ライフサイエンスコーパス: morphogen

1 controlled by the duration of exposure to a morphogen.

2 restricted distribution of a lipid-modified morphogen.

3 ing out positional information in the Bicoid morphogen.

4 tral NSC identity became independent of this morphogen.

5 on Sonic hedgehog (SHH) as a main signaling morphogen.

6 appropriate differentiation and response to morphogens.

7 provides a feedback by actively transporting morphogens.

8 mall RNAs are reminiscent of those of animal morphogens.

9 ding cell fate determination are provided by morphogens.

10 ent by mediating the action of Hedgehog (Hh) morphogens.

11 f hESCs by altering the cellular response to morphogens.

12 sses and have become paradigms for classical morphogens.

13 r mCherry) could be converted into synthetic morphogens.

14 d through the action of spatial gradients of morphogens.

15 sed: one is position-dependent and relies on morphogen accumulation at future organ sites; the other

16 Hedgehog proteins are pivotal morphogens acting through a canonical pathway involving

17 As a central model for morphogen action during animal development, the bone mor

18 y morphogen range and the hormonal gating of morphogen action.

19 because of the loss of two distinct modes of morphogen action: 1) maintenance of growth within the wi

20 , much of this diversity emerges through the morphogen actions of Sonic hedgehog (Shh).

21 se data, as well as published information on morphogen activity, we developed a chemomechanical growt

22 eta molecule and well-established long-range morphogen, acts over one cell diameter to maintain the G

23 ermines the final global distribution of the morphogen and enables reproducible patterning.

24 chemicals, and movement and is important for morphogen and growth factor signaling.

25 of experimental data suggests that chemical morphogen and mechanical processes are strongly coupled.

26 for the formation of patterns with a single morphogen and whose fundamental mode pattern robustly sc

27 enetically encoded program in which secreted morphogens and cell-cell interactions prompt the adoptio

28 oncentration leads to the more production of morphogens and increases the growth rate of cells.

29 otein, or YAP) acts downstream of patterning morphogens and other tissue-intrinsic signals to promote

30 distinguish mobile small RNAs from classical morphogens and present a unique direct mechanism through

31 arization and proliferation are regulated by morphogens and signaling pathways.

32 villus tip epithelium and signal through Bmp morphogens and the non-canonical Wnt5a ligand.

33 Long-range signaling by morphogens and their inhibitors define embryonic pattern

34 P and by earlier reports on the spreading of morphogens and vesicles in multicellular organisms.

35 t concrete examples that rapidly readout the morphogen, and predictions for new experiments.

36 Secreted Wnt morphogens are essential for embryogenesis and homeostas

37 Some receptors that sense these morphogens are known to localize to only the apical or b

38 One mechanism by which morphogens are proposed to traverse extracellular space

39 pment, diffusible signaling molecules called morphogens are thought to determine cell fates in a conc

40 nt5a, a member of the Wnt family of secreted morphogens, as an essential factor in maintaining dendri

41 Typical analysis of morphogens assumes that spatial information is decoded i

42 stems, we were unable to correlate the plant morphogen auxin with bud positioning in Sargassum, nor c

43 Our data link morphogen-based patterning to mechanically controlled sm

44 Here, we investigate the role of morphogenes bolA and mreB during CCA using gene expressi

45 r standard culture conditions BMP4 acts as a morphogen but this requires secondary signals and partic

46 ression domains across fields of cells (e.g. morphogens), but how these domains are refined remains u

47 tion by the developing cell of an inhibitory morphogen, but how this cell becomes immune to self-inhi

48 and/or orthogonal gradients of developmental morphogens can be maintained, resulting in neural tube p

49 Thus, spatial information provided by morphogens can be transitioned to epigenetic mechanisms

50 s, the reaction and diffusion of biochemical morphogens, can create these patterns.

51 could be altered by adding feedback loops or morphogen cascades to receiver cell response circuits.

