dimethylated histone H3 at K4.
16 e malignant brain tumor (MBT) repeats, binds monomethylated and dimethylated lysines, but not trimeth
17 ternal urinary concentrations of iAs and its monomethylated and dimethylated metabolites (MMAs and DM
18 erentiated keratinocytes, where it was found monomethylated and dimethylated on Lys104 and interacted
19 ) under the formation of its corresponding N-monomethylated and N,N'-dimethylated species, respective
20 is a potent substrate for Prmt5-Mep50 and is monomethylated and symmetrically dimethylated at Arg-187
21 ining H3 peptides, and discriminates against monomethylated and unmodified counterparts.
22 as encoding Tam, an O-methyltransferase that monomethylates and detoxifies trans-aconitate, instead e
23 roM) and potentiated the cytotoxicity of the monomethylating antitumor agent Temozolomide by approxim
24 , including those with trimethylated Lys-20, monomethylated Arg-3, and the novel dimethylated Arg-3 (
25 MT9 at arginine 508, which takes the form of monomethylated arginine (MMA) and symmetrically dimethyl
26 ymmetric dimethylarginine (Type II PRMT), or monomethylated arginine (Type III PRMT).
27  initially found to generate only omega-N(G)-monomethylated arginine residues in small peptides, sugg
28 , inorganic arsenate (</= 20 muM), trivalent monomethylated arsenic (MMA3+, </= 1 muM), and trivalent
29 senite are consistent with a scheme in which monomethylated arsenical produced from arsenite is the s
30 s and/or iAs metabolites, measured as %iAs, %monomethylated arsenicals (MMAs), and %dimethylated arse
31 residue, trimethylated at Lys-3 by Rkm2, and monomethylated at Arg-66.
32 wild-type strains, it was found that 78% was monomethylated at both Lys-40 and Lys-55 and that 22% wa
33 l product of the RPL42A and RPL42B genes) is monomethylated at Lys-40 and Lys-55.
34 ts of G9a-like protein (GLP) recognizes RelA monomethylated at Lys310.
35 omains defined by the presence of histone H3 monomethylated at lysine 4.
36 at they preferentially bind histone peptides monomethylated at lysine residues with no apparent seque
37 haromyces cerevisiae), is stoichiometrically monomethylated at position 243, producing a 3-methylhist
38                 We provide evidence that O-8-monomethylated benzo[a]pyrene-7,8-catechol is formed in
39 n at the 4'-position of the dimethylated and monomethylated benzylamines differently influenced SERT
40 s spectrometric analyses reveal that RelA is monomethylated by Set9 at lysine residues 314 and 315 in
41                                              Monomethylated catechol from 4-OH-tam was formed at a 3-
42 er of benzo[a]pyrene-7,8-catechol as the O-8-monomethylated catechol.
43 identified SETD6 as a methyltransferase that monomethylated chromatin-associated transcription factor
44                             An unsymmetrical monomethylated cyclic unsaturated acetal leads to hypero
45 d significant quantities of precorrin-1, the monomethylated derivative of uroporphyrinogen III.
46 iochemical level and find that histone H3 is monomethylated, dimethylated, and trimethylated on lysin
47              PKMTs catalyze the formation of monomethylated, dimethylated, or trimethylated products,
48 itoleoylphosphatidylethanolamine (DPoPE), or monomethylated dioleoyl phosphatidylethanolamine (DOPE-M
49  to 31 amino acids, were incorporated into N-monomethylated dioleoylphosphatidylethanolamine (DOPE-Me
50 d processes in phosphatidylethanolamine or N-monomethylated dioleoylphosphatidylethanolamine systems.
51               We next demonstrate that SETD6 monomethylates E2F1 specifically at K117 in vitro and in
52  requires the combined activities of a H3K27 monomethylating enzyme (PRC2 containing WT EZH2 or EZH1)
53              Methylseleninic acid (MSA) is a monomethylated form of selenium effective in inhibiting
54 ause it is stable in solution and provides a monomethylated form of selenium that can be reduced by c
55 eriments to decipher the biosynthesis of the monomethylated FuFA, methyl 9-(3-methyl-5-pentylfuran-2-
56 d aberrantly elevated H3K27me3 and decreased monomethylated H3K27 (H3K27me1) and dimethylated H3K27 (
57 y demethylates di- and trimethylated but not monomethylated H3K27.