52 proteoglycans interact with growth factors, morphogens, chemokines, and extracellular matrix (ECM) p

53 hat vertebrate Pax6 interacts with a pair of morphogen-coding genes, Tgfb2 and Fst, to form a putativ

54 models where readout is provided not by the morphogen concentration but by its spatial and temporal

55 t of spatial and temporal derivatives of the morphogen concentration can play important roles in defi

56 Morphogen concentration gradients that extend across dev

57 Positional information derived from local morphogen concentration plays an important role in patte

58 erive fundamental limits to the precision of morphogen concentration sensing for two canonical mechan

59 n steady state by measuring the value of the morphogen concentration.

60 ven smaller errors than directly reading the morphogen concentration.

61 nition, gene expression must be sensitive to morphogen concentration.

62 combinations of extracellular cues, such as morphogen concentrations.

63 body content of thyroid hormone (the primary morphogen controlling metamorphosis) and corticosterone

64 etic parameters, like diffusion and decay of morphogens, could play a role in formation of aperture p

65 a wing-a classic paradigm-is governed by two morphogens, Decapentaplegic (Dpp, a BMP) and Wingless (W

66 ducing and -receiving cells to enable direct morphogen delivery.

67 A key question is how morphogen diffusion and gene expression regulation shape

68 t signaling could be due to local changes in morphogen diffusion, representing a novel mechanism in t

69 ctivates the synthesis of its own inhibitory morphogens, diffusion of which establishes the different

70 The Hedgehog (Hh) family of morphogens direct cell fate decisions during embryogenes

71 human haematopoietic stem cells, we perform morphogen-directed differentiation of human pluripotent

72 between adhesion-based self-organization and morphogen-directed patterning.

73 lized signalling filopodia, or cytonemes, in morphogen dispersion and signalling.

74 Recent measurements of morphogen distribution have allowed us to subject this h

75 Buffering variability in morphogen distribution is essential for reproducible pat

76 early Drosophila embryo, measurements of the morphogen Dorsal, which is a transcription factor respon

77 on are paradoxically robust to variations in morphogen dosage, given that, by definition, gene expres

78 gh the formation of concentration gradients, morphogens drive graded responses to extracellular signa

79 Our combined approach of morphogen-driven differentiation and transcription-facto

80 ce of dynamical transients for understanding morphogen-driven transcriptional networks and indicates

81 n of germ layer cells induced by a diffusing morphogen during gastrulation.

82 lighting both the subtlety and importance of morphogen dynamics for understanding mammalian embryogen

83 shape oscillations with tissue mechanics and morphogen dynamics.

84 NODAL, a morphogen essential for embryogenic patterning, is often

85 l communication systems provide insight into morphogen evolution and a platform for engineering tissu

86 the local concentration but also duration of morphogen exposure is critical for correct cell fate dec

87 Synthetic morphogens expressed from a localized source formed a gr

88 y signaling centers, specialized clusters of morphogen-expressing cells.

89 adients, provided the spatial average of the morphogens falls within the region of bistability at the

90 that spreads with minimal loss throughout a morphogen field.

91 During embryogenesis, morphogens form a concentration gradient in responsive t

92 However, in a morphogen-free condition, TET1 deficiency significantly

93 racellular space and the direct transport of morphogen from source cell to target cell, for example,

94 development appears normal, suggesting that morphogens from the skull and dura establish optimal ven

95 Vegf-Dll4/Notch feedback loop underlies the morphogen function of Vegfa in vascular patterning.

96 Notch shaping the interpretation of the Shh morphogen gradient and influencing cell fate determinati

97 By establishing a morphogen gradient at the cellular level, signals become

98 Recent studies of the Drosophila morphogen gradient Bicoid (Bcd), which is required for a

99 The Dpp morphogen gradient derived from the anterior stripe of c

100 induction of Notch ligands by the LIN-3/EGF morphogen gradient during vulva induction in Caenorhabdi

101 e latter half of larval development, the Dpp morphogen gradient emanating from the anterior-posterior

102 omeostasis including growth factor function, morphogen gradient formation, and co-receptor activity.

103 To uncover the minimal requirements for morphogen gradient formation, we have engineered a synth

104 But how the Nodal morphogen gradient forms in vivo remains unclear.

105 To determine how the Nodal morphogen gradient induces distinct gene expression patt

106 egulation reveal how a kinase translates the morphogen gradient input into cellular orientation.

107 t graded mRNA output is a general feature of morphogen gradient interpretation and discuss how this c

108 We use the interpretation of a morphogen gradient into a single stripe of gene expressi

109 have focused on compensatory changes in the morphogen gradient itself.

110 A morphogen gradient of Bone Morphogenetic Protein (BMP) s

111 sal-ventral (DV) embryonic axis depends on a morphogen gradient of Bone Morphogenetic Protein signali

112 The Dorsal morphogen gradient patterns the dorsal-ventral axis of t

113 Thus, the Dorsal morphogen gradient produces three distinct histone signa

114 Thus, growth control by the Dpp morphogen gradient remains under debate.

115 ces differences in patterning time along the morphogen gradient that result in a patterning wave prop

116 rp boundaries and consequently a short-range morphogen gradient that we show is essential for three-d

117 model, the scaling power of the Bicoid (Bcd) morphogen gradient's amplitude nA.

118 ing that Gli TFs are utilized to convey a Hh morphogen gradient, genetic analyses suggest craniofacia

119 l distribution of a signaling molecule, or a morphogen gradient, has been hypothesized to carry posit

120 BMPs would cooperate to establish a unified morphogen gradient.

121 s a paradigm for patterning through a single morphogen gradient.

122 oduce pattern scaling without the need for a morphogen gradient.

123 and destruction collectively shape the Nodal morphogen gradient.

124 ble 3-node network for stripe formation in a morphogen gradient.

125 sion code is regulated by the sonic hedgehog morphogen gradient.

126 This organization arises in response to morphogen gradients acting upstream of a gene regulatory

127 ng have been studied, it remains unclear how morphogen gradients affect this dynamic property of down

128 ded by extracellular soluble factors such as morphogen gradients and cell contact signals, eventually

129 ic inductions as an alternative to classical morphogen gradients and suggests that the range of cell

130 ompting studies into the signaling pathways, morphogen gradients and transcription factors that regul

131 ithelial growth depends on not only chemical morphogen gradients but also mechanical feedback.

132 mechanism by which spatiotemporal changes in morphogen gradients can guide tissue complexity.

133 Morphogen gradients direct the spatial patterning of dev

134 Morphogen gradients expose cells to different signal con

135 How morphogen gradients govern the pattern of gene expressio

136 Soluble morphogen gradients have long been studied in the contex

137 e understanding of biophysical mechanisms of morphogen gradients in order to understand emergent phen

138 proach might be useful to study induction by morphogen gradients in other systems.

139 a potentially favored mechanism to establish morphogen gradients in rapidly expanding developmental s

140 Morphogen gradients induce sharply defined domains of ge

141 et the quantitative information contained in morphogen gradients is an open question.

142 proposed mechanism for interpreting opposing morphogen gradients is mutual inhibition of downstream t

143 or virtually scale-free self-assembly of the morphogen gradients observed in planarian homeostasis an

144 namic reconfiguration of the droplets in the morphogen gradients produces a diversity of membrane-bou

145 Morphogen gradients provide essential spatial informatio

146 Morphogen gradients provide positional information durin

147 which elucidates self-assembly mechanisms of morphogen gradients required for robust body-plan contro

148 Morphogen gradients specify cell fates during developmen

149 titative interrogations of the properties of morphogen gradients that instruct patterning.

150 helial GREM1 disrupts homeostatic intestinal morphogen gradients, altering cell fate that is normally

151 They help form and maintain morphogen gradients, guiding cell migration and differen

152 ns of gene expression in response to dynamic morphogen gradients, provided the spatial average of the

153 ate neural tube is patterned by antiparallel morphogen gradients.