58                         Histone H3K27 can be monomethylated (H3K27me1), dimethylated (H3K27me2), or t
59 reover, a Mut11 mutant showed global loss of monomethylated H3K4 (H3K4me1) and an increase in dimethy
60 s) and resulted in a substantial decrease in monomethylated H3K4 (H3K4me1) and chromatin interaction
61 n analyses, phosphorylated H3T3 (H3T3ph) and monomethylated H3K4 (H3K4me1) are inversely correlated w
62                                      Whereas monomethylated H3K4 (H3K4me1) is found throughout the ge
63  and, together, they prevent accumulation of monomethylated H3K4 (H3K4me1) over the FLC gene body.
64  airway epithelial cells and is enriched for monomethylated H3K4 histones (H3K4me1).
65 le transcriptional enhancers are marked with monomethylated H3K4.
66 ing genes by virtue of its high affinity for monomethylated H3K4.
67                      The MLR COMPASS complex monomethylates H3K4 that serves to epigenetically mark t
68 erminal PR/SET domain of Riz1 preferentially monomethylates H3K9.
69                                   Similarly, monomethylated H4 Lys-20 and H3 Lys-9 partitioned togeth
70   Consistent with this, detailed analysis of monomethylated H4 Lys-20 and H3 Lys-9 revealed that both
71 ne a novel trans-tail histone code involving monomethylated H4 Lys-20 and H3 Lys-9 that act cooperati
72                                              Monomethylated H4-K20 is detected on condensed chromosom
73 s unique properties, including enrichment of monomethylated H4K20 and H3K27, which correlate with the
74                                     Set8 and monomethylated H4K20 are virtually undetectable during G
75                        The selective loss of monomethylated H4K20 at the RUNX1 promoter resulted in t
76 riptional regulatory pathway in vivo whereby monomethylated H4K20 binds the L3MBTL1 repressor protein
77                     Importantly, the lack of monomethylated H4K20 in the human K562 multipotent cell
78                    We therefore propose that monomethylated H4K20 is involved in the maintenance of p
79                      The lack of PR-Set7 and monomethylated H4K20 resulted in a number of aberrant ph
80                                 By contrast, monomethylated H4K31 is enriched in the core body of T.
81 e methyltransferase SET8 is the sole PKMT to monomethylate histone 4 lysine 20 (H4K20) and its functi
82                                MLL4 and MLL3 monomethylate histone H3K4 and contain a set of uncharac
83                                              Monomethylated histone H3 lysine 4 (H3K4me1), together w
84 ly discovered that normal cellular levels of monomethylated histone H3 lysine 9 (H3K9me1) were also d
85 ed a novel trans-tail histone code involving monomethylated histone H4 lysine 20 (H4K20) and H3 lysin
86                                              Monomethylated histone H4 lysine 20 (H4K20me1) is tightl
87 n of Prdm2, a histone methyltransferase that monomethylates histone 3 at the lysine 9 residue (H3K9me
88 heterodimer composed of KMT9a and KMT9B that monomethylates histone H4 at lysine 12 (H4K12me1), as an
89 imer composed of KMT9alpha and KMT9beta that monomethylates histone H4 at lysine 12 (H4K12me1), as an
90 n-fold histone lysine methyltransferases and monomethylates histone H4 at lysine 12 (H4K12me1).
91 re, we demonstrate that PR-SET7/SETD8, which monomethylates histone H4 lysine 20 (H4K20me1), controls
92  histone methyltransferase that specifically monomethylates histone H4 lysine 20 (K20) and is essenti
93 4 methyltransferases and are responsible for monomethylating histone H3K4 on enhancers, which are ess
94 tone methyltransferase in mammals capable of monomethylating histone H4 lysine 20 (H4K20me1).
95 tenance of genomic stability, most likely by monomethylating histone H4K20.
96 HDM1, which mediate demethylation of di- and monomethylated histones.
97 ing either the unmethylated substrate or the monomethylated intermediate.