154 of expression and diversify the response to morphogen gradients.

155 mation through the interpretation of dynamic morphogen gradients.

156 sing their position with respect to external morphogen gradients.

157 e mRNA of genes downstream of the Wg and Dpp morphogen gradients.

158 vironmental cues, including light, odorants, morphogens, growth factors, and contact with cilia of ot

159 , gradients of secreted signalling molecules-morphogens-guide this process by controlling downstream

160 nt formation, we have engineered a synthetic morphogen in Drosophila wing primordia.

161 single cell fate, contrary to its role as a morphogen in other developmental systems.

162 y is required to upregulate INHBA/Activin, a morphogen in the TGFbeta superfamily.

163 (bone morphogenetic proteins) are essential morphogens in angiogenesis and vascular development.

164 is supported by data from a wide variety of morphogens in developing Drosophila and zebrafish.

165 ed as a paradigm to characterize the role of morphogens in regulating patterning.

166 gnaling expression gradient, equivalent to a morphogen, in an array of interconnected compartments at

167 Epidermal growth factor, a kidney morphogen, increased displacement of the front row of co

168 h that combines quantitative measurements of morphogen-induced gene expression at single-mRNA resolut

169 Here, we engineer a synthetic morphogen-induced mutual inhibition circuit in E. coli p

170 l and experimental framework for engineering morphogen-induced spatial patterning in cell populations

171 edicts that the final boundary position of a morphogen-induced toggle switch, although robust to chan

172 In the vertebrate neural tube, a morphogen-induced transcriptional network produces multi

173 Although morphogens initially establish NSC positional identity i

174 mbryo development where spatial gradients of morphogens initiate cellular development.

175 d a characteristic decoding map that relates morphogen input to the positional identity of neural pro

176 Here we show that Wnt morphogen instructs stereotyped neurite pruning for prop

177 Instead, morphogen interpretation is shaped by the kinetics of ta

178 Hedgehog (Hh) is a secreted morphogen involved in both short- and long-range signali

179 ding and favors the local enrichment of this morphogen involved in myelin regeneration.

180 PCSK6 activates Nodal, a morphogen involved in regulating left-right body axis de

181 easurement of the temporal change in the Shh morphogen is a plausible mechanism for determining preci

182 reviously we demonstrated that Hedgehog (Hh) morphogen is transported via vesicles along cytonemes em

183 tivity of secreted signaling proteins called morphogens is required for many developmental processes.

184 leal mucosal dynamics as well as a series of morphogen knock-out/inhibition experiments, SEGMEnT prov

185 c stem cells (hESCs) to address how changing morphogen levels influence differentiation, focusing on

186 ves robustness by combining local sensing of morphogen levels with global modulation of gradient spre

187 Auxin, a cardinal plant hormone with morphogen-like properties, has been previously implicate

188 The stiffness gradient requires morphogen-like signaling to regulate BM incorporation, a

189 Further analysis revealed several new morphogenes; loss of one of these, qseC, caused cells to

190 e SHH/GREM1/FGF feedback loop and the Growth/Morphogen models.

191 more precise due to a higher refresh rate of morphogen molecules.

192 igration of cells beyond the gradient of the morphogen Nodal during zebrafish gastrulation.

193 The morphogen Nodal was proposed to form a long-range signal

194 hair follicle development to understand how morphogens operate within closely spaced, fate-diverging

195 nic development through stepwise exposure to morphogens, or by conversion of one differentiated cell

196 ociated with a self-activator-self-inhibitor morphogen pair.

197 The CXCR4 chemokine and Sonic Hedgehog (SHH) morphogen pathways are well-validated therapeutic target

198 brate neural tube are archetypal examples of morphogen-patterned tissues that create precise spatial

199 that are likely to be broadly applicable to morphogen-patterned tissues.

200 incorporating a simple feedback loop between morphogen patterning and tissue stretch reproduces a wid

201 Finally, we compare different hypothetical morphogen patterning mechanisms (Turing, tissue-curvatur

202 size in ferret and mouse, which would allow morphogen patterning of the ferret NP.