98 methyl-H3K9 and decreases the release of the monomethylated intermediate.
99 known as Pr-Set7) was previously reported to monomethylate Lys(20) of histone H4.
100 re, we provide evidence to support that SET8 monomethylates Lys(20) of histone H4 during S phase by t
101 rectly interacts with DNMT1 and specifically monomethylates Lys-142 of DNMT1.
102 ain containing methyltransferase reported to monomethylate lysine residues on histone and nonhistone
103 (KDM3A) binds to PGC-1alpha and demethylates monomethylated lysine (K) 224 of PGC-1alpha under normox
104 brain tumor (MBT) domain of PHF20L1 binds to monomethylated lysine 142 on DNMT1 (DNMT1K142me1) and co
105 -1 promoter chromatin, which was enriched in monomethylated lysine 20 at histone H4 (H4K20me1), a mar
106                GATA-1 selectively induced H4 monomethylated lysine 20 at repressed, but not activated
107 reported to have the demethylase activity of monomethylated lysine 9 of histone 3 in vivo.
108 nium ions (126 for acetylated lysine, 98 for monomethylated lysine, and 84 for di-, tri-, and unmethy
109 7/Set8 is a cell-cycle-regulated enzyme that monomethylates lysine 20 of histone H4 (H4K20).
110 ic acid already serves as a preformed active monomethylated metabolite, and this could be an underlyi
111 - and trimethylated myricetins and increased monomethylated myricetin.
112                  In addition to H4K20, SETD8 monomethylates non-histone substrates including prolifer
113 d transmembrane protein 3 (IFITM3) was found monomethylated on its lysine 88 residue (IFITM3-K88me1)
114 ent binding of HP1 to full length histone H3 monomethylated on K9 (H3K9me1).
115 ines exhibited higher SERT affinity than the monomethylated ones, (ii) alkyl, alkenyl, or hydroxymeth
116   PRMTs are a family of proteins that either monomethylate or dimethylate the guanidino nitrogen atom
117 , which demonstrated that HR can demethylate monomethylated or dimethylated histone H3 lysine 9 (H3K9
118               We find that SET8 specifically monomethylates p53 at lysine 382 (p53K382me1).
119 larged active site can favorably accommodate monomethylated peptide and provide sufficient space for
120 p mutant has markedly increased affinity for monomethylated peptide with respect to the WT, suggestin
121 l group transfer, S-adenosylhomocysteine and monomethylated polypeptide dissociate from monomethyltra
122 e, one of the most carcinogenic PAHs, has 12 monomethylated positional isomers (MBAPs).
123             The compounds were identified as monomethylated products by HPLC-MS and NMR.
124 nonregiospecific manner to produce meta/para monomethylated products.
125  and enhancer RNA (eRNA) synthesis from H3K4-monomethylated regions.
126 that the beta-lyase-mediated production of a monomethylated selenium metabolite from Se-methylselenoc
127  in support of our earlier hypothesis that a monomethylated selenium metabolite is important for canc
128                                            A monomethylated selenium metabolite, called methylselenin
129 may have only a modest ability to generate a monomethylated selenium species from Se-methylselenocyst
130  the peptide substrate where turnover of the monomethylated species is negligible.
131 ion involves the transient accumulation of a monomethylated species, suggesting that the MLL1 core co
132        Although L. infantum CYP51 prefers C4-monomethylated sterol substrates such as C4-norlanostero
133 cei (TB), which like plant CYP51 requires C4-monomethylated sterol substrates, TCCYP51 prefers C4-dim
134 human PRMT1 using both an unmethylated and a monomethylated substrate peptide based on the N-terminus
135 tion provides necessary interactions with C4-monomethylated substrates, which Ile cannot.
136              SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa
137 ion; the former dimethylates, and the latter monomethylates, the target nucleotide.
138 predict that SET1 family enzymes should only monomethylate their substrates, mono-, di-, and trimethy
139 inine methyltransferase (PRMT) that strictly monomethylates various substrates, thus classifying it a
140 he AcH4-21 and R1 peptides, as well as their monomethylated versions, indicate, in contrast to a prev

 
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