203 ited, impeding our ability to understand how morphogen patterns regulate tissue shape.

204 ion gradients of biochemical stimuli such as morphogens play a critical role in directing cell fate p

205 Nodal morphogens play critical roles in embryonic axis formati

206 the described contact sites might facilitate morphogen presentation and reception.

207 mulation with epidermal growth factor, a key morphogen, primarily increased migration of the front ro

208 -drives-growth" model, in which a diffusible morphogen produced at each notch promotes specified isot

209 We find that direct transport establishes a morphogen profile without adding noise in the process.

210 produced WntD directly impinge on the global morphogen profile.

211 Morphogen profiles allow cells to determine their positi

212 on within a developing organism, but not all morphogen profiles form by the same mechanism.

213 kinase, and provides new insight into how Hh morphogen progressively activates Smo.

214 ilage homeostasis, including growth factors, morphogens, proteases, and their inhibitors, and modulat

215 Bone morphogen proteins (BMPs) are distributed along a dorsal

216 sitional information provided by specialized morphogen proteins.

217 rovide an important molecular link between a morphogen (RA) and the expression of KIT protein, which

218 a precedent for the control of organ size by morphogen range and the hormonal gating of morphogen act

219 e studies articulate the principles of multi-morphogen RD patterning and demonstrate the utility of p

220 Our active description couples morphogen reaction and diffusion, which impact cell diff

221 WASH complex component strumpellin or the ER morphogen REEP1.

222 How thresholds in HH morphogen regulate SMO to promote switch-like transcript

223 Morphogens regulate tissue patterning through their dist

224 ork to explain the temporospatial pattern of morphogen-regulated gene expression.

225 and we propose that RTN, like other membrane morphogens, rely on APHs for their function.

226 en cells temporally integrate signals from a morphogen remains unclear.

227 ll arose from the evolutionary cooption of a morphogen-responsive function in wound repair.

228 echanism in which a changing gradient of the morphogen retinoic acid regulates the expression of guid

229 a model, Tissue Expansion-Modulated Maternal Morphogen Scaling (TEM(3)S), to study scaled anterior-po

230 How such localization affects morphogen sensing and patterning in the developing embry

231 Here, we demonstrate a critical role for morphogen sensing by a gene enhancer, which ultimately d

232 ate use of these devices to spatially define morphogen signal gradients and direct peri-gastrulation

233 tors form stereotypic patterns despite noisy morphogen signaling and large-scale cellular rearrangeme

234 ow these inputs are interpreted, we measured morphogen signaling and target gene expression in mouse

235 Morphogen signaling contributes to the patterned spatiot

236 localization and embryo geometry in shaping morphogen signaling during embryogenesis.

237 ng of tissues in embryos and adults, but how morphogen signaling gradients are generated in tissues r

238 CIPF explicitly links graded morphogen signaling in the telencephalon to switch-like

239 Morphogen signaling is critical for the growth and patte

240 (hESCs) in vitro Systematic investigation of morphogen signaling is hampered by the difficulty of dis

241 l tension regulates development by modifying morphogen signaling is less clear.

242 the signaling mechanisms that disperse these morphogen signaling proteins remain controversial.

243 e from biochemical mechanisms that calibrate morphogen signaling strength, a conclusion broadly relev

244 hogenesis over distances beyond the range of morphogen signaling.

245 rganizers that is a secondary consequence of morphogen signaling.

246 This is often achieved using morphogens, signaling molecules that form spatially vary

247 ing establishment and maintenance of BMP/Dpp morphogen signalling during Drosophila wing development.

248 Our data propose a novel mechanism by which morphogen signalling is regulated.

249 time-specific and reversible manipulation of morphogen signalling.

250 er of proteins have been suggested to act as morphogens-signalling molecules that spread within tissu

251 Morphogen signals are essential for cell fate specificat

252 FGF and Hedgehog morphogen signals are required, with FGF providing a dir

253 ered genes that modify the interpretation of morphogen signals by regulating protein-trafficking even

254 In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteris

255 neural tube in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra fi

256 domain of mid1 expression, controlled by the morphogen Sonic hedgehog (Shh).

257 brate forebrain development via the secreted morphogen Sonic hedgehog (Shh).

258 a patterning wave propagating away from the morphogen source with a velocity determined by the intri

259 The morphogen SpmX defines the site of stalk PG synthesis, b

260 The mechanisms by which morphogens spread through a tissue to establish such a m

261 hoices are regulated by interactions between morphogens such as activin/nodal, BMPs and Wnt/beta-cate

262 nized around a coordinate system provided by morphogens such as the TGF-beta homolog Decapentaplegic

263 m (medial patterning center), which produces morphogens such as Wnt3a, generates Cajal-Retzius neuron

264 Spatial distributions of morphogens, such as BMP-4, play important roles in the p

265 odic modulation of the concentrations of the morphogens, sustained by local activation and long-range

266 Despite their simplicity, these morphogen systems yielded patterns reminiscent of those

267 pmental responses to BMP gradients and other morphogen systems.

268 Here we demonstrate a negative role of the morphogen TGF-beta in tempering these signals under phys

269 Wnt3 is a morphogen that activates the Wnt signaling pathway and r

270 ecapentaplegic has long been thought to be a morphogen that controls patterning and growth in Drosoph

271 ssion of genes activated by Dorsal (Dl), the morphogen that patterns the dorsoventral axis.

272 dly, we identified wingless (wg), a secreted morphogen that regulates synaptic growth at the Drosophi

273 limb is dependent on Sonic hedgehog (Shh), a morphogen that regulates the activity of Gli transcripti

274 Dpp, a member of the BMP family, is a morphogen that specifies positional information in Droso

275 f neural progenitors to Shh and BMP, the two morphogens that are responsible for patterning the ventr

276 ts of extracellular metabolites act as tumor morphogens that impose order within the microenvironment

277 Embryogenesis is directed by morphogens that induce differentiation within a defined

278 Hedgehog proteins are secreted morphogens that play critical roles in development and d

279 or neural stem cells with growth factors and morphogens that recapitulate exogenous developmental sig

280 genetic proteins 4 and 7 (BMP4 and BMP7) are morphogens that signal as either homodimers or heterodim

281 is no strict correspondence between specific morphogen thresholds and boundary positions.

282 r two canonical mechanisms: the diffusion of morphogen through extracellular space and the direct tra

283 MuSK interacts with the Wnt morphogens, through its Frizzled-like domain (cysteine-r

284 broblast Growth Factor, FGF8, disperses as a morphogen to establish the rostral to caudal axis of the

285 aginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing th

286 that the BMPs act as concentration-dependent morphogens to direct IN identity, analogous to the manne

287 l reaction-diffusion gradients of artificial morphogens to induce morphological differentiation and s

288 ibuted in gradients subsequently function as morphogens to subdivide the three germ layers into disti

289 anobodies to the receptors of Dpp, a natural morphogen, to render them responsive to extracellular GF

290 al structure, and sets the platform on which morphogens, transcription programs, and synaptic activit

291 simulations and in vivo experiments how Wnt morphogen transport by cytonemes differs from typically

292 migration and apoptosis, independent of the morphogen transport mechanism.

293 We conclude that a cytoneme-mediated morphogen transport together with directed cell sorting

294 etic studies support cytoneme involvement in morphogen transport, mechanistic insight into how they a

295 inimal model combining tissue mechanics with morphogen turnover and transport to explore routes to pa

296 Vector transport of morphogens was identified as a fundamental requirement t

297 leds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell

298 in-growing thalamic axons, which secrete the morphogen Wingless-related MMTV (mouse mammary tumor vir

299 cadherins Fat and Dachsous, organized by the morphogens Wingless and Decapentaplegic, suppress Warts

300 As a secreted morphogen with diverse functions, Fgf8 expression is lik